Ru Shen

Optimization of 6,7-disubstituted-4-(arylamino)quinoline-3-carbonitriles as orally active, irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity.

Ramaswamy Nilakantan, Allan Wissner, R. Nilakantan, 2005, Journal of medicinal chemistry.

Synthesis and Structure−Activity Relationships of 6,7-Disubstituted 4-Anilinoquinoline-3-carbonitriles. The Design of an Orally Active, Irreversible Inhibitor of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor (EGFR) and the Human Epidermal Growth Factor Receptor-2 (HER-2)

Ramaswamy Nilakantan, Fei Ye, Allan Wissner, 2003 .

Antitumor Activity of HKI-272, an Orally Active, Irreversible Inhibitor of the HER-2 Tyrosine Kinase

Ramaswamy Nilakantan, Allan Wissner, William A. Hallett, 2004, Cancer Research.