V. Rangan

发表

Production of human monoclonal antibody in eggs of chimeric chickens

Shrikant Deshpande, S. Morrison, R. Etches, 2005, Nature Biotechnology.

Hybrid LBA/LC–MS TOP ARTICLES SUPPLEMENT

Huadong, Shrikant, Yan Zhang, 2016 .

Pharmacokinetic characterization of BMS‐936561, an anti‐CD70 antibody‐drug conjugate, in preclinical animal species and prediction of its pharmacokinetics in humans

P. Marathe, M. Srinivasan, P. Cardarelli, 2016, Biopharmaceutics & drug disposition.

Dibromopropanone Cross-linking of the Phosphopantetheine and Active-site Cysteine Thiols of the Animal Fatty Acid Synthase Can Occur Both Inter- and Intrasubunit

H. Witkowska, A. Falick, A. Witkowski, 1999, The Journal of Biological Chemistry.

A Universal Affinity Capture LC-MS Assay for Evaluation of Biotransformation of Site-Specific Antibody Drug Conjugates in Preclinical Studies.

A. Rajpal, G. Dollinger, P. Strop, 2019, Analytical chemistry.

Antibody-drug conjugate bioanalysis using LB-LC-MS/MS hybrid assays: strategies, methodology and correlation to ligand-binding assays.

T. Olah, Yan Zhang, H. Vezina, 2016, Bioanalysis.

An integrated multiplatform bioanalytical strategy for antibody-drug conjugates: a novel case study.

Robert J. Neely, S. Piccoli, H. Vezina, 2015, Bioanalysis.

Identification of an Inverted CCAAT Box Motif in the Fatty-acid Synthase Gene as an Essential Element for Mediation of Transcriptional Regulation by cAMP (*)

B. Oskouian, Stuart Smith, V. Rangan, 1996, The Journal of Biological Chemistry.

Validation of an integrated series of ligand-binding assays for the quantitative determination of antibody-drug conjugates in biological matrices.

Brian K. Hoffpauir, A. Kozhich, J. Cummings, 2016, Bioanalysis.

Chapter 6 Fatty acid synthesis in eukaryotes

Stuart Smith, V. Rangan, 2002 .

Design, Synthesis, and Structure-Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody-Drug Conjugates.

A. Mathur, B. Warrack, A. Rajpal, 2020, Journal of medicinal chemistry.

Alteration of the Substrate Specificity of the Malonyl-CoA/Acetyl-CoA:Acyl Carrier ProteinS-Acyltransferase Domain of the Multifunctional Fatty Acid Synthase by Mutation of a Single Arginine Residue*

Stuart Smith, V. Rangan, 1997, The Journal of Biological Chemistry.

Engineering of an active animal fatty acid synthase dimer with only one competent subunit.

A. Witkowski, A. Joshi, Stuart Smith, 2003, Chemistry & biology.

Mapping binding epitopes of monoclonal antibodies targeting major histocompatibility complex class I chain-related A (MICA) with hydrogen/deuterium exchange and electron-transfer dissociation mass spectrometry

M. Srinivasan, Guodong Chen, Richard Y.-C. Huang, 2020, Analytical and Bioanalytical Chemistry.

Novel detection of DNA-alkylated adducts of antibody-drug conjugates with potentially unique preclinical and biomarker applications.

Zemin Wang, A. Bell, M. Srinivasan, 2013, Bioanalysis.

Fatty Acid Synthase Dimers Containing Catalytically Active β-Ketoacyl Synthase or Malonyl/Acetyltransferase Domains in Only One Subunit Can Support Fatty Acid Synthesis at the Acyl Carrier Protein Domains of Both Subunits*

A. Joshi, Stuart Smith, V. Rangan, 1998, The Journal of Biological Chemistry.

Differential Affinity Labeling of the Two Subunits of the Homodimeric Animal Fatty Acid Synthase Allows Isolation of Heterodimers Consisting of Subunits That Have Been Independently Modified*

A. Joshi, Stuart Smith, V. Rangan, 1998, The Journal of Biological Chemistry.

A Novel, Fully Human Anti–fucosyl-GM1 Antibody Demonstrates Potent In Vitro and In Vivo Antitumor Activity in Preclinical Models of Small Cell Lung Cancer

J. Sage, Kwon-Sik Park, D. Menezes, 2018, Clinical Cancer Research.

Utility of Ion Mobility Mass Spectrometry for Drug-to-Antibody Ratio Measurements in Antibody-Drug Conjugates

Ekaterina G. Deyanova, Guodong Chen, Richard Y.-C. Huang, 2015, Journal of The American Society for Mass Spectrometry.

Mapping the functional topology of the animal fatty acid synthase by mutant complementation in vitro.

A. Joshi, V. Rangan, S. Smith, 2001, Biochemistry.

Structural organization of the multifunctional animal fatty-acid synthase.

A. Witkowski, V. Rangan, Z. Randhawa, 1991, European journal of biochemistry.

Conditional PD-1/PD-L1 Probody Therapeutics Induce Comparable Antitumor Immunity but Reduced Systemic Toxicity Compared with Traditional Anti–PD-1/PD-L1 Agents

O. Vasiljeva, M. Belvin, W. Kavanaugh, 2021, Cancer Immunology Research.

Galectin-1-driven T cell exclusion in the tumor endothelium promotes immunotherapy resistance.

A. Koong, A. Giaccia, Q. Le, 2019, The Journal of clinical investigation.

The Human Thioesterase II Protein Binds to a Site on HIV-1 Nef Critical for CD4 Down-regulation*

D. Baltimore, G. B. Cohen, Stuart Smith, 2000, The Journal of Biological Chemistry.

Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab

S. Almo, J. Bonanno, A. Korman, 2017, Proceedings of the National Academy of Sciences.

Uncialamycin as a novel payload for antibody drug conjugate (ADC) based targeted cancer therapy.

D. Langley, Yichong Wang, P. Sivaprakasam, 2019, Bioorganic & medicinal chemistry letters.

A novel semi‐mechanistic tumor growth fraction model for translation of preclinical efficacy of anti‐glypican 3 antibody drug conjugate to human

F. Lee, P. Marathe, A. Kozhich, 2020, Biopharmaceutics & drug disposition.

Higher-Order Structure Characterization of NKG2A/CD94 Protein Complex and Anti-NKG2A Antibody Binding Epitopes by Mass Spectrometry-Based Protein Footprinting Strategies.

Guodong Chen, Richard Y.-C. Huang, Natalie A. Bezman, 2021, Journal of the American Society for Mass Spectrometry.

Design, synthesis and biological evaluation of phenol-linked uncialamycin antibody-drug conjugates.

A. Mathur, G. Vite, Y. Poudel, 2019, Bioorganic & medicinal chemistry letters.

Passive Immunization with Phospho-Tau Antibodies Reduces Tau Pathology and Functional Deficits in Two Distinct Mouse Tauopathy Models

J. Trojanowski, V. Lee, A. Cacace, 2015, PloS one.

Synthesis and Biological Evaluation of a Carbamate-Containing Tubulysin Antibody Drug Conjugate.

P. Cardarelli, Gregory Vite, C. Rao-Naik, 2020, Bioconjugate chemistry.

Characterization of the malonyl-/acetyltransacylase domain of the multifunctional animal fatty acid synthase by expression in Escherichia coli and refolding in vitro.

H. Witkowska, L. Serre, A. Bari, 1997, Protein engineering.

Expression in Escherichia coli and Refolding of the Malonyl-/Acetyltransferase Domain of the Multifunctional Animal Fatty Acid Synthase*

Stuart Smith, V. Rangan, 1996, The Journal of Biological Chemistry.

Cloning, Expression, and Characterization of a Human 4′-Phosphopantetheinyl Transferase with Broad Substrate Specificity*

A. Joshi, Stuart Smith, Lei Zhang, 2003, Journal of Biological Chemistry.

Challenges in antibody-drug conjugate discovery: a bioconjugation and analytical perspective.

S. Deshpande, V. Rangan, Chetana Rao, 2015, Bioanalysis.

A novel function of CXCL10 in mediating monocyte production of proinflammatory cytokines

M. Struthers, T. Olah, L. Salter-Cid, 2017, Journal of leukocyte biology.

Single, low dose treatment of lymphoma and renal cancer xenografts with human anti-CD70 antibody-toxin conjugates, results in long term cures

J. Terrett, D. King, P. Cardarelli, 2007 .

Ptk7 as a direct and tumor stroma target in multiple solid malignancies

J. Terrett, D. King, Haichun Huang, 2008 .

Quantitative bioanalysis of antibody-conjugated payload in monkey plasma using a hybrid immuno-capture LC-MS/MS approach: Assay development, validation, and a case study.

A. Kozhich, F. Zambito, H. Myler, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Quantitative bioanalysis of antibody-conjugated payload in monkey plasma using a hybrid immuno-capture LC-MS/MS approach: Assay development, validation, and a case study.

A. Kozhich, F. Zambito, H. Myler, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.