Xianling Ning

发表

A Novel Synthetic Precursor of Styryl Sulfone Neuroprotective Agents Inhibits Neuroinflammatory Responses and Oxidative Stress Damage through the P38 Signaling Pathway in the Cell and Animal Model of Parkinson’s Disease

Ying Guo, Junyi Liu, Zhi-zhong Ma, 2021, Molecules.

Neuroprotective effects of (E)-3,4-diacetoxystyryl sulfone and sulfoxide derivatives in vitro models of Parkinson's disease

Ying Guo, Junyi Liu, Xiaowei Wang, 2015, Journal of enzyme inhibition and medicinal chemistry.

Eg5 inhibitor YL001 induces mitotic arrest and inhibits tumor proliferation

Yufei Wang, Yuxin Yin, M. McNutt, 2017, Oncotarget.

Synthesis and neuroprotective evaluation of (E)-3,4-dihydroxystyryl p-substituted-phenethyl ketone derivatives against inflammatory and oxidative injury

Ying Guo, Junyi Liu, Xiaowei Wang, 2016, Medicinal Chemistry Research.

Identification of a new small molecule that initiates ferroptosis in cancer cells by inhibiting the system Xc- to deplete GSH.

Yuxin Yin, Zhiqiang Lin, Xianling Ning, 2022, European journal of pharmacology.

Discovery and structure-activity relationship of novel 4-hydroxy-thiazolidine-2-thione derivatives as tumor cell specific pyruvate kinase M2 activators.

Yuxin Yin, Xingyu Wu, Z. Ge, 2018, European journal of medicinal chemistry.

Discovery of 2,4-diarylaminopyrimidine derivatives bearing dithiocarbamate moiety as novel FAK inhibitors with antitumor and anti-angiogenesis activities.

Juntuo Zhou, Yuxin Yin, Yan Jin, 2019, European journal of medicinal chemistry.

New pyridin-3-ylmethyl carbamodithioic esters activate pyruvate kinase M2 and potential anticancer lead compounds.

Bin Liu, Yuxin Yin, Xingyu Wu, 2015, Bioorganic & medicinal chemistry.

Synthesis and neuroprotective effect of E-3,4-dihydroxy styryl aralkyl ketones derivatives against oxidative stress and inflammation.

Ying Guo, Junyi Liu, Zhi-zhong Ma, 2013, Bioorganic & medicinal chemistry letters.

Design, synthesis and pharmacological evaluation of (E)-3,4-dihydroxy styryl sulfonamides derivatives as multifunctional neuroprotective agents against oxidative and inflammatory injury.

Ying Guo, Junyi Liu, Zhi-zhong Ma, 2013, Bioorganic & medicinal chemistry.

Design, synthesis, and biological evaluation of (e)-3,4-dihydroxystyryl aralkyl sulfones and sulfoxides as novel multifunctional neuroprotective agents.

Ying Guo, Junyi Liu, Zhi-zhong Ma, 2014, Journal of medicinal chemistry.

Design, Synthesis and Biological Evaluation of Novel ( E )‐Hydroxystyryl Aralkyl Sulfones as Neuroprotective Agents

Ying Guo, Junyi Liu, Xiaowei Wang, 2020 .

Synthesis and anti-tumor efficacy of novel 2, 4-diarylaminopyrimidine derivatives bearing N-(3-pyridinylmethyl) urea moiety as anaplastic lymphoma kinase inhibitors.

Yuxin Yin, Yan Jin, Xuyang Zhao, 2019, European journal of medicinal chemistry.

Antrodia camphorata extract (ACE)-induced apoptosis is associated with BMP4 expression and p53-dependent ROS generation in human colon cancer cells.

Yuxin Yin, M. Ye, Xianling Ning, 2020, Journal of ethnopharmacology.

Synthesis and antitumor activity of novel 2, 3-didithiocarbamate substituted naphthoquinones as inhibitors of pyruvate kinase M2 isoform

M. McNutt, Y. Yin, Xianling Ning, 2017, Journal of enzyme inhibition and medicinal chemistry.

Discovery of novel naphthoquinone derivatives as inhibitors of the tumor cell specific M2 isoform of pyruvate kinase.

Yuxin Yin, M. McNutt, Yan Jin, 2017, European journal of medicinal chemistry.

Structure-activity relationship studies of (E)-3,4-dihydroxystyryl alkyl sulfones as novel neuroprotective agents based on improved antioxidant, anti-inflammatory activities and BBB permeability.

Ying Guo, Junyi Liu, Xiaowei Wang, 2019, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of novel dithiocarbamate-substituted diphenylaminopyrimidine derivatives as BTK inhibitors.

Yuxin Yin, Yan Jin, Xuyang Zhao, 2019, Bioorganic & medicinal chemistry.

Anti-cancer effect of a novel 2,3-didithiocarbamate-substituted naphthoquinone as a tumor metabolic suppressor in vitro and in vivo.

Yuxin Yin, Yan Jin, Junyi Liu, 2018, MedChemComm.

Succinylation-dependent mitochondrial translocation of PKM2 promotes cell survival in response to nutritional stress

Yuxin Yin, M. McNutt, Yan Jin, 2019, Cell Death & Disease.

Synthesis of novel sulfonamide derivatives containing pyridin-3-ylmethyl 4-(benzoyl)piperazine-1-carbodithioate moiety as potent PKM2 activators.

Yuxin Yin, Yue Su, Runtao Li, 2021, Bioorganic chemistry.

Design, synthesis and biological evaluation of (E)-3,4-dihydroxystyryl 4-acylaminophenethyl sulfone, sulfoxide derivatives as dual inhibitors of HIV-1 CCR5 and integrase.

Liying Ma, Junyi Liu, Xuefeng Sun, 2017, Bioorganic & medicinal chemistry.

Succinylation-dependent mitochondrial translocation of PKM2 promotes cell survival in response to nutritional stress

Yuxin Yin, M. McNutt, Yan Jin, 2019, Cell Death & Disease.

Discovery of a miniaturized PROTAC with potent activity and high selectivity.

Q. Zhang, Zhiqiang Lin, Xianling Ning, 2023, Bioorganic chemistry.

Synthesis and neuroprotective evaluation of (E)-3,4-dihydroxystyryl p-substituted-phenethyl ketone derivatives against inflammatory and oxidative injury

Ying Guo, Junyi Liu, Xiaowei Wang, 2016, Medicinal Chemistry Research.