Anne-Laure Mahul-Mellier

发表

Specific disintegration of complex II succinate:ubiquinone oxidoreductase links pH changes to oxidative stress for apoptosis induction

S. Grimm, L. Huc, E. Pazarentzos, 2011, Cell Death and Differentiation.

Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations.

A. Gitler, H. Lashuel, D. Eliezer, 2016, ACS chemical biology.

The making of a Lewy body: the role of α-synuclein post-fibrillization modifications in regulating the formation and the maturation of pathological inclusions

G. Knott, C. Strand, M. Citron, 2018, bioRxiv.

Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death

D. Muller, M. Roo, H. Lashuel, 2015, Cell Death and Differentiation.

IκΒα inhibits apoptosis at the outer mitochondrial membrane independently of NF‐κB retention

S. Grimm, E. Pazarentzos, N. Mazarakis, 2014, The EMBO journal.

De-ubiquitinating proteases USP2a and USP2c cause apoptosis by stabilising RIP1.

S. Grimm, E. Pazarentzos, Anne-Laure Mahul-Mellier, 2012, Biochimica et biophysica acta.

Isolation of ORCTL3 in a novel genetic screen for tumor-specific apoptosis inducers

S. Grimm, S. Irshad, A. Lemarié, 2009, Cell Death and Differentiation.

Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes

T. Walz, H. Lashuel, D. Eliezer, 2017, Nature Communications.

A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity

H. Lashuel, F. Sobott, Rani Moons, 2022, Science advances.

Alix, Making a Link between Apoptosis-Linked Gene-2, the Endosomal Sorting Complexes Required for Transport, and Neuronal Death In Vivo

B. Blot, R. Sadoul, S. Fraboulet, 2006, The Journal of Neuroscience.

Alix and ALG-2 make a link between endosomes and neuronal death.

F. Strappazzon, A. Petiot, B. Blot, 2009, Biochemical Society transactions.

Combined multi-plane phase retrieval and super-resolution optical fluctuation imaging for 4D cell microscopy

H. Lashuel, T. Lasser, E. Bostan, 2017, 1705.05766.

Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity

N. Guex, H. Lashuel, C. Iseli, 2022, npj Parkinson's Disease.

The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration

G. Knott, H. Lashuel, J. Burtscher, 2020, Proceedings of the National Academy of Sciences.

CKMT1 regulates the mitochondrial permeability transition pore in a process that provides evidence for alternative forms of the complex

S. Grimm, E. Pazarentzos, Anne-Laure Mahul-Mellier, 2014, Journal of Cell Science.

Fis1 and Bap31 bridge the mitochondria–ER interface to establish a platform for apoptosis induction

S. Grimm, E. Pazarentzos, Anne-Laure Mahul-Mellier, 2011, The EMBO journal.

Alix and ALG-2 Are Involved in Tumor Necrosis Factor Receptor 1-induced Cell Death*

J. Garin, F. Strappazzon, A. Petiot, 2008, Journal of Biological Chemistry.

Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties

G. Knott, H. Lashuel, J. Burtscher, 2020, Nature Communications.

Disentangling the sequence, cellular and ultrastructural determinants of Huntingtin nuclear and cytoplasmic inclusion formation

G. Knott, H. Lashuel, J. Burtscher, 2020 .

The H50Q Mutation Enhances α-Synuclein Aggregation, Secretion, and Toxicity*

H. Lashuel, D. Eliezer, G. Dietler, 2014, The Journal of Biological Chemistry.

Amyloid single-cell cytotoxicity assays by nanomotion detection

H. Lashuel, G. Dietler, G. Longo, 2017, Cell Death Discovery.

De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF

S. Grimm, E. Pazarentzos, Anne-Laure Mahul-Mellier, 2011, Cell Death and Differentiation.

Synergy between histone deacetylase inhibitors and DNA-damaging agents is mediated by histone deacetylase 2 in colorectal cancer

Jimmy D Bell, A. Boobis, M. El-Bahrawy, 2016, Oncotarget.

Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes

T. Walz, H. Lashuel, D. Eliezer, 2017, Nature Communications.

The process of Lewy body formation, rather than simply alpha-synuclein fibrillization, is the major driver of neurodegeneration in synucleinopathies

G. Knott, H. Lashuel, J. Burtscher, 2019, bioRxiv.

c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease.

E. Masliah, O. Hantschel, G. Halliday, 2014, Human molecular genetics.

Health hazards of methylammonium lead iodide based perovskites: cytotoxicity studies.

H. Lashuel, L. Forró, B. Maco, 2016, Toxicology research.

α-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson’s disease

Paul M. Levine, H. Lashuel, Matthew R. Pratt, 2019, Proceedings of the National Academy of Sciences.

Combined multi-plane phase retrieval and super-resolution optical fluctuation imaging for 4D cell microscopy

H. Lashuel, T. Lasser, E. Bostan, 2018, Nature Photonics.

The Nt17 domain and its helical conformation regulate the aggregation, cellular properties and neurotoxicity of mutant huntingtin exon 1.

H. Lashuel, A. Chiki, G. Dietler, 2021, Journal of molecular biology.

Towards deciphering the Nt17 code: How the sequence and conformation of the first 17 amino acids in Huntingtin regulate the aggregation, cellular properties and neurotoxicity of mutant Httex1

H. Lashuel, A. Chiki, G. Dietler, 2021 .

The Nt17 domain and its helical conformation regulate the aggregation, cellular properties and neurotoxicity of mutant huntingtin exon 1

H. Lashuel, A. Chiki, G. Dietler, 2021, bioRxiv.

Neighbouring modifications interfere with the detection of phosphorylated alpha-synuclein at Serine 129: Revisiting the specificity of pS129 antibodies

N. Guex, H. Lashuel, C. Iseli, 2022, bioRxiv.

Post-fibrillization nitration of alpha-synuclein abolishes its seeding activity and pathology formation in primary neurons and in vivo

D. D. Di Monte, H. Lashuel, A. Chiki, 2023, bioRxiv.

O-GlcNAc modification forces the formation of an α-Synuclein amyloid-strain with notably diminished seeding activity and pathology

Virginia M. Y. Lee, H. Lashuel, K. Luk, 2023, bioRxiv.

A novel mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein fibrils and recapitulates its pathological diversity

H. Lashuel, F. Sobott, Rani Moons, 2021, bioRxiv.