J. Marco

发表

Friedländer reaction on 2-amino-3-cyano-4H-pyrans : Synthesis of derivatives of 4H-pyran [2,3-b] quinoline, new tacrine analogues

Angeles Martínez-Grau, J. Marco, JoséL. Marco, 1997 .

Studies into the synthesis of derivatives of 4-amino-2,3-dihydroisothiazole 1,1-dioxides and 4-amino-1,2-oxathiole 2,2-dioxides: The search for linked π-system containing analogues as potential inhibitors of HIV-1 reverse transcriptase

E. Clercq, M. Witvrouw, J. Marco, 1997 .

Acetylenic and allenic derivatives of 2-(5-methoxy-1-methylindolyl) alkylamines: Synthesis and evaluation as selective inhibitors of the monoamine oxidases A and B

J. Marco, C. Garcia, E. Fernández‐Álvarez, 1992 .

Anti‐apoptotic effect of Mao‐B inhibitor PF9601N [N‐(2‐propynyl)‐2‐(5‐benzyloxy‐indolyl) methylamine] is mediated by p53 pathway inhibition in MPP+‐treated SH‐SY5Y human dopaminergic cells

K. Tipton, S. Ambrosio, A. Quintana, 2008, Journal of neurochemistry.

CYP-dependent metabolism of PF9601N, a new monoamine oxidase-B inhibitor, by C57BL/6 mouse and human liver microsomes.

M. Frosini, M. Unzeta, G. Sgaragli, 2007, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

PF9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine] confers MAO-B independent neuroprotection in ER stress-induced cell death

A. Quintana, E. Sanz, M. Unzeta, 2009, Molecular and Cellular Neuroscience.

First asymmetric synthesis of 3-alkoxycarbonyl-2-amino-4-aryl-4H-naphtho[1,2-b]pyrans

N. Martín, F. H. Cano, C. Seoane, 1996 .

11, 11, 12, 12-tetracyano-2-azaanthraquinodimethane (TCAAQ): A new acceptor molecule

M. Hanack, J. Segura, N. Martín, 1991 .

New 2-[(5-methoxy-1-methylindolyl)]-alkylamine derivatives: the effect of branching and elongation of the side chain on MAO inhibition.

M. Unzeta, J. Marco, E. Fernández‐Álvarez, 1998, Journal of enzyme inhibition.

Kinetic Studies of N‐Allenic Analogues of Tryptamine as Monoamine Oxidase Inhibitors

M. Unzeta, J. Marco, E. Fernández‐Álvarez, 1996, The Journal of pharmacy and pharmacology.

Michael Addition of Malononitrile to α‐Acetylcinnamamides

N. Martín, F. H. Cano, C. Seoane, 1993 .

Synthesis of optically pure 1-(3-furyl)-1,2-dihydroxyethane derivatives

J. Marco, J. Hueso-Rodríguez, 1988 .

Novel tacrine derivatives that block neuronal calcium channels.

M. Carreiras, M. Villarroya, Antonio G. García, 2002, Bioorganic & medicinal chemistry.

Michael Additions of .alpha.-Sulfinyl and .alpha.-Sulfonyl Carbanions: The Unprecedented Reaction of .beta.-Keto Sulfoxides and .beta.-Keto Sulfones with Highly Stabilized Michael Acceptors

N. Khiar, I. Fernández, J. Marco, 1995 .

Development of methods for the synthesis of chiral, highly functionalized 2-amino-4-aryl-4H-pyrans

N. Martín, F. H. Cano, C. Seoane, 1994 .

Asymmetric Synthesis IX: Preparation of Chiral a-Substituted Phenethylamines

J. Marco, J. Royer, H. Husson, 1987 .

Synthesis, biological evaluation and molecular modelling of diversely functionalized heterocyclic derivatives as inhibitors of acetylcholinesterase/butyrylcholinesterase and modulators of Ca2+ channels and nicotinic receptors.

F. J. Luque, M. Orozco, A. Morreale, 2004, Bioorganic & medicinal chemistry.

The first asymmetric synthesis of polyfunctionalized 4H-pyrans via Michael addition of malononitrile to 2-acyl acrylates

N. Martín, F. H. Cano, C. Seoane, 1992 .

Asymmetric synthesis. IV: Preparation of chiral α-aminonitriles from a new N-cyanomethyl-1,3-oxazolidine synthon

J. Marco, J. Royer, H. Husson, 1985 .

Synthesis and Acetylcholinesterase/Butyrylcholinesterase Inhibition Activity of 4‐Amino‐2, 3‐diaryl‐5, 6, 7, 8‐tetrahydrofuro(and thieno)[2, 3‐b]‐quinolines, and 4‐Amino‐5, 6, 7, 8, 9‐pentahydro‐2, 3‐diphenylcyclohepta[e]furo(and thieno)‐[2, 3‐b]pyridines

N. Vivas, A. Badía, M. Carreiras, 2002, Archiv der Pharmazie.

Transformations of L-erythrulose: Synthesis of 2-amino-4-[1′R(1′,2′-O-isopropylidene)-1,2-dihydroxyethyl]-3-furancarbonitrile

J. Marco, G. Martin, 1996 .

Michael Reactions of b-Keto Phosphonates with Arylmethylene-malononitriles: The First Synthesis of Densely Functionalized 5-Diethylphosphinyl-2-amino-4H-pyrans

J. Marco, P. M. Chinchón, 1999 .

Synthesis and acetylcholinesterase/butyrylcholinesterase inhibition activity of new tacrine-like analogues.

J. Baños, N. Vivas, A. Badía, 2001, Bioorganic & medicinal chemistry.

Asymmetric synthesis of 3-alkoxycarbonyl-2-amino-5-cyano-4,6-diphenyl-4H-pyrans

N. Martín, F. H. Cano, C. Seoane, 1994 .

Asymmetric alkylation of β-ketoesters: Synthesis and Michael additions of a chiral sultam-derived acetoacetyl equivalent

N. Martín, C. Seoane, Angeles Martínez-Grau, 1993 .

Recent approaches to novel anti-Alzheimer therapy.

M. Carreiras, J. Marco, 2004, Current pharmaceutical design.

Stereocontrolled routes to derivatives of 3-alkoxycarbonyl-2-amino-4-aryl-5-cyano-6-phenyl-4H-pyrans

N. Martín, C. Seoane, Angeles Martínez-Grau, 1995 .

Michael addition of malononitrile to chiral α-acylacrylates

N. Martín, F. H. Cano, C. Seoane, 1993 .

The First Asymmetric Synthesis of Polyfunctionalized 4H‐Pyrans via Michael Addition of Malononitrile to 2‐Acyl Acrylates.

N. Martín, F. H. Cano, C. Seoane, 1992 .

Asymmetric syntheses of 1-amino-2-phenyl(alkyl)cyclopropanecarboxylic acids by diastereoselective cyclopropanation of highly functionalized monochiral olefines

C. Foces-Foces, J. Marco, M. Bernabé, 1994 .

Chemistry of Sulfonate‐ and Sulfonamide‐Stabilized Carbanions − The CSIC Reactions

J. Marco, D. Postel, A. N. V. Nhien, 2003 .

Synthesis of a Heteroannulated Furanose via Intramolecular Michael Addition in an ω-Hydroxy α,β-Unsaturated Nitrile†:

S. Fernández, J. Marco, 1999 .

From α,α-disubstituted α-aminonitriles to heterocycles: Synthesis of derivatives of 4-amino-2,3-dihydroisothiazole 1,1-dioxide, a new heterocyclic ring system

J. Marco, S. Ingate, 1997 .

Asymmetric synthesis via heterocyclic intermediates. I: Synthesis of 3,4-dihydro-11a-(S)-methyl-4-(R)-phenyl-1,4-oxazino[4,3-b]isoquinolin-1(6H,11H)-one

J. Marco, 1987 .

Asymmetric synthesis VII: enantiospecific preparation of β-aminoalcohols from the n-cyanomethyl-4-phenyl-1,3-oxazolidine synthon

J. Marco, J. Royer, H. Husson, 1985 .

Synthesis of 2, 3-dideoxy-4-O-p-methoxybenzyl-L-erythro-hex-2-enono-1, 5-lactone

J. Marco, B. Rodriguez, 1989 .

Reaction of α-azidoketones with highly stabilized michael acceptors: A new synthesis of densely functionalized pyrroles

N. Martín, C. Seoane, Angeles Martínez-Grau, 1995 .

Salviacoccin, a neo-clerodane diterpenoid from Salvia coccinea

J. Marco, G. Savona, M. Paternostro, 1982 .

ITH4012 (Ethyl 5-Amino-6,7,8,9-tetrahydro-2-methyl-4-phenylbenzol[1,8]naphthyridine-3-carboxylate), a Novel Acetylcholinesterase Inhibitor with “Calcium Promotor” and Neuroprotective Properties

R. León, Manuela G. López, E. Arias, 2004, Journal of Pharmacology and Experimental Therapeutics.

ITH4012, a novel acetylcholinesterase inhibitor with “calcium promotor” and neuroprotective properties

R. León, Manuela G. López, E. Arias, 2004 .

and neuroprotective properties

R. León, Manuela G. López, E. Arias, 2004 .

Isolation, Reactivity, Pharmacological Activities and Total Synthesis of Hispanolone and Structurally Related Diterpenes from Labiatae Plants.

J. Marco, 2020, Bioorganic & medicinal chemistry letters.

Iridoid glucosides of Linaria clementei

J. Marco, 1985 .

Triterpenoids from Salvia deserta

J. Marco, G. Savona, M. Bruno, 1987 .

Diterpenoids from Teucrium scorodonia, three neo-clerodane derivatives

J. Marco, F. Piozzi, G. Savona, 1982 .

Modeling of acetylcholinesterase inhibition by tacrine analogues using Bayesian-regularized Genetic Neural Networks and ensemble averaging

Julio Caballero, Michael Fernández, M Carmo Carreiras, 2006, Journal of enzyme inhibition and medicinal chemistry.

Diterpenoids from Salvia candelabrum

M. Jimeno, A. M. Lobo, J. Marco, 1989 .

The C-12 and C-20 configurations of some neo-clerodane diterpenoids isolated from Teucrium species

M. Garcia-Alvarez, J. Marco, F. Piozzi, 1986 .

Teuscorodin, teuscorodonin and 2-hydroxyteuscorolide, neo-clerodane diterpenoids from teucrium scorodonia

J. Marco, F. Piozzi, G. Savona, 1983 .

Neo-clerodane diterpenoids from Teucrium pyrenaicum

M. Garcia-Alvarez, J. Marco, F. Piozzi, 1982 .

Chiral precursors for syntheses of furanoterpenes

J. Marco, 1989 .

Synthesis of rac‐allocoronamic acid hydrochloride

J. Marco, M. Bernabé, B. Sánchez, 1991 .

Synthesis of asymmetric 1-amino-2-phenylcyclopropanecarboxylic acids by diastereoselective cyclopropanation of highly functionalized homochiral olefines

J. Marco, M. Bernabé, E. Fernández‐Álvarez, 1989 .

Enantioselective synthesis of (+)-(1R,2S)-allocoronamic acid

A. Herrero, J. Marco, M. Bernabé, 1992 .

New classes of AChE inhibitors with additional pharmacological effects of interest for the treatment of Alzheimer's disease.

M. Villarroya, J. Marco, A. G. García, 2004, Current pharmaceutical design.

The CSIC Reaction on Substrates Derived From Aldehydes

J. Marco, C. Jaime, S. Ingate, 2000 .

New and unexpected developments of the carbanion-mediated sulfonate (sulfonamide) intramolecular cyclization reaction (CSIC reaction)

J. Marco, S. Ingate, Pilar Manzano, 1998 .

Synthesis of (4S, 5R)-1,4,5-Hexanetriol and D-Amicetose

J. Marco, 1989 .

The CSIC [Carbanion mediated Sulfonate (Sulfonamido) Intramolecular Cyclization] reaction: Scope and limitations

J. Marco, S. Ingate, P. M. Chinchón, 1999 .

Inhibition of Human Immunodeficiency Virus Type (HIV-1) Replication by Some Diversely Functionalized Spirocyclopropyl Derivatives.

C. Pannecouque, E. Clercq, M. Witvrouw, 1999 .

Inhibition of Human Immunodeficiency Virus Type (HIV‐1) Replication by some Diversely Functionalized Spirocyclopropyl Derivatives

E. De Clercq, C. Pannecouque, M. Witvrouw, 1999, Archiv der Pharmazie.

Synthesis of α- and β-methyl derivatives of 2-[(5-methoxy-1-methyl)indol-2-yl]ethylamine as selective inhibitors of monoamine oxidases A and B.

J. Marco, C. García, E. F. Alvarez, 1992 .

Protective effect of N‐(2‐propynyl)‐2‐(5‐benzyloxy‐indolyl) methylamine (PF 9601N), a novel MAO‐B inhibitor, on dopamine‐lesioned PC12 cultured cells

J. Lizcano, M. Unzeta, J. Marco, 2003, The Journal of pharmacy and pharmacology.

Alkaloids asymmetric synthesis from (S)-pyroglutamic acid. II. Attempted asymmetric total synthesis of trans-5-ethyl-2-n-heptylpyrrolidine†

J. Marco, 1986 .

Alkaloids Asymmetric Synthesis from (S)-Pyroglutamic Acid. Part 2. Attempted Asymmetric Total Synthesis of trans-5-Ethyl-2-n-heptylpyrrolidine.

J. Marco, 1987 .

Michael Reactions of β-Keto Sulfoxides and β-Keto Sulfones

J. Marco, 1997 .

Asymmetric synthesis of 4-alkyl-3,5-dialkoxycarbonyl-2,6-dimethyl-1,4-dihydropyridines

N. Martín, F. H. Cano, C. Seoane, 1995 .

Asymmetric Synthesis of 4‐Alkyl‐3,5‐dialkoxycarbonyl‐2,6‐dimethyl‐1,4‐ dihydropyridines.

N. Martín, F. H. Cano, C. Seoane, 1995 .

IMPROVED PREPARATION OF N-PROPARGYL-2-(5-BENZYLOXYINDOLYL)METHYLAMINE A

J. Marco, 1998 .

Acetylenic and allenic derivatives of 2-(5-methoxy-1-methylindolyl)alkylamines as selective inhibitors of MAO-A and MAO-B.

J. Marco, E. Fernández‐Álvarez, C. García, 1994, Journal of neural transmission. Supplementum.