T. Berkhout

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CCR2B receptor antagonists: conversion of a weak HTS hit to a potent lead compound.

I. Forbes, P. Groot, R. Ife, 2000, Bioorganic & Medicinal Chemistry Letters.

The Transmembrane CXC-Chemokine Ligand 16 Is Induced by IFN-γ and TNF-α and Shed by the Activity of the Disintegrin-Like Metalloproteinase ADAM10 1

S. Rose-John, D. Hartmann, P. Saftig, 2004, The Journal of Immunology.

Disintegrin-Like Metalloproteinase ADAM 10 and Shed by the Activity of the α and TNF-γ Ligand 16 Is Induced by IFN-The Transmembrane CXC-Chemokine Saftig

S. Rose-John, D. Hartmann, P. Saftig, 2004 .

The effect of (-)-hydroxycitrate on the activity of the low-density-lipoprotein receptor and 3-hydroxy-3-methylglutaryl-CoA reductase levels in the human hepatoma cell line Hep G2.

L. Havekes, P. Groot, T. Berkhout, 1990, The Biochemical journal.

Cloning, in Vitro Expression, and Functional Characterization of a Novel Human CC Chemokine of the Monocyte Chemotactic Protein (MCP) Family (MCP-4) That Binds and Signals through the CC Chemokine Receptor 2B*

H. Sarau, J. Foley, N. Elshourbagy, 1997, The Journal of Biological Chemistry.

SR-12813 lowers plasma cholesterol in beagle dogs by decreasing cholesterol biosynthesis.

K. Suckling, P. Groot, E. Niesor, 1997, Atherosclerosis.

The role of ATP citrate-lyase in the metabolic regulation of plasma lipids. Hypolipidaemic effects of SB-204990, a lactone prodrug of the potent ATP citrate-lyase inhibitor SB-201076.

D. Tew, H. Boyd, A. Shaw, 1998, The Biochemical journal.

Induction of cytochrome P4503A by the antiglucocorticoid mifepristone and a novel hypocholesterolaemic drug.

G. Hawksworth, R. Chenery, J. A. Williams, 1997, Drug metabolism and disposition: the biological fate of chemicals.

Fractalkine Is Expressed by Smooth Muscle Cells in Response to IFN-γ and TNF-α and Is Modulated by Metalloproteinase Activity1

P. Groot, A. Ludwig, K. Moores, 2002, The Journal of Immunology.

The lipid binding site of the phosphatidylcholine transfer protein from bovine liver.

K. Wirtz, R. Demel, D. van Loon, 1985, Chemistry and physics of lipids.

The Novel Cholesterol-lowering Drug SR-12813 Inhibits Cholesterol Synthesis via an Increased Degradation of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase*

K. Suckling, D. Patel, E. Niesor, 1996, The Journal of Biological Chemistry.

Identification of a truncated form of the CC chemokine CK beta-8 demonstrating greatly enhanced biological activity.

J. White, C. Imburgia, J. Fornwald, 1998, Journal of immunology.

The role of fractalkine in the recruitment of monocytes to the endothelium.

P. Green, K. Moores, T. Berkhout, 2000, European journal of pharmacology.

Labeling of phospholipids in vesicles and human erythrocytes by photoactivable fatty acid derivatives.

K. Wirtz, A. van Amerongen, T. Berkhout, 1984, European journal of biochemistry.

Conformationally restricted indolopiperidine derivatives as potent CCR2B receptor antagonists.

I. Forbes, P. Groot, R. Ife, 2001, Bioorganic & medicinal chemistry letters.

Preferential lipid association and mode of penetration of apocytochrome c in mixed model membranes as monitored by tryptophanyl fluorescence quenching using brominated phospholipids.

B. de Kruijff, A. Rietveld, T. Berkhout, 1987, Biochimica et biophysica acta.

CCR2: characterization of the antagonist binding site from a combined receptor modeling/mutagenesis approach.

I. Forbes, F. Blaney, A. Bridges, 2003, Journal of medicinal chemistry.

Effects of a novel lanosterol 14 alpha-demethylase inhibitor on the regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in Hep G2 cells.

R. Mayer, J. Adams, T. Berkhout, 1991, The Journal of biological chemistry.

Identification of the lipid-binding site of phosphatidylcholine-transfer protein with phosphatidylcholine analogs containing photoactivable carbene precursors.

H. Khorana, K. Wirtz, R. Radhakrishnan, 1983, European journal of biochemistry.

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.

F. Fahrenholz, S. Rose-John, D. Hartmann, 2003, Blood.

Preferential association of apocytochrome c with negatively charged phospholipids in mixed model membranes.

B. de Kruijff, D. Marsh, A. Rietveld, 1986, Biochimica et biophysica acta.

Static and time-resolved fluorescence studies of fluorescent phosphatidylcholine bound to the phosphatidylcholine transfer protein of bovine liver.

K. Wirtz, A. Visser, T. Berkhout, 1984, Biochemistry.

Interaction of the Mitochondrial Precursor Protein Apocytochrome C with Modelmembranes and its Implications for Protein Translocation

D. Marsh, R. Demel, A. Rietveld, 1988 .

CX3CL1-mediated cell-cell adhesion constitutive cleavage of CX3CL1 (fractalkine) and regulates The disintegrin-like metalloproteinase ADAM10 is involved in

F. Fahrenholz, P. Saftig, R. Postina, 2013 .

Selective binding of the truncated form of the chemokine CKbeta8 (25-99) to CC chemokine receptor 1(CCR1).

J. White, P. Groot, K. Moores, 2000, Biochemical pharmacology.

Regulation of the activity of phosphatidylcholine transfer protein by vesicle phosphatidic acid and membrane curvature: a fluorescence study using 2-parinaroylphosphatidylcholine

K. Wirtz, B. Kruijff, T. Berkhout, 1984 .

Fractalkine is expressed by smooth muscle cells in response to IFN-gamma and TNF-alpha and is modulated by metalloproteinase activity.

P. Groot, A. Ludwig, K. Moores, 2002, Journal of immunology.

Separation of immunomodulatory and cholesterol-lowering activities of heterocyclic azaspiranes.

A. Badger, P. Bugelski, A. Organ, 1995, The Journal of pharmacology and experimental therapeutics.

CX 3 CL 1-mediated cell-cell adhesion constitutive cleavage of CX 3 CL 1 ( fractalkine ) and regulates The disintegrin-like metalloproteinase ADAM 10

F. Fahrenholz, D. Hartmann, P. Saftig, 2003 .