J. Tizzano

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Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine.

D. Schoepp, T. Large, M. Baez, 2003, Journal of medicinal chemistry.

Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase.

D. Schoepp, D. Lodge, T. Howe, 1996, Journal of medicinal chemistry.

Design, synthesis, and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): a potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxiolytic properties.

D. Schoepp, T. Howe, S. M. Massey, 1997, Journal of medicinal chemistry.

2-substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioavailability.

P. Ornstein, D. Schoepp, D D Schoepp, 1998, Journal of medicinal chemistry.

Synthesis of the Four Isomers of 4‐Aminopyrrolidine‐2,4‐dicarboxylate: Identification of a Potent, Highly Selective, and Systemically‐Active Agonist for Metabotropic Glutamate Receptors Negatively Coupled to Adenylate Cyclase.

D. Schoepp, D. Lodge, T. Howe, 1996 .

Preclinical Evaluation of the Abuse Potential of the Analgesic Bicifadine

P. Skolnick, K. Nicholson, A. Basile, 2009, Journal of Pharmacology and Experimental Therapeutics.

Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors.

J. Grutsch, D. Schoepp, J. Wepsiec, 1999, Journal of medicinal chemistry.

Receptor Subtypes Linked to Metabotropic Glutamate Receptor Agonist‐Mediated Limbic Seizures in Mice

D. Schoepp, J. Tizzano, K. Griffey, 1995, Annals of the New York Academy of Sciences.

Induction or protection of limbic seizures in mice by mGluR subtype selective agonists

D. Schoepp, J. Tizzano, K. Griffey, 1995, Neuropharmacology.

Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors.

D. Schoepp, J. Tizzano, J. Monn, 1998, The Journal of pharmacology and experimental therapeutics.

In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonist LY404039 in animal models of psychiatric disorders

K. Perry, D. McKinzie, J. Witkin, 2007, Psychopharmacology.

Developmental toxicity of the dopamine agonist pergolide mesylate in CD-1 mice. II: Perinatal and postnatal exposure.

J. Tizzano, I. Cohen, J. Buelke-Sam, 1991, Neurotoxicology and teratology.

Dipeptides as effective prodrugs of the unnatural amino acid (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740), a selective group II metabotropic glutamate receptor agonist.

M. Clay, T. Lindstrom, D. Schoepp, 2005, Journal of medicinal chemistry.

Developmental toxicity of the dopamine agonist pergolide mesylate in CD-1 mice. I: Gestational exposure.

J. Tizzano, J. Buelke-Sam, N. Owen, 1991, Neurotoxicology and teratology.

Developmental toxicity of gemcitabine, an antimetabolite oncolytic, administered during gestation to CD-1 mice.

J. Tizzano, G. Todd, G. Higdon, 1993, Teratology.

Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s)

E. Nisenbaum, D. McKinzie, D. Schoepp, 2005, Psychopharmacology.

Selective protection against AMPA- and kainate-evoked neurotoxicity by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisoquinoline-3-carboxylic acid (LY293558) and its racemate (LY215490)

P. Ornstein, P. May, D. Schoepp, 2005, Journal of Neural Transmission.

Progressive Retinal Toxicity in Neonatal Rats Treated with D, L-2-amino-3-phosphonopropionate (D,L-AP3)

R. L. Hall, A. Fix, J. Tizzano, 1995, Veterinary pathology.

Antidepressant-like actions of an AMPA receptor potentiator (LY392098)

P. Skolnick, M. Clay, T. Lindstrom, 2001, Neuropharmacology.

In vitro and in vivo antagonism of AMPA receptor activation by (3s,4ar,6r,8ar)-6-[2-(1(2)h-tetrazole-5-yl)ethyl]decahydroisoquinoline-3-carboxylic acid

P. Ornstein, D. Schoepp, D. Bleakman, 1995, Neuropharmacology.

Design, Synthesis, and Pharmacological Characterization of (+)-2- Aminobicyclo(3.1.0)hexane-2,6-dicarboxylic Acid (LY354740): A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvulsant and Anxiolytic Properties.

D. Schoepp, T. Howe, S. M. Massey, 1997 .

Blockade of the second messenger functions of the glutamate metabotropic receptor is associated with degenerative changes in the retina and brain of immature rodents

J. Olney, C. Romano, J. Tizzano, 1995, Neuropharmacology.

(2S,1'S,2'R,3'R)-2-(2'-Carboxy-3'-hydroxymethylcyclopropyl) glycine is a highly potent group 2 and 3 metabotropic glutamate receptor agonist with oral activity.

D. Schoepp, C. Pedregal, J. Pérez-Castells, 2004, Journal of medicinal chemistry.

Preclinical and clinical pharmacology of DOV 216,303, a "triple" reuptake inhibitor.

P. Czobor, P. Skolnick, P. Popik, 2006, CNS drug reviews.

Inhibition of group I metabotropic glutamate receptor responses in vivo in rats by a new generation of carboxyphenylglycine-like amino acid antagonists

D. Schoepp, B. Clark, J. Tizzano, 2002, Neuroscience Letters.

The Triple Uptake Inhibitor (1R,5S)-(+)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0] Hexane Hydrochloride (DOV 21947) Reduces Body Weight and Plasma Triglycerides in Rodent Models of Diet-Induced Obesity

M. Tschöp, P. Skolnick, L. Shearman, 2008, Journal of Pharmacology and Experimental Therapeutics.

LY354740: a metabotropic glutamate receptor agonist which ameliorates symptoms of nicotine withdrawal in rats

D. Schoepp, J. Tizzano, J. Monn, 1997, Neuropharmacology.

The anxiolytic action of mGlu2/3 receptor agonist, LY354740, in the fear-potentiated startle model in rats is mechanistically distinct from diazepam

D. Schoepp, J. Tizzano, K. Griffey, 2002, Pharmacology Biochemistry and Behavior.

Intracerebral 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) produces limbic seizures that are not blocked by ionotropic glutamate receptor antagonists

D. Schoepp, A. Fix, J. Tizzano, 1993, Neuroscience Letters.

Neonatal exposure to D,L-2-amino-3-phosphonopropionate (D,L-AP3) produces lesions in the eye and optic nerve of adult rats.

J. Olney, D. Schoepp, J. Tizzano, 1993, Brain research. Developmental brain research.

(3SR,4aRS,6SR,8aRS)-6-(1H-tetrazol-5-yl)decahydroisoquinoline-3-carboxylic acid, a novel, competitive, systemically active NMDA and AMPA receptor antagonist.

P. Ornstein, D. Schoepp, D. Lodge, 1995, Journal of medicinal chemistry.

Some effects of pimozide on nondeprived rats' lever pressing maintained by a sucrose reward in an anhedonia paradigm

S. Fowler, S. Gramling, J. Tizzano, 1987, Pharmacology Biochemistry and Behavior.

Biarylpropylsulfonamides as novel, potent potentiators of 2-amino-3- (5-methyl-3-hydroxyisoxazol-4-yl)- propanoic acid (AMPA) receptors.

P. Ornstein, D. Bleakman, B. Cantrell, 2000, Journal of medicinal chemistry.

Preclinical Evaluation of the Abuse Potential of the Analgesic Bicifadine

P. Skolnick, K. Nicholson, A. Basile, 2009, Journal of Pharmacology and Experimental Therapeutics.

Nicotine withdrawal: a behavioral assessment using schedule controlled responding, locomotor activity, and sensorimotor reactivity

K. Rasmussen, J. Tizzano, D. Helton, 2005, Psychopharmacology.