Qian Wang

发表

A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs

Jincun Zhao, Jie Zhou, Lu Lu, 2022, Cell Research.

A Modified Fibronectin Type III Domain-Conjugated, Long-Acting Pan-Coronavirus Fusion Inhibitor with Extended Half-Life

Lu Lu, S. Xia, Rui Wang, 2022, Viruses.

Identification of fragments binding to SARS-CoV-2 nsp10 reveals ligand-binding sites in conserved interfaces between nsp10 and nsp14/nsp16

Qian Wang, Z. Fisher, F. Kozielski, 2021, RSC chemical biology.

Improved Pharmacological and Structural Properties of HIV Fusion Inhibitor AP3 over Enfuvirtide: Highlighting Advantages of Artificial Peptide Strategy

Q. Wang, Rongguang Zhang, Lu Lu, 2015, Scientific Reports.

neutralizing activity in the presence of HIV fusion inhibitor enfuvirtide: a

F. Yu, Qianqian Qi, Qian Wang, 2015 .

Synergistic Effect Resulting From Combinations of a Bifunctional HIV-1 Antagonist With Antiretroviral Drugs

Lu Lu, Shibo Jiang, F. Yu, 2014, Journal of acquired immune deficiency syndromes.

A Protein-Based, Long-Acting HIV-1 Fusion Inhibitor with an Improved Pharmacokinetic Profile

Lu Lu, Rui Wang, Z. Cong, 2022, Pharmaceuticals.

Enhancement of endocytic uptake of HIV-1 virions into CD4-negative epithelial cells by HIV-1 gp41 via its interaction with POB1

Lu Lu, Shibo Jiang, Ying-hua Chen, 2015, Cellular and Molecular Immunology.

Artificial peptides conjugated with cholesterol and pocket-specific small molecules potently inhibit infection by laboratory-adapted and primary HIV-1 isolates and enfuvirtide-resistant HIV-1 strains.

Liang Xu, Lu Lu, Shibo Jiang, 2014, The Journal of antimicrobial chemotherapy.

Sodium Copper Chlorophyllin Is Highly Effective against Enterovirus (EV) A71 Infection by Blocking Its Entry into the Host Cell.

Lu Lu, Shibo Jiang, W. Xu, 2020, ACS infectious diseases.

Development of variant‐proof severe acute respiratory syndrome coronavirus 2, pan‐sarbecovirus, and pan‐β‐coronavirus vaccines

Jie Zhou, Lu Lu, Zezhong Liu, 2022, Journal of Medical Virology.

A Palmitic Acid-Conjugated, Peptide-Based pan-CoV Fusion Inhibitor Potently Inhibits Infection of SARS-CoV-2 Omicron and Other Variants of Concern

J. Chan, K. Yuen, Jie Zhou, 2022, Viruses.

A pan-sarbecovirus vaccine induces highly potent and durable neutralizing antibody responses in non-human primates against SARS-CoV-2 Omicron variant

J. Chan, K. Yuen, Jie Zhou, 2022, Cell Research.

Anti-HIV antibody and drug combinations exhibit synergistic activity against drug-resistant HIV-1 strains.

D. Dimitrov, Lu Lu, Shibo Jiang, 2017, The Journal of infection.

3-Hydroxyphthalic Anhydride- Modified Rabbit Anti-PAP IgG as a Potential Bifunctional HIV-1 Entry Inhibitor

Suiyi Tan, Shibo Jiang, Shuwen Liu, 2018, Front. Microbiol..

Chemically Modified Bovine β-Lactoglobulin as a Broad-Spectrum Influenza Virus Entry Inhibitor with the Potential to Combat Influenza Outbreaks

Lu Lu, Weihua Li, Zezhong Liu, 2022, Viruses.

Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor

Lu Lu, Shibo Jiang, Yun Zhu, 2014, Nature Communications.

Intranasal Administration of Maleic Anhydride-Modified Human Serum Albumin for Pre-Exposure Prophylaxis of Respiratory Syncytial Virus Infection

Wei Xu, Lu Lu, Shibo Jiang, 2015, Viruses.

An engineered HIV-1 gp41 trimeric coiled coil with increased stability and anti-HIV-1 activity: implication for developing anti-HIV microbicides.

Q. Wang, Lu Lu, Shibo Jiang, 2013, The Journal of antimicrobial chemotherapy.

The recombinant subunit vaccine RBD-Fc, consisting of SARS-CoV-2 RBD and human IgG Fc as an immunopotentiator, elicits robust neutralizing antibody responses against SARS-CoV-2 infection

D. Qu, Jie Zhou, Lu Lu, 2020 .

A variant-proof SARS-CoV-2 vaccine targeting HR1 domain in S2 subunit of spike protein

F. Shen, S. Ouyang, Yong-tang Zheng, 2022, Cell Research.

Lipopeptide-based pan-CoV fusion inhibitors potently inhibit HIV-1 infection

Jie Zhou, Lu Lu, Shibo Jiang, 2021, Microbes and Infection.

Nonneutralizing Antibodies Induced by the HIV-1 gp41 NHR Domain Gain Neutralizing Activity in the Presence of the HIV Fusion Inhibitor Enfuvirtide: a Potential Therapeutic Vaccine Strategy

Q. Wang, Lu Lu, Shibo Jiang, 2015, Journal of Virology.

Predicting unseen antibodies’ neutralizability via adaptive graph neural networks

Hongyan Wu, Pengfei Zhou, Shaoting Zhang, 2022, Nature Machine Intelligence.

Inhibition of viral suppressor of RNAi proteins by designer peptides protects from enteroviral infection in vivo.

Y. Qiu, S. Curry, Yuan Fang, 2021, Immunity.

A randomized open-label clinical trial of an anti-HPV biological dressing (JB01-BD) administered intravaginally to treat high-risk HPV infection.

Lu Lu, Shibo Jiang, Ke Huang, 2016, Microbes and infection.

The Underlying Mechanism of 3-Hydroxyphthalic Anhydride-Modified Bovine Beta-Lactoglobulin to Block Human Papillomavirus Entry Into the Host Cell

Shibo Jiang, L. Sui, Yun Zhu, 2019, Front. Microbiol..

The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin

W. Xu, Lu Lu, Shibo Jiang, 2020, Signal Transduction and Targeted Therapy.

RBD-Fc-based COVID-19 vaccine candidate induces highly potent SARS-CoV-2 neutralizing antibody response

D. Qu, Jie Zhou, W. Xu, 2020, Signal Transduction and Targeted Therapy.

An amphipathic peptide targeting the gp41 cytoplasmic tail kills HIV-1 virions and infected cells

Q. Wang, Lu Lu, Shibo Jiang, 2020, Science Translational Medicine.

The Antihistamine Drugs Carbinoxamine Maleate and Chlorpheniramine Maleate Exhibit Potent Antiviral Activity Against a Broad Spectrum of Influenza Viruses

Wei Xu, Lu Lu, Shibo Jiang, 2018, Front. Microbiol..

Development of oncolytic virotherapy: from genetic modification to combination therapy

W. Xu, Lu Lu, Shibo Jiang, 2020, Frontiers of Medicine.

A Peptide-Based HIV-1 Fusion Inhibitor with Two Tail-Anchors and Palmitic Acid Exhibits Substantially Improved In Vitro and Ex Vivo Anti-HIV-1 Activity and Prolonged In Vivo Half-Life

Q. Wang, Lu Lu, Shibo Jiang, 2019, Molecules.

Crystal Structure of Refolding Fusion Core of Lassa Virus GP2 and Design of Lassa Virus Fusion Inhibitors

Rongguang Zhang, Shibo Jiang, S. Ye, 2019, Front. Microbiol..

Middle East respiratory syndrome coronavirus (MERS-CoV) entry inhibitors targeting spike protein

Lu Lu, Shan Su, Shibo Jiang, 2014, Virus Research.

Broad-Spectrum Coronavirus Fusion Inhibitors to Combat COVID-19 and Other Emerging Coronavirus Diseases

W. Xu, Lu Lu, Shibo Jiang, 2020, International journal of molecular sciences.

Chemically Modified Human Serum Albumin Potently Blocks Entry of Ebola Pseudoviruses and Viruslike Particles

Lu Lu, Shibo Jiang, S. Xia, 2017, Antimicrobial Agents and Chemotherapy.

A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike

Lu Lu, Wenjie Tan, Qian Wang, 2019, Science Advances.

A Peptide-Based Virus Inactivator Protects Male Mice Against Zika Virus-Induced Damage of Testicular Tissue

Lu Lu, Shibo Jiang, Peng Zou, 2019, Front. Microbiol..

Protein- and Peptide-Based Virus Inactivators: Inactivating Viruses Before Their Entry Into Cells

Y. Wen, Lu Lu, Shibo Jiang, 2020, Frontiers in Microbiology.

A highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases

Jie Zhou, Lu Lu, Shibo Jiang, 2021, Acta Pharmaceutica Sinica B.

Facing the challenge of viral mutations in the age of pandemic: Developing highly potent, broad‐spectrum, and safe COVID‐19 vaccines and therapeutics

Shibo Jiang, Shan Su, Qian Wang, 2021, Clinical and translational medicine.

Development of Protein- and Peptide-Based HIV Entry Inhibitors Targeting gp120 or gp41

Lu Lu, Shibo Jiang, J. Pu, 2019, Viruses.

Intranasal application of polyethyleneimine suppresses influenza virus infection in mice

Q. Wang, Lu Lu, Shibo Jiang, 2016, Emerging Microbes & Infections.

IgG Fc-binding motif-conjugated HIV-1 fusion inhibitor exhibits improved potency and in vivo half-life: Potential application in combination with broad neutralizing antibodies

Lu Lu, Shibo Jiang, L. Su, 2019, PLoS pathogens.

An ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope

Y. Wen, Zhenguo Chen, Jie Zhou, 2021, Protein & Cell.

Advancements in Developing Strategies for Sterilizing and Functional HIV Cures

Lu Lu, Shibo Jiang, Weihua Li, 2017, BioMed research international.

SARS‐CoV‐2 Omicron XBB subvariants exhibit enhanced fusogenicity and substantial immune evasion in elderly population, but high sensitivity to pan‐coronavirus fusion inhibitors

Lu Lu, S. Xia, Jinghe Huang, 2023, Journal of medical virology.

ADS-J1 Inhibits Semen-Derived Amyloid Fibril Formation and Blocks Fibril-Mediated Enhancement of HIV-1 Infection

Lu Lu, Suiyi Tan, Shibo Jiang, 2015, Antimicrobial Agents and Chemotherapy.

Development of variant‐proof severe acute respiratory syndrome coronavirus 2, pan‐sarbecovirus, and pan‐β‐coronavirus vaccines

Jie Zhou, Lu Lu, Zezhong Liu, 2022, Journal of medical virology.

Peptide-based pan-CoV fusion inhibitors maintain high potency against SARS-CoV-2 Omicron variant

J. Chan, K. Yuen, Lu Lu, 2022, Cell Research.

Structure-based evidence for the enhanced transmissibility of the dominant SARS-CoV-2 B.1.1.7 variant (Alpha)

Lu Lu, S. Xia, Qiaoshuai Lan, 2021, Cell discovery.

Potent MERS-CoV Fusion Inhibitory Peptides Identified from HR2 Domain in Spike Protein of Bat Coronavirus HKU4

Q. Wang, Lu Lu, Shibo Jiang, 2019, Viruses.

SARS-CoV-2 Omicron subvariants exhibit distinct fusogenicity, but similar sensitivity, to pan-CoV fusion inhibitors

Lu Lu, S. Xia, Yun Zhu, 2023, Emerging microbes & infections.

Structural and functional basis for pan-CoV fusion inhibitors against SARS-CoV-2 and its variants with preclinical evaluation

F. Kirchhoff, Jie Zhou, J. Münch, 2021, Signal Transduction and Targeted Therapy.

Peptide-Based Membrane Fusion Inhibitors Targeting HCoV-229E Spike Protein HR1 and HR2 Domains

Lu Lu, Shibo Jiang, S. Xia, 2018, International journal of molecular sciences.

Adenovirus-based vaccines against avian-origin H5N1 influenza viruses

Lu Lu, Shibo Jiang, L. Du, 2014, Microbes and Infection.

Conjugation of a nonspecific antiviral sapogenin with a specific HIV fusion inhibitor: a promising strategy for discovering new antiviral therapeutics.

Lu Lu, Shibo Jiang, Qian Wang, 2014, Journal of medicinal chemistry.

Multitargeted drug design strategy for discovery of short-peptide-based HIV-1 entry inhibitors with high potency.

Lu Lu, Chao Wang, F. Yu, 2023, European journal of medicinal chemistry.

Visual and Motor Deficits in Grown-up Mice with Congenital Zika Virus Infection

Hao Zheng, Q. Wang, Shibo Jiang, 2017, EBioMedicine.

Combining New Non-Nucleoside Reverse Transcriptase Inhibitors (RTIs) with AZT Results in Strong Synergism against Multi-RTI-Resistant HIV-1 Strains

Q. Wang, Shibo Jiang, F. Yu, 2018, Molecules.

Co-delivery of HIV-1 entry inhibitor and nonnucleoside reverse transcriptase inhibitor shuttled by nanoparticles: cocktail therapeutic strategy for antiviral therapy

Q. Wang, Lu Lu, Shibo Jiang, 2016, AIDS.

Co-delivery of HIV-1 entry inhibitor and NNRTI shuttled by nanoparticles : cocktail therapeutic strategy for antiviral therapy

Lu Lu, Shibo Jiang, F. Yu, 2015 .

A Toxin-Conjugated Recombinant Protein Targeting gp120 and gp41 for Inactivating HIV-1 Virions and Killing Latency-Reversing Agent-Reactivated Latent Cells

Lu Lu, T. Ying, Yanling Wu, 2022, mBio.

Design, synthesis, and biological evaluation of highly potent small molecule-peptide conjugates as new HIV-1 fusion inhibitors.

Liang Xu, Jinglai Li, Lu Lu, 2013, Journal of medicinal chemistry.

A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses

K. Yuen, Lu Lu, Shibo Jiang, 2017, Nature Communications.

25‐hydroxycholesterol inhibits human papillomavirus infection in cervical epithelial cells by perturbing cytoskeletal remodeling

Lu Lu, Qian Wang, Shibo Jiang, 2023, Journal of medical virology.

Supercoiling Structure-Based Design of a Trimeric Coiled-Coil Peptide with High Potency against HIV-1 and Human β-Coronavirus Infection

S. Huo, Lu Lu, Shibo Jiang, 2021, Journal of medicinal chemistry.

Genomic signature analysis of the recently emerged highly pathogenic A(H5N8) avian influenza virus: implying an evolutionary trend for bird-to-human transmission.

Q. Wang, Lu Lu, Shibo Jiang, 2017, Microbes and infection.

Receptor Binding Domain Based HIV Vaccines

Lu Lu, Shibo Jiang, Qian Wang, 2015, BioMed research international.

Rational improvement of gp41-targeting HIV-1 fusion inhibitors: an innovatively designed Ile-Asp-Leu tail with alternative conformations

Rongguang Zhang, Lu Lu, Shibo Jiang, 2016, Scientific Reports.

Chidamide, a histone deacetylase inhibitor-based anticancer drug, effectively reactivates latent HIV-1 provirus.

W. Xu, Lu Lu, Shibo Jiang, 2017, Microbes and infection.

Synergistic Effect by Combining a gp120-Binding Protein and a gp41-Binding Antibody to Inactivate HIV-1 Virions and Inhibit HIV-1 Infection

Lu Lu, Shibo Jiang, T. Ying, 2021, Molecules.

Testing of Middle East Respiratory Syndrome Coronavirus Replication Inhibitors for the Ability To Block Viral Entry

Lu Lu, Shibo Jiang, Qian Wang, 2014, Antimicrobial Agents and Chemotherapy.

An immunogen containing four tandem 10E8 epitope repeats with exposed key residues induces antibodies that neutralize HIV-1 and activates an ADCC reporter gene

Lu Lu, Shibo Jiang, T. Ying, 2016, Emerging Microbes & Infections.

HIV-1 Env DNA prime plus gp120 and gp70-V1V2 boosts induce high level of V1V2-specific IgG and ADCC responses and low level of Env-specific IgA response: implication for improving RV144 vaccine regimen

Lu Lu, Shibo Jiang, Zhiwu Sun, 2017, Emerging microbes & infections.

Identification of a Human Protein-Derived HIV-1 Fusion Inhibitor Targeting the gp41 Fusion Core Structure

Q. Wang, Lu Lu, Shibo Jiang, 2013, PloS one.

Rational Design of A Novel Small-Molecule HIV-1 Inactivator Targeting Both gp120 and gp41 of HIV-1

Lu Lu, Shibo Jiang, Shengqi Wang, 2021, Frontiers in Pharmacology.

Creating an Artificial Tail Anchor as a Novel Strategy To Enhance the Potency of Peptide-Based HIV Fusion Inhibitors

Rongguang Zhang, Q. Wang, Lu Lu, 2016, Journal of Virology.

IgG Fc-Binding Peptide-Conjugated Pan-CoV Fusion Inhibitor Exhibits Extended In Vivo Half-Life and Synergistic Antiviral Effect When Combined with Neutralizing Antibodies

Lu Lu, S. Xia, Qian Wang, 2023, Biomolecules.

HIV-1 gp41-targeting fusion inhibitory peptides enhance the gp120-targeting protein-mediated inactivation of HIV-1 virions

D. Dimitrov, Q. Wang, Lu Lu, 2017, Emerging Microbes &Infections.

A pan-sarbecovirus vaccine based on RBD of SARS-CoV-2 original strain elicits potent neutralizing antibodies against XBB in non-human primates

Jie Zhou, Lu Lu, Jinghe Huang, 2023, Proceedings of the National Academy of Sciences of the United States of America.

A novel HIV-1 gp41 tripartite model for rational design of HIV-1 fusion inhibitors with improved antiviral activity

Lu Lu, Shibo Jiang, Yun Zhu, 2017, AIDS.

An effective strategy for recapitulating N-terminal heptad repeat trimers in enveloped virus surface glycoproteins for therapeutic applications† †Electronic supplementary information (ESI) available: General materials, methods, and the details. See DOI: 10.1039/c5sc04046a

Lu Lu, Shibo Jiang, Keliang Liu, 2015, Chemical science.

Putative suppressing effect of IgG Fc-conjugated haemagglutinin (HA) stalk of influenza virus H7N9 on the neutralizing immunogenicity of Fc-conjugated HA head: implication for rational design of HA-based influenza vaccines.

Lu Lu, S. Xia, F. Yu, 2016, The Journal of general virology.

An engineered HIV-1 gp41 trimeric coiled coil with increased stability and anti-HIV-1 activity: implication for developing anti-HIV microbicides.

Lu Lu, Shibo Jiang, Ying-hua Chen, 2013, The Journal of antimicrobial chemotherapy.

Lineage Replacement and Genetic Changes of Four HR-HPV Types during the Period of Vaccine Coverage: A Six-Year Retrospective Study in Eastern China

Qian Wang, Shibo Jiang, Chen Hua, 2024, Vaccines.

Neutralization of SARS-CoV-2 BA.2.86 and JN.1 by CF501 adjuvant-enhanced immune responses targeting the conserved epitopes in ancestral RBD

Jie Zhou, Yun Zhu, Zezhong Liu, 2024, Cell reports. Medicine.

A dePEGylated Lipopeptide-Based Pan-Coronavirus Fusion Inhibitor Exhibits Potent and Broad-Spectrum Anti-HIV-1 Activity without Eliciting Anti-PEG Antibodies

Jie Zhou, Lu Lu, Chao Wang, 2023, International journal of molecular sciences.

Structure-based evidence for the enhanced transmissibility of the dominant SARS-CoV-2 B.1.1.7 variant (Alpha)

Lu Lu, Qiaoshuai Lan, Fei Sun, 2021, Cell Discovery.

A nanoparticle-encapsulated non-nucleoside reverse-transcriptase inhibitor with enhanced anti-HIV-1 activity and prolonged circulation time in plasma.

Q. Wang, Lu Lu, Shibo Jiang, 2014, Current pharmaceutical design.

Repurposing Navitoclax to block SARS‐CoV‐2 fusion and entry by targeting heptapeptide repeat sequence 1 in S2 protein

A. Tuzikov, Lu Lu, A. Andrianov, 2023, Journal of medical virology.