J. Ready

发表

Development of proneurogenic, neuroprotective small molecules.

S. McKnight, S. Estill, N. Williams, 2011, Journal of the American Chemical Society.

Inhibiting pyrimidine biosynthesis impairs Ebola virus replication through depletion of nucleoside pools and activation of innate immune responses

R. Davey, P. Luthra, C. Basler, 2018, Antiviral research.

Deconvolution of complex NMR spectra in small molecules by multi frequency homonuclear decoupling (MDEC).

J. MacMillan, J. Ready, A. M. Espíndola, 2009, Journal of the American Chemical Society.

Allenes in asymmetric catalysis: asymmetric ring opening of meso-epoxides catalyzed by allene-containing phosphine oxides.

J. Ready, X. Qi, X. Pu, 2009, Journal of the American Chemical Society.

A Concise Total Synthesis of Dictyodendrins F, H, and I Using Aryl Ynol Ethers as Key Building Blocks.

J. Ready, Wenhan Zhang, 2016, Journal of the American Chemical Society.

The ketene-surrogate coupling: catalytic conversion of aryl iodides into aryl ketenes through ynol ethers.

J. Ready, Wenhan Zhang, 2014, Angewandte Chemie.

Chemical intervention of influenza virus mRNA nuclear export

J. Shay, B. Posner, A. García-Sastre, 2020, PLoS pathogens.

Discovery of Cytochrome P450 4F11 Activated Inhibitors of Stearoyl Coenzyme A Desaturase.

B. Posner, P. Mallipeddi, D. Nijhawan, 2018, Journal of medicinal chemistry.

Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration

K. Bae, J. Sanabria, L. Kasturi, 2015, Science.

Discovery of selective non-small cell lung cancer toxins that target mitochondrial Complex I

Prashant Mishra, Nikhil Madhusudhan, D. Nijhawan, 2020 .

Protective efficacy of P7C3-S243 in the 6-hydroxydopamine model of Parkinson's disease

N. Narayanan, N. Williams, A. Pieper, 2015, npj Parkinson's Disease.

Regioselective, Photocatalytic α-Functionalization of Amines.

Yue Fu, Peng Liu, Peng Liu, 2020, Journal of the American Chemical Society.

Copper-promoted cycloaddition of diazocarbonyl compounds and acetylides.

J. Ready, X. Qi, 2007, Angewandte Chemie.

Evolution of a synthetic strategy: total synthesis of (+/-)-welwitindolinone A isonitrile.

S. Reisman, J. L. Wood, K. Tamaki, 2008, Journal of the American Chemical Society.

Total synthesis of (+/-)-welwitindolinone a isonitrile.

S. Reisman, J. L. Wood, J. Ready, 2006, Journal of the American Chemical Society.

A mild and efficient synthesis of oxindoles: progress towards the synthesis of welwitindolinone A isonitrile.

S. Reisman, J. L. Wood, K. Tamaki, 2004, Angewandte Chemie.

Identification of DNMT1 Selective Antagonists Using a Novel Scintillation Proximity Assay*

B. Posner, S. Pradhan, H. Chin, 2013, The Journal of Biological Chemistry.

Tandem carbocupration/oxygenation of terminal alkynes.

J. Ready, Donghui Zhang, 2005, Organic letters.

15-PGDH inhibition activates the splenic niche to promote hematopoietic regeneration

S. Markowitz, D. Dawson, M. Cameron, 2020, bioRxiv.

A practical oligomeric [(salen)Co] catalyst for asymmetric epoxide ring-opening reactions.

E. Jacobsen, J. Ready, 2002, Angewandte Chemie.

Tandem Allylation/1,2-Boronate Rearrangement for the Asymmetric Synthesis of Indolines with Adjacent Quaternary Stereocenters.

J. Ready, S. Panda, 2018, Journal of the American Chemical Society.

Palladium Catalyzed Asymmetric Three-Component Coupling of Boronic Esters, Indoles, and Allylic Acetates.

J. Ready, S. Panda, 2017, Journal of the American Chemical Society.

[3 + 2]-Cycloadditions of Azomethine Imines and Ynolates.

J. Ready, Sarah E Winterton, 2016, Organic letters.

Synthesis and Utility of Dihydropyridine Boronic Esters.

D. Tantillo, J. Ready, Q. N. Nguyen, 2016, Angewandte Chemie.

Iron-catalyzed carbometalation of propargylic and homopropargylic alcohols.

J. Ready, Donghui Zhang, 2006, Journal of the American Chemical Society.

Inhibitors of 15-Prostaglandin Dehydrogenase To Potentiate Tissue Repair.

S. Markowitz, N. Williams, Yongyou Zhang, 2017, Journal of medicinal chemistry.

A fast-killing tyrosine amide ((S)-SW228703) with blood and liver-stage antimalarial activity associated with the Cyclic Amine Resistance Locus (PfCARL)

E. Winzeler, M. Phillips, F. Gamo, 2022, bioRxiv.

Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum.

E. Winzeler, D. Fidock, M. Phillips, 2021, Journal of medicinal chemistry.

Orally Bioavailable Quinoxaline Inhibitors of 15-Prostaglandin Dehydrogenase (15-PGDH) Promote Tissue Repair and Regeneration.

S. Markowitz, B. Hu, Dawn Dawson, 2022, Journal of medicinal chemistry.

Highly active oligomeric (salen)co catalysts for asymmetric epoxide ring-opening reactions.

E. Jacobsen, J. Ready, Eric N. Jacobsen, 2001, Journal of the American Chemical Society.

Zirconocene-Mediated Carbonylative Coupling of Grignard Reagents.

J. Ready, X. Han, Melissa Moss, 2016, Angewandte Chemie.

Titanium-mediated oxidative arylation of homoallylic alcohols.

J. Ready, Kathleen Lee, 2011, Angewandte Chemie.

Synthesis and Biological Evaluation of Kibdelone C and Its Simplified Derivatives.

B. Posner, D. Nijhawan, Janjira Rujirawanich, 2016, Journal of the American Chemical Society.

P7C3 and an unbiased approach to drug discovery for neurodegenerative diseases.

S. McKnight, A. Pieper, J. Ready, 2014, Chemical Society reviews.

Two-, three- and four-component coupling to form isoquinolones based on directed metalation

J. Ready, Monika I. Antczak, 2012 .

Synthetic Studies on the Kigamicins.

J. Ready, Ai-Jun Ma, 2019, Organic letters.

Total synthesis of the dictyodendrins as an arena to highlight emerging synthetic technologies.

J. Ready, Wenhan Zhang, 2017, Natural product reports.

Directed Hydrozirconation of Homopropargylic Alcohols.

Xiao-feng Liu, J. Ready, Xiaofeng Liu, 2008, Tetrahedron.

Directed hydrozirconation of propargylic alcohols.

J. Ready, Donghui Zhang, 2007, Journal of the American Chemical Society.

Chiral allene-containing phosphines in asymmetric catalysis.

Feng Cai, V. Lynch, Vincent Lynch, 2011, Journal of the American Chemical Society.

Asymmetric Catalytic Synthesis of α-Aryloxy Alcohols: Kinetic Resolution of Terminal Epoxides via Highly Enantioselective Ring-Opening with Phenols

E. Jacobsen, J. Ready, 1999 .

Cyclocondensation of amino-propargyl silanes.

J. Ready, Yizhong Wang, 2012, Organic letters.

Enantioselective Allylation of Alkenyl Boronates Promotes a 1,2-Metalate Rearrangement with 1,3-Diastereocontrol.

J. Ready, Irungu K. Luvaga, Colton R Davis, 2021, Journal of the American Chemical Society.

Synthesis of cyclopentenones from cyclopropanes and silyl ynol ethers.

J. Ready, X. Qi, 2008, Angewandte Chemie.

Selective Synthesis of (+)-Dysoline.

J. Ready, Aaron Coffin, 2019, Organic letters.

Preparation of substituted enol derivatives from terminal alkynes and their synthetic utility.

J. Ready, J. R. Debergh, Kathleen M. Spivey, 2008, Journal of the American Chemical Society.

The ketene-surrogate coupling: catalytic conversion of aryl iodides into aryl ketenes through ynol ethers.

J. Ready, Wenhan Zhang, 2014, Angewandte Chemie.

Direct and stereospecific synthesis of allenes via reduction of propargylic alcohols with Cp2Zr(H)Cl.

J. Ready, X. Pu, 2008, Journal of the American Chemical Society.

Enantioselective total synthesis of (+)- and (-)-nigellamine A2.

J. Bian, J. Ready, Matthew M Van Wingerden, 2006, Journal of the American Chemical Society.

Optically Active Allenes from an Allylic Substitution/Isomerization Sequence

J. Ready, Wenhan Zhang, 2013 .

Structure elucidation of nigricanoside A through enantioselective total synthesis

Peng Fu, J. MacMillan, J. Ready, 2015, Chemical science.

Catalytic Cross-Coupling of Alkylzinc Halides with α-Chloroketones

J. Ready, Chrysa F. Malosh, 2004 .

A practical oligomeric [(salen)Co] catalyst for asymmetric epoxide ring-opening reactions.

E. Jacobsen, J. Ready, 2002, Angewandte Chemie.

Asymmetric Catalytic Synthesis of α‐Aryloxy Alcohols: Kinetic Resolution of Terminal Epoxides via Highly Enantioselective Ring‐Opening with Phenols.

E. Jacobsen, J. Ready, 1999 .

A male-derived nonribosomal peptide pheromone controls female schistosome development

J. Collins, R. Deberardinis, R. Chen, 2022, Cell.

Discovery of small-molecule inhibitors of tyrosinase.

A. Miner, Wayne Hao, J. Ready, 2007, Bioorganic & medicinal chemistry letters.

Enantioselective total synthesis of (-)-kibdelone C.

J. Bian, J. Ready, J. R. Butler, 2011, Journal of the American Chemical Society.

A high throughput screen identifies benzoquinoline compounds as inhibitors of Ebola virus replication

B. Posner, P. Luthra, C. Basler, 2018, Antiviral research.

Discovery of Tumor-Specific Irreversible Inhibitors of Stearoyl CoA Desaturase

B. Posner, C. Rodriguez-Navas, D. Nijhawan, 2016, Nature chemical biology.

Aryl Sulfonamide Inhibits Entry and Replication of Diverse Influenza Viruses via the Hemagglutinin Protein.

J. Shay, B. Posner, A. García-Sastre, 2021, Journal of medicinal chemistry.

Tumor-Activated Benzothiazole Inhibitors of Stearoyl-CoA Desaturase.

B. Posner, P. Mallipeddi, D. Nijhawan, 2020, Journal of medicinal chemistry.

Target Discovery of Selective Non-Small-Cell Lung Cancer Toxins Reveals Inhibitors of Mitochondrial Complex I.

Prashant Mishra, Nikhil Madhusudhan, D. Nijhawan, 2019, ACS chemical biology.

Prostaglandin dehydrogenase is a target for successful induction of cervical ripening

S. Markowitz, B. Posner, M. Kanchwala, 2017, Proceedings of the National Academy of Sciences.

Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules

Vishal Khivansara, B. Posner, M. Fang, 2023, bioRxiv.

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis

S. McKnight, S. Estill, N. Williams, 2012, Proceedings of the National Academy of Sciences.

In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration.

Yuemeng Jia, Hao Zhu, Kejin Zhou, 2022, Cell stem cell.

P7C3 Neuroprotective Chemicals Function by Activating the Rate-Limiting Enzyme in NAD Salvage

S. McKnight, D. Nijhawan, Pano Theodoropoulos, 2014, Cell.

An Antiparasitic Compound from the Medicines for Malaria Venture Pathogen Box Promotes Leishmania Tubulin Polymerization.

Imran Ullah, H. Niederstrasser, Christopher Leija, 2020, ACS infectious diseases.

Discovery of a Proneurogenic, Neuroprotective Chemical

D. Brat, S. McKnight, Ching-Han Shen, 2010, Cell.

A second-generation 15-PGDH inhibitor promotes bone marrow transplant recovery independently of age, transplant dose and granulocyte colony-stimulating factor support

L. Kasturi, S. Markowitz, D. Dawson, 2018, Haematologica.

Toward a Best-in-Class Inhibitor of Cholesteryl Ester Transfer Protein (CETP).

J. Ready, 2021, Journal of medicinal chemistry.

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease

S. McKnight, S. Estill, N. Williams, 2012, Proceedings of the National Academy of Sciences.

The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis

J. Zigman, S. Estill, S. Osborne-Lawrence, 2014, Molecular Psychiatry.

Small molecule inhibitors of 15-PGDH exploit a physiologic induced-fit closing system

S. Markowitz, M. Chance, Derek J. Taylor, 2023, Nature Communications.

Dehydrogenative coupling to enable the enantioselective total synthesis of (-)-simaomicin α.

J. Ready, J. R. Butler, Yizhong Wang, 2013, Angewandte Chemie.

Dehydrogenative Coupling to Enable the Enantioselective Total Synthesis of (‐)‐Simaomicin α.

J. Ready, J. R. Butler, Yizhong Wang, 2014 .

Mechanistic Basis for the Iridium-Catalyzed Enantioselective Allylation of Alkenyl Boronates.

P. Liu, Yue Fu, J. Ready, 2022, Journal of the American Chemical Society.

Rhodium-Catalyzed Enantioselective Radical Addition of CX4 Reagents to Olefins.

Peng Liu, J. Ready, Chenglin Fang, 2017, Angewandte Chemie.

P7C3 neuroprotective chemicals block axonal degeneration and preserve function after traumatic brain injury.

A. Bassuk, S. McKnight, J. Shao, 2014, Cell reports.

In silico derived small molecules bind the filovirus VP35 protein and inhibit its polymerase cofactor activity.

Wei Xu, Gaya K Amarasinghe, Zbyszek Otwinowski, 2014, Journal of molecular biology.

Discovery of a Neuroprotective Chemical, (S)-N-(3-(3,6-Dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(−)-P7C3-S243], with Improved Druglike Properties

S. Estill, N. Williams, A. Pieper, 2014, Journal of medicinal chemistry.

Development of a scalable synthesis of P7C3-A20, a potent neuroprotective agent

Jue Liang, A. Pieper, J. Naidoo, 2013 .

Pharmacologic rescue of motor and sensory function by the neuroprotective compound P7C3 following neonatal nerve injury

Michael P. Willand, T. Gordon, G. Borschel, 2015, Neuroscience.

Photocatalytic α-Alkylation of Amines with Alkyl Halides

J. Ready, Lingying Leng, 2020, ACS Catalysis.

Hydroesterification and difunctionalization of olefins with N-hydroxyphthalimide esters.

J. Ready, Lingying Leng, 2021, ACS catalysis.

Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration

K. Bae, J. Sanabria, L. Kasturi, 2015, Science.

Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules.

Brian T. Naughton, Vishal Khivansara, B. Posner, 2023, Cell chemical biology.

Direct and stereospecific synthesis of allenes via reduction of propargylic alcohols with Cp2Zr(H)Cl.

J. Ready, X. Pu, 2008, Journal of the American Chemical Society.

Tandem Allylation/1,2-Boronate Rearrangement for the Asymmetric Synthesis of Indolines with Adjacent Quaternary Stereocenters.

J. Ready, S. Panda, 2018, Journal of the American Chemical Society.

Fast-Killing Tyrosine Amide ((S)-SW228703) with Blood- and Liver-Stage Antimalarial Activity Associated with the Cyclic Amine Resistance Locus (PfCARL).

E. Winzeler, M. Phillips, F. Gamo, 2023, ACS infectious diseases.

Hydroesterification and difunctionalization of olefins with N-hydroxyphthalimide esters.

J. Ready, Lingying Leng, 2021, ACS catalysis.

Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria.

David M. Shackleford, D. Fidock, S. Charman, 2024, Cell chemical biology.

Pseudomonas effector AvrB is a glycosyltransferase that rhamnosylates plant guardee protein RIN4

Jennifer J. Kohler, D. Tomchick, J. Ready, 2024, Science advances.

Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency

S. Haggarty, D. Fass, B. Cenik, 2024, Nature communications.