L. Plum

发表

13,13-Dimethyl-des-C,D analogues of (20S)-1α,25-dihydroxy-2-methylene-19-norvitamin D₃ (2MD): total synthesis, docking to the VDR, and biological evaluation.

H. DeLuca, W. Sicinska, Katarzyna Plonska-Ocypa, 2011, Bioorganic & medicinal chemistry.

Retinoid-regulated gene expression in neural development.

M. Clagett-Dame, L. Plum, 1997, Critical reviews in eukaryotic gene expression.

Novel Superagonist Analogs of 2-Methylene Calcitriol: Design, Molecular Docking, Synthesis and Biological Evaluation

H. DeLuca, R. Sicinski, L. Plum, 2021, Bioorganic Chemistry.

Ring-A-seco analogs of 1α,25-dihydroxy-19-norvitamin D3

H. DeLuca, R. Sicinski, L. Plum, 2013, The Journal of Steroid Biochemistry and Molecular Biology.

Chapter 74 – Alterations in 1,25-Dihydroxyvitamin D3 Structure that Produce Profound Changes in in Vivo Activity

H. DeLuca, L. Plum, 2011 .

Identification of a unique subset of 2-methylene-19-nor analogs of vitamin D with comedolytic activity in the rhino mouse.

H. DeLuca, M. Clagett-Dame, L. Plum, 2010, The Journal of investigative dermatology.

New 1α,25-dihydroxy-19-norvitamin D3 analogs with a frozen A-ring conformation

H. DeLuca, R. Sicinski, L. Plum, 2010, The Journal of Steroid Biochemistry and Molecular Biology.

The Functional Metabolism and Molecular Biology of Vitamin D Action

H. DeLuca, L. Plum, Hector F. DeLuca, 2009 .

Synthesis and biological properties of 2-methylene-19-nor-25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactones--weak agonists.

H. DeLuca, G. Chiellini, M. Clagett-Dame, 2008, Bioorganic & medicinal chemistry.

An analog of 1α,25-dihydroxy-19-norvitamin D3 with the 1α-hydroxy group fixed in the axial position lacks biological activity in vitro

H. DeLuca, R. Sicinski, L. Plum, 2007, The Journal of Steroid Biochemistry and Molecular Biology.

2-Methylene analogs of 1α-hydroxy-19-norvitamin D3: synthesis, biological activities and docking to the ligand binding domain of the rat vitamin D receptor

H. DeLuca, W. Sicinska, J. Prahl, 2004, The Journal of Steroid Biochemistry and Molecular Biology.

2-Methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 Potently Stimulates Gene-specific DNA Binding of the Vitamin D Receptor in Osteoblasts*

H. DeLuca, J. Pike, Hironori Yamamoto, 2003, Journal of Biological Chemistry.

Vitamin D, disease and therapeutic opportunities

H. DeLuca, L. Plum, 2010, Nature Reviews Drug Discovery.

A New Vitamin D Analog, 2MD, Restores Trabecular and Cortical Bone Mass and Strength in Ovariectomized Rats With Established Osteopenia

H. DeLuca, H. Ke, M. Clagett-Dame, 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Pharmacokinetics of a New Oral Vitamin D Receptor Activator (2-Methylene-19-Nor-(20S)-1α,25-Dihydroxyvitamin D3) in Patients with Chronic Kidney Disease and Secondary Hyperparathyroidism on Hemodialysis

H. DeLuca, W. Bedale, D. Coyne, 2017, Drugs in R&D.

Effect of 2‐Methylene‐19‐nor‐(20S)‐1α‐Hydroxy‐Bishomopregnacalciferol (2MbisP), an Analog of Vitamin D, on Secondary Hyperparathyroidism

Alex J. Brown, H. DeLuca, E. Slatopolsky, 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

A Methylene Group on C-2 of 24,24-Difluoro-19-nor-1α,25-dihydroxyvitamin D3 Markedly Increases Bone Calcium Mobilization in Vivo.

H. DeLuca, J. Thoden, I. Massarelli, 2015, Journal of medicinal chemistry.

A 20S combined with a 22R configuration markedly increases both in vivo and in vitro biological activity of 1α,25-dihydroxy-22-methyl-2-methylene-19-norvitamin D3.

H. DeLuca, J. Thoden, M. Clagett-Dame, 2012, Journal of medicinal chemistry.

1,25-Dihydroxyvitamin D is not responsible for toxicity caused by vitamin D or 25-hydroxyvitamin D.

H. DeLuca, J. Prahl, L. Plum, 2011, Archives of biochemistry and biophysics.

Responsiveness of human retinoblastoma and neuroblastoma models to a non-calcemic 19-nor Vitamin D analog

M. Lindstrom, H. DeLuca, D. Albert, 2005, The Journal of Steroid Biochemistry and Molecular Biology.

2MD, a new anabolic agent for osteoporosis treatment

H. DeLuca, N. Binkley, L. Fitzpatrick, 2006, Osteoporosis International.

2MD (DP001), a Single Agent in the Management of Hemodialysis Patients: A Randomized Trial

R. D. Buck, H. DeLuca, R. Thadhani, 2016, American Journal of Nephrology.

Vitamin D esters are the major form of vitamin D produced by UV irradiation in mice

H. DeLuca, L. Plum, Izabela K. Sibilska-Kaminski, 2022, Photochemical & Photobiological Sciences.

13-Methyl-substituted des-C,D analogs of (20S)-1alpha,25-dihydroxy-2-methylene-19-norvitamin D3 (2MD): synthesis and biological evaluation.

H. DeLuca, M. Clagett-Dame, Katarzyna Plonska-Ocypa, 2009, Bioorganic & medicinal chemistry.

Synthesis and Biological Activity of 2,22-Dimethylene Analogues of 19-Norcalcitriol and Related Compounds.

H. DeLuca, R. Sicinski, L. Plum, 2020, Journal of medicinal chemistry.

Synthesis and Biological Activity of 2-Methylene Analogues of Calcitriol and Related Compounds.

H. DeLuca, Izabela K Sibilska, R. Sicinski, 2015, Journal of Medicinal Chemistry.

Synthesis and biological activity of 25-hydroxy-2-methylene-vitamin D3 compounds

H. DeLuca, Izabela K Sibilska, R. Sicinski, 2013, Journal of Steroid Biochemistry and Molecular Biology.

A potent analog of 1α,25-dihydroxyvitamin D3 selectively induces bone formation

H. DeLuca, J. Pike, Hironori Yamamoto, 2002, Proceedings of the National Academy of Sciences of the United States of America.

1-Desoxy analog of 2MD: Synthesis and biological activity of (20S)-25-hydroxy-2-methylene-19-norvitamin D3

H. DeLuca, Izabela K Sibilska, R. Sicinski, 2010, The Journal of Steroid Biochemistry and Molecular Biology.

New 2-alkylidene 1alpha,25-dihydroxy-19-norvitamin D3 analogues of high intestinal activity: synthesis and biological evaluation of 2-(3'-alkoxypropylidene) and 2-(3'-hydroxypropylidene) derivatives.

H. DeLuca, M. Clagett-Dame, R. Sicinski, 2006, Journal of medicinal chemistry.

retmoic acid in support of chick neuronal development

J. Repa, L. Plum, P. Tadikonda, 2004 .

Retinoic Acid Combined with Neurotrophin-3 Enhances the Survival and Neurite Outgrowth of Embryonic Sympathetic Neurons

L. Parada, M. Clagett-Dame, L. Plum, 2001, Experimental biology and medicine.

UVB radiation, vitamin D and multiple sclerosis

H. DeLuca, L. Plum, 2017, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

Novel, Selective Vitamin D Analog Suppresses Parathyroid Hormone in Uremic Animals and Postmenopausal Women

H. DeLuca, M. Clagett-Dame, D. Plowchalk, 2014, American Journal of Nephrology.

Vitamin D deficiency diminishes the severity and delays onset of experimental autoimmune encephalomyelitis.

H. DeLuca, L. Plum, 2011, Archives of biochemistry and biophysics.

A potent analog of 1alpha,25-dihydroxyvitamin D3 selectively induces bone formation.

H. DeLuca, J. Pike, Hironori Yamamoto, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Analogs of 1α,25-Dihydroxyvitamin D₃ in Clinical Use.

H. DeLuca, L. Plum, 2016, Vitamins and hormones.

A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos

R. Merrill, M. Clagett-Dame, L. Plum, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis and biological activities of vitamin D-like inhibitors of CYP24 hydroxylase

A. Bianucci, H. DeLuca, S. Rapposelli, 2012, Steroids.

Vitamin D deficiency independent of hypocalcemia elevates blood pressure in rats.

H. DeLuca, L. Plum, Flora S. Sundersingh, 2015, Biochemical and biophysical research communications.

Antibody production in mice requires neither vitamin D, nor the vitamin D receptor

H. DeLuca, J. Prahl, J. Seeman, 2022, Frontiers in Immunology.

D-seco-Vitamin D analogs having reversed configurations at C-13 and C-14: Synthesis, docking studies and biological evaluation

H. DeLuca, K. Sokołowska, R. Sicinski, 2017, The Journal of Steroid Biochemistry and Molecular Biology.

Synthesis and biological evaluation of a des-C,D-analog of 2-methylene-19-nor-1α,25-(OH)2D3

H. DeLuca, Katarzyna Plonska-Ocypa, R. Sicinski, 2007, The Journal of Steroid Biochemistry and Molecular Biology.

Biologically active noncalcemic analogs of 1alpha,25-dihydroxyvitamin D with an abbreviated side chain containing no hydroxyl.

H. DeLuca, M. Clagett-Dame, J. Prahl, 2004, Proceedings of the National Academy of Sciences of the United States of America.

A New 1,25 Dihydroxy Vitamin D Analog with Strong Bone Anabolic Activity in OVX Rats with Little or no Bone Resorptive Activity

H. DeLuca, M. Clagett-Dame, L. Plum, 2020, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Methyl substitution of the 25-hydroxy group on 2-methylene-19-nor-1alpha,25-dihydroxyvitamin D3 (2MD) reduces potency but allows bone selectivity.

H. DeLuca, M. Clagett-Dame, R. Sicinski, 2007, Archives of biochemistry and biophysics.

Vitamins | Vitamin D

H. DeLuca, L. Plum, 2021, Encyclopedia of Biological Chemistry III.

2-(3′-Hydroxypropylidene)-1α-hydroxy-19-norvitamin D compounds with truncated side chains

H. DeLuca, R. Sicinski, L. Plum, 2007, Journal of Steroid Biochemistry and Molecular Biology.

CHAPTER 87 – 2-Carbon-Modified Analogs of 19-Nor-1α,25-Dihydroxyvitamin D3

H. DeLuca, J. Pike, M. Clagett-Dame, 2005 .

Highly potent 2-methylene analogs of 1α,25-dihydroxyvitamin D3: Synthesis and biological evaluation

H. DeLuca, Izabela K Sibilska, R. Sicinski, 2013, The Journal of Steroid Biochemistry and Molecular Biology.

Synthesis and biological evaluation of novel 6-substituted analogs of 1α,25-dihydroxy-19-norvitamin D3

H. DeLuca, K. Sokołowska, A. Mouriño, 2013, The Journal of Steroid Biochemistry and Molecular Biology.

Synthesis of novel 19-norvitamin D3 analogs with unnatural triene system

H. DeLuca, A. Mouriño, R. Sicinski, 2013, The Journal of Steroid Biochemistry and Molecular Biology.

26- and 27-Methyl groups of 2-substituted, 19-nor-1α,25-dihydroxylated vitamin D compounds are essential for calcium mobilization in vivo.

H. DeLuca, M. Clagett-Dame, L. Plum, 2013, Bioorganic chemistry.

Selective analogs of 1α,25-dihydroxyvitamin D3 for the study of specific functions of Vitamin D

H. DeLuca, M. Clagett-Dame, L. Plum, 2007, The Journal of Steroid Biochemistry and Molecular Biology.

26-Desmethyl-2-methylene-22-ene-19-nor-1α,25-dihydroxyvitamin D3 compounds selectively active on intestine

H. DeLuca, G. Chiellini, M. Clagett-Dame, 2014, Steroids.

Use of 2MD, a Novel Oral Calcitriol Analog, in Hemodialysis Patients with Secondary Hyperparathyroidism

H. DeLuca, D. Coyne, M. Clagett-Dame, 2016, American Journal of Nephrology.

Vitamin D deficiency in the ApcPirc/+ rat does not exacerbate colonic tumorigenesis, while low dietary calcium might be protective

H. DeLuca, A. Jha, L. Plum, 2018, Disease Models & Mechanisms.

All‐trans retinoic acid stimulates and maintains neurite outgrowth in nerve growth factor‐supported developing chick embryonic sympathetic neurons

M. Clagett-Dame, L. Plum, L.A. Plum, 1996, Developmental dynamics : an official publication of the American Association of Anatomists.

New analogs of 2-methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 with conformationally restricted side chains: evaluation of biological activity and structural determination of VDR-bound conformations.

H. DeLuca, M. Benning, J. Vanhooke, 2007, Archives of biochemistry and biophysics.

Design, synthesis and biological properties of seco-d-ring modified 1α,25-dihydroxyvitamin D3 analogues

H. DeLuca, R. Sicinski, L. Plum, 2017, The Journal of Steroid Biochemistry and Molecular Biology.

Removal of the 20-methyl group from 2-methylene-19-nor-(20S)-1alpha,25-dihydroxyvitamin D(3) (2MD) selectively eliminates bone calcium mobilization activity.

H. DeLuca, M. Clagett-Dame, R. Sicinski, 2009, Bioorganic & Medicinal Chemistry.

Salate derivatives found in sunscreens block experimental autoimmune encephalomyelitis in mice

H. DeLuca, L. Plum, Yanping Wang, 2017, Proceedings of the National Academy of Sciences.

Assay variation confounds the diagnosis of hypovitaminosis D: a call for standardization.

M. Drezner, H. DeLuca, N. Binkley, 2004, The Journal of clinical endocrinology and metabolism.

9-cis-retinoic acid selectively activates the cellular retinoic acid binding protein-II gene in human neuroblastoma cells.

M. Clagett-Dame, L. Plum, 1995, Archives of biochemistry and biophysics.

Vitamin D receptor absence does not enhance intestinal tumorigenesis in ApcPirc/+rats

H. DeLuca, J. Seeman, L. Plum, 2022, Biology open.

Cholecalciferol or 25-hydroxycholecalciferol neither prevents nor treats adenomas in a rat model of familial colon cancer.

H. DeLuca, L. Clipson, W. Dove, 2015, The Journal of nutrition.

Supplementation by vitamin D compounds does not affect colonic tumor development in vitamin D sufficient murine models.

H. DeLuca, J. Amos-Landgraf, N. Drinkwater, 2011, Archives of biochemistry and biophysics.

Synthesis and Biological Activity of 25-Hydroxy-2-methylene-vitamin D3 analogues monohydroxylated in the A-ring.

H. DeLuca, Izabela K Sibilska, R. Sicinski, 2014, Journal of medicinal chemistry.

The vitamin D analogue 2MD increases bone turnover but not BMD in postmenopausal women with osteopenia: Results of a 1‐year phase 2 double‐blind, placebo‐controlled, randomized clinical trial

H. DeLuca, J. Aloia, N. Binkley, 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

New 1alpha,25-dihydroxy-19-norvitamin D(3) compounds constrained in a single A-ring conformation: synthesis of the analogues by ring-closing metathesis route and their biological evaluation.

H. DeLuca, K. Sokołowska, R. Sicinski, 2009, Journal of medicinal chemistry.

Nonskeletal effects of vitamin D

H. DeLuca, C. Sempos, B. Dawson-Hughes, 2020 .

Synthesis and Biological Evaluation of Cyclopropylamine Vitamin D‐Like CYP24A1 Inhibitors

H. DeLuca, G. Nesi, S. Sestito, 2017 .

1,25-Dihydroxyvitamin D3 Controls a Cohort of Vitamin D Receptor Target Genes in the Proximal Intestine That Is Enriched for Calcium-regulating Components*

H. DeLuca, J. Pike, M. Meyer, 2015, The Journal of Biological Chemistry.

Highlights from the 24th workshop on vitamin D in Austin, September 2022

S. Ingles, M. Campbell, S. Christakos, 2023, The Journal of Steroid Biochemistry and Molecular Biology.

Removal of the 26-methyl group from 19-nor-1α,25-dihydroxyvitamin D₃ markedly reduces in vivo calcemic activity without altering in vitro VDR binding, HL-60 cell differentiation, and transcription.

H. DeLuca, G. Chiellini, M. Clagett-Dame, 2010, Journal of medicinal chemistry.

Novel 9-Alkyl- and 9-Alkylidene-Substituted 1α,25-Dihydroxyvitamin D3 Analogues: Synthesis and Biological Examinations.

H. DeLuca, A. Mouriño, R. Sicinski, 2015, Journal of medicinal chemistry.

Synthesis and biological evaluation of 6-methyl analog of 1α,25-dihydroxyvitamin D3

H. DeLuca, K. Sokołowska, R. Sigüeiro, 2010, The Journal of Steroid Biochemistry and Molecular Biology.

Suppression of experimental autoimmune encephalomyelitis by ultraviolet light is not mediated by isomerization of urocanic acid

H. DeLuca, L. Plum, Amy A. Irving, 2017, BMC Neuroscience.

Vitamin D binding protein is required to utilize skin-generated vitamin D

H. DeLuca, N. Cooke, J. Seeman, 2019, Proceedings of the National Academy of Sciences.

A new suprasterol by photochemical reaction of 1α,25-dihydroxy-9-methylene-19-norvitamin D3.

H. DeLuca, A. Mouriño, R. Sicinski, 2016, Organic and biomolecular chemistry.

UV light suppression of EAE (a mouse model of multiple sclerosis) is independent of vitamin D and its receptor

H. DeLuca, J. Seeman, L. Plum, 2019, Proceedings of the National Academy of Sciences.

Synthesis and biological activity of 2-(3'-hydroxypropylidene)-1α-hydroxy-19-norvitamin D analogues with shortened alkyl side chains.

H. DeLuca, R. Sicinski, L. Plum, 2011, Journal of medicinal chemistry.

Analogues de 19-nor-vitamine d à cycle 1,2-cyclopentène ou 3,2-cyclopentène

M. Clagett-Dame, R. Sicinski, L. Plum, 2010 .

Analogues de 19-nor-vitamine d avec un cycle 3,2-dihydrofuran

H. DeLuca, K. Sokołowska, M. Clagett-Dame, 2009 .

Design, Synthesis, and Biological Evaluation of a 1α,25-Dihydroxy-19-norvitamin D3 Analogue with a Frozen A-Ring Conformation

H. DeLuca, R. Sicinski, L. Plum, 2007 .

Vitamin D is not required for adaptive immunity to listeria

H. DeLuca, J. Seeman, L. Plum, 2019, Physiological reports.

Vitamin D binding protein greatly improves bioactivity but is not essential for orally administered vitamin D

H. DeLuca, L. Plum, Elizabeth G. Duchow, 2021, Physiological reports.