A. Khilevich

发表

N-(4-((2-(trifluoromethyl)-3-hydroxy-4-(isobutyryl)phenoxy)methyl)benzyl)-1-methyl-1H-imidazole-4-carboxamide (THIIC), a Novel Metabotropic Glutamate 2 Potentiator with Potential Anxiolytic/Antidepressant Properties: In Vivo Profiling Suggests a Link between Behavioral and Central Nervous System Neu

G. Marek, K. Perry, J. Witkin, 2011, Journal of Pharmacology and Experimental Therapeutics.

In vitro anti-human immunodeficiency virus (HIV) activity of the chromanone derivative, 12-oxocalanolide A, a novel NNRTI.

D. Zembower, R. Buckheit, A. Khilevich, 1998, Bioorganic & medicinal chemistry letters.

A Versatile Approach for Synthesis of 2,3-Dimethyl Chroman-4-ones, Intermediate for Calanolide Anti-HIV Agents, VIA Aldol/Mitsunobu Reactions

A. Khilevich, Lin Lin, M. Flavin, 1996 .

Novel approach for synthesis of (±)-calanolide a and its anti-HIV activity

A. Khilevich, M. Flavin, J. Rizzo, 1995 .

Novel bicyclo[3.1.0]hexane analogs as antagonists of metabotropic glutamate 2/3 receptors for the treatment of depression.

J. F. Soriano, P. Ornstein, M. Blanco, 2016, Bioorganic & medicinal chemistry letters.

Activation of metabotropic glutamate (mGlu)2 receptors suppresses histamine release in limbic brain regions following acute ketamine challenge

K. Perry, K. Svensson, J. Katner, 2010, Neuropharmacology.

Synthesis, chromatographic resolution, and anti-human immunodeficiency virus activity of (+/-)-calanolide A and its enantiomers.

S. Hughes, J. Pezzuto, T. Pengsuparp, 1996, Journal of medicinal chemistry.

In vivo anti-HIV activity of (+)-calanolide A in the hollow fiber mouse model.

M. Hollingshead, S. Borgel, A. Khilevich, 1999, Bioorganic & medicinal chemistry letters.

Synthesis of dual 14C-labeled (+)-calanolide A, a naturally occurring anti-HIV agent

A. Khilevich, M. Flavin, J. Rizzo, 1997 .

Synthesis of (+)-calanolide A, an anti-HIV agent, Via enzyme-catalyzed resolution of the aldol products

Wei Chen, D. Zembower, S. Liao, 1996 .

Synthesis, Chromatographic Resolution, and Anti‐Human Immunodeficiency Virus Activity of (.+‐.)‐Calanolide A and Its Enantiomers.

Wei Chen, S. Hughes, J. Pezzuto, 1996 .

Structural analogues of the calanolide anti-HIV agents. Modification of the trans-10,11-dimethyldihydropyran-12-ol ring (ring C).

D. Zembower, R. Buckheit, S. Liao, 1997, Journal of medicinal chemistry.

Effects of substitution on 9-(3-bromo-4-fluorophenyl)-5,9-dihydro-3H,4H-2,6-dioxa-4- azacyclopenta[b]naphthalene-1,8-dione, a dihydropyridine ATP-sensitive potassium channel opener.

R. Henry, M. Gopalakrishnan, M. Kort, 2006, Journal of medicinal chemistry.

Structural analogues of the calanolide anti-HIV agents. Modification of the trans-10,11-dimethyldihydropyran-12-ol ring (ring C).

D. Zembower, R. Buckheit, S. Liao, 1997, Journal of medicinal chemistry.

Discovery of the First α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8.

D. Bredt, G. Stephenson, P. Ornstein, 2016, Journal of medicinal chemistry.

N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine.

J. Sullivan, M. Nakane, M. Williams, 2002, Journal of medicinal chemistry.

Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache.

Kirk W. Johnson, M. Blanco, D. Benesh, 2017, Bioorganic & medicinal chemistry letters.

Discovery of the First α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8.

D. Bredt, P. Ornstein, J. Witkin, 2016, Journal of medicinal chemistry.

Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist.

J. Sullivan, M. Nakane, J. Kuk, 2004, Journal of medicinal chemistry.