M. Dunne

P. Rorsman, S. Cross, K. Kadler, 2017, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Causes and therapy of hyperinsulinism in infancy

M. Dunne, K. Cosgrove, R. Shepherd, 2004 .

Ions, genes and insulin release: from basic science to clinical disease Based on the 1998 R. D. Lawrence Lecture

M. Dunne, 2000, Diabetic medicine : a journal of the British Diabetic Association.

Potassium Channels, Sulphonylurea Receptors and Control of Insulin Release

R. M. Shepherd, C. Ämmälä, M. Dunne, 1999, Trends in Endocrinology & Metabolism.

Engineering a Glucose-responsive Human Insulin-secreting Cell Line from Islets of Langerhans Isolated from a Patient with Persistent Hyperinsulinemic Hypoglycemia of Infancy*

R. M. Shepherd, K. Docherty, J. Chapman, 1999, The Journal of Biological Chemistry.

Characterisation of new efaroxan derivatives for use in purification of imidazoline-binding sites.

C. A. Ramsden, N. Morgan, J. Chapman, 1998, European journal of pharmacology.

Hyperinsulinism of infancy: towards an understanding of unregulated insulin release

R. M. Shepherd, C. Ämmälä, M. Dunne, 2000, Archives of disease in childhood. Fetal and neonatal edition.

Protein phosphorylation is required for diazoxide to open ATP‐sensitive potassium channels in insulin (RINm5F) secreting cells

M. Dunne, 1989, FEBS letters.

Acute insulin responses to calcium and tolbutamide do not differentiate focal from diffuse congenital hyperinsulinism.

C. Stanley, C. Sempoux, F. Brunelle, 2004, The Journal of clinical endocrinology and metabolism.

Genetics and Pathophysiology of Hyperinsulinism in Infancy

R. M. Shepherd, A. Aynsley-Green, K. Lindley, 2004, Hormone Research in Paediatrics.

Sulfonylurea receptor 1 and Kir6.2 expression in the novel human insulin-secreting cell line NES2Y.

K. Docherty, A. Aynsley-Green, W. Macfarlane, 2000, Diabetes.

Peripheral channelopathies as targets for potassium channel openers

K. Lawson, M. Dunne, 2001, Expert opinion on investigational drugs.

Hyperinsulinism of infancy: the regulated release of insulin by KATP channel-independent pathways.

B. Glaser, J. Chapman, A. Aynsley-Green, 2001, Diabetes.

Glucose activates both K(ATP) channel-dependent and K(ATP) channel-independent signaling pathways in human islets.

M. Dunne, G. Sharp, R. James, 1998, Diabetes.

ATP-sensitive potassium channels and efaroxan-induced insulin release in the electrofusion-derived BRIN-BD11 beta-cell line.

R. M. Shepherd, J. Chapman, P. Flatt, 1999, Diabetes.

Persistent hyperinsulinaemic hyperglycaemia of infancy-derived cells; implications for beta-cells that replicate in vitro.

A. Aynsley-Green, W. Macfarlane, M. Dunne, 2000, Journal of molecular endocrinology.

A point mutation inactivating the sulfonylurea receptor causes the severe form of persistent hyperinsulinemic hypoglycemia of infancy in Finland.

H. Huopio, J. Kere, F. Ashcroft, 1999, Diabetes.

Intracellular Ca2+ signals in human-derived pancreatic somatostatin-secreting cells (QGP-1N)

P. Squires, B. Amiranoff, M. Dunne, 1994, Pflügers Archiv.

Somatostatin receptors in congenital hyperinsulinism: Biology to bedside

S. Betz, K. Mohnike, M. Dunne, 2022, Frontiers in Endocrinology.

Increased proliferation and altered cell cycle regulation in pancreatic stem cells derived from patients with congenital hyperinsulinism

M. Newbould, I. Banerjee, M. Dunne, 2019, PloS one.

Galanin activates nucleotide‐dependent K+ channels in insulin‐secreting cells via a pertussis toxin‐sensitive G‐protein.

O. Petersen, C. Wollheim, O. Petersen, 1989, The EMBO journal.

Molecular Studies of the Human T-Cell Antigen Receptor

M. Collins, M. Owen, M. Dunne, 1985 .

The α2-adrenoceptor antagonist efaroxan modulates K+ATP channels in insulin-secreting cells

N. Morgan, M. Stillings, M. Dunne, 1991 .

Peripheral channelopathies as targets for potassium channel

M. Dunne, 2001 .

The effects of cromakalim on ATP‐sensitive potassium channels in insulin‐secreting cells

O. Petersen, M. Dunne, O. Petersen, 1990, British journal of pharmacology.

Effects of pinacidil, RP 49356 and nicorandil on ATP‐sensitive potassium channels in insulin‐secreting cells

M. Dunne, 1990, British journal of pharmacology.

Organisation and Expression of Human T Cell Receptor Genes

S. John, M. Collins, M. Owen, 1986 .

Phorbol myristate acetate and ATP-sensitive potassium channels in insulin-secreting cells.

M. Dunne, 1994, The American journal of physiology.

Modulation of Three Types of Potassium Selective Channels by NAD and Other Pyridine Nucleotides in Human Pancreatic β-Cells

N. London, M. Dunne, C. Kane, 1997 .

Effects of 5-hydroxydecanoate on ATP-regulated potassium ion channels in insulin secreting cells.

P. Squires, J. Jaggar, M. Dunne, 1993, Biochemical Society transactions.

Congenital hyperinsulinism: From bench to bedside

R. M. Shepherd, M. Dunne, K. Cosgrove, 2007 .

Glucose augmentation of mastoparan-stimulated insulin secretion in rat and human pancreatic islets.

M. Dunne, G. Sharp, R. James, 1998, Diabetes.

The hypoglycaemia error grid: A UK-wide consensus on CGM accuracy assessment in hyperinsulinism

S. Senniappan, I. Banerjee, M. Dunne, 2022, Frontiers in Endocrinology.

Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: implications for stimulus‐response coupling of insulin release

R. M. Shepherd, P. Squires, M. Dunne, 1996, British journal of pharmacology.

Glucose modulation of insulin mRNA levels is dependent on transcription factor PDX-1 and occurs independently of changes in intracellular Ca2+.

K. Docherty, R. James, W. Macfarlane, 2000, Diabetes.

Regulation of K+ channels plays a crucial role in the control of insulin secretion

O. Petersen, M. Dunne, 2004, Pflügers Archiv.

Synthesis and characterization of a quinolinonic compound activating ATP‐sensitive K+ channels in endocrine and smooth muscle tissues

B. Pirotte, M. Antoine, B. Rigo, 2001, British journal of pharmacology.

Novel actions of the potassium channel modulator SDZ PCO 400 on ATP-regulated potassium channels in insulin secreting cells. SDZ PCO 400 and beta-cells.

M. Dunne, E. Harding, 1997, Advances in experimental medicine and biology.

Potassium Channels, Imidazolines, and Insulin‐Secreting Cells fn1

R. James, N. London, P. Squires, 1995, Annals of the New York Academy of Sciences.

Nutrient and pharmacological stimulation of insulin‐secreting cells: marked differences in the onset of electrical activity

M. Dunne, M. Dunne, 1990, Experimental physiology.

Inhibition of K-channels in insulin secreting cells.

O. Petersen, I. Findlay, M. Dunne, 1986, Advances in experimental medicine and biology.

Activators of protein kinase C depolarize insulin‐secreting cells by closing K+ channels.

T. Pozzan, R. Bruzzone, O. Petersen, 1988, The EMBO journal.

Clinical Diversity in Focal Congenital Hyperinsulinism in Infancy Correlates With Histological Heterogeneity of Islet Cell Lesions

S. Ellard, M. Newbould, B. Han, 2018, Front. Endocrinol..

Glucose Regulates Islet Amyloid Polypeptide Gene Transcription in a PDX1- and Calcium-dependent Manner*

K. Docherty, A. Aynsley-Green, R. James, 2000, The Journal of Biological Chemistry.

Affinity isolation of imidazoline binding proteins from rat brain using 5‐amino‐efaroxan as a ligand

C. A. Ramsden, M. Dunne, K. Cosgrove, 1999, FEBS letters.

Glucose Activates Both K AT P C h a n n e l - D e p e n d e n t and K AT P Channel-Independent Signaling Pathways in Human Islets

M. Dunne, S. G. Straub, 1998 .

Insulinotropic effect of new glibenclamide isosteres.

B. Masereel, L. Pochet, M. Dunne, 1999, The Journal of pharmacology and experimental therapeutics.

Insulinotropic Effect of New Glibenclamide Isosteres 1

B. Masereel, L. Pochet, M. Dunne, 1999 .

Altered Phenotype of β-Cells and Other Pancreatic Cell Lineages in Patients With Diffuse Congenital Hyperinsulinism in Infancy Caused by Mutations in the ATP-Sensitive K-Channel

S. Cross, N. Hanley, M. Newbould, 2015, Diabetes.

Block of ATP‐regulated potassium channels by phentolamine and other α‐adrenoceptor antagonists

M. Dunne, 1991 .

Non-coding variants disrupting a tissue-specific regulatory element in HK1 cause congenital hyperinsulinism

M. Weedon, A. Hattersley, S. Ellard, 2022, Nature Genetics.

Therapies and outcomes of congenital hyperinsulinism‐induced hypoglycaemia

I. Banerjee, K. Cosgrove, M. Dunne, 2018, Diabetic medicine : a journal of the British Diabetic Association.

A human T‐cell antigen receptor beta chain gene maps to chromosome 7.

P. Goodfellow, M. Collins, N. Spurr, 1984, The EMBO journal.

Activation of ATP-dependent K+ channels and inhibition of insulin release: effect of BPDZ 62.

B. Masereel, A. Herchuelz, B. Pirotte, 1996, The Journal of pharmacology and experimental therapeutics.

HYPO-CHEAT’s aggregated weekly visualisations of risk reduce real world hypoglycaemia

I. Banerjee, M. Dunne, P. Nutter, 2022, Digital health.

Longitudinal Auxological recovery in a cohort of children with Hyperinsulinaemic Hypoglycaemia

S. Flanagan, E. O’Shea, I. Banerjee, 2020, Orphanet Journal of Rare Diseases.

Feeding Problems Are Persistent in Children with Severe Congenital Hyperinsulinism

P. Clayton, L. Patel, I. Banerjee, 2016, Front. Endocrinol..

The phosphorus budget of a field-grown strawberry (Fragaria x ananassa cv. Hapil) crop: evidence for a mycorrhizal contribution

A. Fitter, M. Dunne, 1989 .

ATP-induced intracellular Ca2+ signals in isolated human insulin-secreting cells

P. E. Squires, R. F. L. James, N. J. M. London, 1994, Pflügers Archiv.

Extracellular ATP causes Ca2(+)-dependent and -independent insulin secretion in RINm5F cells. Phospholipase C mediates Ca2+ mobilization but not Ca2+ influx and membrane depolarization.

O. Petersen, C. Wollheim, G. Li, 1991, Journal of Biological Chemistry.

Block of ATP-regulated potassium channels by phentolamine and other alpha-adrenoceptor antagonists.

M. Dunne, 1991, British journal of pharmacology.

PAX4 Enhances Beta-Cell Differentiation of Human Embryonic Stem Cells

R. M. Shepherd, P. Andrews, H. Moore, 2008, PloS one.

Comparative study of the effects of cromakalim (BRL 34915) and diazoxide on membrane potential, [Ca2+]i and ATP-sensitive potassium currents in insulin-secreting cells

O. Petersen, D. Yule, M. Dunne, 1990, The Journal of Membrane Biology.

Stimulant-evoked depolarization and increase in [Ca2+]i in insulin-secreting cells is dependent on external Na+

O. Petersen, D. Yule, M. Dunne, 1990, The Journal of Membrane Biology.

Uncontrolled insulin secretion from a childhood pancreatic beta-cell adenoma is not due to the functional loss of ATP-sensitive potassium channels.

B. Glaser, K. Hussain, J. Chapman, 2002, Endocrine-related cancer.

ATP maintains ATP-inhibited K+ channels in an operational state

I. Findlay, M. Dunne, 1986, Pflügers Archiv.

Regulation of Intracellular Ca2+ in Response to Muscarinic and Glutamate Receptor Agonists During the Differentiation of NTERA2 Human Embryonal Carcinoma Cells into Neurons

P. Andrews, M. Fidock, P. Squires, 1996, The European journal of neuroscience.

Human embryonic stem cells: Possibilities for human cell transplantation

P. Andrews, H. Moore, L. Ruban, 2005, Annals of medicine.

Purification of cytochrome b-245 from human neutrophils.

A. Segal, M. Dunne, A. Harper, 1984, The Biochemical journal.

Messenger-mediated control of potassium channels in secretory cells.

O. Petersen, I. Findlay, M. Dunne, 1986, The Journal of experimental biology.

Hyperinsulinism in infancy: from basic science to clinical disease.

R. M. Shepherd, A. Aynsley-Green, K. Lindley, 2004, Physiological reviews.

A recessive contiguous gene deletion causing infantile hyperinsulinism, enteropathy and deafness identifies the Usher type 1C gene

Sue Malcolm, Khalid Hussain, Peter J. Milla, 2000, Nature Genetics.

Insulinoma in childhood: clinical, radiological, molecular and histological aspects of nine patients.

M. Newbould, P. Clayton, K. Hussain, 2014, European journal of endocrinology.

Hyperinsulinism of infancy: novel ABCC8 and KCNJ11 mutations and evidence for additional locus heterogeneity.

A. Eliakim, B. Glaser, L. Aguilar-Bryan, 2004, The Journal of clinical endocrinology and metabolism.

Familial persistent hyperinsulinemic hypoglycemia of infancy and mutations in the sulfonylurea receptor.

R. M. Shepherd, L. Aguilar-Bryan, S. Seino, 1997, The New England journal of medicine.

Loss of functional KATP channels in pancreatic β–cells causes persistent hyperinsulinemic hypoglycemia of infancy

Peter J. Milla, Mark J. Dunne, Albert Aynsley-Green, 1996, Nature Medicine.

Infantile hyperinsulinism associated with enteropathy, deafness and renal tubulopathy: clinical manifestations of a syndrome caused by a contiguous gene deletion located on chromosome 11p.

M. Bitner-Glindzicz, K. Hussain, A. Aynsley-Green, 2004, Journal of pediatric endocrinology & metabolism : JPEM.

Contemporary strategies in the diagnosis and management of neonatal hyperinsulinaemic hypoglycaemia.

K. Lindley, M. Dunne, 2005, Early human development.

BPDZ 154 activates adenosine 5'-triphosphate-sensitive potassium channels: in vitro studies using rodent insulin-secreting cells and islets isolated from patients with hyperinsulinism.

P. Clayton, K. Hussain, J. Saudubray, 2002, The Journal of clinical endocrinology and metabolism.

Congenital hyperinsulinism and mosaic abnormalities of the ploidy

C. Junien, C. Sempoux, F. Brunelle, 2005, Journal of Medical Genetics.

Functional and Metabolomic Consequences of KATP Channel Inactivation in Human Islets

J. Schug, K. Kaestner, C. Stanley, 2017, Diabetes.

Hyperinsulinemic hypoglycemia in Beckwith-Wiedemann syndrome due to defects in the function of pancreatic beta-cell adenosine triphosphate-sensitive potassium channels.

M. Dattani, P. Hindmarsh, B. Glaser, 2005, The Journal of clinical endocrinology and metabolism.

Unravelling the genetic causes of mosaic islet morphology in congenital hyperinsulinism

T. Laver, S. Flanagan, J. Houghton, 2019, The journal of pathology. Clinical research.

Integrating genetic and imaging investigations into the clinical management of congenital hyperinsulinism

A. Stevens, P. Clayton, I. Banerjee, 2013, Clinical endocrinology.

Can network biology unravel the aetiology of congenital hyperinsulinism?

A. Stevens, P. Clayton, I. Banerjee, 2013, Orphanet Journal of Rare Diseases.

Pancreatic ductal adenocarcinoma cells employ integrin α6β4 to form hemidesmosomes and regulate cell proliferation.

M. Humphries, Aleksandr Mironov, J. Askari, 2022, Matrix biology : journal of the International Society for Matrix Biology.

Pancreatic ductal adenocarcinoma cells employ integrin α6β4 to form hemidesmosomes and regulate cell proliferation

M. Humphries, Aleksandr Mironov, J. Burns, 2021, bioRxiv.

Timing of Hypoglycaemia in Patients with Hyperinsulinism (HI): Extension of the Digital Phenotype.

I. Banerjee, M. Dunne, C. Worth, 2021, Journal of Medical Internet Research.

Vineland adaptive behavior scales to identify neurodevelopmental problems in children with Congenital Hyperinsulinism (CHI)

I. Banerjee, M. Michaelidou, L. Rigby, 2017, Orphanet Journal of Rare Diseases.

CLINICAL CASE SEMINAR Hyperinsulinemic Hypoglycemia in Beckwith- Wiedemann Syndrome due to Defects in the Function of Pancreatic -Cell Adenosine Triphosphate-Sensitive Potassium Channels

M. Dattani, P. Hindmarsh, B. Glaser, 2005 .

Intracellular ADP activates K+ channels that are inhibited by ATP in an insulin‐secreting cell line

O. Petersen, M. Dunne, 1986, FEBS letters.

Characterization of purinergic receptor-evoked increases in intracellular Ca2+ transients in isolated human and rodent insulin-secreting cells. Purinergic receptor signalling and [Ca2+]i in human beta-cells.

N. London, P. Squires, M. Dunne, 1997, Advances in experimental medicine and biology.

Ion channels and the molecular control of insulin secretion.

P. Squires, J. Jaggar, M. Dunne, 1994, Biochemical Society transactions.

A novel disease mechanism leading to the expression of a disallowed gene in the pancreatic beta-cell identified by non-coding, regulatory mutations controlling HK1

M. Weedon, A. Hattersley, S. Ellard, 2021, medRxiv.

Verapamil, a phenylalkylamine Ca2 + channel blocker, inhibits ATP-sensitive K + channels in insulin-secreting cells from rats

A. Herchuelz, B. Pirotte, R. Ouédraogo, 1997, Diabetologia.

Effects of pyridine nucleotides on the gating of ATP-sensitive potassium channels in insulin-secreting cells

O. Petersen, I. Findlay, M. Dunne, 1988, The Journal of Membrane Biology.

Polymyxin B has multiple blocking actions on the ATP-sensitive potassium channel in insulin-secreting cells

P. Squires, J. Jaggar, M. Dunne, 2004, Pflügers Archiv.

35th Annual meeting of the European Association for the Study of Diabetes. Brussels, Belgium, 28 September-2 October, 1999. Abstracts.

Thomas J. Smith, B. M. Rasmussen, V. C. Phan, 1999, Diabetologia.

Reduced Glycemic Variability in Diazoxide-Responsive Children with Congenital Hyperinsulinism Using Supplemental Omega-3-Polyunsaturated Fatty Acids; A Pilot Trial with MaxEPAR

P. Clayton, L. Patel, A. Vail, 2014, Front. Endocrinol..

Conservatively treated Congenital Hyperinsulinism (CHI) due to K-ATP channel gene mutations: reducing severity over time

S. Ellard, N. Murphy, S. Flanagan, 2016, Orphanet Journal of Rare Diseases.

Variation in Glycemic Outcomes in Focal Forms of Congenital Hyperinsulinism—The UK Perspective

P. de Coppi, S. Flanagan, J. Houghton, 2022, Journal of the Endocrine Society.

Laparoscopic Diagnosis and Cure of Hyperinsulinism in Two Cases of Focal Adenomatous Hyperplasia in Infancy

F. Groenendaal, K. Brusgaard, M. Dunne, 2004, Pediatrics.

Intra-arterial calcium stimulation test in the investigation of hyperinsulinaemic hypoglycaemia

D. Davidson, M. Dunne, R. Shepherd, 1998, Archives of disease in childhood.

ATP-sensitive inward rectifier and voltage- and calcium-activated K+ channels in cultured pancreatic islet cells

O. Petersen, I. Findlay, M. Dunne, 2005, The Journal of Membrane Biology.

Protein kinase C and the modulation of ATP-sensitive potassium channels in insulin-secreting cells.

P. Squires, J. Jaggar, M. Dunne, 1993, Biochemical Society transactions.

Interaction of diazoxide and cromakalim with ATP-regulated K+ channels in rodent and clonal insulin-secreting cells.

J. Jaggar, M. Dunne, E. Harding, 1993, Journal of molecular endocrinology.

The alpha 2-adrenoceptor antagonist efaroxan modulates K+ATP channels in insulin-secreting cells.

N. Morgan, M. Stillings, M. Dunne, 1991, European Journal of Pharmacology.

Abnormal Neurodevelopmental Outcomes are Common in Children with Transient Congenital Hyperinsulinism

P. Clayton, L. Patel, I. Banerjee, 2013, Front. Endocrinol..

Vasopressin directly closes ATP‐sensitive potassium channels evoking membrane depolarization and an increase in the free intracellular Ca2+ concentration in insulin‐secreting cells.

D. Yule, M. Dunne, O. Petersen, 1989, The EMBO journal.

Extreme caution on the use of sirolimus for the congenital hyperinsulinism in infancy patient

I. Banerjee, Diva D. De León, M. Dunne, 2017, Orphanet Journal of Rare Diseases.

In Vitro Recovery of ATP-Sensitive Potassium Channels in β-Cells From Patients With Congenital Hyperinsulinism of Infancy

S. Ellard, Raoul Rooman, P. Clayton, 2011, Diabetes.

Y-26763: ATP-sensitive K+ channel activation and the inhibition of insulin release from human pancreatic beta-cells.

J. Chapman, M. Dunne, K. Cosgrove, 2004, European journal of pharmacology.

GTP and GDP activation of K+ channels that can be inhibited by ATP

O. Petersen, M. Dunne, 1986, Pflügers Archiv.

Hyperinsulinemic hypoglycemia in children.

C. Junien, C. Sempoux, F. Brunelle, 2004, Annales d'endocrinologie.

Efficacy of Dose-Titrated Glucagon Infusions in the Management of Congenital Hyperinsulinism: A Case Series

I. Banerjee, D. Yau, Sune Birch, 2020, Frontiers in Endocrinology.

The gating of nucleotide-sensitive K+ channels in insulin-secreting cells can be modulated by changes in the ratio ATP4−/ADP3− and by nonhydrolyzable derivatives of both ATP and ADP

R. J. Abraham, O. Petersen, R. Edwards, 1988, The Journal of Membrane Biology.

Focal Congenital Hyperinsulinism as a Cause for Sudden Infant Death

S. Ellard, B. Han, S. Flanagan, 2019, Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.

Interaction of diazoxide, tolbutamide and ATP4− on nucleotide-dependent K+ channels in an insulin-secreting cell line

O. Petersen, M. Dunne, M. C. Illot, 2005, The Journal of Membrane Biology.

Case report: contradictory genetics and imaging in focal congenital hyperinsulinism reinforces the need for pancreatic biopsy

I. Banerjee, D. Yau, K. Mohnike, 2020, International Journal of Pediatric Endocrinology.

Delayed Resolution of Feeding Problems in Patients With Congenital Hyperinsulinism

I. Banerjee, M. Dunne, C. Worth, 2020, Frontiers in Endocrinology.

Central venous catheter-associated thrombosis in children with congenital hyperinsulinism

P. Murray, I. Banerjee, D. Yau, 2018, Endocrinology, diabetes & metabolism case reports.

Enhanced Islet Cell Nucleomegaly Defines Diffuse Congenital Hyperinsulinism in Infancy but Not Other Forms of the Disease

M. Newbould, K. Kadler, B. Han, 2016, American journal of clinical pathology.

Increased plasma incretin concentrations identifies a subset of patients with persistent congenital hyperinsulinism without KATP channel gene defects.

S. Ellard, M. Newbould, P. Clayton, 2015, The Journal of pediatrics.