T. Josephs

发表

Negative allosteric modulators of the human calcium‐sensing receptor bind to overlapping and distinct sites within the 7‐transmembrane domain

C. Langmead, K. Gregory, I. Kufareva, 2019, British journal of pharmacology.

Fasting-induced adipose factor identified as a key adipokine that is up-regulated in white adipose tissue during pregnancy and lactation in the rat.

D. Grattan, Hayley S. Waugh, T. Josephs, 2007, The Journal of endocrinology.

Interspecies Variation in the Functional Consequences of Mutation of Cytochrome c

I. Morison, E. Ledgerwood, T. Josephs, 2015, PloS one.

Therapeutic Opportunities of Targeting Allosteric Binding Sites on the Calcium-Sensing Receptor.

K. Gregory, J. Bourke, K. Leach, 2021, ACS pharmacology & translational science.

Enhancing the peroxidase activity of cytochrome c by mutation of residue 41: implications for the peroxidase mechanism and cytochrome c release.

C. Day, I. Morison, E. Ledgerwood, 2014, The Biochemical journal.

International Union of Basic and Clinical Pharmacology. CVIII. Calcium-Sensing Receptor Nomenclature, Pharmacology, and Function

R. Thakker, R. Mason, D. Ward, 2020, Pharmacological Reviews.

Broad CD8+ T cell cross-recognition of distinct influenza A strains in humans

L. Loh, E. B. Clemens, K. Kedzierska, 2018, Nature Communications.

A T Cell Receptor Locus Harbors a Malaria‐Specific Immune Response Gene

J. Rossjohn, S. Gras, K. Ladell, 2017, Immunity.

Reversed T cell receptor docking on a Major Histocompatibility Class I complex within the naïve T cell repertoire limits involvement in the immune response

N. Gruta, J. Rossjohn, S. Gras, 2018 .

Reversed T Cell Receptor Docking on a Major Histocompatibility Class I Complex Limits Involvement in the Immune Response.

Kylie M. Quinn, J. Rossjohn, S. Gras, 2016, Immunity.

Molecular basis for universal HLA-A*0201–restricted CD8+ T-cell immunity against influenza viruses

P. Doherty, S. Tong, G. Wang, 2016, Proceedings of the National Academy of Sciences.

HIV-1–Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection

J. Carlson, J. Rossjohn, S. Gras, 2016, The Journal of Immunology.

Epitope length variants balance protective immune responses and viral escape in HIV-1 infection

P. van Endert, S. Tenzer, H. Schild, 2022, Cell reports.

Lack of Heterologous Cross-reactivity toward HLA-A*02:01 Restricted Viral Epitopes Is Underpinned by Distinct αβT Cell Receptor Signatures*

M. Hellard, K. Kedzierska, J. Rossjohn, 2016, The Journal of Biological Chemistry.

A structural basis for amylin receptor phenotype

P. Sexton, A. Christopoulos, R. Danev, 2022, Science.

Structure and dynamics of the CGRP receptor in apo and peptide-bound forms

K. Gregory, P. Sexton, A. Christopoulos, 2021, Science.

Identification of Global and Ligand-Specific Calcium Sensing Receptor Activation Mechanisms

K. Gregory, A. Christopoulos, I. Kufareva, 2018, Molecular Pharmacology.

Development of AC265347‐Inspired Calcium‐Sensing Receptor Ago‐Positive Allosteric Modulators

K. Gregory, K. Leach, B. Capuano, 2021, ChemMedChem.

Conformational change and human cytochrome c function: mutation of residue 41 modulates caspase activation and destabilizes Met-80 coordination

Sigurd M. Wilbanks, M. Liptak, Kara L. Bren, 2013, JBIC Journal of Biological Inorganic Chemistry.

Molecular challenges imposed by MHC-I restricted long epitopes on T cell immunity

S. Gras, T. Josephs, E. Grant, 2017, Biological chemistry.