J. Legg

发表

Enhancement of antibody-dependent cell-mediated cytotoxicity by endowing IgG with FcαRI (CD89) binding

Herren Wu, N. Luheshi, Nurten Beyaz, 2015, mAbs.

Identification and functional analysis of the ezrin-binding site in the hyaluronan receptor, CD44

C. Isacke, J. Legg, 1998, Current Biology.

The role of the CD44 transmembrane and cytoplasmic domains in co-ordinating adhesive and signalling events

C. Isacke, R. Thorne, J. Legg, 2003, Journal of Cell Science.

Increased Tumor Penetration of Single-Domain Antibody Drug Conjugates Improves In Vivo Efficacy in Prostate Cancer Models.

Adnan O. Abu-Yousif, Greg M. Thurber, T. Keating, 2020, Cancer research.

The multi-specific VH-based Humabody CB213 co-targets PD1 and LAG3 on T cells to promote anti-tumour activity

Isabelle H. Osuch, Phillipa Bartlett, G. Kochan, 2021, British Journal of Cancer.

Understanding the influence of the tumor microenvironment on macrophage responses to CD40 agonists

N. Luheshi, G. Davies, J. Legg, 2014, Oncoimmunology.

Role of melanoma chondroitin sulphate proteoglycan in patterning stem cells in human interfollicular epidermis

F. Watt, U. Jensen, I. Leigh, 2003, Development.

The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44.

C. Haipek, C. Isacke, D. Gutmann, 2001, Genes & development.

PD-1/LAG-3 DYSFUNCTIONALITY SIGNATURES IN HUMAN CANCERS

C. Johnston, J. Fernández-Irigoyen, G. Kochan, 2023, medRxiv.

Th1 cytokines are more effective than Th2 cytokines at licensing anti‐tumour functions in CD40‐activated human macrophages in vitro

James Legg, N. Luheshi, M. Mccourt, 2014, European journal of immunology.

A novel PKC-regulated mechanism controls CD44–ezrin association and directional cell motility

Maddy Parsons, Clare M. Isacke, C. Isacke, 2002, Nature Cell Biology.

Discrete domains within the hyaluronan receptor CD44 regulate membrane localization and cell migration.

C. Isacke, D. Peck, J. Legg, 1998, Cell adhesion and communication.

Abstract 3352: Tumor dependent co-stimulation of CD137/4-1BB in PSMA positive tumors: Preclinical characterization of CB307, a half-life extended PSMAxCD137 bispecific Humabody therapeutic

J. Legg, 2020 .

Syntenin mediates Delta1-induced cohesiveness of epidermal stem cells in culture

F. Watt, S. Estrach, J. Legg, 2007, Journal of Cell Science.

Abstract 930: CB213: A half-life extended bispecific Humabody VHdelivering dual checkpoint blockade to reverse the dysfunction of LAG3+PD-1+double-positive T cells

G. Kochan, D. Escors, H. Arasanz, 2020 .