Wupeng Yan

发表

IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions

G. Georgiou, N. Varadarajan, P. Bruhns, 2017, Nature Immunology.

Therapeutic monoclonal antibodies (mAbs) ameliorate disease by two mechanisms that involve the binding and resultant modulation of the function of proteins associated with pathophysiology and the recruitment of effector mechanisms dependent on the crystallizable

G. Georgiou, N. Varadarajan, P. Bruhns, 2017 .

Structural basis for a reciprocating mechanism of negative cooperativity in dimeric phosphagen kinase activity

Zihe Rao, Sheng Ye, Z. Rao, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR

D. Esposito, F. McCormick, K. Scheffzek, 2020, Cell reports.

Structural Snapshots of an Engineered Cystathionine-γ-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site.

E. Stone, Wupeng Yan, Y. Zhang, 2017, Biochemistry.

Enhanced effects of reducing agent on oxalate chelated Fe(II) catalyzed percarbonate system for benzene degradation

Shuguang Lyu, Wupeng Yan, Xiaori Fu, 2021, Water Supply.

Endoperoxide formation by an α-ketoglutarate-dependent mononuclear non-haem iron enzyme

C. Costello, Lixin Zhang, M. Hendrich, 2015, Nature.

Structures of N-terminally processed KRAS provide insight into the role of N-acetylation

P. Alexander, D. Esposito, F. McCormick, 2019, Scientific Reports.

Dissecting the Mechanism of the Nonheme Iron Endoperoxidase FtmOx1 Using Substrate Analogues

C. Costello, X. Xia, Xueting Liu, 2022, JACS Au.

novel modifications on C-terminal domain of RNA polymerase II can fine-tune the phosphatase activity of Ssu72.

A. Ellington, Joe R. Cannon, J. Brodbelt, 2013, ACS chemical biology.

Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth

G. Georgiou, Peng Huang, M. Keating, 2016, Nature Medicine.

Enzyme-mediated depletion of serum l-Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity

G. Georgiou, E. Stone, Achinto Saha, 2020, Proceedings of the National Academy of Sciences.

Systemic depletion of serum l-Cyst(e)ine with an engineered human enzyme induces production of reactive oxygen species and suppresses tumor growth in mice

G. Georgiou, Peng Huang, M. Keating, 2016, Nature medicine.

Kinetic, crystallographic, and mechanistic characterization of TomN: elucidation of a function for a 4-oxalocrotonate tautomerase homologue in the tomaymycin biosynthetic pathway.

B. Gerratana, W. Johnson, Wenzong Li, 2011, Biochemistry.

novel modifications on C-terminal domain of RNA polymerase II can fine-tune the phosphatase activity of Ssu72.

A. Ellington, Joe R. Cannon, J. Brodbelt, 2013, ACS chemical biology.

Structures of N-terminally processed KRAS provide insight into the role of N-acetylation

P. Alexander, D. Esposito, F. McCormick, 2019, Scientific Reports.

Discovery and Engineering of the l-Threonine Aldolase from Neptunomonas marine for the Efficient Synthesis of β-Hydroxy-α-amino Acids via C–C Formation

Qi Zhang, J. Wang, Yuanzhi He, 2023, ACS Catalysis.

Discovery and Engineering of the l-Threonine Aldolase from Neptunomonas Marine for Efficient Synthesis of β-Hydroxy-α-Amino Acids via C–C Formation

Qi Zhang, Yuanzhi He, Zaigao Tan, 2023, bioRxiv.