B. Johnson

发表

Use of MGLUR2 and MGLUR3 knockout mice to explore in vivo receptor specificity of the MGLUR2/3 selective antagonist LY341495

D. Schoepp, E. Korpi, A. Linden, 2009, Neuropharmacology.

Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase.

D. Schoepp, D. Lodge, T. Howe, 1996, Journal of medicinal chemistry.

Design, synthesis, and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): a potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxiolytic properties.

D. Schoepp, T. Howe, S. M. Massey, 1997, Journal of medicinal chemistry.

LY354740 is a Potent and Highly Selective Group II Metabotropic Glutamate Receptor Agonist in Cells Expressing Human Glutamate Receptors

D. Schoepp, D. Bleakman, J. Monn, 1997, Neuropharmacology.

Increased anxiety-related behavior in mice deficient for metabotropic glutamate 8 (mGlu8) receptor

D. Schoepp, M. Baez, A. Linden, 2002, Neuropharmacology.

2-substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioavailability.

P. Ornstein, D. Schoepp, D D Schoepp, 1998, Journal of medicinal chemistry.

Selective inhibition of forskolin-stimulated cyclic AMP formation in rat hippocampus by a novel mGluR agonist, 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate

D. Schoepp, D. D. Schoepp, B. G. Johnson, 1995, Neuropharmacology.

The Novel Metabotropic Glutamate Receptor Agonist 2R,4R-APDC Potentiates Stimulation of Phosphoinositide Hydrolysis in the Rat Hippocampus by 3,5-dihydroxyphenylglycine: Evidence for a Synergistic Interaction Between Group 1 and Group 2 Receptors

D. Schoepp, J. Monn, B. Johnson, 1996, Neuropharmacology.

(2S,4S)-2-amino-4-(4,4-diphenylbut-1-yl)- pentane-1,5-dioic acid: a potent and selective antagonist for metabotropic glutamate receptors negatively linked to adenylate cyclase.

C. Wermuth, A. Mann, D. Schoepp, 1996, Journal of medicinal chemistry.

Neuromodulatory effect of the atrial natriuretic factor clearance receptor binding peptide, cANF(4-23)-NH2 in rabbit isolated vasa deferentia.

B. Johnson, J. Drewett, G. Trachte, 1991, The Journal of pharmacology and experimental therapeutics.

The Rapidly Acting Antidepressant Ketamine and the mGlu2/3 Receptor Antagonist LY341495 Rapidly Engage Dopaminergic Mood Circuits

S. Mitchell, J. Witkin, D. Schoepp, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Sigma opioid receptor: characterization and co-identity with the phencyclidine receptor.

B. Johnson, L. Mendelsohn, G. Kerchner, 1985, The Journal of pharmacology and experimental therapeutics.

Synthesis and metabotropic glutamate receptor antagonist activity of N1-substituted analogs of 2R,4R-4-aminopyrrolidine-2,4-dicarboxylic acid.

D. Schoepp, J. Monn, A. Kingston, 1998, Bioorganic & medicinal chemistry letters.

Discovery of a potent, peripherally selective trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonist for the treatment of gastrointestinal motility disorders.

J. Gidda, D. Schoepp, B. Cantrell, 1994, Journal of medicinal chemistry.

Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors.

J. Grutsch, D. Schoepp, J. Wepsiec, 1999, Journal of medicinal chemistry.

3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity.

D. Wong, C. Mitch, A. Takemori, 1993, Journal of medicinal chemistry.

2,3'-disubstituted-2-(2'-carboxycyclopropyl)glycines as potent and selective antagonists of metabotropic glutamate receptors.

D. Schoepp, C. Pedregal, A. Mazon, 1998, Bioorganic & medicinal chemistry letters.

Stereoselectivity and mode of inhibition of phosphoinositide-coupled excitatory amino acid receptors by 2-amino-3-phosphonopropionic acid.

D. Schoepp, B. Johnson, E. C. Smith, 1990, Molecular pharmacology.

Comparison of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD)- and 1R,3S-ACPD-stimulated brain phosphoinositide hydrolysis.

D. Schoepp, J. Monn, B. Johnson, 1991, European journal of pharmacology.

2-Substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 1. Effects of alkyl, arylalkyl, and diarylalkyl substitution.

P. Ornstein, D. Schoepp, B. Johnson, 1998, Journal of medicinal chemistry.

(2S,4S)-amino-4-(2,2-diphenylethyl)pentanedioic acid selective group 2 metabotropic glutamate receptor antagonist.

D. Schoepp, C. Pedregal, B. Johnson, 1998, Bioorganic & medicinal chemistry letters.

Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells.

D. Schoepp, J. Arnold, S. Burgett, 1998, Brain research. Molecular brain research.

Preclinical predictors that the orthosteric mGlu2/3 receptor antagonist LY3020371 will not engender ketamine-associated neurotoxic, motor, cognitive, subjective, or abuse-liability-related effects

D. McKinzie, G. Gilmour, J. Witkin, 2017, Pharmacology Biochemistry and Behavior.

Contractile serotonin-2A receptor signal transduction in guinea pig trachea: importance of protein kinase C and extracellular and intracellular calcium but not phosphoinositide hydrolysis.

D. Cox, D. Schoepp, M. Cohen, 1994, The Journal of pharmacology and experimental therapeutics.

LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors

P. Ornstein, D. Schoepp, A. Kingston, 1998, Neuropharmacology.

Selective inhibition of excitatory amino acid-stimulated phosphoinositide hydrolysis in the rat hippocampus by activation of protein kinase C.

D. Schoepp, B. Johnson, Bryan G. Johnson, 1988, Biochemical pharmacology.

Evaluation of the activity of a novel metabotropic glutamate receptor antagonist (±)-2-amino-2-(3-cis and trans-carboxycyclobutyl-3-(9-thioxanthyl)propionic acid) in the in vitro neonatal spinal cord and in an in vivo pain model

E. Sher, D. Schoepp, B. Clark, 1999, Neuroscience.

Mediation of serotonin-induced analgesia by the 5HT2 receptor in the pentobarbital anesthetized mouse model

W. Banks, A. Kastin, T. Trentman, 1988, Brain Research Bulletin.

Excitatory amino acid-induced convulsions in neonatal rats mediated by distinct receptor subtypes.

P. Ornstein, D. Schoepp, B. Johnson, 1990, European journal of pharmacology.