Karen S Macmillan

发表

Development of proneurogenic, neuroprotective small molecules.

S. McKnight, S. Estill, N. Williams, 2011, Journal of the American Chemical Society.

Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) alkylation subunit.

D. Boger, James P. Lajiness, Kristopher E. Boyle, 2010, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of a thio analogue of duocarmycin SA.

D. Boger, P. Baraldi, R. Romagnoli, 2009, Bioorganic & medicinal chemistry letters.

Potent cytotoxic C-11 modified geldanamycin analogues.

Yaoquan Liu, T. Mueller, D. Myles, 2009, Journal of medicinal chemistry.

The structure of importin α and the nuclear localization peptide of ChREBP, and small compound inhibitors of ChREBP–importin α interactions

B. Posner, T. Nakagawa, K. Uyeda, 2020, The Biochemical journal.

Fundamental relationships between structure, reactivity, and biological activity for the duocarmycins and CC-1065.

D. Boger, Karen S Macmillan, 2009, Journal of medicinal chemistry.

Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) alkylation subunit.

D. Boger, James P. Lajiness, Kristopher E. Boyle, 2010, Bioorganic & medicinal chemistry letters.

Synthesis and Preliminary Evaluation of Duocarmycin Analogues Incorporating the 1,2,11,11a-Tetrahydrocyclopropa[c]naphtho[2,3-e]indol-4-one (CNI) and 1,2,11,11a-Tetrahydrocyclopropa[c]naphtho[1,2-e]indol-4-one (iso-CNI) Alkylation Subunits.

D. Boger, C. Gauss, Karen S Macmillan, 2009, Tetrahedron.

Total synthesis and evaluation of iso-duocarmycin SA and iso-yatakemycin.

D. Boger, Trinh-Don Nguyen, Karen S Macmillan, 2009, Journal of the American Chemical Society.

Systematic exploration of the structural features of yatakemycin impacting DNA alkylation and biological activity.

D. Boger, Karen S Macmillan, Mark S Tichenor, 2007, Journal of the American Chemical Society.

Rational design, synthesis, and evaluation of key analogues of CC-1065 and the duocarmycins.

D. Boger, A. Zaid, P. Baraldi, 2007, Journal of the American Chemical Society.

Discovery of a Proneurogenic, Neuroprotective Chemical

D. Brat, S. McKnight, Ching-Han Shen, 2010, Cell.

An additional spirocyclization for duocarmycin SA.

D. Boger, Karen S Macmillan, 2008, Journal of the American Chemical Society.

Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity.

T. E. Richardson, M. Phillips, M. Peel, 2017, Bioorganic & medicinal chemistry.

Chemobiosynthesis of Novel 6-Deoxyerythronolide B Analogues by Mutation of the Loading Module of 6-Deoxyerythronolide B Synthase 1

J. Kealey, J. Kennedy, G. Ashley, 2005, Applied and Environmental Microbiology.

In silico derived small molecules bind the filovirus VP35 protein and inhibit its polymerase cofactor activity.

Wei Xu, Gaya K Amarasinghe, Zbyszek Otwinowski, 2014, Journal of molecular biology.

Rational design, synthesis, and evaluation of key analogues of CC-1065 and the duocarmycins.

D. Boger, A. Zaid, P. Baraldi, 2007, Journal of the American Chemical Society.

Potent cytotoxic C-11 modified geldanamycin analogues.

Yaoquan Liu, T. Mueller, D. Myles, 2009, Journal of medicinal chemistry.