R. Gogliotti

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Unique Signaling Profiles of Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Determine Differences in In Vivo Activity

F. Dudek, K. Gregory, Z. Xiang, 2013, Biological Psychiatry.

Discovery and characterization of a novel series of N-phenylsulfonyl-1H-pyrrole picolinamides as positive allosteric modulators of the metabotropic glutamate receptor 4 (mGlu4).

Anna L. Blobaum, C. Lindsley, C. Hopkins, 2016, Bioorganic & medicinal chemistry letters.

The human immunodeficiency virus type 1 (HIV-1) nucleocapsid protein zinc ejection activity of disulfide benzamides and benzisothiazolones: correlation with anti-HIV and virucidal activities

J. Domagala, D. Hupe, Y. Song, 1997, Antimicrobial agents and chemotherapy.

High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein–Protein Interaction

Craig W. Lindsley, Shaun R. Stauffer, Jolanta Grembecka, 2014, Journal of medicinal chemistry.

Discovery and Structure-Based optimization of potent and selective WDR5 inhibitors containing a dihydroisoquinolinone bicyclic core

S. Fesik, R. Coffey, J. Sai, 2020 .

A new class of anti-HIV-1 agents targeted toward the nucleocapsid protein NCp7: the 2,2'-dithiobisbenzamides.

J. Domagala, D. Hupe, R. Schultz, 1997, Bioorganic & medicinal chemistry.

The in vitro ejection of zinc from human immunodeficiency virus (HIV) type 1 nucleocapsid protein by disulfide benzamides with cellular anti-HIV activity.

J. Domagala, D. Hupe, P. Harvey, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Discovery, Synthesis, SAR Development of a Series of N -4-(2,5-dioxopyrrolidin-1-yl)-phenylpicolinamides (VU0400195, ML182): Characterization of a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu 4 ) with Oral Efficacy in an anti-Parkinsonian Animal Model

Colleen, Y. Smith, C. Lindsley, 2011 .

Biotransformation of a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Contributes to Seizure-Like Adverse Events in Rats Involving a Receptor Agonism-Dependent Mechanism

Z. Xiang, C. Lindsley, P. Conn, 2013, Drug Metabolism and Disposition.

Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor.

Brian A. Chauder, Bruce J. Melancon, D. Sheffler, 2012, Bioorganic & medicinal chemistry letters.

Eliciting Renal Failure in Mosquitoes with a Small-Molecule Inhibitor of Inward-Rectifying Potassium Channels

C. Hopkins, K. Lovell, K. Beyenbach, 2013, PloS one.

Biophysical characterization of zinc ejection from HIV nucleocapsid protein by anti-HIV 2,2'-dithiobis[benzamides] and benzisothiazolones.

M. Reily, J. Loo, T. Holler, 1996, Journal of medicinal chemistry.

2,2′-dithiobisbenzamides derived from α-, β- and γ-amino acids possessing anti-HIV activities: synthesis and structure–activity relationship

D. P. Mack, W. J. Turner, J. Domagala, 1998 .

Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide (ML254).

K. Gregory, J. Meiler, Z. Xiang, 2013, Journal of medicinal chemistry.

The Synthesis of a Series of 7-Amino-1-cyclopropyl-8-fluoro-1,4- dihydro-4-oxo-1,6-naphthyridine-3-carboxylic Acids as Potential Antibacterial Agents.

R. Gogliotti, J. P. Sanchez, 1994 .

The synthesis of a series of 7-amino-1-cyclopropyl-8-fluoro-1,4-dihydro-4-oxo-1,6-naphthyridine-3-carboxylic acids as potential antibacterial agents

J. Sánchez, R. Gogliotti, J. P. Sanchez, 1993 .

Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design.

E. Olejniczak, S. Fesik, O. Rossanese, 2018, Journal of medicinal chemistry.

Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkins

Anna L. Blobaum, Y. Smith, S. Jadhav, 2011, Journal of medicinal chemistry.

The synthesis, structure-activity, and structure-side effect relationships of a series of 8-alkoxy- and 5-amino-8-alkoxyquinolone antibacterial agents.

M. Cohen, J. Domagala, S. Gracheck, 1995, Journal of medicinal chemistry.

Discovery, Synthesis, and Preclinical Characterization of N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4).

Anna L. Blobaum, J. Macor, C. Lindsley, 2016, ACS chemical neuroscience.

Inhibitors of HIV Nucleocapsid Protein Zinc Fingers as Candidates for the Treatment of AIDS

L. Arthur, J. Domagala, J. Supko, 1995, Science.

New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk.

S. Hagen, J. Domagala, M. Shapiro, 1992, Journal of medicinal chemistry.

Discovery, Characterization, and Structure–Activity Relationships of an Inhibitor of Inward Rectifier Potassium (Kir) Channels with Preference for Kir2.3, Kir3.X, and Kir7.1

C. Lindsley, C. Hopkins, C. Weaver, 2011, Front. Pharmacol..

Discovery and Structure-Based Optimization of Potent and Selective WD repeat domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core.

S. Fesik, R. Coffey, M. Inoue, 2019, Journal of medicinal chemistry.

Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity

S. Fesik, M. Hall, Qi Liu, 2019, Cell reports.

Fragment-Based Discovery of Small Molecules Bound to T-Cell Immunoglobulin and Mucin Domain-Containing Molecule 3 (TIM-3).

S. Fesik, Taekyu Lee, R. Gogliotti, 2021, Journal of medicinal chemistry.

Progress towards small molecule menin-mixed lineage leukemia (MLL) interaction inhibitors with in vivo utility.

C. Lindsley, T. Cierpicki, J. Grembecka, 2015, Bioorganic & medicinal chemistry letters.

A fragment‐based approach to discovery of Receptor for Advanced Glycation End products inhibitors

A. Waterson, W. Chazin, R. Gogliotti, 2021, Proteins: Structure, Function, and Bioinformatics.

Inhibition of the early phase of HIV replication by an isothiazolone, PD 161374.

J. Domagala, S. Gracheck, R. Gogliotti, 2001, Antiviral research.

A fragment‐based approach to discovery of Receptor for Advanced Glycation End products inhibitors

A. Waterson, W. Chazin, R. Gogliotti, 2021, Proteins.

Quinolone antibacterials: preparation and activity of bridged bicyclic analogues of the C7-piperazine.

J. Kiely, R. Gogliotti, M. P. Hutt, 1991, Journal of Medicinal Chemistry.

Quinolone Antibacterials: Preparation and Activity of Bridged Bicyclic Analogues of the C7‐Piperazine.

J. Kiely, R. Gogliotti, M. P. Hutt, 1991 .

C. Lindsley, P. Conn, C. Niswender, 2013 .