J. Hao

发表

Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator.

D. McKinzie, S. Iyengar, B. Clark, 2013, Bioorganic & medicinal chemistry letters.

In Vitro and In Vivo Correlation of Hepatic Fraction of Metabolism by P450 in Dogs.

M. Mohutsky, E. Hembre, Y. Hui, 2019, Journal of pharmaceutical sciences.

Biomimetic studies towards the C28–C40 polycyclic domain of the azaspiracids

C. Forsyth, J. Hao, J. Aiguadé, 2001 .

Synthesis and pharmacological characterization of 4-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: identification of new potent and selective metabotropic glutamate 2/3 receptor agonists.

G. Stephenson, D. McKinzie, M. Bures, 2013, Journal of medicinal chemistry.

On the origin of the 2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate scaffold's unique group II selectivity for the mGlu receptors.

J. Hao, Qi Chen, 2019, Bioorganic & medicinal chemistry letters.

Determination of L-AP4-bound human mGlu8 receptor amino terminal domain structure and the molecular basis for L-AP4's group III mGlu receptor functional potency and selectivity.

S. Atwell, J. Ho, J. Monn, 2018, Bioorganic & medicinal chemistry letters.

Absolute configuration of monodentate phosphine ligand enantiomers on Cu(111).

L. Wan, Q. Fan, C. Bai, 2004, Analytical chemistry.

Ensemble Docking Approach to Mitigate Pregnane X Receptor-Mediated CYP3A4 Induction Risk

E. Hembre, J. Rehmel, J. Hao, 2022, J. Chem. Inf. Model..

Chemistry and biology of diazonamide A: second total synthesis and biological investigations.

K. Nicolaou, P. Giannakakou, A. O'brate, 2004, Journal of the American Chemical Society.

Remarkably chemoselective indium-mediated coupling en route to the C21–C40 acyclic portion of the azaspiracids

C. Forsyth, J. Hao, J. Aiguadé, 2001 .

The second total synthesis of diazonamide A.

K. Nicolaou, S. Snyder, G. Rassias, 2003, Angewandte Chemie.

Synthesis of the (+)-C26–C40 Domain of the Azaspiracids by a Novel Double Intramolecular Hetero-Michael Addition Strategy†

C. Forsyth, J. Hao, J. Aiguadé, 2001 .

Application of the double intramolecular hetero-Michael addition (DIHMA) approach in spiroketal synthesis: total synthesis of (±)-(4S*,6S*)-4-hydroxy-1,7-dioxaspiro[5.5]undecane, a Dacus oleae olive fly pheromone

C. Forsyth, J. Hao, 2002 .

Remarkably Chemoselective Indium‐Mediated Coupling en Route to the C21—C40 Acyclic Portion of the Azaspiracids.

C. Forsyth, J. Hao, J. Aiguadé, 2001 .

Stereochemistry of pteriatoxins A, B, and C.

T. Iwashita, Y. Kishi, D. Uemura, 2006, Journal of the American Chemical Society.

Unified total synthesis of pteriatoxins and their diastereomers.

R. Peters, Y. Kishi, J. Hao, 2006, Journal of the American Chemical Society.

Total synthesis and stereochemistry of pinnatoxins B and C.

R. Reents, Y. Kishi, J. Hao, 2006, Organic letters.

Insights into the Structural Aspects of the mGlu Receptor Orthosteric Binding Site.

J. Hao, Qi Chen, 2019, Current topics in medicinal chemistry.

Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective

D. McKinzie, D. Clawson, S. Atwell, 2015, Journal of medicinal chemistry.

Synthesis and pharmacological characterization of C4-disubstituted analogs of 1S,2S,5R,6S-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: identification of a potent, selective metabotropic glutamate receptor agonist and determination of agonist-bound human mGlu2 and mGlu3 amino terminal domain struct

D. McKinzie, D. Clawson, S. Atwell, 2015, Journal of medicinal chemistry.

Development of a Scalable Synthesis of Mevidalen (LY3154207), an Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor

D. Richards, K. P. Cole, Ping Huang, 2020 .

Synthesis and Pharmacological Characterization of 2-(2,6-dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one (LY3154207), a potent, subtype selective, and orally available positive allosteric modulator of the human dopamine D1

G. Stephenson, Charles R. Yang, S. Mitchell, 2019, Journal of medicinal chemistry.

Enterohepatic circulation of glucuronide metabolites of drugs in dog

K. Cassidy, M. Mohutsky, G. Sawada, 2019, Pharmacology research & perspectives.

An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis

Todd R. Wiernicki, Charles R. Yang, T. Suter, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Positive allosteric modulators of the dopamine D1 receptor: A new mechanism for the treatment of neuropsychiatric disorders.

K. Svensson, J. Hao, R. F. Bruns, 2019, Advances in pharmacology.

The allosteric dopamine D1 receptor potentiator, DETQ, ameliorates subchronic phencyclidine-induced object recognition memory deficits and enhances cortical acetylcholine efflux in male humanized D1 receptor knock-in mice

H. Meltzer, K. Svensson, Mei Huang, 2019, Behavioural Brain Research.

Preclinical profile of a dopamine D1 potentiator suggests therapeutic utility in neurological and psychiatric disorders

Hong Wang, Charles R. Yang, M. O'Neill, 2018, Neuropharmacology.

Intracellular Binding Site for a Positive Allosteric Modulator of the Dopamine D1 Receptor

Charles R. Yang, Y. Qian, B. Heinz, 2018, Molecular Pharmacology.

Effects of DPTQ, a novel positive allosteric modulator of the dopamine D1 receptor, on spontaneous eye blink rate and spatial working memory in the nonhuman primate

Graham V. Williams, S. Castner, H. Marston, 2023, Psychopharmacology.

Synthesis and Preclinical Characterization of LY3154885, a Human Dopamine D1 Receptor Positive Allosteric Modulator with an Improved Nonclinical Drug-Drug Interaction Risk Profile.

M. Mohutsky, M. Posada, E. Hembre, 2022, Journal of medicinal chemistry.

Structural Basis for ( S)-3,4-Dicarboxyphenylglycine (DCPG) As a Potent and Subtype Selective Agonist of the mGlu8 Receptor.

S. Atwell, M. Bures, J. Ho, 2018, Journal of medicinal chemistry.

A concise review on hPXR ligand-recognizing residues and structure-based strategies to alleviate hPXR transactivation risk.

T. Liu, J. Hao, J. Beck, 2022, RSC medicinal chemistry.

Synthesis of a 2,9-dioxabicyclo[3.3.1]nonane via double intramolecular hetero-Michael addition: entry to the F-G ring system of the azaspiracids.

C. Forsyth, J. Hao, J. Hao, 2001, Organic letters.

Synthesis and Pharmacological Characterization of C4β-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 S,2 S,4 S,5 R,6 S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3 Receptor Agon

K. Adragni, D. McKinzie, D. Clawson, 2018, Journal of Medicinal Chemistry.