Amy Shen

发表

Identification of IgG(1) variants with increased affinity to FcγRIIIa and unaltered affinity to FcγRI and FcRn: comparison of soluble receptor-based and cell-based binding assays.

L. Presta, G. Nakamura, Yanmei Lu, 2011, Journal of immunological methods.

Balancing the Affinity and Pharmacokinetics of Antibodies by Modulating the Size of Charge Patches on Complementarity-Determining Regions.

A. Kamath, Jinpian Diao, Zhilan Hu, 2020, Journal of pharmaceutical sciences.

Decreasing lactate level and increasing antibody production in Chinese Hamster Ovary cells (CHO) by reducing the expression of lactate dehydrogenase and pyruvate dehydrogenase kinases.

N. Vijayasankaran, B. Snedecor, J. Joly, 2011, Journal of biotechnology.

Versatile LC-MS-Based Workflow with Robust 0.1 ppm Sensitivity for Identifying Residual HCPs in Biotherapeutic Products.

Jennifer Zhang, S. Wohlrab, Hong Li, 2021, Analytical Chemistry.

Maximizing Antibody Production in a Targeted Integration Host by Optimization of Subunit Gene Dosage and Position.

B. Snedecor, David Shaw, Michael W. Laird, 2020, Biotechnology progress.

Fast identification of reliable hosts for targeted cell line development from a limited‐genome screening using combined φC31 integrase and CRE‐Lox technologies

B. Snedecor, J. Joly, Zhilan Hu, 2013, Biotechnology progress.

Contribution of Antibody Hydrodynamic Size to Vitreal Clearance Revealed through Rabbit Studies Using a Species-Matched Fab.

P. Hass, R. Kelley, M. Maia, 2016, Molecular pharmaceutics.

Controlling glycation of recombinant antibody in fed‐batch cell cultures

N. Vijayasankaran, B. Snedecor, J. Joly, 2011, Biotechnology and bioengineering.

Evaluation of heavy chain C‐terminal deletions on productivity and product quality of monoclonal antibodies in Chinese hamster ovary (CHO) cells

B. Snedecor, Michael W. Laird, S. Misaghi, 2017, Biotechnology progress.

Methode de production d'anticorps presentant une fonction amelioree

B. Snedecor, Domingos Ng, Amy Shen, 2006 .

Probing the importance of clonality: Single cell subcloning of clonally derived CHO cell lines yields widely diverse clones differing in growth, productivity, and product quality

B. Snedecor, David Shaw, Michael W. Laird, 2018, Biotechnology progress.

A strategy to accelerate protein production from a pool of clones in Chinese hamster ovary cells for toxicology studies

B. Snedecor, Michael W. Laird, J. Joly, 2017, Biotechnology progress.

Engineering Upper Hinge Improves Stability and Effector Function of a Human IgG1

B. Yan, P. Carter, G. Schaefer, 2011, The Journal of Biological Chemistry.

C-Terminal Lysine Processing of IgG in Human Suction Blister Fluid: Implications for Subcutaneous Administration.

Yan Chen, Zhilan Hu, Luladey Ayalew, 2022, Molecular pharmaceutics.

Identification and Characterization of Polysorbate-Degrading Enzymes in a Monoclonal Antibody Formulation.

S. Wohlrab, Hong Li, Inn H Yuk, 2021, Journal of pharmaceutical sciences.

High Intracellular Seed Train BiP Levels Correlate With Poor Production Culture Performance in CHO Cells.

B. Snedecor, S. Misaghi, Szu-Han Wang, 2018, Biotechnology journal.

Role of surface exposed tryptophan as substrate generators for the antibody catalyzed water oxidation pathway.

Alavattam Sreedhara, Yvonne Lentz, Amy Shen, 2013, Molecular pharmaceutics.

Cell culture processes for monoclonal antibody production

Feng Li, Ashraf Amanullah, Natarajan Vijayasankaran, 2010, mAbs.

Chinese hamster ovary K1 host cell enables stable cell line development for antibody molecules which are difficult to express in DUXB11‐derived dihydrofolate reductase deficient host cell

B. Snedecor, J. Joly, S. Misaghi, 2013, Biotechnology progress.

Mechanisms of unintended amino acid sequence changes in recombinant monoclonal antibodies expressed in Chinese Hamster Ovary (CHO) cells

B. Snedecor, Michael W. Laird, J. Joly, 2010, Biotechnology and bioengineering.

Development of a targeted integration Chinese hamster ovary host directly targeting either one or two vectors simultaneously to a single locus using the Cre/Lox recombinase‐mediated cassette exchange system

B. Snedecor, Z. Modrušan, Michael W. Laird, 2021, Biotechnology progress.

Carboxypeptidase D is the only enzyme responsible for antibody C‐terminal lysine cleavage in Chinese hamster ovary (CHO) cells

B. Snedecor, J. Joly, S. Misaghi, 2016, Biotechnology and bioengineering.

Quantitative evaluation of fucose reducing effects in a humanized antibody on Fcγ receptor binding and antibody-dependent cell-mediated cytotoxicity activities

V. Quarmby, M. Vanderlaan, Shan Chung, 2012, mAbs.

Réduction du niveau de lactate et augmentation de la production de polypeptides par régulation négative de l'expression de la lactate déshydrogénase et de la pyruvate déshydrogénase kinase

B. Snedecor, Meixia Zhou, Amy Shen, 2011 .

Eliminating tyrosine sequence variants in CHO cell lines producing recombinant monoclonal antibodies

Amy Shen, Michael W. Laird, D. Michels, 2013, Biotechnology and bioengineering.

Efficient production of bispecific IgG of different isotypes and species of origin in single mammalian cells

Meric A. Ovacik, P. Carter, W. Sandoval, 2016, mAbs.

Characterization of Recombinantly-Expressed Hydrolytic Enzymes from Chinese Hamster Ovary Cells: Identification of Host Cell Proteins that Degrade Polysorbate.

A. Tomlinson, Inn H. Yuk, Tobias Graf, 2023, Journal of pharmaceutical sciences.

Detecting low level sequence variants in recombinant monoclonal antibodies

V. Katta, J. Ouyang, Boyan Zhang, 2010, mAbs.

High-throughput antibody screening from complex matrices using intact protein electrospray mass spectrometry

Amy Shen, Yichin Liu, J. C. Tran, 2020, Proceedings of the National Academy of Sciences.

Expressing antigen binding fragments with high titers in a targeted integration CHO host by optimizing expression vector gene copy numbers and position: A case study

B. Snedecor, S. Misaghi, Amy Shen, 2022, Biotechnology progress.

An efficient route to bispecific antibody production using single-reactor mammalian co-culture

Athena W Wong, J. Scheer, W. Shatz, 2016, mAbs.

Understanding the intracellular effect of enhanced nutrient feeding toward high titer antibody production process

Natarajan Vijayasankaran, Amy Shen, Marcella Yu, 2011, Biotechnology and bioengineering.

Complete Knockout of the Lactate Dehydrogenase A Gene is Lethal in Pyruvate Dehydrogenase Kinase 1, 2, 3 Down-Regulated CHO Cells

B. Snedecor, J. Joly, Meixia Zhou, 2014, Molecular Biotechnology.

An arrayed CRISPR screen reveals Myc depletion to increase productivity of difficult-to-express complex antibodies in CHO cells

S. Misaghi, Simon Ausländer, Julian Stingele, 2022, Synthetic biology.

High-level production of recombinant proteins in CHO cells using a dicistronic DHFR intron expression vector.

C. Crowley, V. Chisholm, L. Giere, 1996, Nucleic acids research.

Evaluation of Heavy-Chain C-Terminal Deletion on Product Quality and Pharmacokinetics of Monoclonal Antibodies.

Y. J. Wang, Kai Zheng, P. Wong, 2016, Journal of pharmaceutical sciences.

Fast identification of reliable hosts for targeted cell line development from a limited‐genome screening using combined φC31 integrase and CRE‐Lox technologies

B. Snedecor, J. Joly, Zhilan Hu, 2013, Biotechnology progress.

Identification of IgG(1) variants with increased affinity to FcγRIIIa and unaltered affinity to FcγRI and FcRn: comparison of soluble receptor-based and cell-based binding assays.

L. Presta, G. Nakamura, Yanmei Lu, 2011, Journal of immunological methods.

Utilizing targeted integration CHO pools to potentially accelerate the GMP manufacturing of monoclonal and bispecific antibodies

Inn H. Yuk, Amy Shen, Michelle Zhou, 2023, Biotechnology progress.