J. Hyde

发表

A mutation-specific PCR system to detect sequence variation in the dihydropteroate synthetase gene of Plasmodium falciparum.

J. E. Hyde, P. Sims, D. Brooks, 1995, Molecular and biochemical parasitology.

Protooncogene amplification and tumor ploidy in human ovarian neoplasms.

C. Garrett, D. Wilkinson, S. Silverberg, 1990, Human pathology.

Translational up-regulation of antifolate drug targets in the human malaria parasite Plasmodium falciparum upon challenge with inhibitors.

J. Hyde, P. Sims, N. Nirmalan, 2004, Molecular and biochemical parasitology.

Rational drug design approach for overcoming drug resistance: application to pyrimethamine resistance in malaria.

M Read, J. E. Hyde, W. Sirawaraporn, 1998, Journal of medicinal chemistry.

Pyrimethamine analogs as strong inhibitors of double and quadruple mutants of dihydrofolate reductase in human malaria parasites.

W. Sirawaraporn, K. Douglas, R. Sirawaraporn, 2003, Organic & biomolecular chemistry.

The photoaddition of trimethylpsoralen to Drosophila melanogaster nuclei: a probe for chromatin substructure.

J. E. Hyde, J. Hearst, J. Hyde, 1977, Biochemistry.

Dynamic subcellular localization of isoforms of the folate pathway enzyme serine hydroxymethyltransferase (SHMT) through the erythrocytic cycle of Plasmodium falciparum

J. E. Hyde, S. L. Mitchell, J. Hyde, 2010, Malaria Journal.

Isolation of parasite genes using synthetic oligonucleotides.

S. Holloway, J. Hyde, 1993, Methods in molecular biology.

Point mutations and pyrimethamine resistance in Plasmodium falciparum.

J. Hyde, 1989, Parasitology today.

Folate metabolism in human malaria parasites--75 years on.

J. E. Hyde, J. Hyde, I. Müller, 2013, Molecular and biochemical parasitology.

Characterisation and translation studies of messenger RNA from the human malaria parasite Plasmodium falciparum and construction of a cDNA library.

J. E. Hyde, I. Hope, A. Osland, 1984, Molecular and biochemical parasitology.

Antigens of Plasmodiwn falciparum blood stages with clinical interest cloned and expressed in E. coli

I. Hope, N. Bone, G. Langsley, 1986, Parasitology.

Drug-resistant malaria.

J. E. Hyde, J. Hyde, 2005, Trends in parasitology.

The reactivity of the thiol groups of calf thymus deoxyribonucleohistone.

I. O. Walker, J. Hyde, 1974, Nucleic acids research.

Isolation of α‐tubulin genes from the human malaria parasite, Plasmodium falciparum: sequence analysis of α‐tubulin

S. Holloway, C. Delves, J. Scaife, 1989 .

Microtubular organization visualized by immunofluorescence microscopy during erythrocytic schizogony in Plasmodium falciparum and investigation of post-translational modifications of parasite tubulin

J. E. Hyde, K. Gull, S. Holloway, 1993, Parasitology.

Cloning and characterisation of the rRNA genes from the human malaria parasite Plasmodium falciparum.

J. E. Hyde, G. Langsley, J. Scaife, 1983, Nucleic acids research.

Green roots of malaria.

J. E. Hyde, P. Sims, J. Hyde, 1994, Parasitology today.

Targeting purine and pyrimidine metabolism in human apicomplexan parasites.

J. Hyde, 2007, Current drug targets.

Molecular evidence for multiple Toxoplasma gondii infections in individual patients in England and Wales: public health implications.

J. E. Hyde, K. Roberts, E. Guy, 2003, International journal for parasitology.

Major surface antigen gene of a human malaria parasite cloned and expressed in bacteria

J. E. Hyde, I. Hope, J. Stocker, 1984, Nature.

The interaction of core histones with DNA: equilibrium binding studies.

D. Burton, M. J. Butler, C. Skidmore, 1978, Nucleic acids research.

Functional expression of the dihydrofolate reductase and thymidylate synthetase activities of the human malaria parasite Plasmodium falciparum in Escherichia coli.

P. Sims, S. Hall, J. Hyde, 1991, Molecular and biochemical parasitology.

Functional identification of orthologous genes encoding pterin recycling activity in Plasmodium falciparum and Toxoplasma gondii.

J. E. Hyde, A. Hanson, J. Hyde, 2006, Molecular and biochemical parasitology.

Cloning of a β‐tubulin gene from Plasmodium falciparum

S. Holloway, C. Delves, R. Ridley, 1989 .

Mechanisms of resistance of Plasmodium falciparum to antimalarial drugs.

J. E. Hyde, John E Hyde, J. Hyde, 2002, Microbes and infection.

A bifunctional dihydrofolate synthetase--folylpolyglutamate synthetase in Plasmodium falciparum identified by functional complementation in yeast and bacteria.

J. E. Hyde, C. Plowe, P. Sims, 2001, Molecular and biochemical parasitology.

Exploring the folate pathway in Plasmodium falciparum.

J. E. Hyde, J. Hyde, 2005, Acta tropica.

Utilization of exogenous folate in the human malaria parasite Plasmodium falciparum and its critical role in antifolate drug synergy

J. E. Hyde, T. Horii, P F Sims, 1999, Molecular microbiology.

Prevalence of Toxoplasma gondii in commercial meat products as monitored by polymerase chain reaction--food for thought?

J. E. Hyde, Damian Marlee, J. Hyde, 2002, International journal for parasitology.

Drug‐resistant malaria − an insight

J. E. Hyde, J. Hyde, 2007, The FEBS journal.

Development and comparison of quantitative assays for the dihydropteroate synthetase codon 540 mutation associated with sulfadoxine resistance in Plasmodium falciparum

P. Sims, J. Hyde, C. S. Lee, 1998, Parasitology.

The establishment of genomic DNA libraries for the human malaria parasite Plasmodium falciparum and identification of individual clones by hybridisation.

G. Langsley, J. Scaife, M. Goman, 1982, Molecular and biochemical parasitology.

Isolation and characterisation of ribosomal RNA from the human malaria parasite Plasmodium falciparum.

J. Scaife, J. Hyde, J. Zolg, 1981, Molecular and biochemical parasitology.

Binding of psoralen derivatives to DNA and chromatin: influence of the ionic environment on dark binding and photoreactivity.

J. E. Hyde, J. Hearst, J. Hyde, 1978, Biochemistry.

Mapping the origins and spread of antifolate-resistant malaria parasites.

J. Hyde, 2009, Future microbiology.

Allelic exchange at the endogenous genomic locus in Plasmodium falciparum proves the role of dihydropteroate synthase in sulfadoxine‐resistant malaria

J. E. Hyde, T. Triglia, A. Cowman, 1998, The EMBO journal.

On ;the efficacy of antifolate antimalarial combinations in Africa'.

P. Sims, J. Hyde, P. Wang, 1998, Parasitology today.

Resistance to antifolates in Plasmodium falciparum monitored by sequence analysis of dihydropteroate synthetase and dihydrofolate reductase alleles in a large number of field samples of diverse origins.

J. E. Hyde, O. Doumbo, M. Tanner, 1997, Molecular and biochemical parasitology.

Expression of α and β tubulin genes during the asexual and sexual blood stages of Plasmodium falciparum

J. E. Hyde, S. Holloway, C. Delves, 1990 .

Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxine.

J. E. Hyde, P. Sims, D. Brooks, 1994, European journal of biochemistry.

Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next?

J. E. Hyde, J. Kublin, A. Cowman, 2001, Trends in parasitology.

Antimalarial drugs: modes of action and mechanisms of parasite resistance.

J. E. Hyde, J. Hyde, I. Müller, 2010, Future microbiology.

Sulfadoxine resistance in the human malaria parasite Plasmodium falciparum is determined by mutations in dihydropteroate synthetase and an additional factor associated with folate utilization

J. E. Hyde, P. Sims, J. Hyde, 1997, Molecular microbiology.

Selection and synergy in Plasmodium falciparum.

P. Sims, J. Hyde, P. Wang, 1999, Parasitology today.

A modified in vitro sulfadoxine susceptibility assay for Plasmodium falciparum suitable for investigating Fansidar resistance

J. E. Hyde, P. Sims, J. Hyde, 1997, Parasitology.

Antifolate resistance in Africa and the 164-dollar question.

J. E. Hyde, J. Hyde, 2008, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Characterisation of the dihydrofolate reductase-thymidylate synthetase gene from human malaria parasites highly resistant to pyrimethamine.

P. Sims, J. Hyde, V. A. Snewin, 1989, Gene.

The dihydrofolate reductase-thymidylate synthetase gene in the drug resistance of malaria parasites.

J. E. Hyde, J. Hyde, 1990, Pharmacology & therapeutics.

Genetic and metabolic analysis of folate salvage in the human malaria parasite Plasmodium falciparum.

J. E. Hyde, J. Hyde, P. Sims, 2004, Molecular and biochemical parasitology.

Transfection studies to explore essential folate metabolism and antifolate drug synergy in the human malaria parasite Plasmodium falciparum

J. E. Hyde, J. Hyde, P. Sims, 2004, Molecular microbiology.

Polymorphism of the precursor for the major surface antigens of Plasmodium falciparum merozoites: studies at the genetic level.

H. Bujard, H. Stunnenberg, U. Certa, 1985, The EMBO journal.

Characterisation of the gene encoding an unusually divergent TATA-binding protein (TBP) from the extremely A+T-rich human malaria parasite Plasmodium falciparum.

J. E. Hyde, P. Sims, M Read, 1993, Gene.

Histones F2a1 and F3 interact reversibly and cooperatively with DNA to form an equimolar complex in chromatin

J. E. Hyde, I. O. Walker, J. Hyde, 1975, FEBS letters.

A model for chromatin sub-structure incorporating symmetry considerations of histone oligomers.

I. O. Walker, J. Hyde, 1975, Nucleic acids research.

Evidence for immunological cross-reaction between sporozoites and blood stages of a human malaria parasite

J. E. Hyde, I. Hope, J. Scaife, 1984, Nature.

The gene for an exported antigen of the malaria parasite Plasmodium falciparum cloned and expressed in Escherichia coli.

J. E. Hyde, I. Hope, J. Scaife, 1985, Nucleic acids research.

Anomalous dinucleotide frequencies in both coding and non-coding regions from the genome of the human malaria parasite Plasmodium falciparum.

J. E. Hyde, P. Sims, J. Hyde, 1987, Gene.

A mass spectrometric strategy for absolute quantification of Plasmodium falciparum proteins of low abundance

Paul M Southworth, John E Hyde, Paul FG Sims, 2011, Malaria Journal.

Cloning studies on the gene coding for L-(+)-lactate dehydrogenase of Plasmodium falciparum.

D. Simmons, J. Scaife, M. Goman, 1985, Molecular and biochemical parasitology (Print).

6-Pyruvoyltetrahydropterin Synthase Paralogs Replace the Folate Synthesis Enzyme Dihydroneopterin Aldolase in Diverse Bacteria

J. E. Hyde, V. de Crécy-Lagard, A. Hanson, 2009, Journal of bacteriology.

Characterisation of the bifunctional dihydrofolate synthase–folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial antifolate inhibition

J. E. Hyde, A. Nzila, J. Coward, 2010, Molecular and biochemical parasitology.

Characterisation of exogenous folate transport in Plasmodium falciparum

J. E. Hyde, J. Hyde, P. Sims, 2007, Molecular and biochemical parasitology.

The non-histone proteins of the rat liver nucleus and their distribution amongst chromatin fractions as produced by nuclease digestion

H. G. Zachau, J. E. Hyde, T. Igo-Kemenes, 1979, Nucleic Acids Res..

Expansion of chicken erythrocyte nuclei upon limited micrococcal nuclease digestion. Correlation with higher order chromatin structure.

J. Hyde, 1982, Experimental cell research.

Quantitative proteomics of the human malaria parasite Plasmodium falciparum and its application to studies of development and inhibition

John E Hyde, J. Hyde, Niroshini Nirmalan, 2004, Molecular microbiology.

Molecular characterisation of the enolase gene from the human malaria parasite Plasmodium falciparum. Evidence for ancestry within a photosynthetic lineage.

Kevin E. Hicks, J. E. Hyde, P. Sims, 1994, European journal of biochemistry.

The molecular basis of sulfonamide resistance in Toxoplasma gondii and implications for the clinical management of toxoplasmosis.

J. E. Hyde, E. Guy, J. Hyde, 2002, The Journal of infectious diseases.

Protocols in molecular parasitology.

J. E. Hyde, J. Hyde, 1993, Methods in molecular biology.

Urine sediment analysis by the Yellow IRIS automated urinalysis workstation.

J. E. Hyde, D. Karcher, D. Wilkinson, 1987, American journal of clinical pathology.

Comparative folate metabolism in humans and malaria parasites (part I): pointers for malaria treatment from cancer chemotherapy.

J. E. Hyde, A. Nzila, K. Marsh, 2005, Trends in parasitology.

Transcriptional analysis of genes encoding enzymes of the folate pathway in the human malaria parasite Plasmodium falciparum

J. E. Hyde, J. Hyde, P. Sims, 2002, Molecular microbiology.

Proteomics of the human malaria parasite Plasmodium falciparum

J. E. Hyde, J. Hyde, P. Sims, 2006, Expert review of proteomics.

Covalent cross‐linking of histones in chromatin

J. E. Hyde, I. O. Walker, J. Hyde, 1975, FEBS letters.

A photochemical characterisation of reactions of psoralen derivatives with DNA.

J. E. Hyde, J. Hearst, H. Rapoport, 1982 .

A protein-centric approach for the identification of folate enzymes from the malarial parasite, Plasmodium falciparum, using OFFGEL™ solution-based isoelectric focussing and mass spectrometry

J. Hyde, P. Sims, R. O'cualain, 2010, Malaria Journal.

Glycolytic pathway of the human malaria parasite Plasmodium falciparum: primary sequence analysis of the gene encoding 3-phosphoglycerate kinase and chromosomal mapping studies.

J. E. Hyde, S. Holloway, P. Sims, 1991, Gene.

Vitamin B metabolism in Plasmodium falciparum as a source of drug targets.

J. E. Hyde, C. Wrenger, John E Hyde, 2010, Trends in parasitology.

Characterization of three genes encoding enzymes of the folate biosynthetic pathway in Plasmodium falciparum

J. E. Hyde, P. Sims, J. Hyde, 2001, Parasitology.

Comparative folate metabolism in humans and malaria parasites (part II): activities as yet untargeted or specific to Plasmodium.

J. E. Hyde, A. Nzila, K. Marsh, 2005, Trends in parasitology.

An atypical orthologue of 6-pyruvoyltetrahydropterin synthase can provide the missing link in the folate biosynthesis pathway of malaria parasites

J. E. Hyde, S. L. Mitchell, A. Blagborough, 2007, Molecular Microbiology.

Rapid positive selection of stable integrants following transfection of Plasmodium falciparum.

J. E. Hyde, J. Hyde, P. Sims, 2002, Molecular and biochemical parasitology.

A glycine-cleavage complex as part of the folate one-carbon metabolism of Plasmodium falciparum.

J. Hyde, P. Sims, E. Salcedo, 2005, Trends in parasitology.

A general approach to isolating Plasmodium falciparum genes using non-redundant oligonucleotides inferred from protein sequences of other organisms.

S. Kelly, S. Holloway, P. Sims, 1989, Molecular and biochemical parasitology.

Processing, polymorphism, and biological significance of P190, a major surface antigen of the erythrocytic forms of Plasmodium falciparum.

J. E. Hyde, I. Hope, A. Osland, 1984, Molecular and biochemical parasitology.

Plasmodium falciparum: a paradigm for alternative folate biosynthesis in diverse microorganisms?

J. E. Hyde, V. de Crécy-Lagard, A. Hanson, 2008, Trends in parasitology.

The use of human plasmas and plasma-depleted blood fractions in the in vitro cultivation of the malaria parasite Plasmodium falciparum.

J. Hyde, Martin Read, 1988, Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit.

On malaria and the cell cycle.

J. E. Hyde, J. Hyde, M. Read, 1997, Parasitology today.

The tubulin genes of the human malaria parasite Plasmodium falciparum, their chromosomal location and sequence analysis of the alpha-tubulin II gene.

J. E. Hyde, S. Holloway, P. Sims, 1990, Molecular and biochemical parasitology.

DRUG-RESISTANT MALARIA

J. Hyde, 1981, The Lancet.

Left-ventricular peak ejection rate, filling rate, and ejection fraction--frame rate requirements at rest and exercise: concise communication.

Michael V. Green, S L Bacharach, G S Johnston, 1979, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Isolation and molecular characterization of the bifunctional hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase gene from Toxoplasma gondii.

J. E. Hyde, P. Sims, C. Delves, 1997, Molecular and biochemical parasitology.