Ken H. Ho

Pharmacological Characterization of the Competitive GLUK5 Receptor Antagonist Decahydroisoquinoline LY466195 in Vitro and in Vivo

David Bleakman, Kirk W. Johnson, Andrew Alt, 2006, Journal of Pharmacology and Experimental Therapeutics.

GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: in vitro profile and in vivo analgesic efficacy.

D. Clawson, P. Ornstein, S. Iyengar, 2013, Bioorganic & medicinal chemistry letters.

A novel class of positive allosteric modulators of AMPA receptors: design, synthesis, and structure-activity relationships of 3-biphenyl-4-yl-4-cyano-5-ethyl-1-methyl-1H-pyrrole-2-carboxylic acid, LY2059346.

E. Nisenbaum, N. Rankl, Alma Jiménez, 2006, Bioorganic & medicinal chemistry letters.

Design and synthesis of a novel series of 1,2-disubstituted cyclopentanes as small, potent potentiators of 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid (AMPA) receptors.

G. Stephenson, D. Bleakman, B. Cantrell, 2002, Journal of medicinal chemistry.

Kainate receptors are involved in synaptic plasticity

G. Collingridge, Z. Bortolotto, P. Ornstein, 1999, Nature.

Antagonists of GLUK5-containing kainate receptors prevent pilocarpine-induced limbic seizures

G. Collingridge, Z. Bortolotto, Y. Michotte, 2002, Nature Neuroscience.

GluK1 antagonists from 6-(carboxy)phenyl decahydroisoquinoline derivatives. SAR and evaluation of a prodrug strategy for oral efficacy in pain models.

P. Ornstein, S. Iyengar, M. del Prado, 2013, Bioorganic & medicinal chemistry letters.

Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain.

P. Ornstein, S. Iyengar, M. del Prado, 2005, Journal of medicinal chemistry.

Ethyl (3S,4aR,6S,8aR)-6-(4-ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso-quinoline-3-carboxylic ester: a prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine.

Kirk W. Johnson, P. Ornstein, M. del Prado, 2002, Journal of medicinal chemistry.