A. Kubo

发表

The structure of a novel antitumor antibiotic, saframycin A

K. Takahashi, T. Arai, S. Nakahara, 1980, Experientia.

Time‐dependent changes in the seroprevalence of COVID‐19 in asymptomatic liver disease outpatients in an area in Japan undergoing a second wave of COVID‐19

N. Sakamoto, M. Natsuizaka, A. Kubo, 2020, Hepatology research : the official journal of the Japan Society of Hepatology.

Baseline serum angiopoietin-2 and VEGF levels predict the deterioration of the liver functional reserve during lenvatinib treatment for hepatocellular carcinoma

N. Sakamoto, M. Natsuizaka, Masaru Baba, 2021, PloS one.

Early response and safety of atezolizumab plus bevacizumab for unresectable hepatocellular carcinoma in patients who do not meet IMbrave150 eligibility criteria

T. Miyagishima, N. Sakamoto, S. Ohnishi, 2021, Hepatology research : the official journal of the Japan Society of Hepatology.

Ecteinascidins 770 and 786 from the Thai tunicate Ecteinascidia thurstoni.

K. Suwanborirux, A. Kubo, N. Saito, 2002, Journal of natural products.

Characteristics and Lenvatinib Treatment Response of Unresectable Hepatocellular Carcinoma with Iso-High Intensity in the Hepatobiliary Phase of EOB-MRI

N. Sakamoto, S. Ohnishi, M. Natsuizaka, 2021, Cancers.

Synthesis of 1,2,3,4,5,6,7,10-Octahydro-1,5-imino-7,10-dioxo-3-benzazocine-4-carbonitrile Derivative and Evaluation of Antitumor Activity Related to Saframycin and Renieramycin Isoquinolinequinones

A. Kubo, N. Saito, Yu-ichi Koizumi, 2006 .

Chemistry of ecteinascidins. Part 2. Preparation of 6'-O-acyl derivatives of stable ecteinascidin and evaluation of cytotoxicity.

K. Suwanborirux, A. Kubo, N. Saito, 2006, Chemical & pharmaceutical bulletin.

Structure of Saframycin R

A. Kubo, N. Saito, N. Kameyama, 2000 .

Possible correlation between increased serum free carnitine levels and increased skeletal muscle mass following HCV eradication by direct acting antivirals

N. Sakamoto, S. Ohnishi, M. Natsuizaka, 2021, Scientific Reports.

A toxic substance produced by Nocardia otitidiscaviarum isolated from cutaneous nocardiosis

K. Yazawa, Y. Mikami, Ken-ichiro Suzuki, 1990, Mycopathologia.

Studies on the N-Oxides of π-Deficient N-Heteroaromatics. XIII. Mass Spectra of Azanaphthalene N-Oxides and Their Photochemical Reaction Products

S. Yamada, A. Kubo, I. Yokoe, 1968 .

Durable response without recurrence to Tolvaptan improves long-term survival

N. Sakamoto, A. Kubo, T. Sho, 2020, Journal of Gastroenterology.

SYNTHESIS OF MERIDINE, A PENTACYCLIC AZA-AROMATIC ALKALOID

A. Kubo, Y. Kitahara, F. Tamura, 1994 .

Total synthesis of eupomatidines-1,2, and 3

A. Kubo, Y. Kitahara, 1992 .

A Concise Route to 3-Hydroxy-4-Methoxy-5-Methylbenzaldehyde Derivative

A. Kubo, N. Saito, M. Tachi, 2000 .

Synthetic studies of benzo[b]pyrrolo[4,3,2-de][1,10]phenanthroline

A. Kubo, Y. Kitahara, T. Mizuno, 2004 .

Chemistry of renieramycins. Part 6: Transformation of renieramycin M into jorumycin and renieramycin J including oxidative degradation products, mimosamycin, renierone, and renierol acetate ☆

K. Suwanborirux, A. Kubo, N. Saito, 2004 .

Chemistry of renieramycins. Part 4.synthesis of a simple natural marine product, 6-hydroxy-7-methoxyisoquinolinemethanol.

A. Kubo, N. Saito, Chigusa Oyama, 2004, Chemical & pharmaceutical bulletin.

Inhibition of avian myeloblastosis virus reverse transcriptase by heterocyclic quinones: structure-activity correlation.

A. Kubo, S. Nakamura, Y. Inouye, 1991, Chemical & pharmaceutical bulletin.

Synthesis of Renierone, Antimicrobial Metabolite from a Marine Sponge Reniera sp.

S. Nakahara, A. Kubo, 1981 .

Synthesis of meridine, cystodamine, and related compounds including iminoquinolinequinone structure

A. Kubo, Y. Kitahara, F. Tamura, 1998 .

Synthetic studies on pentacyclic aromatic alkaloids, kuanoniamine A, 11-hydroxyascididemin, and neocalliactine acetate

S. Nakahara, A. Kubo, Y. Kitahara, 1997 .

Synthesis of cystodamine, a pentacyclic aza-aromatic alkaloid

A. Kubo, Y. Kitahara, F. Tamura, 1997 .

A Simple, General Method for the Conversion of 2-Indolinones into Indoles

A. Kubo, T. Nakai, 1980 .

Oxidation of 2,3-Disubstituted Indole Derivatives with Selenium Dioxide

A. Kubo, S. Sakai, K. Katsuura, 1972 .

Jorunnamycins A-C, new stabilized renieramycin-type bistetrahydroisoquinolines isolated from the Thai nudibranch Jorunna funebris.

K. Suwanborirux, A. Kubo, N. Saito, 2007, Chemical & pharmaceutical bulletin.

Chemistry of renieramycins. Part 3.(1) isolation and structure of stabilized renieramycin type derivatives possessing antitumor activity from Thai sponge Xestospongia species, pretreated with potassium cyanide.

K. Suwanborirux, A. Kubo, N. Saito, 2003, Journal of natural products.

Chemistry of renieramycins. Part 2. Partial reduction and nucleophilic substitution of hexahydro-1,5-imino-4-oxo-3-benzazocine-7,10-dione: Promising method to construct renieramycin J from renieramycin G via renieramycin E

K. Suwanborirux, A. Kubo, N. Saito, 2002 .

SYNTHESIS OF CRIBROSTATINS 1 AND 2

S. Nakahara, A. Kubo, Yoshihiro Tanaka, 1995 .

Synthesis of saframycins. VII, The synthesis of novel renieramycin congeners

A. Kubo, N. Saito, R. Yamaguchi, 1991 .

Synthesis of new isoquinolinequinone metabolites of a marine sponge, Xestospongia sp., and the nudibranch Jorunna funebris.

S. Nakahara, A. Kubo, Y. Kitahara, 1989 .

Synthesis of renierone, 7-methoxy-1,6-dimethyl-5,8-dihydroisoquinoline-5,8-dione and N-formyl-1,2-dihydrorenierone, antimicrobial metabolites from a marine sponge, Reniera sp.

A. Kubo, Y. Kitahara, S. Nakahara, 1986, Chemical & pharmaceutical bulletin.

Chemistry of Renieramycins. Part 4. Synthesis of a Simple Natural Marine Product, 6-Hydroxy-7-methoxyisoquinolinemethanol.

A. Kubo, N. Saito, Chigusa Oyama, 2004 .

Synthesis of imbiline 1, a tetracyclic aza-aromatic alkaloid

A. Kubo, M. Mochii, Y. Kitahara, 2000 .

Synthesis of pantherinine, a cytotoxic fused tetracyclic aromatic alkaloid

S. Nakahara, A. Kubo, J. Matsui, 1998 .

13C NMR Spectral Assignment of 5-Hydroxy-1,5-imino-3-benzazocin-4,7,10-trione Derivatives: The Revised Structure of Renieramycin H

K. Suwanborirux, A. Kubo, N. Saito, 2001 .

Synthesis and Antitumor Evaluation of Octahydro-5-hydroxy-1,5-imino-3-benzazocin-4,7,10-triones.

K. Yazawa, Y. Mikami, A. Kubo, 1998 .

Synthesis of saframycins. XII. 1 total synthesis of (-)-N-acetylsaframycin Mx 2 and Its epi-(+)-enantiomer

K. Yamaguchi, A. Kubo, N. Saito, 1995 .

Synthesis of saframycins. V. Selenium oxide oxidation of hexahydro-1,5-imino-3-benzazocin-7,10-dione; a useful method for constructing saframycins C and D from saframycin B

N. Wada, A. Kubo, N. Saito, 1990 .

Synthesis of saframycins. II. Preparations and reactions of N-methyl-2,5-piperazinediones.

A. Kubo, N. Saito, S. Inoue, 1988, Chemical & pharmaceutical bulletin.

Stereoselective total synthesis of (±)-saframycin B

A. Kubo, N. Saito, Madoka Nakamura, 1988 .

Preparations and Reactions of (Z) -3-Arylidene-6-arylmethyl-2, 5-piperazinediones Having Highly Oxygenated Benzene Rings

A. Kubo, N. Saito, H. Yamato, 1987 .

Synthetic studies of imbiline 1, a constituent of Eupomatia species

A. Kubo, M. Mochii, Y. Kitahara, 2003 .

Potent estrogen agonists based on carborane as a hydrophobic skeletal structure. A new medicinal application of boron clusters.

A. Itai, Y. Endo, C. Miyaura, 2001, Chemistry & biology.

Synthesis of 4, 7-Indolequinones. The Oxidative Demethylation of 4, 7-Dimethoxyindoles with Ceric Ammonium Nitrate

S. Nakahara, A. Kubo, Y. Kitahara, 1985 .

Mechanism of inhibition of reverse transcriptase by quinone antibiotics.

E. Nakata, A. Kubo, S. Nakamura, 1987, The Journal of antibiotics.

Mechanism of inhibition of reverse transcriptase by quinone antibiotics. II. Dependence on putative quinone pocket on the enzyme molecule.

S. Nakahara, A. Kubo, S. Nakamura, 1988, The Journal of antibiotics.

The quinoline quinone as the minimum entity for reverse transcriptase inhibitory activity of streptonigrin.

A. Kubo, S. Nakamura, Y. Inouye, 1987, Journal of antibiotics (Tokyo. 1968).

Comparative studies of the inhibitory properties of antibiotics on human immunodeficiency virus and avian myeloblastosis virus reverse transcriptases and cellular DNA polymerases.

A. Kubo, S. Nakamura, Y. Inouye, 1989, The Journal of antibiotics.

Comparative study on biological activities of heterocyclic quinones and streptonigrin.

A. Kubo, S. Nakamura, Y. Inouye, 1987, The Journal of antibiotics.

The Assignment of the Carbon-13 Nuclear Magnetic Resonance Spectra of Isoquinoline and Quinoline Quinones

S. Nakahara, A. Kubo, Y. Kitahara, 1985 .

Isolation and structural elucidation of new saframycins Y3, Yd-1, Yd-2, Ad-1, Y2b and Y2b-d.

N. Saito, K. Yazawa, Y. Mikami, 1986, The Journal of antibiotics.

Chapter 3 Isoquinolinequinones from Actinomycetes and Sponges

T. Arai, A. Kubo, 1983 .

Structure-activity study of estrogenic agonists bearing dicarba-closo-dodecaborane. Effect of geometry and separation distance of hydroxyl groups at the ends of molecules.

A. Itai, Y. Endo, A. Kubo, 1999, Bioorganic & medicinal chemistry letters.

Inactivation of Kanamycin A by Phosphorylation in Pathogenic Nocardia

T. Kudo, K. Yazawa, Y. Mikami, 1991, Microbiology and immunology.

Diketopiperazines containing L-proline from Streptomyces lavendulae and their stereochemistry in solution

K. Takahashi, T. Arai, A. Kubo, 2005, Experientia.

Structure-Activity study of retinoid agonists bearing substituted dicarba-closo-dodecaborane. Relation between retinoidal activity and conformation of two aromatic nuclei.

A. Itai, H. Kagechika, Y. Endo, 2001, Bioorganic & medicinal chemistry letters.

Prospect of lenvatinib for unresectable hepatocellular carcinoma in the new era of systemic chemotherapy

M. Natsuizaka, A. Kubo, T. Sho, 2021, World journal of gastrointestinal oncology.

ISOLATION AND CHARACTERIZATION OF SATELLITE ANTIBIOTICS , MIMOSAMYCIN AND CHLOROCARCINS

Katsuhiro Takahashi, A. Kubo, 2006 .

Mimosamycin, a novel antibiotic produced by streptomyces lavendulae no. 314: structure and synthesis

T. Hata, T. Arai, A. Kubo, 1977 .

Synthesis of mimocin, an isoquinolinequinone antibiotic from Streptomyces lavendulae, and its congeners.

S. Nakahara, A. Kubo, Y. Kitahara, 1988, Chemical & pharmaceutical bulletin.

Mimocin, a new isoquinolinequinone antibiotic.

Katsuhiro Takahashi, T. Arai, S. Nakahara, 1980 .

Chemistry of renieramycins. Part 5. Structure elucidation of renieramycin-type derivatives O, Q, R, and S from thai marine sponge Xestospongia species pretreated with potassium cyanide.

K. Suwanborirux, A. Kubo, N. Saito, 2004, Journal of natural products.

Baseline elevated serum angiopoietin-2 predicts long-term non-regression of liver fibrosis after direct-acting antiviral therapy for hepatitis C

N. Sakamoto, M. Natsuizaka, M. Nishida, 2021, Scientific Reports.

SYNTHETIC APPROACHES TOWARD ECTEINASCIDINS. PART 1. PREPARATION OF AN (E)-2-ARYLIDENE-3-BENZYL-1,5-IMINO-3-BENZAZOCIN-4-ONE HAVING A PROTECTED PHENOL IN THE E-RING

K. Yamaguchi, A. Kubo, N. Saito, 1997 .

Synthesis of saframycins. 3. Preparation of a key tricyclic lactam intermediate to saframycin A

A. Kubo, Satoko Ida, N. Saito, 1989 .

A Synthesis of the Derivatives of 1,2,3,5,10,10a‐Hexahydrobenz(f) indolizine‐6,9‐dione Having Antifungal Activity as a Simple Model of Saframycin A.

K. Yazawa, Y. Mikami, A. Kubo, 1996 .

A Synthesis of the Derivative of 1,2,3,5,10,10a-Hexahydrobenz[f]indolizine-6,9-dione Having Antifungal Activity as a Simple Model of SaframycinA

K. Yazawa, Y. Mikami, A. Kubo, 1996 .

Antifungal activity of SL-1, a beta-nitrostyrene type pigment and its synthetic congeners.

N. Saito, K. Yazawa, Y. Mikami, 1991, The Journal of antibiotics.

A new pigment from Streptomyces lavendulae.

N. Saito, K. Yazawa, Y. Mikami, 1987, The Journal of antibiotics.

Synthesis of saframycins. X. Transformation of (-)-saframycin A to (-)-saframycin Mx type compound with the structure proposed for saframycin E.

A. Kubo, N. Saito, M. Nishida, 1995, Chemical and pharmaceutical bulletin.

Structure of a 3‐acetonylideneindolin‐2‐one dimer

A. Itai, Y. Iitaka, A. Kubo, 1978 .

A practical synthesis of the ABC ring model of ecteinascidins.

A. Kubo, N. Saito, M. Tachi, 2000, Chemical & pharmaceutical bulletin.

Synthesis of saframycins. VIII: Synthesis of the ABC ring of safracins

A. Kubo, N. Saito, Yasuko Obara, 1992 .

Synthesis of saframycins. I. Total synthesis (+/-)-saframycin B and its congeners.

A. Kubo, N. Saito, R. Yamauchi, 1987, Chemical & pharmaceutical bulletin.

An Improved Synthesis of the ABC Ring Model of Ecteinascidins

A. Kubo, N. Saito, M. Tachi, 1999 .

A promising cyclization of the 3-arylidene-6-arylmethyl-2,5-piperazinedione to construct tricyclic lactam as an intermediate to saframycin synthesis

A. Kubo, N. Saito, S. Sakai, 1987 .

New antibiotics saframycins A, B, C, D and E.

K. Takahashi, T. Arai, A. Kubo, 1977, The Journal of antibiotics.

SYNTHESIS OF NEOAMPHIMEDINE

Y. Mukai, S. Nakahara, A. Kubo, 2012 .

[Synthesis of 5,6-(dihydropyrrolo[2,1-a]) -isoquinolines].

A. Kubo, K. Tanno, M. Katagiri, 1966, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Synthesis of Novel Octahydro-1, 5-imino-3-benzazocin-4, 7, 10-trione Derivatives Having a Methyl Group at the C-2 Position as ABC Ring Models of Saframycins

A. Kubo, N. Saito, M. Tanitsu, 1997 .

Synthesis of 2(1H)-quinolinonequinones and 2-alkoxy-quinolinequinones using oxidative demethylation with cerium (IV) ammonium nitrate

S. Nakahara, A. Kubo, Y. Kitahara, 1993 .

Gardneria alkaloids. XII. Carbon magnetic resonance spectra of gardneria alkaloids. A study on the configuration of the side chain double bonds of indole alkaloids.

A. Kubo, N. Aimi, S. Sakai, 1978 .

[Transformation of indole alkaloids. II. On the C-D ring opening and closing reactions of indole alkaloids and the syntheses of vobasine type alkaloids (author's transl)].

A. Kubo, S. Sakai, K. Sasago, 1973, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

The Structures of Gardnerine, Gardnutine and Hydroxygardnutine and the Absolute Configuration of Gardnerine

Katsuhiro Takahashi, A. Kubo, S. Sakai, 1973 .

Gardneria alkaloids II. The structures of gardnerine, gardnutine and hydroxygardnutine.

S. Sakai, A. Kubo, J. Haginiwa, 1969, Tetrahedron letters.

Structure of Gardneramine and 18-Demethylgardneramine

A. Kubo, N. Aimi, M. Kitagawa, 1975 .

Gardneria alkaloids - VI structures of gardneramine and alkaloid G (demethylgardneramine)

A. Kubo, N. Aimi, M. Kitagawa, 1971 .

Synthesis of Eupomatidines 1, 2 and 3 and Related Compounds Including Iminoquinolinequinone Structure

Y. Mikami, Satoshi Watanabe, A. Kubo, 1997 .

Synthesis of saframycins. XI. Synthetic studies toward a total synthesis of safracin A

K. Yamaguchi, A. Kubo, Takeshi Saito, 1995 .

Structural studies on minor components of saframycin group antibiotics saframycins F, G and H.

N. Saito, K. Yazawa, Y. Mikami, 1988, Journal of antibiotics (Tokyo. 1968).

Synthetic approaches toward ecteinascidins. Part 2. Preparation of the ABCDE ring system of ecteinascidins having characteristic substituents in both benzene rings.

A. Kubo, N. Saito, N. Kameyama, 2003, Chemical & pharmaceutical bulletin.

Synthesis of Saframycins. Part 11. Synthetic Studies Toward a Total Synthesis of Safracin A (I).

K. Yamaguchi, A. Kubo, N. Saito, 1995 .

A Facile Synthesis of 1,2,3,4-Tetrahydroisoquinolines Through Cyclization of O,N-Acetals

Yasuo Matsuyama, A. Kubo, N. Saito, 1988 .

Synthesis of Isoquinolinequinone Antibiotics.

S. Nakahara, A. Kubo, N. Saito, 1982 .

SYNTHESIS OF SAFRAMYCINS. VI. THE USEFUL TRANSFORMATION OF (-)-SAFRAMYCIN A TO (-)-SAFRAMYCIN Mx TYPE COMPOUND

A. Kubo, N. Saito, M. Nishida, 1991 .

Total synthesis of isoquinolinequinone antibiotics.

A. Kubo, N. Saito, 1988 .