R. Gilmore

发表

The evolution of N-glycan-dependent endoplasmic reticulum quality control factors for glycoprotein folding and degradation

Daniel J. Kelleher, Jike Cui, P. Robbins, 2007, Proceedings of the National Academy of Sciences.

Preparation of a fluorescent derivative of cytochrome b5 and its interaction with phospholipids.

M. Glaser, R. Gilmore, 1982, Biochemistry.

Fluidity of LM cell membranes with modified lipid compositions as determined with 1,6-diphenyl-1,3,5-hexatriene.

M. Glaser, R. Gilmore, N. Cohn, 1979, Biochemistry.

A Role for Presenilins in Autophagy Revisited: Normal Acidification of Lysosomes in Cells Lacking PSEN1 and PSEN2

K. Mirnics, K. Garbett, Xulun Zhang, 2012, Journal of Neuroscience.

Conserved motifs on the cytoplasmic face of the protein translocation channel are critical for the transition between resting and active conformations

R. Gilmore, E. Mandon, Cameron Butova, 2018, The Journal of Biological Chemistry.

An interaction between the SRP receptor and the translocon is critical during cotranslational protein translocation

R. Gilmore, Ying Jiang, E. Mandon, 2008, The Journal of cell biology.

Identification of cytoplasmic residues of Sec61p involved in ribosome binding and cotranslational translocation

R. Gilmore, Ying Jiang, E. Mandon, 2005, The Journal of cell biology.

Extreme C-terminal sites are posttranslocationally glycosylated by the STT3B isoform of the OST

R. Gilmore, Shiteshu Shrimal, Steven F. Trueman, 2013, The Journal of cell biology.

Glycosylation of closely spaced acceptor sites in human glycoproteins

R. Gilmore, Shiteshu Shrimal, 2013, Journal of Cell Science.

Structural biology: Porthole to catalysis

R. Gilmore, 2011, Nature.

Mapping the Interaction of the STT3 Subunit of the Oligosaccharyl Transferase Complex with Nascent Polypeptide Chains*

G. von Heijne, I. Nilsson, D. Kelleher, 2005, Journal of Biological Chemistry.

Photocross-linking of nascent chains to the STT3 subunit of the oligosaccharyltransferase complex

G. von Heijne, I. Nilsson, G. Kreibich, 2003, The Journal of cell biology.

Allosteric regulation provides a molecular mechanism for preferential utilization of the fully assembled dolichol-linked oligosaccharide by the yeast oligosaccharyltransferase.

D. Karaoglu, D. Kelleher, R. Gilmore, 2001, Biochemistry.

Mutations in MAGT1 lead to a glycosylation disorder with a variable phenotype

G. Matthijs, R. Sparkes, V. Racé, 2019, Proceedings of the National Academy of Sciences.

Targeting STT3A‐oligosaccharyltransferase with NGI‐1 causes herpes simplex virus 1 dysfunction

J. Contessa, M. Lehrman, R. Gilmore, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Cotranslational and Posttranslational N-Glycosylation of Polypeptides by Distinct Mammalian OST Isoforms

C. Ruiz-Cañada, D. Kelleher, R. Gilmore, 2009, Cell.

A cytosolic reductase pathway is required for efficient N-glycosylation of an STT3B-dependent acceptor site

M. van Lith, M. Pringle, N. Bulleid, 2021, Journal of cell science.

A Cytosolic Reductase Pathway is Required for Complete N-Glycosylation of an STT3B-Dependent Acceptor Site

M. van Lith, M. Pringle, N. Bulleid, 2021, bioRxiv.

Editing N-Glycan Site Occupancy with Small-Molecule Oligosaccharyltransferase Inhibitors.

Jennifer E. Golden, J. Carette, J. Contessa, 2018, Cell chemical biology.

Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum

F. Förster, T. Becker, R. Beckmann, 2018, Science.

Mammalian STT3A/B oligosaccharyltransferases segregate N-glycosylation at the translocon from lipid-linked oligosaccharide hydrolysis

Nan Yan, M. Lehrman, R. Gilmore, 2018, Proceedings of the National Academy of Sciences.

N-linked glycosylation and homeostasis of the endoplasmic reticulum.

R. Gilmore, N. Cherepanova, Shiteshu Shrimal, 2016, Current opinion in cell biology.

Reduced expression of the oligosaccharyltransferase exacerbates protein hypoglycosylation in cells lacking the fully assembled oligosaccharide donor.

R. Gilmore, Shiteshu Shrimal, 2015, Glycobiology.

Cotranslational and posttranslocational N-glycosylation of proteins in the endoplasmic reticulum.

R. Gilmore, N. Cherepanova, Shiteshu Shrimal, 2015, Seminars in cell & developmental biology.

Dolichol-linked oligosaccharide selection by the oligosaccharyltransferase in protist and fungal organisms

J. Samuelson, A. Cura, Sulagna Banerjee, 2007, The Journal of cell biology.

Deficiency of UDP‐GlcNAc:Dolichol Phosphate N‐Acetylglucosamine‐1 Phosphate Transferase (DPAGT1) Causes a Novel Congenital Disorder of Glycosylation Type Ij

H. Freeze, D. Krasnewich, M. Lubinsky, 2003, Human mutation.

Biochemistry, molecular biology, and genetics of the oligosaccharyltransferase

R. Gilmore, S. Silberstein, 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The 48-kDa subunit of the mammalian oligosaccharyltransferase complex is homologous to the essential yeast protein WBP1.

D. Kelleher, R. Gilmore, S. Silberstein, 1992, The Journal of biological chemistry.

The Saccharomyces cerevisiae oligosaccharyltransferase is a protein complex composed of Wbp1p, Swp1p, and four additional polypeptides.

D. Kelleher, R. Gilmore, 1994, The Journal of biological chemistry.

The Saccharomyces cerevisiae oligosaccharyltransferase: a large hetero-oligomeric complex in the endoplasmic reticulum.

D. Karaoglu, D. Kelleher, R. Gilmore, 1995, Cold Spring Harbor symposia on quantitative biology.

Mutations in STT3A and STT3B cause two congenital disorders of glycosylation.

H. Freeze, R. Gilmore, B. Ng, 2013, Human molecular genetics.

Translational control of insulin biosynthesis. Evidence for regulation of elongation, initiation and signal-recognition-particle-mediated translational arrest by glucose.

D. Steiner, M. Welsh, M Welsh, 1986, The Biochemical journal.

The protein translocation machinery of the endoplasmic reticulum.

G. Blobel, P. Walter, M. Müller, 1982, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Transcription of full-length and truncated mRNA transcripts to study protein translocation across the endoplasmic reticulum.

P. Rapiejko, R. Gilmore, J. Johnson, 1991, Methods in cell biology.

Empty Site Forms of the SRP54 and SRα GTPases Mediate Targeting of Ribosome–Nascent Chain Complexes to the Endoplasmic Reticulum

P. Rapiejko, R. Gilmore, 1997, Cell.

Role of Sec61α in the Regulated Transfer of the Ribosome–Nascent Chain Complex from the Signal Recognition Particle to the Translocation Channel

D. Raden, R. Gilmore, E. Mandon, 2000, Cell.

Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor

G. Blobel, P. Walter, R. Gilmore, 1982, The Journal of cell biology.

Role of the Cytoplasmic Segments of Sec61α in the Ribosome-Binding and Translocation-Promoting Activities of the Sec61 Complex

D. Raden, R. Gilmore, W. Song, 2000, The Journal of cell biology.

Social function of adult men with attention-deficit/hyperactivity disorder in the context of military service

G. Blobel, P. Walter, G. Bahn, 2018, Neuropsychiatric disease and treatment.

Translocation channel gating kinetics balances protein translocation efficiency with signal sequence recognition fidelity

R. Gilmore, E. Mandon, Steven F. Trueman, 2011, Molecular biology of the cell.

Intracellular protein topogenesis.

G. Blobel, P. Walter, R. Gilmore, 1980, Progress in clinical and biological research.

Integration of a small integral membrane protein, M2, of influenza virus into the endoplasmic reticulum: analysis of the internal signal- anchor domain of a protein with an ectoplasmic NH2 terminus

R. Lamb, R. Gilmore, J. Hull, 1988, The Journal of cell biology.

The protein translocation machinery of the endoplasmic reticulum

G. Blobel, P. Walter, M. Müller, 1982 .

AGI January 41/1

J. Teckman, D. Perlmutter, R. Gilmore, 2000 .

Integration of membrane proteins into the endoplasmic reticulum requires GTP

C. Wilson, T. Morrison, T. Connolly, 1988, The Journal of cell biology.

Transmembrane Protein Translocation: Signal Recognition Particle and Its Receptor in the Endoplasmic Reticulum

P. Rapiejko, R. Gilmore, 1993 .

Large-scale isolation of dolichol-linked oligosaccharides with homogeneous oligosaccharide structures: determination of steady-state dolichol-linked oligosaccharide compositions.

D. Karaoglu, D. Kelleher, R. Gilmore, 2001, Glycobiology.

Rotational relaxation times of 1,6-diphenyl-1,3,5-hexatriene in phospholipids isolated from LM cell membranes. Effects of phospholipid polar head-group and fatty acid composition.

M. Glaser, R. Gilmore, N. Cohn, 1979, Biochemistry.

Oligosaccharyltransferase activity is associated with a protein complex composed of ribophorins I and II and a 48 kd protein

G. Kreibich, D. Kelleher, R. Gilmore, 1992, Cell.

Lack of NKG2D in MAGT1-deficient patients is caused by hypoglycosylation

G. Matthijs, J. Jaeken, R. Schrijvers, 2022, Human Genetics.

An evolving view of the eukaryotic oligosaccharyltransferase.

D. Kelleher, R. Gilmore, Reid Gilmore, 2006, Glycobiology.

Purification of microsomal signal peptidase as a complex.

G. Blobel, R. Gilmore, E. A. Evans, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of high molecular weight transforming growth factor alpha produced by rat hepatocellular carcinoma cells.

J. Massagué, David C. Lee, G. Michalopoulos, 1988, Biochemistry.

Integral membrane glycoprotein properties of the prohormone pro-transforming growth factor-α

J. Massagué, David C. Lee, R. Gilmore, 1987, Nature.

Protein translocation across the endoplasmic reticulum

Peter Walter, G. Blobel, P. Walter, 1984, Cell.

Deuterium nuclear magnetic resonance investigation of the effects of proteins and polypeptides on hydrocarbon chain order in model membrane systems.

H. S. Gutowsky, E. Oldfield, D. Rice, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Formation of a functional ribosome-membrane junction during translocation requires the participation of a GTP-binding protein

T. Connolly, R. Gilmore, Timothy Connol ly, 1986, The Journal of cell biology.

Selective inhibition of N-linked glycosylation impairs receptor tyrosine kinase processing

H. Freeze, J. Contessa, L. Wells, 2019, Disease Models & Mechanisms.

Two alternative binding mechanisms connect the protein translocation Sec71-Sec72 complex with heat shock proteins

T. Rapoport, R. Gilmore, E. Mandon, 2017, The Journal of Biological Chemistry.

Protein translocation across the rough endoplasmic reticulum.

R. Gilmore, E. Mandon, Steven F. Trueman, 2013, Cold Spring Harbor perspectives in biology.

Translocation of Proteins across and Integration of Membrane Proteins into the Rough Endoplasmic Reticulum

R. Gilmore, K. Kellaris, 1992, Annals of the New York Academy of Sciences.

Molecular characterization of mitofilin (HMP), a mitochondria-associated protein with predicted coiled coil and intermembrane space targeting domains.

E. Fey, P. Odgren, R. Gilmore, 1996, Journal of cell science.

The diversity of dolichol-linked precursors to Asn-linked glycans likely results from secondary loss of sets of glycosyltransferases.

P. Robbins, J. Samuelson, J. Cui, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Pol I transcription and pre-rRNA processing are coordinated in a transcription-dependent manner in mammalian cells.

J. Gasiorowski, D. Dean, D. Chen, 2006, Molecular biology of the cell.

A Role for the DnaJ Homologue Scj1p in Protein Folding in the Yeast Endoplasmic Reticulum

P. Silver, G. Schlenstedt, R. Gilmore, 1998, The Journal of cell biology.

DAD1, the defender against apoptotic cell death, is a subunit of the mammalian oligosaccharyltransferase.

D. Kelleher, R. Gilmore, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Dengue Virus Hijacks a Noncanonical Oxidoreductase Function of a Cellular Oligosaccharyltransferase Complex

A. Tai, M. MacDonald, D. L. Lin, 2017, mBio.

The Highly Conserved Stt3 Protein Is a Subunit of the Yeast Oligosaccharyltransferase and Forms a Subcomplex with Ost3p and Ost4p*

D. Karaoglu, D. Kelleher, R. Gilmore, 1997, The Journal of Biological Chemistry.

Structure of Monomeric Yeast and Mammalian Sec61 Complexes Interacting with the Translating Ribosome

Klaus Schulten, Eric Westhof, Shashi Bhushan, 2009, Science.

Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells.

Jennifer E. Golden, Lance Wells, Carol Khodier, 2016, Nature chemical biology.

DC2 and KCP2 mediate the interaction between the oligosaccharyltransferase and the ER translocon

R. Gilmore, N. Cherepanova, Shiteshu Shrimal, 2017, The Journal of cell biology.

Transient involvement of signal recognition particle and its receptor in the microsomal membrane prior to protein translocation

G. Blobel, R. Gilmore, 1983, Cell.

Asparagine-linked glycosylation is not directly coupled to protein translocation across the endoplasmic reticulum in Saccharomyces cerevisiae

Sergey V. Venev, R. Gilmore, N. Cherepanova, 2019, Molecular biology of the cell.

Quantitative glycoproteomics reveals new classes of STT3A- and STT3B-dependent N-glycosylation sites

S. Shaffer, Sergey V. Venev, J. Leszyk, 2019, The Journal of cell biology.

A gating motif in the translocation channel sets the hydrophobicity threshold for signal sequence function

R. Gilmore, E. Mandon, Steven F. Trueman, 2012, The Journal of cell biology.

The Tail End of Membrane Insertion

R. Gilmore, E. Mandon, 2007, Cell.

Mammalian cells lacking either the cotranslational or posttranslocational oligosaccharyltransferase complex display substrate-dependent defects in asparagine linked glycosylation

R. Gilmore, N. Cherepanova, 2016, Scientific Reports.

Protein translocation across the endoplasmic reticulum.

G. Blobel, P. Walter, R. Gilmore, 1994, Current opinion in cell biology.

The alpha subunit of the Saccharomyces cerevisiae oligosaccharyltransferase complex is essential for vegetative growth of yeast and is homologous to mammalian ribophorin I

P. Rapiejko, D. Kelleher, R. Gilmore, 1995, The Journal of cell biology.

A specific screen for oligosaccharyltransferase mutations identifies the 9 kDa OST5 protein required for optimal activity in vivo and in vitro

M. Aebi, R. Zufferey, R. Gilmore, 1997, The EMBO journal.

Access of proteinase K to partially translocated nascent polypeptides in intact and detergent-solubilized membranes

T. Connolly, R. Gilmore, P. Collins, 1989, The Journal of cell biology.

Understanding integration of α-helical membrane proteins: the next steps.

R. Gilmore, E. Mandon, 2012, Trends in biochemical sciences.

Factor VIII and vWF deficiency in STT3A‐CDG

H. Freeze, Christina Lam, J. Merritt, 2019, Journal of inherited metabolic disease.

The signal recognition particle receptor mediates the GTP-dependent displacement of SRP from the signal sequence of the nascent polypeptide

T. Connolly, R. Gilmore, 1989, Cell.

Slow translocon gating causes cytosolic exposure of transmembrane and lumenal domains during membrane protein integration

R. Gilmore, Zhiliang Cheng, 2006, Nature Structural &Molecular Biology.

REVIEW An evolving view of the eukaryotic oligosaccharyltransferase

D. Kelleher, R. Gilmore, 2006 .

Dual recognition of the ribosome and the signal recognition particle by the SRP receptor during protein targeting to the endoplasmic reticulum

R. Gilmore, Reid Gilmore, Elisabet C. Mandon, 2003, The Journal of cell biology.

GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocation

L. Gierasch, P. Walter, R. Gilmore, 1993, Nature.

Protein translocation across the ER requires a functional GTP binding site in the alpha subunit of the signal recognition particle receptor

P. Rapiejko, R. Gilmore, 1992, The Journal of cell biology.

Translocation of secretory proteins across the microsomal membrane occurs through an environment accessible to aqueous perturbants

G. Blobel, R. Gilmore, 1985, Cell.

Oligosaccharyltransferase structures provide novel insight into the mechanism of asparagine-linked glycosylation in prokaryotic and eukaryotic cells.

R. Gilmore, Shiteshu Shrimal, 2018, Glycobiology.

The essential OST2 gene encodes the 16-kD subunit of the yeast oligosaccharyltransferase, a highly conserved protein expressed in diverse eukaryotic organisms

D. Kelleher, R. Gilmore, S. Silberstein, 1995, The Journal of cell biology.

Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties.

D. Karaoglu, D. Kelleher, R. Gilmore, 2003, Molecular cell.

Functional characterization of Ost3p. Loss of the 34-kD subunit of the Saccharomyces cerevisiae oligosaccharyltransferase results in biased underglycosylation of acceptor substrates

D. Karaoglu, D. Kelleher, R. Gilmore, 1995, The Journal of cell biology.

Molecular mechanisms of missense mutations that generate ectopic N-glycosylation sites in coagulation factor VIII.

S. Misra, Bin Zhang, M. Cannon, 2018, The Biochemical journal.

Translocation of proteins through the Sec61 and SecYEG channels.

R. Gilmore, Reid Gilmore, Elisabet C Mandon, 2009, Current opinion in cell biology.

GTP hydrolysis by complexes of the signal recognition particle and the signal recognition particle receptor

T. Connolly, R. Gilmore, T. Connolly, 1993, The Journal of cell biology.

Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins

R. Gilmore, N. Cherepanova, Shiteshu Shrimal, 2014, The Journal of cell biology.

Requirement of GTP hydrolysis for dissociation of the signal recognition particle from its receptor

P. Rapiejko, T. Connolly, R. Gilmore, 1991, Science.

Role of ubiquitin in proteasomal degradation of mutant alpha(1)-antitrypsin Z in the endoplasmic reticulum.

J. Teckman, D. Perlmutter, R. Gilmore, 2000, American journal of physiology. Gastrointestinal and liver physiology.

Post-translational N-Glycosylation of Type I Transmembrane KCNE1 Peptides

William R. Kobertz, W. R. Kobertz, A. Lvov, 2011, The Journal of Biological Chemistry.

One flexible loop in OST lassos both substrates

R. Gilmore, N. Cherepanova, Shiteshu Shrimal, 2017, Nature Structural & Molecular Biology.

Signal recognition particle-dependent targeting of ribosomes to the rough endoplasmic reticulum in the absence and presence of the nascent polypeptide-associated complex.

D. Raden, R. Gilmore, 1998, Molecular biology of the cell.

Unique Asn-linked Oligosaccharides of the Human Pathogen Entamoeba histolytica*

P. Robbins, J. Samuelson, J. Cui, 2008, Journal of Biological Chemistry.

Protein translocation across the endoplasmic reticulum: A tunnel with toll booths at entry and exit

R. Gilmore, 1993, Cell.

Guanosine triphosphate promotes the post-translational integration of opsin into the endoplasmic reticulum membrane.

R. Gilmore, K. Hoffman, 1988, The Journal of biological chemistry.

A phosphatidylinositol transfer protein integrates phosphoinositide signaling with lipid droplet metabolism to regulate a developmental program of nutrient stress–induced membrane biogenesis

A. Neiman, E. Ortlund, K. Bloom, 2014, Molecular biology of the cell.

Intracellular protein topogenesis.

G. Blobel, G Blobel, R. Gilmore, 1980, Proceedings of the National Academy of Sciences of the United States of America.

The protein translocation apparatus of the rough endoplasmic reticulum, its associated proteins, and the mechanism of translocation.

R. Gilmore, 1991, Current opinion in cell biology.

Ribosome binding to the endoplasmic reticulum: a 180-kD protein identified by crosslinking to membrane-bound ribosomes is not required for ribosome binding activity

R. Gilmore, Pallia G. Collins, 1991, The Journal of cell biology.

ER translocation intermediates are adjacent to a nonglycosylated 34-kD integral membrane protein

R. Gilmore, K. Kellaris, S. Bowen, 1991, The Journal of cell biology.

Aberrant membrane insertion of a cytoplasmic tail deletion mutant of the hemagglutinin-neuraminidase glycoprotein of Newcastle disease virus

C. Wilson, T. Morrison, R. Gilmore, 1990, Molecular and cellular biology.

Selective inhibition of N-linked glycosylation impairs receptor tyrosine kinase processing

H. Freeze, J. Contessa, L. Wells, 2019, Disease Models & Mechanisms.

N-linked glycosylation and homeostasis of the endoplasmic reticulum.

R. Gilmore, N. Cherepanova, Shiteshu Shrimal, 2016, Current opinion in cell biology.

Molecular mechanisms of missense mutations that generate ectopic N-glycosylation sites in coagulation factor VIII.

S. Misra, Bin Zhang, M. Cannon, 2018, The Biochemical journal.

Extreme C-terminal sites are posttranslocationally glycosylated by the STT3B isoform of the OST

R. Gilmore, Shiteshu Shrimal, Steven F. Trueman, 2013, The Journal of cell biology.

Rapid inactivation of the yeast Sec complex selectively blocks transport of post-translationally translocated proteins

R. Gilmore, Jae Kyo Yi, E. Mandon, 2021, The Journal of biological chemistry.

Protein translocation across the endoplasmic reticulum. I. Detection in the microsomal membrane of a receptor for the signal recognition particle

G. Blobel, P. Walter, R. Gilmore, 1982, The Journal of cell biology.

Signal sequence recognition and targeting of ribosomes to the endoplasmic reticulum by the signal recognition particle do not require GTP.

P. Rapiejko, R. Gilmore, 1994, Molecular biology of the cell.

Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum

F. Förster, T. Becker, R. Beckmann, 2018, Science.

Signal recognition particle receptor-β (SR-β) coordinates cotranslational N-glycosylation

J. Contessa, M. Lehrman, R. Gilmore, 2023, Science advances.