Z. Xiang

发表

Pharmacological characterization of 30 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists, synthetic agonists, and the endogenous agouti-related protein antagonist.

B. Proneth, C. Haskell-Luevano, M. Dirain, 2010, Biochemistry.

Peptide and small molecules rescue the functional activity and agonist potency of dysfunctional human melanocortin-4 receptor polymorphisms.

W. Millard, I. Pogozheva, H. Mosberg, 2007, Biochemistry.

Elongation studies of the human agouti-related protein (AGRP) core decapeptide (Yc[CRFFNAFC]Y) results in antagonism at the mouse melanocortin-3 receptor

W. Millard, C. Haskell-Luevano, Z. Xiang, 2003, Peptides.

Characterization of aliphatic, cyclic, and aromatic N-terminally "capped" His-D-Phe-Arg-Trp-NH2 tetrapeptides at the melanocortin receptors.

C. Haskell-Luevano, Z. Xiang, J. R. Holder, 2003, European journal of pharmacology.

Incorporation of a bioactive reverse-turn heterocycle into a peptide template using solid-phase synthesis to probe melanocortin receptor selectivity and ligand conformations by 2D 1H NMR.

A. Edison, C. Haskell-Luevano, M. Dirain, 2011, Journal of medicinal chemistry.

Urea small molecule agonists on mouse melanocortin receptors.

C. Haskell-Luevano, Z. Xiang, C. Joseph, 2003, Bioorganic & medicinal chemistry letters.

Discovery of a ligand that compensates for decreased endogenous agonist potency of melanocortin-4 receptor polymorphisms identified in obese humans.

W. Millard, I. Pogozheva, H. Mosberg, 2009, Advances in experimental medicine and biology.

Ac-Trp-DPhe(p-I)-Arg-Trp-NH2, a 250-Fold Selective Melanocortin-4 Receptor (MC4R) Antagonist over the Melanocortin-3 Receptor (MC3R), Affects Energy Homeostasis in Male and Female Mice Differently.

Cody J Lensing, Danielle Adank, C. Haskell-Luevano, 2016, ACS chemical neuroscience.

Structure-activity relationship and metabolic stability studies of backbone cyclization and N-methylation of melanocortin peptides.

C. Gilon, A. Hoffman, C. Haskell-Luevano, 2008, Biopolymers.

Chimeric NDP-MSH and MTII melanocortin peptides with agouti-related protein (AGRP) Arg-Phe-Phe amino acids possess agonist melanocortin receptor activity

C. Haskell-Luevano, Z. Xiang, A. Wilczynski, 2003, Peptides.

Modified melanocortin tetrapeptide Ac-His-dPhe-Arg-Trp-NH at the arginine side chain with ureas and thioureas.

Michael S. Wood, C. Haskell-Luevano, Z. Xiang, 2005, The journal of peptide research : official journal of the American Peptide Society.

Structural characterization and pharmacology of a potent (Cys101-Cys119, Cys110-Cys117) bicyclic agouti-related protein (AGRP) melanocortin receptor antagonist.

W. Millard, N. Richards, A. Edison, 2004, Journal of medicinal chemistry.

Implication of the melanocortin-3 receptor in the regulation of food intake.

W. Millard, D. Clegg, H. Yarandi, 2011, European journal of pharmacology.

A solid-phase approach to mouse melanocortin receptor agonists derived from a novel thioether cyclized peptidomimetic scaffold.

M. Meldal, C. Haskell-Luevano, Jon Bondebjerg, 2002, Journal of the American Chemical Society.

Structure-activity relationships of the melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH(2) at the mouse melanocortin receptors. 1. Modifications at the His position.

C. Haskell-Luevano, Z. Xiang, J. R. Holder, 2002, Journal of medicinal chemistry.

Prevalence of pathogenetic MC4R mutations in Italian children with early Onset obesity, tall stature and familial history of obesity

A. Salvatoni, L. Perrone, E. D. del Giudice, 2009, BMC Medical Genetics.

Aza‐scanning of the Potent Melanocortin Receptor Agonist Ac‐His‐d‐Phe‐Arg‐Trp‐NH2

Michael S. Wood, W. Lubell, C. Haskell-Luevano, 2006, Chemical biology & drug design.

Structure-Activity Relationship Studies (SAR) of Melanocortin Agonists Central His-Phe-Arg-Trp Sequence

C. Haskell-Luevano, Z. Xiang, J. R. Holder, 2001 .

Discovery of Molecular Interactions of the Human Melanocortin-4 Receptor (hMC4R) Asp189 (D189) Amino Acid with the Endogenous G-Protein-Coupled Receptor (GPCR) Antagonist Agouti-Related Protein (AGRP) Provides Insights to AGRP's Inverse Agonist Pharmacology at the hMC4R.

Mark D. Ericson, R. Speth, K. Freeman, 2021, ACS chemical neuroscience.

Structure-activity relationships of the melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH(2) at the mouse melanocortin receptors. 1. Modifications at the His position.

Zhimin Xiang, C. Haskell-Luevano, Carrie Haskell-Luevano, 2002, Journal of medicinal chemistry.

Semi-rigid tripeptide agonists of melanocortin receptors.

Z. Abdel‐Malek, J. Knittel, C. Haskell-Luevano, 2009, Bioorganic & medicinal chemistry letters.

Voluntary exercise prevents the obese and diabetic metabolic syndrome of the melanocortin‐4 receptor knockout mouse

W. Millard, H. Baker, Glenn A Walter, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The Melanocortin Pathway: Effects of Voluntary Exercise on the Melanocortin‐4 Receptor Knockout Mice and ACTH(1–24) Ligand Structure Activity Relationships at the Melanocortin‐2 Receptor

C. Haskell-Luevano, Z. Xiang, N. Sorenson, 2004, Endocrine research.

Identification of putative agouti-related protein(87-132)-melanocortin-4 receptor interactions by homology molecular modeling and validation using chimeric peptide ligands.

Andrzej Wilczynski, Zhimin Xiang, W. Millard, 2004, Journal of medicinal chemistry.

The 1,4-benzodiazepine-2,5-dione small molecule template results in melanocortin receptor agonists with nanomolar potencies.

C. Haskell-Luevano, Z. Xiang, N. Sorenson, 2008, Journal of medicinal chemistry.

Pharmacological characterization of 40 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists and the agouti-related protein (AGRP) antagonist.

Zhimin Xiang, Michael S. Wood, W. Millard, 2006, Biochemistry.

Backbone cyclic peptidomimetic melanocortin-4 receptor agonist as a novel orally administrated drug lead for treating obesity.

Zhimin Xiang, Chaim Gilon, Eli Safrai, 2008, Journal of medicinal chemistry.

Design and pharmacology of peptoids and peptide-peptoid hybrids based on the melanocortin agonists core tetrapeptide sequence.

C. Haskell-Luevano, Z. Xiang, J. R. Holder, 2003, Bioorganic & medicinal chemistry letters.

Discovery of a β-Hairpin Octapeptide, c[Pro-Arg-Phe-Phe-Dap-Ala-Phe-DPro], Mimetic of Agouti-Related Protein(87-132) [AGRP(87-132)] with Equipotent Mouse Melanocortin-4 Receptor (mMC4R) Antagonist Pharmacology.

Mark D. Ericson, C. Haskell-Luevano, Z. Xiang, 2015, Journal of medicinal chemistry.

Molecular Mechanism of the Constitutive Activation of the L250Q Human Melanocortin‐4 Receptor Polymorphism ‡

W. Millard, I. Pogozheva, H. Mosberg, 2006, Chemical biology & drug design.

Voluntary exercise delays monogenetic obesity and overcomes reproductive dysfunction of the melanocortin-4 receptor knockout mouse.

R. Mandel, C. Haskell-Luevano, Z. Xiang, 2005, Biochemical and biophysical research communications.

Comparative Functional Alanine Positional Scanning of the α-Melanocyte Stimulating Hormone and NDP-Melanocyte Stimulating Hormone Demonstrates Differential Structure-Activity Relationships at the Mouse Melanocortin Receptors.

Mark D. Ericson, Ryan Palusak, C. Haskell-Luevano, 2016, ACS chemical neuroscience.

Stereochemical studies of the monocyclic agouti-related protein (103-122) Arg-Phe-Phe residues: conversion of a melanocortin-4 receptor antagonist into an agonist and results in the discovery of a potent and selective melanocortin-1 agonist.

Zhimin Xiang, N. Richards, C. Haskell-Luevano, 2004, Journal of medicinal chemistry.

Structure–activity relationships of the melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH2 at the mouse melanocortin receptors Part 3: modifications at the Arg position

C. Haskell-Luevano, Z. Xiang, J. R. Holder, 2003, Peptides.

Structure-activity relationships of the melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH(2) at the mouse melanocortin receptors: part 2 modifications at the Phe position.

C. Haskell-Luevano, Z. Xiang, J. R. Holder, 2002, Journal of medicinal chemistry.

Voluntary exercise prevents the obese and diabetic metabolic syndrome of the melanocortin‐4 receptor knockout mouse

W. Millard, H. Baker, Glenn A Walter, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The 1,4-benzodiazepine-2,5-dione small molecule template results in melanocortin receptor agonists with nanomolar potencies.

Michael S. Wood, C. Haskell-Luevano, Z. Xiang, 2008, Journal of medicinal chemistry.