Randall K. Johnson

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Fasicularin, a novel tricyclic alkaloid from the ascidian Nephteis fasicularis with selective activity against a DNA repair-deficient organism

L. Faucette, D. Faulkner, B. Carté, 1997 .

Copper(I) complexes with bidentate tertiary phosphine ligands: solution chemistry and antitumor activity

Peter J. Sadler, P. Sadler, C. Mirabelli, 1987 .

An alternate synthesis, x-ray crystal structure and p388 activity of 1,2-bis(dibenzophospholyl-1)ethane †

L. Faucette, D. Eggleston, P. Baures, 1990 .

Antitumor Activity of Bis(diphenylphosphino)alkanes, Their Gold(I) Coordination Complexes, and Related Compounds.

S. Crooke, J. Bartus, C. Mirabelli, 1988 .

A phase I clinical and pharmacokinetic study of the topoisomerase I inhibitor topotecan (SK&F 104864) given as an intravenous bolus every 21 days

G. Weiss, D. V. Von Hoff, G. Clark, 1992, Anti-cancer drugs.

Z-Axinohydantoin and Debromo-Z-Axinohydantoin from the Sponge Stylotella aurantium: Inhibitors of Protein Kinase C

G. Hofmann, A. Patil, A. Freyer, 1997 .

Cantuzumab mertansine, a maytansinoid immunoconjugate directed to the CanAg antigen: a phase I, pharmacokinetic, and biologic correlative study.

A. Tolcher, C. Takimoto, L. Smith, 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Chapter 14. Mechanism-Based Discovery of Anticancer Agents

R. Hertzberg, Randall K. Johnson, 1990 .

Biochemical Modulation of Anticancer Agents: An Overview

F. Valeriote, Randall K. Johnson, 1986 .

Frondosins, five new sesquiterpene hydroquinone derivatives with novel skeletons from the sponge Dysidea frondosa: Inhibitors of interleukin-8 receptors

B. Carté, A. Freyer, L. Killmer, 1997 .

The plakortones, novel bicyclic lactones from the sponge Plakortis halichondrioides: Activators of cardiac SR-Ca2+-pumping ATPase

M. F. Bean, J. Westley, B. Carté, 1996 .

Treatment of murine tumors with 5-fluorouracil in combination with de novo pyrimidine synthesis inhibitors pala or pyrazofurin. Abstr.

J. Clement, Randall K. Johnson, W. S. Howard, 1980 .

DNA damaging activity of ellagic acid derivatives.

S. Hecht, Ji Ma, S. H. Jones, 2003, Bioorganic & medicinal chemistry.

Response of rat and human prostatic cancers to the novel 5α‐reductase inhibitor, SK&F 105657

J. Isaacs, Randall K. Johnson, J. Lamb, 1992 .

Cantuzumab M ertansine, a M aytansinoid I mmunoconjugate Directed t o t he C anAg A ntigen: A P hase I , P harmacokinetic, and B iologic C orrelative S tudy

A. Tolcher, C. Takimoto, L. Smith, 2003 .

Chapter 18. Antineoplastic Agents

R. Hertzberg, Randall K. Johnson, 1993 .

DNA-damaging agents from Crypteronia paniculata.

S. Hecht, S. H. Jones, Randall K. Johnson, 2002, Journal of natural products.

Isolation and characterization of a Tie2 kinase inhibitory sulfated triterpenoid from a green alga of the Tuemoya genus: complete assignment of the 1H and 13C spectra of a sulfated triterpenoid Tie2 kinase inhibitor

D. Kingston, David J. I. Kingston, Randall K. Johnson, 2003 .

New Cytotoxic Manzamine Alkaloids from a Palaun Sponge

D. Kingston, M. Mattern, C. Slebodnick, 2000 .

Amphibian Melanophore Technology as a Functional Screen for Antagonists of G-Protein Coupled 7-Transmembrane Receptors

John C. Lee, P. Murdock, Jonathan A. Lee, 1999, Journal of biomolecular screening.

Polybrominated diphenyl ethers from a sponge of the Dysidea genus that inhibit Tie2 kinase.

S. Hecht, Randall K. Johnson, Ya-ming Xu, 2005, Bioorganic & medicinal chemistry.

(. mu. -1,1 prime -Bis(diphenylphosphine)ferrocene)bis(chlorogold): Synthesis, iron-57 and gold-197 Moessbauer spectroscopy, x-ray crystal structure, and antitumor activity

P. Stupik, D. Eggleston, W. Reiff, 1989 .

4-Aryl-1,2,3-triazole: a novel template for a reversible methionine aminopeptidase 2 inhibitor, optimized to inhibit angiogenesis in vivo.

Guang Yang, Keith W Ward, D. Veber, 2005, Journal of medicinal chemistry.

Three new tricyclic guanidine alkaloids from the sponge Batzella sp.

M. F. Bean, A. Freyer, Randall K. Johnson, 1997 .

Purpurone, an inhibitor of ATP-citrate lyase: a novel alkaloid from the marine sponge Iotrochota sp

G. Chan, D. Faulkner, J. Westley, 1993 .

(μ‐1,1′‐Bis(diphenylphosphino)ferrocene)bis(chlorogold): Synthesis, Iron‐57 and Gold‐197 Moessbauer Spectroscopy, X‐Ray Crystal Structure, and Antitumor Activity.

P. Stupik, D. Eggleston, W. Reiff, 1989 .

Antitumor Agent Merbarone and Intracellular Inhibition of Topoisomerase II by the In Vitro Updated

R. Hertzberg, G. Hofmann, J. Bartus, 2006 .

New cytotoxic lupane triterpenoids from the twigs of Coussarea paniculata.

David G I Kingston, D. Kingston, Randall K Johnson, 2003, Journal of natural products.

Piperpense, a Tetrahydropyridine Alkaloid from Piper Ponapense Stems and Leaves

G. Hofmann, A. Freyer, R. Reichwein, 1997 .

Pulcherrimins A-D, novel diterpene dibenzoates from Caesalpinia pulcherrima with selective activity against DNA repair-deficient yeast mutants

M. F. Bean, L. Faucette, A. Freyer, 1997 .

lissoclin Disulfoxide, A Novel Dimeric Alkaloid from the Ascidian lissoclinum Sp.: Inhibitor of Interleukin-8 Receptors

B. Carté, A. Freyer, L. Killmer, 1997 .

Structure and stereochemistry of a novel bioactive sphingolipid from a Calyx sp.

D. Kingston, Randall K. Johnson, Bing-nan Zhou, 2001 .

Mechanism of Resistance of a Variant of P388 Leukemia to L-(αS,5S)-α-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic Acid (Acivicin)

B. Ardalan, Randall K. Johnson, H. Jayaram, 1985 .

Effects of cyclophosphamide and adriamycin on the healing of surgical wounds in mice

A. Goldin, H. Gabelnick, Randall K. Johnson, 1975, Cancer.

Chemotherapy of human colon cancer xenografts in athymic nude mice

A. Goldin, R. Osieka, R. Johnson, 1977, Cancer.

Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore.

Keizo Yamashita, Guang Yang, D. Veber, 2007, Journal of medicinal chemistry.

Antitumor Activityof N-(Phosphonacetyl)-L-asparticAcid, a Transition-StateInhibitorof Aspartate Transcarbamylase

G. Stark, A. Goldin, Randall K. Johnson, 1976 .

Collateral Sensitivity to N-(Phosphonacetyl)-l-aspartic Acid in a Line of P388 Leukemia Cells Selected for Resistance to l-(αS,5S)-α-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic Acid (Acivicin)

B. Ardalan, Randall K. Johnson, H. Jayaram, 1983 .

Therapy of mouse tumors and human tumor xenografts by the antitumor antibiotic at-125 (nsc-163501). Abstr.

D. Houchens, Randall K. Johnson, Neil Gl, 1978 .

Synthesis and antineoplastic activity of alanyl-2-glycyl peptide derivatives of nocodazole

K. Erhard, S. Ross, F. McCabe, 1989 .

Original paperSynthesis and antineoplastic activity of alanyl-2-glycyl peptide derivatives of nocodazoleSynthèse et activité antinéoplastique de dérivés alanyl-2-glycyl peptide de nocodazole

K. Erhard, S. Ross, F. McCabe, 1989 .

Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

S. Carr, M. Hurle, R. Annan, 1999, Oncogene.

Nonclinical pharmacokinetics and activity of etirinotecan pegol (NKTR-102), a long-acting topoisomerase 1 inhibitor, in multiple cancer models

U. Hoch, Randall K. Johnson, M. Eldon, 2014, Cancer Chemotherapy and Pharmacology.

A New Cycloartanol Sulfate from the Green Alga Tuemoya Sp.: An Inhibitor of VZV Protease

A. Freyer, L. Killmer, Randall K. Johnson, 1997 .

Relationship between the Intracellular Effects of Camptothecin and the Inhibition of DNA Topoisomerase I in Cultured LI 210 Cells1

S. Crooke, M. Mattern, C. Mirabelli, 2006 .

High-Dose Recombinant Interleukin-18 Induces an Effective Th1 Immune Response to Murine MOPC-315 Plasmacytoma

M. Lotze, K. Johanson, R. Kirkpatrick, 2002, Journal of immunotherapy.

Probenecid alters topotecan (TPT) systemic and renal disposition

P. Houghton, C. Stewart, P. Cheshire, 1997 .

A revised structure for sibiromycin

J. R. Hoover, S. Hecht, Randall K. Johnson, 1988 .

A new dimeric dihydrochalcone and a new prenylated flavone from the bud covers of Artocarpus altilis: potent inhibitors of cathepsin K.

Paul B Taylor, B. Votta, Alan J Freyer, 2002, Journal of natural products.

A DNA-damaging oxoaporphine alkaloid from Piper caninum.

S. Hecht, Ji Ma, S. H. Jones, 2004, Journal of natural products.

Preulithiacyclamide, a New Cyclic Peptide from the Ascidian Lissoclinum patella

A. Freyer, L. Killmer, Randall K. Johnson, 1997 .

CARBOXYIMAMIDATE, A LOW-MOLECULAR-WEIGHT POLYELECTROLYTE WITH ANTITUMOR PROPERTIES AND LOW TOXICITY

Randall K. Johnson, J. Fields, S. Asculai, 1983 .

Haploscleridamine, a novel tryptamine-derived alkaloid from a sponge of the order haplosclerida: an inhibitor of cathepsin K.

D. Faulkner, B. Carté, A. Freyer, 2002, Journal of natural products.

Yeast TOR (DRR) proteins: amino-acid sequence alignment and identification of structural motifs.

M. Mclaughlin, G. P. Livi, P. Young, 1994, Gene.

Synergistic cell killing by ionizing radiation and topoisomerase I inhibitor topotecan (SK&F 104864).

G. Hofmann, M. Mattern, R. Johnson, 1991, Cancer research.

Modification of the hydroxy lactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity.

R. Hertzberg, J. Bartus, M. Mattern, 1989, Journal of medicinal chemistry.

Bioactive Ergost-5-ene-3β/,7α-diol Derivatives from Pseudobersama mossambicensis

D. Kingston, R. Johnson, A. Gunatilaka, 1992 .

Isolation of bioactive and other oxoaporphine alkaloids from two annonaceous plants, Xylopia aethiopica and Miliusa cf. banacea.

G. Harrigan, D. Kingston, G. Chan, 1994, Journal of natural products.

Synthesis of water-soluble (aminoalkyl)camptothecin analogs: inhibition of topoisomerase I and antitumor activity

J. Boehm, R. Hertzberg, S. Hecht, 1991 .

Enhancement of antitumor activity of alkylating agents by the radiation sensitizer misonidazole.

I. Wodinsky, R. Johnson, R. Catane, 1980, Cancer research.

The CYP2 gene of Saccharomyces cerevisiae encodes a cyclosporin A-sensitive peptidyl-prolyl cis-trans isomerase with an N-terminal signal sequence.

M. Mclaughlin, D. Bergsma, G. P. Livi, 1991, Gene.

Correlation of the in vitro cytotoxic and in vivo antitumor activities of gold(I) coordination complexes.

S. Crooke, C. Mirabelli, R. Johnson, 1986, Journal of medicinal chemistry.

Prostatic involution in rats induced by a novel 5 alpha-reductase inhibitor, SK&F 105657: role for testosterone in the androgenic response.

J. Isaacs, R. Johnson, G. Rhodes, 1992, Endocrinology.

Fasicularin, a Novel Tricyclic Alkaloid from the Ascidian Nephteis fasicularis with Selective Activity Against a DNA Repair‐Deficient Organism.

L. Faucette, D. Faulkner, B. Carté, 1997 .