K. Carlson

发表

Discovery of N-isoxazolyl biphenylsulfonamides as potent dual angiotensin II and endothelin A receptor antagonists.

Natesan Murugesan, S. Chong, J. Barrish, 2002, Journal of medicinal chemistry.

Dual angiotensin II and endothelin A receptor antagonists: synthesis of 2'-substituted N-3-isoxazolyl biphenylsulfonamides with improved potency and pharmacokinetics.

W. Humphreys, J. Macor, M. Kowala, 2005, Journal of medicinal chemistry.

Sodium salicylate inhibits TNF-&agr;-induced NF-κB activation, cell migration, invasion and ICAM-1 expression in human melanoma cells

J. Haycock, P. Lorigan, Yifan Yang, 2006, Melanoma research.

Discovery and Characterization of a Potent Interleukin-6 Binding Peptide with Neutralizing Activity In Vivo

J. Masferrer, M. Smythe, Courtney M. Shea, 2015, PloS one.

An exploratory, randomised, placebo-controlled, 14 day trial of the soluble guanylate cyclase stimulator praliciguat in participants with type 2 diabetes and hypertension

M. Currie, A. Michelson, A. L. Frelinger, 2019, Diabetologia.

Effects of the Soluble Guanylate Cyclase Stimulator Praliciguat in Diabetic Kidney Disease: A Randomized Placebo-Controlled Clinical Trial.

I. D. de Boer, G. Bakris, M. Currie, 2020, Clinical journal of the American Society of Nephrology : CJASN.

Cannabinoid receptor antagonist-induced striated muscle toxicity and ethylmalonic-adipic aciduria in beagle dogs.

O. Flint, N. Araníbar, J. Charlap, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

The melanocortin MC1 receptor agonist BMS‐470539 inhibits leucocyte trafficking in the inflamed vasculature

G. Leoni, M. Perretti, S. Nourshargh, 2010, British journal of pharmacology.

Different HMGCR-inhibiting statins vary in their association with increased survival in patients with COVID-19

Rani K. Powers, D. Ingber, M. Sirota, 2022, medRxiv.

Thrombin and phorbol esters cause the selective phosphorylation of a G protein other than Gi in human platelets.

L. Brass, D. Manning, K. Carlson, 1989, The Journal of biological chemistry.

Self-assembling short immunostimulatory duplex RNAs with broad-spectrum antiviral activity

D. Ingber, S. Gygi, Dong Yang, 2022, Molecular therapy. Nucleic acids.

G protein–coupled receptor modulation with pepducins: moving closer to the clinic

T. Schwartz, G. Milligan, T. Sakmar, 2011, Annals of the New York Academy of Sciences.

PIKfyve-specific inhibitors restrict replication of multiple coronaviruses in vitro but not in a murine model of COVID-19

D. Ingber, M. DePamphilis, A. Chakraborty, 2022, Communications Biology.

Self-assembling short immunostimulatory duplex RNAs with broad-spectrum antiviral activity

D. Ingber, S. Gygi, Dong Yang, 2022, Molecular therapy. Nucleic acids.

Characterization of a novel and selective CB1 antagonist as a radioligand for receptor occupancy studies.

K. Behnia, N. Murugesan, Z. Gu, 2011, Bioorganic & medicinal chemistry letters.

Pepducins: lipopeptide allosteric modulators of GPCR signaling.

T. McMurry, K. Carlson, Stephen W. Hunt, 2012, Drug discovery today. Technologies.

Selective Phosphorylation of a G Protein within Permeabilized and Intact Platelets Caused by Activators of Protein Kinase C

L. Brass, D. Manning, K. Carlson, 1990 .

Discovery of pyrazine carboxamide CB1 antagonists: the introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy of the series.

Ying Wang, Samuel W Gerritz, William R Ewing, 2007, Bioorganic & medicinal chemistry letters.

Immobilized α-melanocyte stimulating hormone 10–13 (GKPV) inhibits tumor necrosis factor-α stimulated NF-κB activity

J. Haycock, A. Moir, Y. Yang, 2006, Peptides.

Discovery of tyrosine-based potent and selective melanocortin-1 receptor small-molecule agonists with anti-inflammatory properties.

J. Tokarski, J. Macor, A. Khanna, 2003, Journal of medicinal chemistry.

Discovery of 4'-[(imidazol-1-yl)methyl]biphenyl-2-sulfonamides as dual endothelin/angiotensin II receptor antagonists.

J. Macor, M. Kowala, M. Valentine, 2003, Bioorganic & medicinal chemistry letters.

Reductions in log P improved protein binding and clearance predictions enabling the prospective design of cannabinoid receptor (CB1) antagonists with desired pharmacokinetic properties.

K. Behnia, N. Murugesan, Z. Gu, 2013, Journal of medicinal chemistry.

A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics

Rani K. Powers, D. Ingber, S. Gygi, 2021, Nature Biomedical Engineering.

Chemoattractant-stimulated GTPase activity is decreased on membranes from polymorphonuclear leukocytes incubated in chemoattractant.

S. Zigmond, D. Manning, K. Carlson, 1989, The Journal of biological chemistry.

Human organ chip-enabled pipeline to rapidly repurpose therapeutics during viral pandemics

Kohei Oishi, Donald E. Ingber, Rani K. Powers, 2020, bioRxiv.

A selective small molecule agonist of the melanocortin‐1 receptor inhibits lipopolysaccharide‐induced cytokine accumulation and leukocyte infiltration in mice

J. Haycock, K. McIntyre, J. Macor, 2006, Journal of leukocyte biology.

Fractionation of the beta subunit common to guanine nucleotide-binding regulatory proteins with the cytoskeleton.

M. Woolkalís, D. Manning, K. Carlson, 1986, Molecular pharmacology.

Selective retrograde axonal transport of free glycine in identified neurons ofAplysia

C. H. Price, E. Aizenman, K. Carlson, 1984, Cellular and Molecular Neurobiology.

Novel Dual Action AT1 and ETA Receptor Antagonists Reduce Blood Pressure in Experimental Hypertension

J. Barrish, J. Macor, M. Kowala, 2004, Journal of Pharmacology and Experimental Therapeutics.

Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein

J. Benovic, M. Bouvier, V. Lukashova, 2013, Proceedings of the National Academy of Sciences.

Direct interaction between an allosteric agonist pepducin and the chemokine receptor CXCR4.

Pallavi Sachdev, Tom W Muir, Christoph Seibert, 2011, Journal of the American Chemical Society.

Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients

Rani K. Powers, D. Ingber, M. Sirota, 2023, PLoS computational biology.

Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells

Pallavi Sachdev, T. Sakmar, M. Kazmi, 2010, Proceedings of the National Academy of Sciences.

Pertussis toxin modifies the characteristics of both the inhibitory GTP binding proteins and the somatostatin receptor in anterior pituitary tumor cells.

N. Mahy, M. Woolkalís, K. Thermos, 1988, The Journal of pharmacology and experimental therapeutics.

Cannabinoid receptor antagonist-induced striated muscle toxicity and ethylmalonic-adipic aciduria in beagle dogs.

Julieta M. Panzica-Kelly, O. Flint, N. Araníbar, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Cannabinoid CB(1) receptor ligand binding and function examined through mutagenesis studies of F200 and S383.

W. R. Ewing, M. Pelleymounter, Qi Huang, 2011, European journal of pharmacology.