Mizuki Watanabe

发表

Cyclopropane-based stereochemical diversity-oriented conformational restriction strategy: histamine H3 and/or H4 receptor ligands with the 2,3-methanobutane backbone.

T. Hirokawa, S. Shuto, S. Yamada, 2012, Organic & biomolecular chemistry.

Investigation of the bioactive conformation of histamine H3 receptor antagonists by the cyclopropylic strain-based conformational restriction strategy.

T. Hirokawa, S. Shuto, S. Yamada, 2010, Journal of medicinal chemistry.

Conformational Restriction of Histamine with a Rigid Bicyclo[3.1.0]hexane Scaffold Provided Selective H3 Receptor Ligands

S. Shuto, S. Yamada, Yoshihiko Ito, 2020, Molecules.

A macrocyclic peptide library with a structurally constrained cyclopropane-containing building block leads to thiol-independent inhibitors of phosphoglycerate mutase.

S. Shuto, James Inglese, H. Suga, 2020, Chemistry, an Asian journal.

Tracing protein evolution through ancestral structures of fish galectin.

T. Shirai, T. Ogawa, Ayumu Konno, 2011, Structure.

Oxytocin Dynamics in the Body and Brain Regulated by the Receptor for Advanced Glycation End-Products, CD38, CD157, and Nicotinamide Riboside

S. Shuto, Zhongyu Liu, H. Higashida, 2022, Frontiers in Neuroscience.

Resolvin E1, but not resolvins E2 and E3, promotes fMLF‐induced ROS generation in human neutrophils

S. Shuto, Hiroyuki Ikeda, H. Fukuda, 2018, FEBS letters.

Design and Synthesis of Cyclopropane Congeners of Resolvin E3, an Endogenous Pro-Resolving Lipid Mediator, as Its Stable Equivalents.

S. Shuto, Tsugumichi Saito, H. Aoki-Saito, 2022, The Journal of organic chemistry.

Synthesis of Resolvin E3, a Proresolving Lipid Mediator, and Its Deoxy Derivatives: Identification of 18-Deoxy-resolvin E3 as a Potent Anti-inflammatory Agent.

S. Shuto, T. Matsuda, H. Aoki-Saito, 2020, The Journal of organic chemistry.

Design and Synthesis of Benzene Congeners of Resolvin E2, a Proresolving Lipid Mediator, as Its Stable Equivalents.

S. Shuto, T. Matsuda, H. Fukuda, 2020, ACS medicinal chemistry letters.

Synthesis of a series of 3,4-methanoarginines as side-chain conformationally restricted analogues of arginine.

S. Shuto, R. Silverman, K. Yamaguchi, 2011, Bioorganic & medicinal chemistry.

Design and synthesis of cyclopropane-based conformationally restricted GABA analogues as selective inhibitors for betaine/GABA transporter 1.

S. Shuto, H. Fukuda, Mizuki Watanabe, 2018, Bioorganic & medicinal chemistry letters.

Nutrient-Based Chemical Library as a Source of Energy Metabolism Modulators.

H. Waldmann, M. Uesugi, Shin-ichi Sato, 2019, ACS chemical biology.

Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP.

M. Uesugi, Shin-ichi Sato, K. Nagasawa, 2017, Cell chemical biology.

Synthesis of Resolvin E1 and Its Conformationally Restricted Cyclopropane Congeners with Potent Anti-Inflammatory Effect.

S. Shuto, T. Matsuda, H. Fukuda, 2021, ACS medicinal chemistry letters.

Synthetic molecules that protect cells from anoikis and their use in cell transplantation.

N. Koizumi, M. Uesugi, Shin-ichi Sato, 2014, Angewandte Chemie.

Determination of Eicosapentaenoic, Docosahexaenoic, and Arachidonic Acids in Human Plasma by High-Performance Liquid Chromatography with Electrochemical Detection

A. Kotani, H. Hakamata, F. Kusu, 2016, Analytical Sciences.

Preparation of chiral bromomethylenecyclopropane and its use in Suzuki-Miyaura coupling: synthesis of the arylmethyl-(Z)-cyclopropane structure core.

S. Shuto, H. Fukuda, M. Tanabe, 2013, The Journal of organic chemistry.

Synthesis of 8-Substituted Analogues of Cyclic ADP-4-Thioribose and Their Unexpected Identification as Ca2+-Mobilizing Full Agonists.

S. Shuto, T. Kameda, H. Fukuda, 2017, Journal of medicinal chemistry.

Galectins in the abdominal cavity of the conger eel Conger myriaster participate in the cellular encapsulation of parasitic nematodes by host cells.

T. Ogawa, K. Ogawa, K. Muramoto, 2012, Fish & shellfish immunology.

Design, Synthesis, and Identification of 4″α-Azidoethyl-cyclic ADP-Carbocyclic-ribose as a Highly Potent Analogue of Cyclic ADP-Ribose, a Ca(2+)-Mobilizing Second Messenger.

S. Shuto, T. Kameda, H. Fukuda, 2016, Journal of medicinal chemistry.

Design, synthesis, and structural characterization of helix-forming aliphatic homo-δ-peptides based on conformational restriction due to the structural characteristics of cyclopropane

S. Shuto, T. Kameda, K. Takeuchi, 2021 .

Synthesis of Enantiomerically Pure 1,2,3-Trisubstituted Cyclopropane Nucleosides Using Pd-Catalyzed Substitution via Directing Group-Mediated C(sp3)-H Activation as a Key Step.

S. Shuto, H. Fukuda, Mizuki Watanabe, 2019, Organic Letters.

Cyclopropane-Based Peptidomimetics Mimicking Wide-Ranging Secondary Structures of Peptides: Conformational Analysis and Their Use in Rational Ligand Optimization.

S. Shuto, S. Yamada, T. Kameda, 2017, Chemistry.

Three-dimensional structural diversity-oriented peptidomimetics based on the cyclopropylic strain.

S. Shuto, S. Yamada, Y. Kogami, 2013, Organic letters.

Stereochemical diversity-oriented conformational restriction strategy. Development of potent histamine H3 and/or H4 receptor antagonists with an imidazolylcyclopropane structure.

S. Shuto, A. Matsuda, S. Yamada, 2006, Journal of medicinal chemistry.

Synthesis of Chiral cis-Cyclopropane Bearing Indole and Chromone as Potential TNFα Inhibitors.

S. Shuto, T. Matsuda, H. Fukuda, 2018, The Journal of organic chemistry.

Molecular Determinants and Pharmacological Analysis for a Class of Competitive Non-transported Bicyclic Inhibitors of the Betaine/GABA Transporter BGT1

S. Shuto, G. Ecker, P. Wellendorph, 2021, Frontiers in Chemistry.

Design and synthesis of histamine H3/H4 receptor ligands with a cyclopropane scaffold.

S. Shuto, S. Yamada, H. Fukuda, 2018, Bioorganic & medicinal chemistry letters.

Synthesis and structural and pharmacological properties of cyclopropane-based conformationally restricted analogs of 4-methylhistamine as histamine H3/H4 receptor ligands.

S. Shuto, S. Yamada, Yoshihiro Ito, 2010, Bioorganic & medicinal chemistry.

Diversified Carbohydrate-Binding Lectins from Marine Resources

Tomohisa Ogawa, T. Ogawa, T. Naganuma, 2011, Journal of amino acids.

Development of a Highly Potent Analogue and a Long-Acting Analogue of Oxytocin for the Treatment of Social Impairment-Like Behaviors.

S. Shuto, Yasuhiko Yamamoto, N. Mano, 2019, Journal of medicinal chemistry.

Allosteric Regulation of the Carbohydrate-binding Ability of a Novel Conger Eel Galectin by d-Mannoside

T. Ogawa, K. Muramoto, O. Nakamura, 2012, The Journal of Biological Chemistry.

Small-molecule inhibitors of SREBP activation – potential for new treatment of metabolic disorders

M. Uesugi, Mizuki Watanabe, 2013 .

Live-cell imaging of endogenous mRNAs with a small molecule.

Shin-ichi Sato, M. Uesugi, Shin-ichi Sato, 2015, Angewandte Chemie.

Live-cell imaging of multiple endogenous mRNAs permits the direct observation of RNA granule dynamics.

M. Uesugi, Shin-ichi Sato, Y. Katsuda, 2018, Chemical communications.

Synthesis of mevalonate- and fluorinated mevalonate prodrugs and their in vitro human plasma stability.

V. Nizet, T. Leyh, R. Silverman, 2015, European journal of medicinal chemistry.

Synthesis of oxytocin derivatives lipidated via a carbonate or carbamate linkage as a long-acting therapeutic agent for social impairment-like behaviors.

S. Shuto, H. Fukuda, H. Higashida, 2019, Bioorganic & medicinal chemistry.

Delivering mRNA to Secondary Lymphoid Tissues by Phosphatidylserine‐Loaded Lipid Nanoparticles

Hiroki Tanaka, H. Akita, H. Hatakeyama, 2022, Advanced healthcare materials.

Structure, solubility, and permeability relationships in a diverse middle molecule library.

S. Shuto, A. Matsuda, Takashi Tadokoro, 2021, Bioorganic & medicinal chemistry letters.

Design and Synthesis of Cyclopropane Congeners of Resolvin E3, an Endogenous Pro-Resolving Lipid Mediator, as Its Stable Equivalents.

S. Shuto, Tsugumichi Saito, H. Fukuda, 2022, The Journal of organic chemistry.

Design, Synthesis, and Identification of 4″α-Azidoethyl-cyclic ADP-Carbocyclic-ribose as a Highly Potent Analogue of Cyclic ADP-Ribose, a Ca(2+)-Mobilizing Second Messenger.

S. Shuto, T. Kameda, H. Fukuda, 2016, Journal of medicinal chemistry.

Three-dimensional structural diversity-oriented peptidomimetics based on the cyclopropylic strain.

S. Shuto, S. Yamada, Y. Kogami, 2013, Organic letters.