David A. Carcache

发表

Benzimidazoles as Potent and Orally Active mGlu5 Receptor Antagonists with an Improved PK Profile.

M. Fendt, I. Vranesic, S. Desrayaud, 2011, ACS medicinal chemistry letters.

6-Amino quinazolinedione sulfonamides as orally active competitive AMPA receptor antagonists.

S. Urwyler, W. Froestl, K. Lingenhoehl, 2012, Bioorganic & medicinal chemistry letters.

A new class of inhibitors for the malarial aspartic protease plasmepsin II based on a central 11-azatricyclo[6.2.1.02,7]undeca-2,4,6-triene scaffold

F. Diederich, H. Märki, A. Dorn, 2003 .

Development of a New Class of Inhibitors for the Malarial Aspartic Protease Plasmepsin II Based on a Central 7‐Azabicyclo[2.2.1]heptane Scaffold

F. Diederich, H. Märki, P. Seiler, 2003 .

Compound Property Optimization in Drug Discovery Using Quantitative Surface Sampling Micro Liquid Chromatography with Tandem Mass Spectrometry.

K. Mansfield, S. Hintermann, Adam Bentley, 2016, Analytical chemistry.

Total synthesis of (+/-)-jiadifenin and studies directed to understanding its SAR: probing mechanistic and stereochemical issues in palladium-mediated allylation of enolate-like structures.

S. Danishefsky, Y. Cho, Yue-Ming Li, 2006, Journal of the American Chemical Society.

Total synthesis of (+/-)-jiadifenin, a non-peptidyl neurotrophic modulator.

S. Danishefsky, Y. Cho, Yue-Ming Li, 2004, Journal of the American Chemical Society.

Design and Synthesis of Selurampanel, a Novel Orally Active and Competitive AMPA Receptor Antagonist

A. Picard, S. Urwyler, K. Lingenhoehl, 2017, ChemMedChem.

Malonylation/Decarbalkoxylation of Furan Derivatives as Key Steps for the Preparation of Nonactic Acid Derivatives. Part I [1]

P. Bobál, Jean-Mary Simone, R. Neier, 2007 .

Optimizing a Weakly Binding Fragment into a Potent RORγt Inverse Agonist with Efficacy in an in Vivo Inflammation Model.

S. Hintermann, R. Wolf, A. Vulpetti, 2018, Journal of medicinal chemistry.

Metabolism and Disposition of the Metabotropic Glutamate Receptor 5 Antagonist (mGluR5) Mavoglurant (AFQ056) in Healthy Subjects

Yi Jin, Thierry Wolf, Matthias Kittelmann, 2013, Drug Metabolism and Disposition.

alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonists: from bench to bedside.

David A. Carcache, H. Mattes, M. Koller, 2010, Journal of medicinal chemistry.

The synthesis and preliminary biological evaluation of a novel steroid with neurotrophic activity: NGA0187.

S. Danishefsky, Yue-Ming Li, David A. Carcache, 2005, The Journal of organic chemistry.

Quinazolinedione sulfonamides: a novel class of competitive AMPA receptor antagonists with oral activity.

Y. Auberson, I. Vranesic, S. Urwyler, 2011, Bioorganic & medicinal chemistry letters.

De Novo Design, Synthesis, and In Vitro Evaluation of a New Class of Nonpeptidic Inhibitors of the Malarial Enzyme Plasmepsin II

F. Diederich, H. Märki, A. Dorn, 2002, Chembiochem : a European journal of chemical biology.

Synthesis and Biological Evaluation of New Triazolo‐ and Imidazolopyridine RORγt Inverse Agonists

S. Hintermann, A. Vulpetti, K. Kaupmann, 2016, ChemMedChem.

Metabolism and Disposition of the Metabotropic Glutamate Receptor 5 Antagonist ( mGluR 5 ) Mavoglurant ( AFQ 056 ) in Healthy Subjects

R. Woessner, L. Leuthold, A. Chakraborty, 2013 .

Radical Couplings as Key Steps for the Preparation of Derivatives of Nonactic Acid

P. Bobál, Jean-Mary Simone, R. Neier, 2007 .

Discovery of 1H-pyrrolo[2,3-c]pyridine-7-carboxamides as novel, allosteric mGluR5 antagonists.

P. Ertl, I. Vranesic, G. Laue, 2012, Bioorganic & medicinal chemistry letters.