J. Saito

发表

Structural comparison of fucosylated and nonfucosylated Fc fragments of human immunoglobulin G1.

Yoshiki Yamaguchi, Mitsuo Satoh, K. Shitara, 2007, Journal of molecular biology.

The structure of L-amino-acid ligase from Bacillus licheniformis.

K. Kino, A. Noguchi, T. Arai, 2012, Acta crystallographica. Section D, Biological crystallography.

Bacillus circulans MH-K1 chitosanase: amino acid residues responsible for substrate binding.

K. Miki, K. Yamaguchi, S. Amano, 2005, Journal of biochemistry.

Prediction of the site of CYP 3 A 4 metabolism of tolterodine by molecular dynamics simulation from multiple initial structures of the CYP 3 A 4-tolterodine complex

A. Konagaya, T. Honma, C. Watanabe, 2017 .

Prediction of the site of CYP3A4 metabolism of tolterodine by molecular dynamics simulation from multiple initial structures of the CYP3A4-tolterodine complex

A. Konagaya, T. Honma, C. Watanabe, 2017 .

X-ray crystallographic analysis of IMP-1 metallo-β-lactamase complexed with a 3-aminophthalic acid derivative, structure-based drug design, and synthesis of 3,6-disubstituted phthalic acid derivative inhibitors.

T. Kudo, J. Saito, Takashi Watanabe, 2014, Bioorganic & medicinal chemistry letters.

Crystallization and preliminary crystallographic analysis of the transpeptidase domain of penicillin-binding protein 2B from Streptococcus pneumoniae.

J. Saito, Takashi Watanabe, Y. Takeuchi, 2008, Acta crystallographica. Section F, Structural biology and crystallization communications.

X-ray crystallographic characterization and phasing of a fucose-specific lectin from Aleuria aurantia.

Y. Higuchi, K. Miki, N. Kamiya, 2003, Acta crystallographica. Section D, Biological crystallography.

Phenylimidazole derivatives of 4-pyridone as dual inhibitors of bacterial enoyl-acyl carrier protein reductases FabI and FabK.

T. Ozawa, J. Saito, M. Iida, 2007, Journal of medicinal chemistry.

Substrate-Binding Mode of Bacterial Chitosanases

K. Miki, R. Brzezinski, S. Amano, 2005 .

Crystal Structure of Chitosanase from Bacillus circulans MH-K1 at 1.6-Å Resolution and Its Substrate Recognition Mechanism*

Y. Higuchi, K. Miki, J Saito, 1999, The Journal of Biological Chemistry.

Mechanistic analysis of the enhanced RNAi activity by 6-mCEPh-purine at the 5′ end of the siRNA guide strand

H. Seitz, Y. Tomari, J. Saito, 2020, RNA.

Development of a novel class of peroxisome proliferator-activated receptor (PPAR) gamma ligands as an anticancer agent with a unique binding mode based on a non-thiazolidinedione scaffold.

S. Shuto, T. Tamura, T. Uemori, 2019, Bioorganic & medicinal chemistry.

siRNA potency enhancement via chemical modifications of nucleotide bases at the 5′-end of the siRNA guide strand

T. Oashi, J. Saito, T. Nishikawa, 2020, RNA.

The Discovery and Characterization of K-756, a Novel Wnt/β-Catenin Pathway Inhibitor Targeting Tankyrase

Yasuo Watanabe, A. Asai, H. Ishida, 2016, Molecular Cancer Therapeutics.

The discovery of a new antibody for BRIL-fused GPCR structure determination

S. Iwata, H. Asada, J. Saito, 2020, Scientific Reports.

Development of Dihydrodibenzooxepine Peroxisome Proliferator-Activated Receptor (PPAR) Gamma Ligands of a Novel Binding Mode as Anticancer Agents: Effective Mimicry of Chiral Structures by Olefinic E/ Z-Isomers.

S. Shuto, T. Tamura, J. Saito, 2018, Journal of medicinal chemistry.

PP2C family members play key roles in regulation of cell survival and apoptosis

Tada-aki Kudo, S. Tamura, Takayasu Kobayashi, 2006, Cancer science.

The novel potent TEAD inhibitor, K-975, inhibits YAP1/TAZ-TEAD protein-protein interactions and exerts an anti-tumor effect on malignant pleural mesothelioma.

T. Seike, Y. Sekido, R. Yatsunami, 2020, American journal of cancer research.

Structural and enzymatic characterization of BacD, an L‐amino acid dipeptide ligase from Bacillus subtilis

H. Komori, Y. Higuchi, Y. Yonetani, 2012, Protein science : a publication of the Protein Society.

Regulation of apoptosis signal-regulating kinase 1 by protein phosphatase 2Cepsilon.

H. Ichijo, S. Tamura, Takayasu Kobayashi, 2007, The Biochemical journal.

Crystallization and preliminary X-ray analysis of enoyl-acyl carrier protein reductase (FabK) from Streptococcus pneumoniae.

J. Saito, Takashi Watanabe, H. Kitagawa, 2006, Acta crystallographica. Section F, Structural biology and crystallization communications.

Crystal Structure of Cefditoren Complexed with Streptococcus pneumoniae Penicillin-Binding Protein 2X: Structural Basis for Its High Antimicrobial Activity

Mototsugu Yamada, Takashi Watanabe, Takako Miyara, 2007, Antimicrobial Agents and Chemotherapy.

The dual pocket binding novel tankyrase inhibitor K-476 enhances the efficacy of immune checkpoint inhibitor by attracting CD8+ T cells to tumors.

T. Ishii, H. Ishida, R. Nakai, 2021, American journal of cancer research.

Structure-guided screening strategy combining surface plasmon resonance with nuclear magnetic resonance for identification of small-molecule Argonaute 2 inhibitors

J. Saito, A. Sato, F. Shinohara, 2020, PloS one.

Abstract 3086: Discovery of afirst-in-classTEAD inhibitor which directly inhibits YAP/TAZ-TEAD protein-protein interaction and shows a potent anti-tumor effect in malignant pleural mesothelioma

T. Ishii, T. Seike, T. Nakajima, 2019, Experimental and Molecular Therapeutics.

Crystal structure of enoyl–acyl carrier protein reductase (FabK) from Streptococcus pneumoniae reveals the binding mode of an inhibitor

T. Ozawa, J. Saito, M. Iida, 2008, Protein science : a publication of the Protein Society.