D. Chan

发表

Customized MethylC-Capture Sequencing to Evaluate Variation in the Human Sperm DNA Methylome Representative of Altered Folate Metabolism

G. Bourque, T. Pastinen, T. Kwan, 2019, Environmental health perspectives.

Haploinsufficiency of the paternal-effect gene Dnmt3L results in transient DNA hypomethylation in progenitor cells of the male germline.

M. Nagano, J. Trasler, J. Yeh, 2013, Human reproduction.

The Sperm Epigenome

J. Trasler, D. Chan, 2011 .

Rapid Multiplexed Reduced Representation Bisulfite Sequencing Library Prep (rRRBS).

S. McGraw, D. Chan, L. Legault, 2019, Bio-protocol.

Exposure of Greenlandic Inuit and South African VhaVenda men to the persistent DDT metabolite is associated with an altered sperm epigenome at regions implicated in paternal epigenetic transmission and developmental disease – a cross-sectional study

V. Dumeaux, J. Bonde, R. Bornman, 2022, bioRxiv.

Impact of the Chemotherapy Cocktail Used to Treat Testicular Cancer on the Gene Expression Profile of Germ Cells from Male Brown-Norway Rats1

B. Hales, P. Pakarinen, B. Robaire, 2009, Biology of reproduction.

Stability of the human sperm DNA methylome to folic acid fortification and short-term supplementation

C. Plass, R. Jacob, B. Robaire, 2017, Human reproduction.

High-dose folic acid supplementation alters the human sperm methylome and is influenced by the MTHFR C677T polymorphism.

G. Bourque, T. Pastinen, M. Caron, 2015, Human molecular genetics.

Paternal MTHFR deficiency leads to hypomethylation of young retrotransposons and reproductive decline across two successive generations

M. Lorincz, K. Shirane, J. Baltz, 2021, Development.

Developmental windows of susceptibility for epigenetic inheritance through the male germline.

J. Trasler, D. Chan, Lundi Ly, 2015, Seminars in cell & developmental biology.

Intergenerational impact of paternal lifetime exposures to both folic acid deficiency and supplementation on reproductive outcomes and imprinted gene methylation

M. Aarabi, A. MacFarlane, J. Trasler, 2017, Molecular human reproduction.

Moderate maternal folic acid supplementation ameliorates adverse embryonic and epigenetic outcomes associated with assisted reproduction in a mouse model.

A. MacFarlane, J. Trasler, D. Chan, 2019, Human reproduction.

Compromised oocyte quality and assisted reproduction contribute to sex-specific effects on offspring outcomes and epigenetic patterning.

J. Trasler, J. Chaillet, D. Chan, 2016, Human molecular genetics.

The Dnmt1 Intrinsically Disordered Domain Regulates Genomic Methylation During Development

S. McGraw, J. Trasler, Siyu C. Xiao, 2014, Genetics.

Sperm DNA methylome abnormalities occur both pre- and post-treatment in men with Hodgkin disease and testicular cancer

C. O’Flaherty, B. Robaire, J. Trasler, 2023, Clinical Epigenetics.

Critical Period of Nonpromoter DNA Methylation Acquisition during Prenatal Male Germ Cell Development

C. Oakes, J. Trasler, S. La Salle, 2011, PloS one.

Reproductive and epigenetic outcomes associated with aging mouse oocytes.

N. Darricarrère, A. Fortier, J. Trasler, 2009, Human molecular genetics.

Transient DNMT1 suppression reveals hidden heritable marks in the genome

C. Plass, G. Bourque, T. Pastinen, 2015, Nucleic acids research.

Epigenetic alterations in sperm DNA associated with testicular cancer treatment.

B. Robaire, J. Trasler, D. Chan, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Strain-specific defects in testicular development and sperm epigenetic patterns in 5,10-methylenetetrahydrofolate reductase-deficient mice.

R. Rozen, J. Trasler, D. Chan, 2010, Endocrinology.

Testicular MTHFR deficiency may explain sperm DNA hypomethylation associated with high dose folic acid supplementation

R. Rozen, M. Aarabi, D. Leclerc, 2018, Human molecular genetics.

DNA methyltransferase 1 (Dnmt1) mutation affects Snrpn imprinting in the mouse male germ line.

R. Rozen, A. Naumova, Taiping Chen, 2012, Genome.

Selective induction of glutathione S-transferases in round spermatids from the Brown-Norway rat by the chemotherapeutic regimen for testicular cancer.

B. Hales, B. Robaire, J. Trasler, 2013, Reproductive toxicology.

Developmental Genome-Wide DNA Methylation Asymmetry Between Mouse Placenta and Embryo

G. Bourque, S. McGraw, M. Caron, 2019, bioRxiv.

Impact of mothers' early life exposure to low or high folate on progeny outcome and DNA methylation patterns

J. Trasler, D. Chan, J. Martel, 2020, Environmental epigenetics.

Whole-genome sequencing of H3K4me3 and DNA methylation in human sperm reveals regions of overlap linked to fertility and development.

G. Bourque, T. Kwan, V. Dumeaux, 2021, Cell reports.

The effect of secretor status and the vaginal microbiome on birth outcome

A. Dell, Y. Lee, S. Haslam, 2021, medRxiv.

Capturing sex-specific and hypofertility-linked effects of assisted reproductive technologies on the cord blood DNA methylome

G. Bourque, T. Kwan, Marie-Michelle Simon, 2023, Clinical Epigenetics.

Early-Life Exposure to Environmental Contaminants Perturbs the Sperm Epigenome and Induces Negative Pregnancy Outcomes for Three Generations via the Paternal Lineage

J. Flaws, M. Dalvai, Marie-Pier Scott-Boyer, 2021, Epigenomes.

Transgenerational impact of grand‐paternal lifetime exposures to both folic acid deficiency and supplementation on genome‐wide DNA methylation in male germ cells

Marie-Pier Scott-Boyer, A. Droit, J. Trasler, 2023, Andrology.

Developmental windows of susceptibility for epigenetic inheritance through the male germline.

J. Trasler, D. Chan, Lundi Ly, 2015, Seminars in cell & developmental biology.

Sperm DNA methylation defects in a new mouse model of the 5,10-methylenetetrahydrofolate reductase 677C>T variant and correction with moderate dose folic acid supplementation

J. Trasler, D. Chan, Alaina M Reagan, 2024, Molecular human reproduction.