S. Deshpande

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Production of human monoclonal antibody in eggs of chimeric chickens

Shrikant Deshpande, S. Morrison, R. Etches, 2005, Nature Biotechnology.

Recent advances in the discovery and development of antibody – drug conjugates have led to FDA approvals and a rich clinical pipeline of promising new cancer therapies . Antibody – drug conjugates : current status and future directions

R. Borzilleri, P. Cardarelli, G. Vite, 2013 .

Pharmacokinetic characterization of BMS‐936561, an anti‐CD70 antibody‐drug conjugate, in preclinical animal species and prediction of its pharmacokinetics in humans

P. Marathe, M. Srinivasan, P. Cardarelli, 2016, Biopharmaceutics & drug disposition.

Novel methods to rapidly and sensitively analyze antigenic peptide binding to MHC class II molecules.

S. Deshpande, B. Nag, B. Clark, 1991, Journal of immunological methods.

Localization of soluble major histocompatibility class II‐peptide complexes on T cell surface

S. Deshpande, B. Nag, S. Arimilli, 2000, Microscopy research and technique.

Antigenic peptide binding to MHC class II molecules at increased peptide concentrations.

J. Winkelhake, S. Deshpande, B. Nag, 1994, Molecular immunology.

A Universal Affinity Capture LC-MS Assay for Evaluation of Biotransformation of Site-Specific Antibody Drug Conjugates in Preclinical Studies.

A. Rajpal, G. Dollinger, P. Strop, 2019, Analytical chemistry.

Antibody-drug conjugate bioanalysis using LB-LC-MS/MS hybrid assays: strategies, methodology and correlation to ligand-binding assays.

T. Olah, Yan Zhang, H. Vezina, 2016, Bioanalysis.

An integrated multiplatform bioanalytical strategy for antibody-drug conjugates: a novel case study.

Robert J. Neely, S. Piccoli, H. Vezina, 2015, Bioanalysis.

Macrocyclic chelates of radiometals for diagnosis and therapy.

S. Denardo, D. Kukis, C. Meares, 1990, The British journal of cancer. Supplement.

Design, Synthesis, and Structure-Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody-Drug Conjugates.

A. Mathur, B. Warrack, A. Rajpal, 2020, Journal of medicinal chemistry.

Copper-67-labeled monoclonal antibody Lym-1, a potential radiopharmaceutical for cancer therapy: labeling and biodistribution in RAJI tumored mice.

G. Denardo, S. Denardo, G. Adams, 1988, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Chelate radiochemistry: Cleavable linkers lead to altered levels of radioactivity in the liver

S. Denardo, C. Meares, M. Mccall, 1988, International journal of cancer. Supplement = Journal international du cancer. Supplement.

Effect of mass of 111In-benzyl-EDTA monoclonal antibody on hepatic uptake and processing in mice.

G. Denardo, S. Denardo, G. Adams, 1989, Cancer research.

The Design of a Radiolabeled Monoclonal Antibody for Radioimmunodiagnosis and Radioimmunotherapy

G. Denardo, S. Denardo, G. Adams, 1988 .

Metabolism of indium chelates attached to monoclonal antibody: minimal transchelation of indium from benzyl-EDTA chelate in vivo.

G. Denardo, S. Denardo, C. Meares, 1990, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

X-ray crystal structure of a macrocyclic copper chelate stable enough for use in living systems: Copper(II) dihydrogen 6-(p-nitrobenzyl)-1,4,8,11-tetraazacyclotetradecane-1,4,8,11-tetraacetate

S. Denardo, C. Meares, H. Hope, 1987 .

Mapping binding epitopes of monoclonal antibodies targeting major histocompatibility complex class I chain-related A (MICA) with hydrogen/deuterium exchange and electron-transfer dissociation mass spectrometry

M. Srinivasan, Guodong Chen, Richard Y.-C. Huang, 2020, Analytical and Bioanalytical Chemistry.

Effect of different linkages between chelates and monoclonal antibodies on levels of radioactivity in the liver.

G. Denardo, S. Denardo, G. Adams, 1989, International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology.

Radiopharmaceutical preparation of a monoclonal antibody, lym‐1, and its F(ab')2 fragment for imaging lymphoma with In‐111

G. Denardo, S. Denardo, A. Epstein, 1989 .

Identification of core structure and critical T cell receptor contact residues in an antigenic peptide by measuring acidification rates.

S. Deshpande, B. Nag, S. Arimilli, 1998, Journal of immunological methods.

Yttrium-90-labeled monoclonal antibody for therapy: labeling by a new macrocyclic bifunctional chelating agent.

G. Denardo, S. Denardo, D. Kukis, 1990, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Rapid identification of antigenic T‐cell epitopes by extracellular acidification rate signals

M. Howard, S. Deshpande, S. Arimilli, 2000 .

A conformationally-constrained MHC class II I-Ag7-derived peptide protects NOD mice from the development of diabetes.

N. Solvason, K. Lafferty, T. Baumgart, 1999, Journal of autoimmunity.

Novel detection of DNA-alkylated adducts of antibody-drug conjugates with potentially unique preclinical and biomarker applications.

Zemin Wang, A. Bell, M. Srinivasan, 2013, Bioanalysis.

A Novel, Fully Human Anti–fucosyl-GM1 Antibody Demonstrates Potent In Vitro and In Vivo Antitumor Activity in Preclinical Models of Small Cell Lung Cancer

J. Sage, Kwon-Sik Park, D. Menezes, 2018, Clinical Cancer Research.

Utility of Ion Mobility Mass Spectrometry for Drug-to-Antibody Ratio Measurements in Antibody-Drug Conjugates

Ekaterina G. Deyanova, Guodong Chen, Richard Y.-C. Huang, 2015, Journal of The American Society for Mass Spectrometry.

Chemokines in autoimmune diseases

N. Solvason, M. Howard, W. Ferlin, 2000, Immunological reviews.

Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab

S. Almo, J. Bonanno, A. Korman, 2017, Proceedings of the National Academy of Sciences.

Uncialamycin as a novel payload for antibody drug conjugate (ADC) based targeted cancer therapy.

D. Langley, Yichong Wang, P. Sivaprakasam, 2019, Bioorganic & medicinal chemistry letters.

Higher-Order Structure Characterization of NKG2A/CD94 Protein Complex and Anti-NKG2A Antibody Binding Epitopes by Mass Spectrometry-Based Protein Footprinting Strategies.

Guodong Chen, Richard Y.-C. Huang, Natalie A. Bezman, 2021, Journal of the American Society for Mass Spectrometry.

Separation of complexes of major histocompatibility class II molecules and known antigenic peptide by metal chelate affinity chromatography.

S. Sharma, S. Deshpande, B. Nag, 1994, Journal of immunological methods.

In vitro maximum binding of antigenic peptides to murine MHC class II molecules does not always take place at the acidic pH of the in vivo endosomal compartment.

D. Passmore, S. Deshpande, B. Nag, 1992, Journal of immunology.

Antibody-drug conjugates: current status and future directions.

R. Borzilleri, P. Cardarelli, G. Vite, 2014, Drug discovery today.

Design, synthesis and biological evaluation of phenol-linked uncialamycin antibody-drug conjugates.

A. Mathur, G. Vite, Y. Poudel, 2019, Bioorganic & medicinal chemistry letters.

Synthesis and Biological Evaluation of a Carbamate-Containing Tubulysin Antibody Drug Conjugate.

P. Cardarelli, Gregory Vite, C. Rao-Naik, 2020, Bioconjugate chemistry.

Copper-67-Labeled Monoclonal Antibody Lym- 1, A Potential Radiopharmaceutical for CancerTherapy:Labelingand Biodistribution in RAJI Tumored Mice

G. Denardo, S. Denardo, G. Adams, 2022 .

Challenges in antibody-drug conjugate discovery: a bioconjugation and analytical perspective.

S. Deshpande, V. Rangan, Chetana Rao, 2015, Bioanalysis.

A novel function of CXCL10 in mediating monocyte production of proinflammatory cytokines

M. Struthers, T. Olah, L. Salter-Cid, 2017, Journal of leukocyte biology.

Antigen-specific deletion of cloned T cells using peptide-toxin conjugate complexed with purified class II major histocompatibility complex antigen.

S. Sharma, S. Deshpande, B. Nag, 1994, The Journal of biological chemistry.

Single, low dose treatment of lymphoma and renal cancer xenografts with human anti-CD70 antibody-toxin conjugates, results in long term cures

J. Terrett, D. King, P. Cardarelli, 2007 .

Human antibody conjugates of potential utility for prostate cancer therapy: A comparison of MGBA conjugates with antibodies targeting a cell surface target (prostate-specific membrane antigen) and an extracellular matrix target (Mindin/RG-1)

J. Terrett, D. King, P. Cardarelli, 2008 .

Cloned T cells internalize peptide from bound complexes of peptide and purified class II major histocompatibility complex antigen.

S. Sharma, S. Deshpande, B. Nag, 1993, The Journal of biological chemistry.