A. Palazón

发表

Treatment with anti-CD137 mAbs causes intense accumulations of liver T cells without selective antitumor immunotherapeutic effects in this organ

Lieping Chen, J. Prieto, I. Melero, 2010, Cancer Immunology, Immunotherapy.

Delivery of immunostimulatory monoclonal antibodies by encapsulated hybridoma cells

I. Melero, J. Pérez-Gracia, S. Hervás-Stubbs, 2010, Cancer Immunology, Immunotherapy.

Immune response regulation in the tumor microenvironment by hypoxia.

I. Melero, S. Labiano, A. Palazón, 2015, Seminars in oncology.

CAR-T Cells Hit the Tumor Microenvironment: Strategies to Overcome Tumor Escape

D. Powell, A. Palazón, A. Rodríguez-García, 2020, Frontiers in Immunology.

Synergistic effects of CTLA‐4 blockade with tremelimumab and elimination of regulatory T lymphocytes in vitro and in vivo

B. Sangro, I. Melero, S. Martín-Algarra, 2011, International journal of cancer.

Effects of IFN‐α as a signal‐3 cytokine on human naïve and antigen‐experienced CD8+ T cells

J. Prieto, I. Melero, S. Hervás-Stubbs, 2010, European journal of immunology.

Combined Immunostimulatory Monoclonal Antibodies Extend Survival in an Aggressive Transgenic Hepatocellular Carcinoma Mouse Model

B. Sangro, I. Melero, S. Hervás-Stubbs, 2013, Clinical Cancer Research.

S-2-hydroxyglutarate regulates CD 8 + T-lymphocyte fate

J. Griffiths, L. Poellinger, A. Goldrath, 2016 .

Structural Characterization of N‐Linked Glycans in the Receptor Binding Domain of the SARS‐CoV‐2 Spike Protein and their Interactions with Human Lectins

Jon I. Quintana, M. Valle, N. Abrescia, 2020, Angewandte Chemie.

Sensitive detection of SARS-CoV-2 seroconversion by flow cytometry reveals the presence of nucleoprotein-reactive antibodies in Covid-19-naive individuals

R. Gil-Redondo, N. Abrescia, So young Lee, 2020, medRxiv.

SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum

Shelly C. Lu, R. Gil-Redondo, F. Lopitz-Otsoa, 2020, iScience.

Design and efficacy of a monovalent bispecific PD-1/CTLA-4 antibody that enhances CTLA-4 blockade on PD-1+ activated T cells.

Daniel J. Freeman, Des C. Jones, B. Tran, 2021, Cancer discovery.

Intensive pharmacological immunosuppression allows for repetitive liver gene transfer with recombinant adenovirus in nonhuman primates.

J. Prieto, I. Melero, S. Hervás-Stubbs, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function

R. Johnson, B. Nicolet, M. Wolkers, 2022, bioRxiv.

The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes

L. A. Martínez-Cruz, M. Martínez-Chantar, R. Nogueiras, 2022, Communications Biology.

Surfing the waves of the tide model of T cell co-stimulation

I. Melero, I. Martinez-Forero, A. Palazón, 2012 .

Neddylation tunes peripheral blood mononuclear cells immune response in COVID-19 patients

M. Martínez-Chantar, J. Lozano, R. Nogueiras, 2022, Cell death discovery.

SARS-CoV-2 infects human GnRH neurons and tanycytes, disrupting hypothalamic-pituitary hormonal axes

Sreekala S. Nampoothiri, F. Pasquier, L. Storme, 2021 .

Essential complicity of perforin-granzyme and FAS-L mechanisms to achieve tumor rejection following treatment with anti-CD137 mAb

I. Melero, A. Anel, S. Hervás-Stubbs, 2013, Journal of Immunotherapy for Cancer.

Hypoxia-induced soluble CD137 in malignant cells blocks CD137L-costimulation as an immune escape mechanism

I. Melero, M. Rodriguez-Ruiz, J. Pérez-Gracia, 2014, Journal of Immunotherapy for Cancer.

Liver Gene Transfer of Interkeukin-15 Constructs That Become Part of Circulating High Density Lipoproteins for Immunotherapy

J. Prieto, I. Melero, P. Berraondo, 2012, PloS one.

Therapeutic Antitumor Efficacy of Anti-CD137 Agonistic Monoclonal Antibody in Mouse Models of Myeloma

I. Melero, J. Pérez-Gracia, A. Arina, 2008, Clinical Cancer Research.

Intratumoral injection of interferon‐α and systemic delivery of agonist anti‐CD137 monoclonal antibodies synergize for immunotherapy

I. Melero, P. Berraondo, S. Hervás-Stubbs, 2011, International journal of cancer.

In vivo depletion of DC impairs the anti‐tumor effect of agonistic anti‐CD137 mAb

I. Melero, P. Berraondo, A. Arina, 2009, European journal of immunology.

A flow cytometry-based neutralization assay for simultaneous evaluation of blocking antibodies against SARS-CoV-2 variants

O. Millet, M. Martínez-Chantar, M. López-Hoyos, 2022, Frontiers in Immunology.

CD137 on inflamed lymphatic endothelial cells enhances CCL21‐guided migration of dendritic cells

I. Melero, A. Rogel, F. Lang, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment

C. Isacke, F. Calvo, J. Flores, 2022, The Journal of clinical investigation.

A cell-engineered system to assess tumor cell sensitivity to CD8+ T cell-mediated cytotoxicity

S. Barry, Paul D. Smith, R. Wilkinson, 2019, Oncoimmunology.

Lysine 63 Polyubiquitination in Immunotherapy and in Cancer-promoting Inflammation

I. Melero, I. Martinez-Forero, A. Rouzaut, 2009, Clinical Cancer Research.

CD69 is a direct HIF-1α target gene in hypoxia as a mechanism enhancing expression on tumor-infiltrating T lymphocytes

F. Sánchez‐Madrid, I. Melero, P. Maiso, 2017, Oncoimmunology.

An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression

J. Bergh, I. Hedenfalk, N. Loman, 2017, Cancer cell.

The immunometabolite S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate

J. Griffiths, L. Poellinger, A. Goldrath, 2016, Nature.

HIF transcription factors, inflammation, and immunity.

V. Nizet, A. Goldrath, R. Johnson, 2014, Immunity.

Polly Matzinger's “danger model” finds its predicted danger-denoting self moieties

I. Melero, J. Pérez-Gracia, S. Hervás-Stubbs, 2008 .

A Phase I Pharmacologic Study of Necitumumab (imc-11f8), a Fully Human Igg1 Monoclonal Antibody the Hif-1␣ Hypoxia Response in Tumor-infi Ltrating T Lymphocytes Induces Functional Cd137 (4-1bb) for Immunotherapy

I. Melero, J. Aragonés, J. Pérez-Gracia, 2022 .

Constitutive Glycolytic Metabolism Supports CD8+ T Cell Effector Memory Differentiation during Viral Infection.

A. Goldrath, R. Johnson, A. Doedens, 2016, Immunity.

T Cell Costimulation with Anti-CD137 Monoclonal Antibodies Is Mediated by K63–Polyubiquitin-Dependent Signals from Endosomes

J. Zapata, I. Melero, O. Murillo, 2013, The Journal of Immunology.

Polyubiquitin-Dependent Signals from - Monoclonal Antibodies Is Mediated by K63 T Cell Costimulation with Anti-CD137

Ivan Martinez-Forero, Juan M. Zapata, Ignacio Melero, 2013 .

Modelling pulmonary microthrombosis coupled to metastasis: distinct effects of thrombogenesis on tumorigenesis

P. Bendahl, R. Johnson, M. Belting, 2017, Biology Open.

Cardiotrophin-1 determines liver engraftment of syngenic colon carcinoma cells through an immune system-mediated mechanism

C. Ortiz de Solórzano, I. Melero, J. Pérez-Gracia, 2012, Oncoimmunology.

Carcinoma-Derived Interleukin-8 Disorients Dendritic Cell Migration Without Impairing T-Cell Stimulation

I. Melero, J. Pérez-Gracia, Álvaro González, 2011, PloS one.

Dendritic cells adhere to and transmigrate across lymphatic endothelium in response to IFN‐α

I. Melero, S. Hervás-Stubbs, I. Martinez-Forero, 2010, European journal of immunology.

Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment of activated T lymphocytes.

I. Melero, J. Pérez-Gracia, S. Hervás-Stubbs, 2011, Cancer research.

Influence of bevacizumab, sunitinib and sorafenib as single agents or in combination on the inhibitory effects of VEGF on human dendritic cell differentiation from monocytes

I. Melero, J. Pérez-Gracia, S. Hervás-Stubbs, 2009, British Journal of Cancer.

Molecular Pathways: Hypoxia Response in Immune Cells Fighting or Promoting Cancer

I. Melero, J. Aragonés, A. Palazón, 2011, Clinical Cancer Research.

SimB16: Modeling Induced Immune System Response against B16-Melanoma

Francesco Pappalardo, Marzio Pennisi, Santo Motta, 2011, PloS one.

SimB 16 : Modeling Induced Immune System Response against B 16-Melanoma

Francesco Pappalardo, Marzio Pennisi, Santo Motta, 2011 .

Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate

E. Berra, J. Ereño-Orbea, So Young Lee, 2021, bioRxiv.

Interferon producing killer dendritic cells (IKDC): A matter of controversy

I. Melero, S. Hervás-Stubbs, Ivan Martinez Forero, 2010 .

Palettes of Vaccines and Immunostimulatory Monoclonal Antibodies for Combination

Lieping Chen, I. Melero, I. Martinez-Forero, 2009, Clinical Cancer Research.

The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia

D. Peet, R. Johnson, A. Cowburn, 2018, Cell metabolism.

An NMR-Based Model to Investigate the Metabolic Phenoreversion of COVID-19 Patients throughout a Longitudinal Study

Shelly C. Lu, R. Gil-Redondo, M. Spraul, 2022, Metabolites.

Enabling CAR-T cells for solid tumors: Rage against the suppressive tumor microenvironment.

A. Palazón, S. Zanetti, A. Antoñana-Vildosola, 2022, International review of cell and molecular biology.

Assessing the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans by Structural and Computational Methods

D. Charro, N. Abrescia, S. Connell, 2022, Frontiers in Microbiology.

Sensitive detection of SARS-CoV-2 seroconversion by flow cytometry reveals the presence of nucleoprotein-reactive antibodies in unexposed individuals

R. Gil-Redondo, N. Abrescia, J. Mato, 2021, Communications Biology.

Sensitive detection of SARS-CoV-2 seroconversion by flow cytometry reveals the presence of nucleoprotein-reactive antibodies in unexposed individuals

R. Gil-Redondo, N. Abrescia, J. Mato, 2021, Communications Biology.

Hypoxia Promotes Syndecan-3 Expression in the Tumor Microenvironment

So Young Lee, A. Palazón, A. Antoñana-Vildosola, 2020, Frontiers in Immunology.

Dendritic Cells Take up and Present Antigens from Viable and Apoptotic Polymorphonuclear Leukocytes

I. Melero, J. Pérez-Gracia, Álvaro González, 2011, PloS one.

Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b

Jon I. Quintana, J. Sutherland, M. Azkargorta, 2023, Nature communications.

Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment

C. Isacke, F. Calvo, J. Flores, 2022, The Journal of clinical investigation.

The outcome of boosting mitochondrial activity in alcohol-associated liver disease is organ-dependent

M. Fraga, R. Bataller, L. A. Martínez-Cruz, 2023, Hepatology.

Factor-inhibiting HIF (FIH) promotes lung cancer progression

A. Palazón, Ander de Blas, Adrián Barreira-Manrique, 2023, JCI insight.

Long-COVID cognitive impairments and reproductive hormone deficits in men may stem from GnRH neuronal death

Sreekala S. Nampoothiri, M. Schwaninger, C. Maurage, 2023, EBioMedicine.

The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function.

M. Giera, C. Jorgensen, R. Johnson, 2023, Cell reports.