K. Kane

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Remodelling of human atrial K+ currents but not ion channel expression by chronic β-blockade

John Dempster, Mark R. Boyett, Antony J. Workman, 2011, Pflügers Archiv - European Journal of Physiology.

Atrial cellular electrophysiological changes in patients with ventricular dysfunction may predispose to AF.

J. Norrie, A. Workman, A. Rankin, 2009, Heart rhythm.

Interaction between anandamide and sphingosine‐1‐phosphate in mediating vasorelaxation in rat coronary artery

S. Pyne, N. Pyne, E. Robinson, 2010, British journal of pharmacology.

Facilitation of spontaneous defibrillation by moxonidine during regional ischaemia in an isolated working rabbit heart model.

S. Cobbe, R. Wolk, K. Kane, 1999, European journal of pharmacology.

Comparative Antifibrillatory Effects of d- and dl-Sotalol in Normal and Ischaemic Ventricular Muscle of the Cat

Y. Kwan, R. Wadsworth, K. Kane, 1990, Journal of cardiovascular pharmacology.

Targeting sphingosine-1-phosphate signalling for cardioprotection.

S. Pyne, N. Pyne, K. Kane, 2009, Current opinion in pharmacology.

Evidence for the involvement of peroxynitrite in ischaemic preconditioning in rat isolated hearts

A. T. Demiryürek, S. Altuğ, K. Kane, 2000, British journal of pharmacology.

The influence of maturation and gender on the anti-arrhythnmic effect of ischaemic preconditioning in rats

J. Parratt, K. Kane, R. A. Humphreys, 1999, Basic Research in Cardiology.

Lack of involvement of mast cell degranulation in the antiarrhythmic effect of preconditioning in rats.

J. Parratt, K. Kane, R. A. Humphreys, 1998, Journal of cardiovascular pharmacology.

Hypoxic constrictor response in the isolated pulmonary artery from chronically hypoxic rats.

M. Maclean, R. Wadsworth, K. Kane, 1996, Respiration physiology.

The effects of chronic low lead treatment and hypertension on the severity of cardiac arrhythmias induced by coronary artery ligation in anesthetized rats.

J. Parratt, M. Moore, K. Kane, 1985, Toxicology and applied pharmacology.

Electrophysiological Effects of Lidocaine, l-Chlorpheniramine, and Bepridil on Rabbit Sinus Node Pacemaker Cells

K. Kane, G. Pastelín, S. Sánchez-Pérez, 1983, Journal of cardiovascular pharmacology.

Activation of mouse protease‐activated receptor‐2 induces lymphocyte adhesion and generation of reactive oxygen species

C. Wainwright, K. Kane, S. Kennedy, 2006, British journal of pharmacology.

Effects of the xanthine oxidase system on cardiac function in anaesthetised rats.

J. McMurray, J. Parratt, S. Laycock, 1993, Free radical biology & medicine.

Antidysrhythmic and electrophysiological effects of a new antianginal agent, bepridil.

K. Kane, E. Winslow, 1980, Journal of cardiovascular pharmacology.

Accumulation of nitrotyrosine correlates with endothelial NO synthase in pulmonary resistance arteries during chronic hypoxia in the rat.

M. Maclean, R. Wadsworth, A. T. Demiryürek, 2000, Pulmonary pharmacology & therapeutics.

Influences of hypothermia, cold, and isolation stress on the severity of coronary artery ligation-induced arrhythmias in rats.

K. Kane, E. Winslow, A. Muir, 1982, Journal of pharmacological methods.

Anti-adrenergic effects of endothelin on human atrial action potentials are potentially anti-arrhythmic.

A. Workman, A. Rankin, C. Redpath, 2006, Journal of molecular and cellular cardiology.

Endothelin and the ischaemic heart.

C. Wainwright, C. McCabe, K. Kane, 2005, Current vascular pharmacology.

Adrenomedullin acts via nitric oxide and peroxynitrite to protect against myocardial ischaemia‐induced arrhythmias in anaesthetized rats

C. Wainwright, K. Kane, Y. H. Looi, 2006, British journal of pharmacology.

Electrophysiological Effects of Prucalopride, a Novel Enterokinetic Agent, on Isolated Atrial Myocytes from Patients Treated with β-Adrenoceptor Antagonists

A. Workman, A. Rankin, K. Kane, 2005, Journal of Pharmacology and Experimental Therapeutics.

The effects of chronic hypoxia on the pharmacological responsiveness of the pulmonary artery.

R. Wadsworth, K. Kane, V. S. Karamsetty, 1995, Pharmacology & therapeutics.

KATP channels in ischaemic preconditioning.

J. Parratt, K. Kane, 1994, Cardiovascular research.

Pharmacological evidence for the role of mediators in hypoxia-induced vasoconstriction in sheep isolated intrapulmonary artery rings.

R. Wadsworth, K. Kane, A. Demiryurek, 1991, European journal of pharmacology.

Effects of hypoxia on isolated intrapulmonary arteries from the sheep.

R. Wadsworth, K. Kane, A. Demiryurek, 1991, Pulmonary pharmacology.

An investigation into the characteristics of reperfusion‐induced arrhythmias in the anaesthetized rat and their susceptibility to antiarrhythmic agents

J. Parratt, K. Kane, F. M. Williams, 1984, British journal of pharmacology.

Comparison of the effects of diltiazem and its analogue siratiazem on contractility in arteries, ileum and cardiac muscle.

R. Wadsworth, K. Kane, M. Panesar, 1995, Journal of autonomic pharmacology.

Electrophysiological and haemodynamic effects of endothelin ETA and ETB receptors in normal and ischaemic working rabbit hearts

C. Wainwright, C. McCabe, K. Kane, 2005, British journal of pharmacology.

Sarafotoxin 6c (S6c) Reduces Infarct Size and Preserves mRNA for the ETB Receptor in the Ischemic/Reperfused Myocardium of Anesthetized Rats

C. Wainwright, G. Gray, K. Kane, 2004, Journal of cardiovascular pharmacology.

The effects of verapamil, prenylamine, flunarizine and cinnarizine on coronary artery occlusion‐induced arrhythmias in anaesthetized rats

J. Parratt, A. Rothaul, K. Kane, 1984, British journal of pharmacology.

Anti-arrhythmic and electrophysiological effects of the endothelin receptor antagonists, BQ-123 and PD161721.

C. Wainwright, K. Kane, N. McGowan, 2000, European journal of pharmacology.

Potentiation of E‐4031‐induced torsade de pointes by HMR1556 or ATX‐II is not predicted by action potential short‐term variability or triangulation

J. Dempster, K. Kane, S. Coker, 2007, British journal of pharmacology.

Attenuation by phentolamine of hypoxia and levcromakalim‐induced abbreviation of the cardiac action potential

D. Tweedie, K. Kane, G. Boachie-Anash, 1993, British journal of pharmacology.

Glibenclamide, but not class III drugs, prevents ischaemic shortening of the refractory period in guinea-pig hearts.

D. Tweedie, K. Kane, C. Henderson, 1993, European journal of pharmacology.

Mast cells, peptides and cardioprotection - an unlikely marriage?

C. Wainwright, K. Kane, S. Walsh, 2009, Autonomic & autacoid pharmacology.

Cellular bases for human atrial fibrillation

A. Workman, A. Rankin, K. Kane, 2008, Heart rhythm.

Effects of a Combination of Acidosis, Lactate, and Lysophosphatidylcholine on Action Potentials and Ionic Currents in Guinea Pig Ventricular Myocytes

A. Rankin, K. Kane, G. Boachie-Ansah, 1992, Journal of cardiovascular pharmacology.

C haracterisation of the Na, K pump current in atrial cells from patients with and without chronic atrial ﬁbrillation

A. Workman, A. Rankin, K. Kane, 2003 .

haracterisation of the Na , K pump current in atrial cells from patients with and without chronic atrial fibrillation

A. Workman, A. Rankin, K. Kane, 2003 .

Modification by hypoxia, hyperkalaemia and acidosis of the cardiac electrophysiological effects of a range of antiarrhythmic drugs

K. Kane, D. Pacini, G. Boachie-Ansah, 1992, British journal of pharmacology.

The electrophysiological effects of opioid receptor-selective antagonists on sheep Purkinje fibres.

J. Parratt, K. Kane, M. McIntosh, 1992, European journal of pharmacology.

Comparison of the Cardiac Electrophysiologic Effects of NE-10064 with Sotalol and E-4031 and Their Modification by Simulated Ischaemia

M. Tanira, K. Kane, D. Pacini, 1994, Journal of cardiovascular pharmacology.

Rate-dependency of action potential duration and refractoriness in isolated myocytes from the rabbit AV node and atrium.

A. Workman, A C Rankin, A. Rankin, 2000, Journal of molecular and cellular cardiology.

The relationship between coronary artery occlusion-induced arrhythmias and myocardial cyclic nucleotide levels in the anaesthetized rat.

J. Parratt, M. Shahid, K. Kane, 1985, British journal of pharmacology.

The effects of endothelin-1 on ischaemia-induced ventricular arrhythmias in rat isolated hearts.

C. Wainwright, K. Kane, I. Sharif, 2001, European journal of pharmacology.

Effects of Hypoxia on Endothelin-1 Release from Human, Sheep and Rabbit Pulmonary Artery Rings

M. Maclean, R. Wadsworth, A. T. Demiryürek, 1994 .

Antiarrhythmic actions of meptazinol, a partial agonist at opiate receptors, in acute myocardial ischaemia

J. Parratt, L. Szekeres, K. Kane, 1983, British journal of pharmacology.

The role of endothelium in hypoxic constriction of human pulmonary artery rings.

A. Peacock, R. Wadsworth, K. Kane, 1993, The American review of respiratory disease.

Effect of K+ channel blocking drugs and nitric oxide synthase inhibition on the response to hypoxia in rat pulmonary artery rings.

R. Wadsworth, K. Kane, M. Karamsetty, 1998, Journal of autonomic pharmacology.

Effects of chronic norepinephrine administration on cardiac function in rats.

J. McMurray, J. Parratt, S. Laycock, 1995, Journal of cardiovascular pharmacology.

Influence of nitric oxide on luminol-enhanced chemiluminescence measured from porcine-stimulated leukocytes.

C. Wainwright, R. Wadsworth, A. T. Demiryürek, 1997, Journal of cardiovascular pharmacology.

The effects of chronic lead treatment and hypertension on the severity of cardiac arrhythmias induced by coronary artery occlusion or by noradrenaline in anaesthetised rats

J. Parratt, M. Moore, K. Kane, 1987, Archives of Toxicology.

The effects of ethanol and lead, alone and in combination, on the severity of arrhythmias induced by coronary artery occlusion, and by noradrenaline, in anaesthetised rats

J. Parratt, M. Moore, K. Kane, 1986, Archives of Toxicology.

Regional electrophysiological effects of left ventricular hypertrophy in isolated rabbit hearts under normal and ischaemic conditions.

S. Cobbe, R. Wolk, K. Kane, 2000, Cardiovascular research.

Effects of NS-2, a new class 1 antiarrhythmic agent, and AFD-19, its active metabolite, on ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized rats: comparison with disopyramide and mexiletine.

J. Parratt, K. Tamura, S. Komori, 1994, Japanese journal of pharmacology.

The Effects of Opioid Peptides on Cardiovascular Function and Sympathetic Neurotransmission in Rats

J. Parratt, K. Kane, M. McIntosh, 1995 .

Coronary artery ligation in anesthetized rats as a method for the production of experimental dysrhythmias and for the determination of infarct size.

J. Parratt, M. I. Foreman, K. Kane, 1980, Journal of pharmacological methods.

Captopril and norepinephrine-induced hypertrophy and haemodynamics in rats.

J. McMurray, J. Parratt, S. Laycock, 1996, Journal of cardiovascular pharmacology.

Antiarrhythmic, Electrophysiological and Haemodynamic Effects of Prolonged Oral Dosing with Org 7797 in the Anaesthetized Rat

L. Delbressine, K. Kane, E. Winslow, 1992, The Journal of pharmacy and pharmacology.

Aspects of the cardiovascular pharmacology of exaprolol

J. Parratt, K. Kane, B. Hughes, 1984, The Journal of pharmacy and pharmacology.

ANTIARRHYTHMIC EFFECTS OF ORG 6001 IN RATS: CORRELATION WITH PLASMA AND TISSUE DRUG CONCENTRATIONS

J. Parratt, K. Kane, C. Timmer, 1982, British journal of pharmacology.

Coronary artery ligation in anaesthetized rats as a model for the assessment of antidysrhythmic activity; the effects of lignocaine, propranolol and ORG 6001 [proceedings].

J. Parratt, K. Kane, F. McDonald, 1979, British journal of pharmacology.

ellular bases for human atrial fibrillation

A. Rankin, K. Kane, ntony J. Workman, 2008 .

IP(3)R-mediated Ca(2+) release is modulated by anandamide in isolated cardiac nuclei.

J. McCarron, S. Currie, S. Kitson, 2008, Journal of molecular and cellular cardiology.

Effects of hypoxia on the pharmacological responsiveness of isolated coronary artery rings from the sheep

K. Kane, R. Wadsworth, Y. W. Kwan, 1989, British Journal of Pharmacology.

Effect of hypoxia on contraction and 45Ca2+ uptake induced by the thromboxane mimetic U46619 in sheep coronary artery.

R. Wadsworth, K. Kane, T. Dalen, 1994, European journal of pharmacology.

Modification of the ischaemic‐induced contraction in the sheep circumflex coronary artery by various pharmacological antagonists

K. Kane, R. Wadsworth, Y. W. Kwan, 1990, British journal of pharmacology.

Effects of neuropeptide Y and calcitonin gene‐related peptide on sheep coronary artery rings under oxygenated, hypoxic and simulated myocardial ischaemic conditions

K. Kane, R. Wadsworth, Y. W. Kwan, 1990, British journal of pharmacology.

Responsiveness of sheep isolated coronary artery rings under simulated myocardial ischaemia.

Y. Kwan, R. Wadsworth, K. Kane, 1989, European journal of pharmacology.

Hypoxia‐ and endothelium‐mediated changes in the pharmacological responsiveness of circumflex coronary artery rings from the sheep

K. Kane, R. Wadsworth, Y. W. Kwan, 1989, British journal of pharmacology.

Effects of selective receptor agonists and antagonists during myocardial ischaemia

J. Parratt, K. Kane, M. McIntosh, 1992 .

The antiarrhythmic and cardiac electrophysiological effects of buprenorphine

J. Parratt, R. Sitsapesan, K. Kane, 1989, British journal of pharmacology.

THE EFFECT OF THE AMINOSTEROID, ORG 6001, ON HYPOTHERMIA‐INDUCED VENTRICULAR FIBRILLATION IN THE CAT

J. Parratt, K. Kane, F. McDonald, 1979, British journal of pharmacology.

Mast cell degranulation – a mechanism for the anti‐arrhythmic effect of endothelin‐1?

K. Kane, S. Walsh, C. Wainwright, 2009, British journal of pharmacology.

The contribution of ionic currents to changes in refractoriness of human atrial myocytes associated with chronic atrial fibrillation.

A. Workman, A C Rankin, A. Rankin, 2001, Cardiovascular research.

Chronic beta-adrenoceptor blockade and human atrial cell electrophysiology: evidence of pharmacological remodelling.

J. Norrie, A. Workman, A. Rankin, 2003, Cardiovascular research.

Characterisation of the Na, K pump current in atrial cells from patients with and without chronic atrial fibrillation.

Kathleen A Kane, A. Workman, Antony J Workman, 2003, Cardiovascular research.

Post‐Operative Atrial Fibrillation Is Influenced by Beta‐Blocker Therapy But Not by Pre‐Operative Atrial Cellular Electrophysiology

J. Norrie, A. Workman, A. Rankin, 2006, Journal of cardiovascular electrophysiology.

COMPARATIVE ELECTROPHYSIOLOGICAL EFFECTS OF Org 6001, A NEW ORALLY ACTIVE ANTIDYSRHYTHMIC AGENT, AND LIGNOCAINE ON HUMAN VENTRICULAR MUSCLE

K. Kane, 1980, British journal of pharmacology.

Comparative effects of a new orally active antidysrhythmic agent, Organon 6001, on the cardiac action potential of human ventricular muscle and sheep Purkinje fibres [proceedings].

K. Kane, 1977, British journal of pharmacology.

Acute administration of cannabidiol in vivo suppresses ischaemia‐induced cardiac arrhythmias and reduces infarct size when given at reperfusion

C. Wainwright, K. Kane, S. Walsh, 2010, British journal of pharmacology.

Activation of Protease Activated Receptor-2 Induces Delayed Cardioprotection in Anesthetized Mice

C. Wainwright, Shiang Y. Lim, K. Kane, 2009, Cardiovascular Drugs and Therapy.

Electrophysiological and arrhythmogenic effects of 5-hydroxytryptamine on human atrial cells are reduced in atrial fibrillation

Antony J. Workman, A. Workman, A. Rankin, 2007, Journal of molecular and cellular cardiology.

Functional, structural, and dynamic basis of electrical heterogeneity in healthy and diseased cardiac muscle: implications for arrhythmogenesis and anti-arrhythmic drug therapy.

S M Cobbe, S. Cobbe, R. Wolk, 1999, Pharmacology & therapeutics.

Electrophysiological effects of adenosine and adenosine triphosphate on sheep Purkinje fibres under normal and simulated ischaemic conditions

J. Parratt, K. Kane, G. Boachie-Ansah, 1989, British journal of pharmacology.

Antagonism by adenosine and ATP of an isoprenaline-induced background current in guinea-pig ventricular myocytes.

R. Sitsapesan, A. Rankin, K. Kane, 1990, Journal of molecular and cellular cardiology.

Ionic basis of a differential effect of adenosine on refractoriness in rabbit AV nodal and atrial isolated myocytes.

A. Workman, A C Rankin, A. Rankin, 1999, Cardiovascular research.

Role of nitric oxide, cyclic GMP and superoxide in inhibition by adenosine of calcium current in rabbit atrioventricular nodal cells.

S. Cobbe, A. Martynyuk, A. Rankin, 1997, Cardiovascular research.

Endothelin and ischaemic arrhythmias-antiarrhythmic or arrhythmogenic?

C. Wainwright, K. Kane, I. Sharif, 1998, Cardiovascular research.

Comparison of Antiarrhythmic and Electrophysiologic Effects of Diltiazem and Its Analogue Siratiazem

K. Kane, M. Guc, G. Boachie-Ansah, 1993, Journal of cardiovascular pharmacology.

Adrenaline reveals the torsadogenic effect of combined blockade of potassium channels in anaesthetized guinea pigs

K. Kane, S. Coker, G Michael, 2008, British journal of pharmacology.

The cardiovascular actions of prostaglandins C1 and C2 in the cat (T)

R. L. Jones, K. Kane, A. Ungar, 1973 .

Apex-to-base dispersion of refractoriness underlies the proarrhythmic effect of hypokalaemia/hypomagnesaemia in the rabbit heart.

S. Cobbe, R. Wolk, K. Kane, 2002, Journal of electrocardiology.

CARDIOVASCULAR ACTIONS OF PROSTAGLANDIN C IN THE CAT AND DOG

K. Kane, A. Ungar, R. Jones, 1974, British journal of pharmacology.

Regional electrophysiological effects of hypokalaemia, hypomagnesaemia and hyponatraemia in isolated rabbit hearts in normal and ischaemic conditions.

S M Cobbe, S. Cobbe, R. Wolk, 1998, Cardiovascular research.

Erratum to: Remodelling of human atrial K+ currents but not ion channel expression by chronic β-blockade

P. Jhund, M. Boyett, J. Tellez, 2014, Pflügers Archiv - European Journal of Physiology.

The Effects of Prolonged Oral Administration of a New Antidysrhythmic Drug (Org 6001) on Coronary Artery Ligation Dysrhythmias in Conscious and Anesthetized Rats

J. Parratt, L. Szekeres, K. Kane, 1980, Journal of cardiovascular pharmacology.

Remodelling of human atrial K+ currents but not ion channel expression by chronic β-blockade

P. Jhund, M. Boyett, J. Tellez, 2012, Pflügers Archiv - European Journal of Physiology.

Electrophysiological effects of 5‐hydroxytryptamine on isolated human atrial myocytes, and the influence of chronic β‐adrenoceptor blockade

A. Workman, A. Rankin, K. Kane, 2003, British journal of pharmacology.

Cardiac Electrophysiological Effects of Isoprenaline, Phenylephrine, and Noradrenaline on Normal and Mildly “Ischaemic” Sheep Purkinje Fibers

J. Parratt, K. Kane, G. Boachie-Ansah, 1989, Journal of cardiovascular pharmacology.

The In‐vivo Cardiovascular Effects of a Putative Class III Anti‐arrhythmic Drug, AM 92016

C. Wainwright, K. Kane, M. Hagerty, 1996, The Journal of pharmacy and pharmacology.

The effects of ICS 205-930, a 5-HT antagonist, on arrhythmias and catecholamine release during canine myocardial ischaemia and reperfusion.

J. Parratt, K. Kane, S. Coker, 1986, European journal of pharmacology.

Characterization of a method for the detection of drugs with free radical scavenging activity using porcine leukocytes.

C. Wainwright, R. Wadsworth, K. Kane, 1994, Journal of pharmacological and toxicological methods.

Effects of Prolonged Administration of Oxprenolol on Severity of Ischaemic Arrhythmias, Enzyme Leakage, Infarct Size, and Intracellular Cardiac Muscle Action Potentials

J. Parratt, G. Bullock, K. Kane, 1984, Journal of cardiovascular pharmacology.

Electrophysiological Effects of Lidocaine, l-Chlorpheniramine, and Bepridil on Normal and Ouabain‐Intoxicated Canine Purkinje Fibers

K. Kane, G. Pastelín, S. Sánchez-Pérez, 1983, Journal of Cardiovascular Pharmacology.

Supraventricular Antidysrhythmic and Electrophysiological Effects of Bepridil, a New Antianginal Agent

K. Kane, E. Winslow, 1981, Journal of Cardiovascular Pharmacology.

Creatine Phosphate Suppresses Ventricular Arrhythmias Resulting from Coronary Artery Ligation

J. Parratt, K. Kane, O. Fagbemi, 1982, Journal of Cardiovascular Pharmacology.

Nitric oxide mediates the anti-adrenergic effect of adenosine on calcium current in isolated rabbit atrioventricular nodal cells

S. Cobbe, A. Martynyuk, A. Rankin, 2005, Pflügers Archiv.

Effects of diltiazem and its analogue siratiazem on contraction and 45Ca2+ uptake in sheep coronary artery rings.

R. Wadsworth, K. Kane, M. Panesar, 1995, General pharmacology.

Adenosine increases potassium conductance in isolated rabbit atrioventricular nodal myocytes.

S M Cobbe, S. Cobbe, A C Rankin, 1995, Cardiovascular research.

Is adenosine an endogenous myocardial protective (antiarrhythmic) substance under conditions of ischaemia?

J. Parratt, K. Kane, G. Boachie-Ansah, 1993, Cardiovascular research.