H. R. Bridges

发表

Mössbauer Spectroscopy on Respiratory Complex I: The Iron–Sulfur Cluster Ensemble in the NADH-Reduced Enzyme Is Partially Oxidized

J. Hirst, E. Bill, H. R. Bridges, 2011, Biochemistry.

Reverse Electron Transfer by Respiratory Complex I Catalyzed in a Modular Proteoliposome System

J. Hirst, H. R. Bridges, N. Burger, 2022, Journal of the American Chemical Society.

Structure of inhibitor-bound mammalian complex I

Ville R. I. Kaila, J. Hirst, Maxie M. Roessler, 2020, Nature Communications.

The Subunit Composition of Mitochondrial NADH:Ubiquinone Oxidoreductase (Complex I) From Pichia pastoris

J. Hirst, I. Fearnley, H. R. Bridges, 2010, Molecular & Cellular Proteomics.

Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy

Caroline S. Pereira, J. Hirst, G. M. Arantes, 2022, Nature Communications.

Using Hyperfine Electron Paramagnetic Resonance Spectroscopy to Define the Proton-Coupled Electron Transfer Reaction at Fe-S Cluster N2 in Respiratory Complex I.

J. Hirst, E. Salvadori, Maxie M. Roessler, 2017, Journal of the American Chemical Society.

Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects

J. Griffiths, R. Springett, C. D’Santos, 2017, Cell Reports.

Cryo-electron microscopy reveals how acetogenins inhibit mitochondrial respiratory complex I

H. Miyoshi, J. Hirst, Z. Yin, 2022, The Journal of biological chemistry.

Small-volume potentiometric titrations: EPR investigations of Fe-S cluster N2 in mitochondrial complex I.

J. Hirst, E. Salvadori, Maxie M. Roessler, 2016, Journal of inorganic biochemistry.

Structural basis for a complex I mutation that blocks pathological ROS production

J. Hirst, D. Aksentijević, T. Krieg, 2021, Nature Communications.

The mitochondrial-encoded subunits of respiratory complex I (NADH:ubiquinone oxidoreductase): identifying residues important in mechanism and disease.

J. Hirst, H. R. Bridges, James A. Birrell, 2011, Biochemical Society transactions.

The respiratory complexes I from the mitochondria of two Pichia species.

J. Hirst, M. Harbour, L. Grgic, 2009, The Biochemical journal.

Subunit NDUFV3 is present in two distinct isoforms in mammalian complex I

J. Hirst, M. Harbour, H. R. Bridges, 2017, Biochimica et biophysica acta. Bioenergetics.

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

M. Pollak, J. Hirst, H. R. Bridges, 2014, The Biochemical journal.

Hydroxylated Rotenoids Selectively Inhibit the Proliferation of Prostate Cancer Cells.

D. A. Russell, D. Spring, D. Russell, 2020, Journal of natural products.

CryoEM structures of complex I from mouse heart mitochondria in two biochemically-defined states

S. Rawson, S. Muench, J. Hirst, 2018, Nature Structural & Molecular Biology.

Characterization of clinically identified mutations in NDUFV1, the flavin-binding subunit of respiratory complex I, using a yeast model system

J. Hirst, H. R. Bridges, Erwan Atcheson, 2015, Human molecular genetics.

Structural Basis of Mammalian Respiratory Complex I Inhibition by Medicinal Biguanides

J. Hirst, M. N. Pollak, H. R. Bridges, 2022, bioRxiv.

Complexome profile of Toxoplasma gondii mitochondria identifies divergent subunits of respiratory chain complexes including new subunits of cytochrome bc1 complex

J. Hirst, Shujing Ding, H. R. Bridges, 2021, PLoS pathogens.

Structure of the NDH-2 – HQNO inhibited complex provides molecular insight into quinone-binding site inhibitors

E. Parker, W. Jiao, G. Cook, 2018, Biochimica et biophysica acta. Bioenergetics.

A Self‐Assembled Respiratory Chain that Catalyzes NADH Oxidation by Ubiquinone‐10 Cycling between Complex I and the Alternative Oxidase

J. Hirst, A. Moore, H. R. Bridges, 2015, Angewandte Chemie.

Investigating the function of [2Fe–2S] cluster N1a, the off-pathway cluster in complex I, by manipulating its reduction potential

J. Hirst, T. Friedrich, H. R. Bridges, 2013, The Biochemical journal.

CryoEM structures of complex I from mouse heart mitochondria in two biochemically-defined states

S. Rawson, S. Muench, J. Hirst, 2018, Nature Structural & Molecular Biology.

Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase

J. Hirst, H. R. Bridges, Ahmed-Noor A. Agip, 2016, BMC Biology.

The mechanism of catalysis by type-II NADH:quinone oxidoreductases

J. Hirst, G. Cook, D. Aragão, 2017, Scientific Reports.

Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states

S. Rawson, S. Muench, J. Hirst, 2018, Nature Structural & Molecular Biology.

Research priorities for autosomal dominant polycystic kidney disease: a UK priority setting partnership

P. Winyard, R. Sandford, A. Ong, 2022, BMJ Open.

Cryo-EM structures reveal ubiquinone-10 binding to mitochondrial complex I and conformational transitions associated with Q-site occupancy

Caroline S. Pereira, J. Hirst, G. M. Arantes, 2022, bioRxiv.

Complexome profile of Toxoplasma gondii mitochondria identifies a divergent cytochrome bc1 complex

J. Hirst, Shujing Ding, H. R. Bridges, 2020, bioRxiv.

Mouse mitochondrial complex I in the deactive state

S. Rawson, S. Muench, J. Hirst, 2018 .

Investigation of hydrated channels and proton pathways in a high-resolution cryo-EM structure of mammalian complex I

J. Hirst, H. R. Bridges, D. Grba, 2023, Science advances.

Structure of the turnover-ready state of an ancestral respiratory complex I

J. Hirst, H. R. Bridges, Owen D. Jarman, 2024, bioRxiv.

Tamoxifen for the treatment of myeloproliferative neoplasms: A Phase II clinical trial and exploratory analysis

A. Mead, A. Godfrey, M. McMullin, 2023, Nature communications.