Khai Phan

发表

Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound A₂A adenosine receptor.

Fei Xu, Francesca Deflorian, Vsevolod Katritch, 2012, Journal of medicinal chemistry.

Structure-activity relationships of truncated C2- or C8-substituted adenosine derivatives as dual acting A₂A and A₃ adenosine receptor ligands.

K. Jacobson, Sun Choi, Zhang-Guo Gao, 2012, Journal of medicinal chemistry.

Modulation of G protein-coupled adenosine receptors by strategically functionalized agonists and antagonists immobilized on gold nanoparticles

Steven M. Moss, K. Jacobson, Zhang-Guo Gao, 2013, Purinergic Signalling.

Synthesis and Anti-Renal Fibrosis Activity of Conformationally Locked Truncated 2-Hexynyl-N6-Substituted-(N)-Methanocarba-nucleosides as A3 Adenosine Receptor Antagonists and Partial Agonists

Steven M. Moss, K. Jacobson, M. Cui, 2014, Journal of medicinal chemistry.

Novel fluorescent antagonist as a molecular probe in A(3) adenosine receptor binding assays using flow cytometry.

S. Moro, S. Federico, G. Spalluto, 2012, Biochemical pharmacology.

Regio- and stereoselective synthesis of truncated 3'-aminocarbanucleosides and their binding affinity at the A3 adenosine receptor.

K. Jacobson, W. J. Choi, L. Jeong, 2011, Organic & biomolecular chemistry.

Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening.

Ruben Abagyan, Fei Xu, Francesca Deflorian, 2012, Journal of medicinal chemistry.

Subtle Chemical Changes Cross the Boundary between Agonist and Antagonist: New A3 Adenosine Receptor Homology Models and Structural Network Analysis Can Predict This Boundary.

K. Jacobson, Sun Choi, Zhang-Guo Gao, 2021, Journal of Medicinal Chemistry.

Structure-guided design of A(3) adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions.

Francesca Deflorian, Kenneth A Jacobson, K. Jacobson, 2012, Journal of medicinal chemistry.

Limits of Ligand Selectivity from Docking to Models: In Silico Screening for A1 Adenosine Receptor Antagonists

Peter Kolb, Andrej Sali, Kenneth A. Jacobson, 2012, PloS one.

Anti-ischemic effects of multivalent dendrimeric A₃ adenosine receptor agonists in cultured cardiomyocytes and in the isolated rat heart.

K. Jacobson, Zhang-Guo Gao, D. Tosh, 2012, Pharmacological research.

Structural sweet spot for A1 adenosine receptor activation by truncated (N)-methanocarba nucleosides: receptor docking and potent anticonvulsant activity.

Steven M. Moss, K. Jacobson, F. Deflorian, 2012, Journal of medicinal chemistry.

Truncated (N)-Methanocarba Nucleosides as A(1) Adenosine Receptor Agonists and Partial Agonists: Overcoming Lack of a Recognition Element.

K. Jacobson, F. Deflorian, Zhang-Guo Gao, 2011, ACS medicinal chemistry letters.

Modulation of G protein-coupled adenosine receptors by strategically functionalized agonists and antagonists immobilized on gold nanoparticles

Steven M. Moss, K. Jacobson, Zhang-Guo Gao, 2013, Purinergic Signalling.

Truncated Nucleosides as A(3) Adenosine Receptor Ligands: Combined 2-Arylethynyl and Bicyclohexane Substitutions.

K. Jacobson, Zhang-Guo Gao, S. Paoletta, 2012, ACS medicinal chemistry letters.

Adenosine Receptor Agonists Using Structure-Based Ligand Design

R. Abagyan, R. Stevens, K. Jacobson, 2012 .

Structure-activity relationships and molecular modeling of 1,2,4-triazoles as adenosine receptor antagonists.

Jens Carlsson, Kenneth A Jacobson, K. Jacobson, 2012, ACS medicinal chemistry letters.

Click modification in the N6 region of A3 adenosine receptor-selective carbocyclic nucleosides for dendrimeric tethering that preserves pharmacophore recognition.

K. Jacobson, F. Deflorian, Zhang-Guo Gao, 2012, Bioconjugate chemistry.

Molecular probes for the A2A adenosine receptor based on a pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine scaffold.

K. Jacobson, F. Deflorian, Zhang-Guo Gao, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and Anti-Renal Fibrosis Activity of Conformationally Locked Truncated 2-Hexynyl-N6-Substituted-(N)-Methanocarba-nucleosides as A3 Adenosine Receptor Antagonists and Partial Agonists

Steven M. Moss, M. Cui, Sun Choi, 2014, Journal of Medicinal Chemistry.

Novel fluorescent antagonist as a molecular probe in A(3) adenosine receptor binding assays using flow cytometry.

S. Moro, S. Federico, G. Spalluto, 2012, Biochemical pharmacology.

Programmable Nanoscaffolds That Control Ligand Display to a G-Protein-Coupled Receptor in Membranes To Allow Dissection of Multivalent Effects

Steven M. Moss, S. Durell, K. Jacobson, 2014, Journal of the American Chemical Society.

Structure-guided design of A(3) adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions.

K. Jacobson, F. Deflorian, Zhang-Guo Gao, 2012, Journal of medicinal chemistry.