P. Floersheim

发表

Chiral resolution, pharmacological characterization, and receptor docking of the noncompetitive mGlu1 receptor antagonist (+/-)-2-hydroxyimino- 1a, 2-dihydro-1H-7-oxacyclopropa[b]naphthalene-7a-carboxylic acid ethyl ester.

F. Gasparini, E. Francotte, P. Flor, 2000, Journal of medicinal chemistry.

The Non-competitive Antagonists 2-Methyl-6-(phenylethynyl)pyridine and 7-Hydroxyiminocyclopropan[b]chromen-1a-carboxylic Acid Ethyl Ester Interact with Overlapping Binding Pockets in the Transmembrane Region of Group I Metabotropic Glutamate Receptors*

F. Gasparini, L. Prézeau, I. Vranesic, 2000, The Journal of Biological Chemistry.

Discovery and characterization of non-competitive antagonists of group I metabotropic glutamate receptors.

F. Gasparini, I. Vranesic, P. Flor, 2001, Farmaco.

6-Amino quinazolinedione sulfonamides as orally active competitive AMPA receptor antagonists.

S. Urwyler, W. Froestl, K. Lingenhoehl, 2012, Bioorganic & medicinal chemistry letters.

Estrogen receptor modulators: identification and structure-activity relationships of potent ERalpha-selective tetrahydroisoquinoline ligands.

B. Fournier, J. Renaud, C. Halleux, 2003, Journal of medicinal chemistry.

Experience with comparative molecular field analysis

H. Weber, P. Floersheim, J. Nozulak, 1993 .

Toward selective ERbeta agonists for central nervous system disorders: synthesis and characterization of aryl benzthiophenes.

U. Schopfer, P. Schoeffter, S. Bischoff, 2002, Journal of medicinal chemistry.

Cholinesterase Inhibitors: An Overview of their Mechanisms of Action

A. Enz, P. Floersheim, 1997 .

Selective estrogen receptor modulators with conformationally restricted side chains. Synthesis and structure-activity relationship of ERalpha-selective tetrahydroisoquinoline ligands.

M. Geiser, B. Fournier, J. Renaud, 2005, Journal of medicinal chemistry.

(+)-cis-4,5,7a,8,9,10,11,11a-octahydro-7H-10-methylindolo[1,7- bc][2,6]-naphthyridine: a 5-HT2C/2B receptor antagonist with low 5-HT2A receptor affinity.

P. Schoeffter, P. Floersheim, J. Nozulak, 1995, Journal of medicinal chemistry.

Isosterism and Bioisosterism Case Studies with Muscarinic Agonists

P. Floersheim, E. Pombo-Villar, G. Shapiro, 1992, CHIMIA.

Enantiomeric separation of chiral sulphoxides : screening of cellulose-based sorbents with particular reference to cellulose tribenzoate

V. Loux, P. Floersheim, E. Küsters, 1994 .

2,6-Naphthyridines as potent and selective inhibitors of the novel protein kinase C isozymes.

G. Rummel, S. Cowan-Jacob, E. Vangrevelinghe, 2011, Bioorganic & medicinal chemistry letters.

Pierre Acklin, Edgar Jacoby, Ansgar Schuffenhauer, 2003, J. Chem. Inf. Comput. Sci..

Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptors.

W. Froestl, K. Kaupmann, P. Floersheim, 2007, Bioorganic & medicinal chemistry letters.

SAR of the arylpiperazine moiety of obeline somatostatin sst1 receptor antagonists.

D. Hoyer, T. Troxler, A. Enz, 2007, Bioorganic & medicinal chemistry letters.

Inhibition of cyclosporin-resistant B-cell antigen responses by pyrazoles: a tool for the identification of novel molecular mechanisms of B-cell activation.

M. Zurini, M. Schreier, R. Albert, 2001, Transplantation proceedings.

Pyrazole bioisosteres of leflunomide as B-cell immunosuppressants for xenotransplantation and chronic rejection: scope and limitations.

M. Schreier, H. Weber, M. Lemaire, 1998, Journal of medicinal chemistry.

Muscarinic activity of the thiolactone, lactam, lactol, and thiolactol analogues of pilocarpine and a hypothetical model for the binding of agonists to the m1 receptor.

G Bolliger, M. Walkinshaw, R. Amstutz., 1992, Journal of medicinal chemistry.

Hydrophilicity of proteins and DNA

M. Walkinshaw, P. Floersheim, 1990 .

Bisvertinols: a new group of dimeric vertinoids from verticillium intertextum

D. Rast, L. Trifonov, H. Hilpert, 1986 .

Generation and comparison of space-filling molecular models

Mario Marsili, Philipp Floersheim, Andre S. Dreiding, 1983, Comput. Chem..

NMR reporter screening for the detection of high-affinity ligands.

W. Jahnke, C. Ostermeier, R. Hemmig, 2002, Angewandte Chemie.

Chemogenomics knowledge-based strategies in drug discovery.

Edgar Jacoby, Ansgar Schuffenhauer, Philipp Floersheim, 2003, Drug news & perspectives.

2,6-Naphthyridines as potent and selective inhibitors of the novel protein kinase C isozymes.

G. Rummel, S. Cowan-Jacob, E. Vangrevelinghe, 2011, Bioorganic & medicinal chemistry letters.