G. Huang

发表

Identification of Insulin Signaling Elements in Human β-Cells

Peter M. Jones, S. Amiel, S. Persaud, 2006, Diabetes.

A comparative analysis of human and mouse islet G-protein coupled receptor expression

A. Salehi, S. Persaud, G. Huang, 2017, Scientific Reports.

Short chain fatty acids stimulate insulin secretion and reduce apoptosis in mouse and human islets in vitro: Role of free fatty acid receptor 2

G. Frost, N. González-Abuín, S. Persaud, 2018, Diabetes, obesity & metabolism.

Defining G protein-coupled receptor peptide ligand expressomes and signalomes in human and mouse islets

A. Salehi, S. Persaud, G. Huang, 2018, Cellular and Molecular Life Sciences.

C3aR and C5aR1 act as key regulators of human and mouse β-cell function

S. Persaud, A. Pingitore, G. Huang, 2017, Cellular and Molecular Life Sciences.

Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 diabetes

P. Barran, S. Poppitt, D. Hodson, 2019, Diabetologia.

Function and expression of melatonin receptors on human pancreatic islets

Peter M. Jones, S. Amiel, D. Sugden, 2008, Journal of pineal research.

Prolonged activation of human islet cannabinoid receptors in vitro induces adaptation but not dysfunction

Peter M. Jones, P. Choudhary, S. Persaud, 2016, BBA clinical.

GLP-1 and glucagon secretion from a pancreatic neuroendocrine tumor causing diabetes and hyperinsulinemic hypoglycemia.

J. Ramage, S. Aylwin, A. Quaglia, 2012, The Journal of clinical endocrinology and metabolism.

Neuropeptide Neuromedin B does not alter body weight and glucose homeostasis nor does it act as an insulin-releasing peptide

J. Penninger, S. Cronin, S. Persaud, 2021, Scientific Reports.

The role of the CCL25-CCR9 axis in beta-cell function: potential for therapeutic intervention in type 2 diabetes.

S. Persaud, G. Huang, P. Atanes, 2020, Metabolism: clinical and experimental.

Version-2 A role for PFK-2 / FBPase-2 as distinct from fructose 2 , 6-bisphosphate in regulation of insulin secretion in pancreatic beta-cells

S. Khan, A. Lange, L. Agius, 2008 .

Characterisation of the Insulinotropic Activity of an Aqueous Extract of Gymnema Sylvestre in Mouse β-Cells and Human Islets of Langerhans

Peter M. Jones, S. Amiel, S. Persaud, 2009, Cellular Physiology and Biochemistry.

ExVivo Expanded Human Regulatory T Cells Delay Islet Allograft Rejection via Inhibiting Islet-Derived Monocyte Chemoattractant Protein-1 Production in CD34 + Stem Cells-Reconstituted NOD-scidIL2r c null Mice

R. Lechler, G. Lombardi, G. Huang, 2014 .

Ex Vivo Expanded Human Regulatory T Cells Delay Islet Allograft Rejection via Inhibiting Islet-Derived Monocyte Chemoattractant Protein-1 Production in CD34+ Stem Cells-Reconstituted NOD-scid IL2rγnull Mice

R. Lechler, G. Lombardi, G. Huang, 2014, PloS one.

Adult human exocrine pancreas differentiation to hepatocytes – potential source of a human hepatocyte progenitor for use in toxicology research

K. Wallace, A. Burt, M. Wright, 2013 .

The development of new density gradient media for purifying human islets and islet-quality assessments.

Peter M. Jones, N. Heaton, S. Amiel, 2004, Transplantation.

Evidence for the presence of stem cell-like progenitor cells in human adult pancreas.

M. Rela, N. Heaton, S. Amiel, 2007, The Journal of endocrinology.

Generation of Insulin Producing Cells for the Treatment of Diabetes.

G. Huang, Min Zhao, 2011 .

Direct Stimulatory Effects of the CB2 Ligand JTE 907 in Human and Mouse Islets

S. Persaud, G. Huang, P. Atanes, 2021, Cells.

The cannabinoid ligands SR141716A and AM251 enhance human and mouse islet function via GPR55-independent signalling

P. Choudhary, S. Persaud, A. Pingitore, 2020, Cellular and Molecular Life Sciences.

Human pancreatic islet endothelial cells express coxsackievirus and adenovirus receptor and are activated by coxsackie B virus infection

M. Peakman, G. Camussi, N. Klein, 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Expression of CD86 on Human Islet Endothelial Cells Facilitates T Cell Adhesion and Migration1

M. Peakman, N. Klein, G. Huang, 2008, The Journal of Immunology.

Activation of the extracellular calcium-sensing receptor initiates insulin secretion from human islets of Langerhans: involvement of protein kinases.

Peter M. Jones, S. Amiel, P. Squires, 2006, The Journal of endocrinology.

Association of ErbB2 Ser1113 phosphorylation with epidermal growth factor receptor co-expression and poor prognosis in human breast cancer

R. Epstein, G. Huang, T. Gulliford, 2001, Molecular and Cellular Biochemistry.

Detection of ErbB2 o versignalling in a majority of breast cancers with phosphorylation-state-specific antibodies

R. Epstein, A. Doherty, G. Huang, 1999, The Lancet.

The Role of Arachidonic Acid and Its Metabolites in Insulin Secretion From Human Islets of Langerhans

Peter M. Jones, S. Amiel, C. Burns, 2007, Diabetes.

Conversion of non-endocrine human pancreatic cells to insulin-producing cells for treatment of diabetes.

G. Huang, Min Zhao, 2012, Methods in molecular biology.

Commiphora myrrha stimulates insulin secretion from mouse and human islets of Langerhans.

Peter M. Jones, S. Persaud, G. Huang, 2020, Journal of ethnopharmacology.

Costus Pictus Extracts Stimulate Insulin Secretion from Mouse and Human Islets of Langerhans In Vitro

Peter M. Jones, S. Amiel, S. Persaud, 2011, Cellular Physiology and Biochemistry.

The diet‐derived short chain fatty acid propionate improves beta‐cell function in humans and stimulates insulin secretion from human islets in vitro

E. Chambers, G. Frost, T. Preston, 2017, Diabetes, obesity & metabolism.

Expression and function of cyclooxygenase and lipoxygenase enzymes in human islets of Langerhans

Peter M. Jones, S. Amiel, S. Persaud, 2007, Archives of physiology and biochemistry.

and Migration Endothelial Cells Facilitates T Cell Adhesion Expression of CD86 on Human Islet

M. Peakman, N. Klein, G. Huang, 2008 .

Different regulated expression of the tyrosine phosphatase-like proteins IA-2 and phogrin by glucose and insulin in pancreatic islets: relationship to development of insulin secretory responses in early life.

H. Steinbrenner, D. Pipeleers, S. Piquer, 2002, Diabetes.

Mesenchymal stromal cells improve human islet function through released products and extracellular matrix.

Peter M. Jones, N. Nardi, P. Choudhary, 2017, Clinical science.

Characterization of the Effects of Mesenchymal Stromal Cells on Mouse and Human Islet Function

Peter M. Jones, P. Choudhary, A. King, 2019, Stem cells translational medicine.

The novel chemokine receptor, G-protein-coupled receptor 75, is expressed by islets and is coupled to stimulation of insulin secretion and improved glucose homeostasis

Peter M. Jones, A. King, S. Persaud, 2013, Diabetologia.

CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope.

J. Drijfhout, A. Sewell, A. Skowera, 2008, The Journal of clinical investigation.

Commiphora myrrha stimulates insulin secretion from β-cells through activation of atypical protein kinase C and mitogen-activated protein kinase.

Peter M. Jones, S. Oyedemi, Sulaiman K. Marafie, 2022, Journal of ethnopharmacology.

GPR55‐dependent stimulation of insulin secretion from isolated mouse and human islets of Langerhans

Peter M. Jones, S. Persaud, D. Baker, 2016, Diabetes, obesity & metabolism.

Effect of 17β-Estradiol on Insulin Secretion and Cytosolic Calcium in Min6 Mouse Insulinoma Cells and Human Islets of Langerhans

Peter M. Jones, S. Amiel, P. Squires, 2005, Pancreas.

Identification of Insulin Signaling Elements in Human β-Cells

Peter M. Jones, S. Amiel, S. Persaud, 2006, Diabetes.

Defining G protein-coupled receptor peptide ligand expressomes and signalomes in human and mouse islets

A. Salehi, S. Persaud, G. Huang, 2018, Cellular and Molecular Life Sciences.

A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic beta-cells.

S. Khan, A. Lange, L. Agius, 2008, The Biochemical journal.

Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated β-Cell Death

P. Marchetti, R. Planas, D. Eizirik, 2011, Diabetes.

Structural basis of human β-cell killing by CD8+ T cells in Type 1 diabetes

J. Drijfhout, A. Sewell, B. Jakobsen, 2011, Nature Immunology.

Structural basis for the killing of human beta cells by CD 8 + T cells in type 1 diabetes

J. Drijfhout, A. Sewell, B. Jakobsen, 2012 .

Circulating Preproinsulin Signal Peptide–Specific CD8 T Cells Restricted by the Susceptibility Molecule HLA-A24 Are Expanded at Onset of Type 1 Diabetes and Kill β-Cells

M. Kester, A. Skowera, M. Peakman, 2012, Diabetes.

APT070 (mirococept), a membrane‐localizing C3 convertase inhibitor, attenuates early human islet allograft damage in vitro and in vivo in a humanized mouse model

R. Lechler, R. Smith, G. Lombardi, 2016, British journal of pharmacology.

APT070 (mirococept), a membrane‐localizing C3 convertase inhibitor, attenuates early human islet allograft damage in vitro and in vivo in a humanized mouse model

R. Lechler, R. Smith, G. Lombardi, 2016, British journal of pharmacology.

LH‐21 and abnormal cannabidiol improve β‐cell function in isolated human and mouse islets through GPR55‐dependent and ‐independent signalling

F. Bermúdez-Silva, S. Persaud, D. Baker, 2018, Diabetes, obesity & metabolism.

Dynamic Profiling of Insulin Secretion and ATP Generation in Isolated Human and Mouse Islets Reveals Differential Glucose Sensitivity

P. Choudhary, S. Persaud, A. Pingitore, 2017, Cellular Physiology and Biochemistry.

Virus-like infection induces human β cell dedifferentiation.

R. Scharfmann, M. Bugliani, P. Marchetti, 2018, JCI insight.

Fine tuning of insulin secretion by release of nerve growth factor from mouse and human islet β-cells

E. Cione, S. Persaud, A. Pingitore, 2015, Molecular and Cellular Endocrinology.

Running title : GAD 65 epitopes on β-cells

A. Sewell, A. Skowera, G. Dolton, 2014 .

Expression of Mesenchymal and α-Cell Phenotypic Markers in Islet β-Cells in Recently Diagnosed Diabetes

H. Marshall, A. Amer, G. Huang, 2013, Diabetes Care.

Multisite phosphotyping of the ErbB-2 oncoprotein in human breast cancer.

S. Shousha, R. Epstein, C. Harper-wynne, 2001 .

Lipid-induced glucose intolerance is driven by impaired glucose kinetics and insulin metabolism in healthy individuals.

S. Amiel, A. Mengozzi, D. Tricò, 2022, Metabolism: clinical and experimental.

Human β-Cell Killing by Autoreactive Preproinsulin-Specific CD8 T Cells Is Predominantly Granule-Mediated With the Potency Dependent Upon T-Cell Receptor Avidity

A. Sewell, L. Wooldridge, A. Skowera, 2012, Diabetes.

Amelioration of Streptozotocin-Induced Diabetes in Mice with Cells Derived from Human Marrow Stromal Cells

M. Rela, N. Heaton, S. Amiel, 2008, PloS one.

Islet neuropeptide Y receptors are functionally conserved and novel targets for the preservation of beta‐cell mass

G. Bewick, A. King, S. Persaud, 2018, Diabetes, obesity & metabolism.

SNAP-tag-enabled super-resolution imaging reveals constitutive and agonist-dependent trafficking of GPR56 in pancreatic β-cells

D. Hodson, A. King, S. Persaud, 2021, Molecular metabolism.

Insulin Producing Cells Derived from Human Marrow Stromal Cells

Min Zhao, Stephanie A. Amiel, Nigel Heaton, 2008, 2008 International Conference on BioMedical Engineering and Informatics.

Expression of nephrin by human pancreatic islet endothelial cells

M. Peakman, G. Camussi, N. Klein, 2005, Diabetologia.

Validation of Islet Transport From a Geographically Distant Isolation Center Enabling Equitable Access and National Health Service Funding of a Clinical Islet Transplant Program for England.

S. Amiel, S. Hughes, A. Dickinson, 2011, Cell Medicine.

Primary and immortalised human pancreatic islet endothelial cells: phenotypic and immunological characterisation