A. Pähler

发表

Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases.

W. Guba, W. Spooren, J. Peters, 2015, Journal of medicinal chemistry.

In vivo and in vitro characterization of ethyl methanesulfonate pharmacokinetics in animals and in human.

T. Lavé, A. Pähler, H. Birnböck, 2009, Toxicology letters.

Rapid detection and identification of N-acetyl-L-cysteine thioethers using constant neutral loss and theoretical multiple reaction monitoring combined with enhanced product-ion scans on a linear ion trap mass spectrometer

W. Dekant, W. Völkel, K. Scholz, 2005, Journal of the American Society for Mass Spectrometry.

Gas chromatography-negative ion chemical ionization mass spectrometry as a powerful tool for the detection of mercapturic acids and DNA and protein adducts as biomarkers of exposure to halogenated olefins.

W. Dekant, W. Völkel, A. Pähler, 1999, Journal of chromatography. A.

Biotransformation of perchloroethene: dose-dependent excretion of trichloroacetic acid, dichloroacetic acid, and N-acetyl-S-(trichlorovinyl)-L-cysteine in rats and humans after inhalation.

E. Lederer, M. Friedewald, W. Dekant, 1998, Toxicology and applied pharmacology.

Ochratoxin A-induced tumor formation: is there a role of reactive ochratoxin A metabolites?

W. Dekant, U. Schauer, A. Pähler, 2001, Toxicological sciences : an official journal of the Society of Toxicology.

Biomarkers of Flutamide-Bioactivation and Oxidative Stress In Vitro and In Vivo

B. Ernst, F. Boess, A. Pähler, 2016, Drug Metabolism and Disposition.

Quantitative profiling of prostaglandins as oxidative stress biomarkers in vitro and in vivo by negative ion online solid phase extraction - Liquid chromatography-tandem mass spectrometry.

B. Ernst, C. Husser, M. Zell, 2016, Analytical biochemistry.

LC-MS/MS methods for the detection of isoprostanes (iPF2α-III and 8,12-iso-iPF2α-VI) as biomarkers of CCl4-induced oxidative damage to hepatic tissue

A. Mally, W. Völkel, U. Schauer, 2008 .

Glutathione conjugates of 4-hydroxy-2(E)-nonenal as biomarkers of hepatic oxidative stress-induced lipid peroxidation in rats.

A. Mally, W. Dekant, W. Völkel, 2005, Free radical biology & medicine.

Profiling of dalcetrapib metabolites in human plasma by accelerator mass spectrometry and investigation of the free phenothiol by derivatisation with methylacrylate

C. Husser, M. Zell, S. Schadt, 2018, Journal of pharmaceutical and biomedical analysis.

Discovery and Characterization of 2-Aminooxazolines as Highly Potent, Selective, and Orally Active TAAR1 Agonists.

S. Mohr, M. Hoener, D. Türck, 2016, ACS medicinal chemistry letters.

Post-acquisition analysis of untargeted accurate mass quadrupole time-of-flight MS(E) data for multiple collision-induced neutral losses and fragment ions of glutathione conjugates.

I. Zamora, Fabien Fontaine, A. Pähler, 2014, Rapid communications in mass spectrometry : RCM.

Metabolism and mass balance of SGLT2 inhibitor tofogliflozin following oral administration to humans

C. Husser, M. Zell, O. Kuhlmann, 2014, Xenobiotica; the fate of foreign compounds in biological systems.

Quantitation of N epsilon-(dichloroacetyl)-L-lysine in proteins after perchloroethene exposure by gas chromatography-mass spectrometry using chemical ionization and negative ion detection followingimmunoaffinity chromatography.

W. Dekant, W. Völkel, A. Pähler, 1999, Journal of chromatography. A.

Neoantigen formation and clastogenic action of HCFC-123 and perchloroethylene in human MCL-5 cells.

W. Dekant, I. White, M. Manno, 2001, Toxicology letters.

A targeted proteomics approach to the identification of peptides modified by reactive metabolites.

A. Pähler, M. Tzouros, 2009, Chemical research in toxicology.

Reactive Metabolite Assessment in Drug Discovery and Development in Support of Safe Drug Design

A. Pähler, 2018 .

Meeting report of the first European biotransformation workshop

M. Walles, A. Pähler, E. Isin, 2021, Xenobiotica; the fate of foreign compounds in biological systems.

Quantitation of Nϵ-(dichloroacetyl)-l-lysine in proteins after perchloroethene exposure by gas chromatography–mass spectrometry using chemical ionization and negative ion detection following immunoaffinity chromatography

W. Dekant, W. Völkel, A. Pähler, 1999 .

Application of lipid peroxidation products as biomarkers for flutamide-induced oxidative stress in vitro.

B. Ernst, A. Pähler, Marieke Teppner, 2015, Toxicology letters.

Increased brain levels of 4-hydroxy-2-nonenal glutathione conjugates in severe Alzheimer's disease

K. Jellinger, P. Riederer, F. Leblhuber, 2006, Neurochemistry International.

Software-aided cytochrome P450 reaction phenotyping and kinetic analysis in early drug discovery.

I. Zamora, Fabien Fontaine, A. Pähler, 2016, Rapid communications in mass spectrometry : RCM.

Computational toxicology in drug development.

Wolfgang Muster, Lutz Müller, Alexander Breidenbach, 2008, Drug discovery today.

In Vivo Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1 Analyzed by Ligand-Binding Mass Spectrometry Combined with Quantitation by ELISA.

C. Husser, M. Zell, S. Schadt, 2016, Analytical chemistry.

Biotransformation and male rat-specific renal toxicity of diethyl ethyl- and dimethyl methylphosphonate.

W. Dekant, A. Pähler, K. Blumbach, 2000, Toxicological sciences : an official journal of the Society of Toxicology.

Dose-dependent protein adduct formation in kidney, liver, and blood of rats and in human blood after perchloroethene inhalation.

W. Dekant, W Dekant, A. Pähler, 1999, Toxicological sciences : an official journal of the Society of Toxicology.

Binding of Hexachlorobutadiene to α2u-Globulin and Its Role in Nephrotoxicity in Rats

W. Dekant, A. Pähler, G. Birner, 1997 .

Metabolites in safety testing (MIST)

Simon Hauri, S. Schadt, A. Pähler, 2020 .

Software aided approaches to structure-based metabolite identification in drug discovery and development.

Axel Pähler, Andreas Brink, A. Pähler, 2013, Drug discovery today. Technologies.

Determination of dalcetrapib by liquid chromatography-tandem mass spectrometry.

K. Heinig, M. Zell, O. Kuhlmann, 2012, Journal of pharmaceutical and biomedical analysis.

Thiazolidinedione bioactivation: a comparison of the bioactivation potentials of troglitazone, rosiglitazone, and pioglitazone using stable isotope-labeled analogues and liquid chromatography tandem mass spectrometry.

T. Hartung, F. Montavon, A. Pähler, 2006, Chemical research in toxicology.

Sembragiline: A Novel, Selective Monoamine Oxidase Type B Inhibitor for the Treatment of Alzheimer’s Disease

J. Andersen, H. Loetscher, S. Nave, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Minimizing the risk of chemically reactive metabolite formation of new drug candidates: implications for preclinical drug design.

C. Funk, F. Schuler, S. Schadt, 2017, Drug discovery today.

Strategies for Using Computational Toxicology Methods in Pharmaceutical R&D

Wolfgang Muster, Lutz Müller, Alexander Breidenbach, 2006 .

Quantitation of α2u-Globulin in Rat Kidney Cytosol by Capillary Electrophoresis

W. Dekant, A. Pähler, K. Blumbach, 1999 .

Chapter 2 Drug-Induced Hepatotoxicity: Learning from Recent Cases of Drug Attrition

C. Funk, A. Pähler, 2008 .

Generation of antibodies to Di- and trichloroacetylated proteins and immunochemical detection of protein adducts in rats treated with perchloroethene.

W. Dekant, A. Pähler, G. Birner, 1998, Chemical Research in Toxicology.

Enhancing Throughput of Glutathione Adduct Formation Studies and Structural Identification Using a Software-Assisted Workflow Based on High-Resolution Mass Spectrometry (HRMS) Data

I. Zamora, Fabien Fontaine, A. Pähler, 2016 .