Ivan Rusyn

发表

The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring county-level vulnerability using visualization, statistical modeling, and machine learning

Skylar W. Marvel, John S. House, Matthew Wheeler, 2020, medRxiv.

The Use of Cell Viability Assay Data Improves the Prediction Accuracy of Conventional Quantitative Structure Activity Relationship Models of Animal Carcinogenicity

Ivan Rusyn, Hao Zhu, Ann Richard, 2007 .

The Impact of Novel Assessment Methodologies in Toxicology on Green Chemistry and Chemical Alternatives

Ivan Rusyn, Nigel Greene, I. Rusyn, 2018, Toxicological sciences : an official journal of the Society of Toxicology.

SAFEGUI: resampling-based tests of categorical significance in gene expression data made easy

Fred A. Wright, Ivan Rusyn, Daniel M. Gatti, 2009, Bioinform..

Supporting Computational Systems Science: Genomic Analysis Tool Federations Using Aspects and AOP

Ivan Rusyn, David Stotts, Keith L. Lee, 2008, ISBRA.

A tiered, Bayesian approach to estimating of population variability for regulatory decision-making.

Ivan Rusyn, Fred A Wright, Weihsueh A Chiu, 2017, ALTEX.

Cheminformatics-aided pharmacovigilance: application to Stevens-Johnson Syndrome

Ivan Rusyn, G. Niklas Norén, I. Ralph Edwards, 2015, J. Am. Medical Informatics Assoc..

Optimal Chemical Grouping and Sorbent Material Design by Data Analysis, Modeling and Dimensionality Reduction Techniques.

Ivan Rusyn, Melis Onel, Burcu Beykal, 2018, ESCAPE. European Symposium on Computer Aided Process Engineering.

Standardizing Benchmark Dose Calculations to Improve Science-Based Decisions in Human Health Assessments

Fred A. Wright, Weihsueh A. Chiu, Ivan Rusyn, 2014, Environmental health perspectives.

A Novel Two-Step Hierarchical Quantitative Structure–Activity Relationship Modeling Work Flow for Predicting Acute Toxicity of Chemicals in Rodents

Alexander Golbraikh, Fred A. Wright, Ivan Rusyn, 2009, Environmental health perspectives.

ToxPi GUI: an interactive visualization tool for transparent integration of data from diverse sources of evidence

Fred A. Wright, Ivan Rusyn, David M. Reif, 2013, Bioinform..

The Next Generation of Risk Assessment Multi-Year Study—Highlights of Findings, Applications to Risk Assessment, and Future Directions

Paul A. Schulte, Linda S. Birnbaum, Melvin E. Andersen, 2016, Environmental health perspectives.

An empirical Bayes approach for multiple tissue eQTL analysis

Ivan Rusyn, Fred A Wright, Andrew B Nobel, 2013, Biostatistics.

A chemical–biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6gc01147k Click here for additional data file.

Fred A. Wright, Ivan Rusyn, David M. Reif, 2016, Green chemistry : an international journal and green chemistry resource : GC.

Environmental exposures due to natural disasters

Ivan Rusyn, Anthony H. Knap, I. Rusyn, 2016, Reviews on environmental health.

Oy Vey! A Comment on "Machine Learning of Toxicological Big Data Enables Read-Across Structure Activity Relationships Outperforming Animal Test Reproducibility".

Ivan Rusyn, Alexander Tropsha, Eugene Muratov, 2019, Toxicological sciences : an official journal of the Society of Toxicology.

Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip

Ivan Rusyn, Weihsueh A Chiu, Courtney M. Sakolish, 2018, Scientific Reports.

ToxPi Graphical User Interface 2.0: Dynamic exploration, visualization, and sharing of integrated data models

Skylar W. Marvel, Fred A. Wright, Ivan Rusyn, 2018, BMC Bioinformatics.

FastMap: Fast eQTL mapping in homozygous populations

Andrew B. Nobel, Fred A. Wright, Ivan Rusyn, 2008, Bioinform..

Inferring missing genotypes in large SNP panels using fast nearest-neighbor searches over sliding windows

Joel Parker, Ivan Rusyn, Wei Wang, 2007, ISMB/ECCB.

Rapid Hazard Characterization of Environmental Chemicals Using a Compendium of Human Cell Lines from Different Organs

Fred A. Wright, Weihsueh A. Chiu, Ivan Rusyn, 2020, ALTEX.

Effects of ethylene oxide and ethylene inhalation on DNA adducts, apurinic/apyrimidinic sites and expression of base excision DNA repair genes in rat brain, spleen, and liver.

Ivan Rusyn, Jun Nakamura, Oksana Kosyk, 2005, DNA repair.

Integrative QTL analysis of gene expression and chromatin accessibility identifies multi-tissue patterns of genetic regulation

Ivan Rusyn, William Valdar, Gregory E Crawford, 2020, PLoS genetics.

Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses.

Ivan Rusyn, Kathleen F. Kerr, Kathleen F Kerr, 2007, Toxicological sciences : an official journal of the Society of Toxicology.

High-Content Assay Multiplexing for Toxicity Screening in Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Hepatocytes

Ivan Rusyn, Oksana Sirenko, Fabian A. Grimm, 2015, Assay and drug development technologies.

Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups.

Ivan Rusyn, David M. Reif, Weihsueh A Chiu, 2018, ALTEX.

Grouping of Petroleum Substances as Example UVCBs by Ion Mobility-Mass Spectrometry to Enable Chemical Composition-Based Read-Across.

Weihsueh A. Chiu, Ivan Rusyn, Yu-Syuan Luo, 2017, Environmental science & technology.

In Vitro Bioavailability of the Hydrocarbon Fractions of Dimethyl Sulfoxide (DMSO) Extracts of Petroleum Substances.

Ivan Rusyn, Yu-Syuan Luo, Weihsueh A Chiu, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

Prediction of binding affinity and efficacy of thyroid hormone receptor ligands using QSAR and structure-based modeling methods.

Ivan Rusyn, Alexander Tropsha, Regina Politi, 2014, Toxicology and applied pharmacology.

Systems biology and functional genomics approaches for the identification of cellular responses to drug toxicity.

Ivan Rusyn, I. Rusyn, A. Harrill, 2008, Expert opinion on drug metabolism & toxicology.

Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis

Ivan Rusyn, Stephen S. Hecht, Robert J. Kavlock, 2015, Environmental health perspectives.

Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice

Ivan Rusyn, I. Rusyn, T. Han, 2010, Laboratory Investigation.

A Pipeline for High-Throughput Concentration Response Modeling of Gene Expression for Toxicogenomics

John S. House, Fred A. Wright, Ivan Rusyn, 2017, Front. Genet..

Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis.

Ivan Rusyn, James E Klaunig, I. Rusyn, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

Predicting drug-induced hepatotoxicity using QSAR and toxicogenomics approaches.

Ivan Rusyn, Alexander Tropsha, Denis Fourches, 2011, Chemical research in toxicology.

Addressing Human Variability in Next-Generation Human Health Risk Assessments of Environmental Chemicals

Weihsueh A. Chiu, Ivan Rusyn, Dale Hattis, 2012, Environmental health perspectives.

Physiologically Based Pharmacokinetic (PBPK) Modeling of Interstrain Variability in Trichloroethylene Metabolism in the Mouse

Harvey J. Clewell, Fred A. Wright, Weihsueh A. Chiu, 2014, Environmental health perspectives.

Phenotypic anchoring of acetaminophen-induced oxidative stress with gene expression profiles in rat liver.

Ivan Rusyn, Oksana Kosyk, Richard S Paules, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity.

Ivan Rusyn, Fred A Wright, Oksana Sirenko, 2013, Toxicology and applied pharmacology.

Integrative chemical-biological read-across approach for chemical hazard classification.

Alexander Golbraikh, Ivan Rusyn, Alexander Tropsha, 2013, Chemical research in toxicology.

Chemical Safety Assessment Using Read-Across: Assessing the Use of Novel Testing Methods to Strengthen the Evidence Base for Decision Making

Andrew Worth, Detlef Keller, Catherine Mahony, 2015, Environmental health perspectives.

Application of the key characteristics of carcinogens in cancer hazard identification

Ivan Rusyn, David C Christiani, Martin van den Berg, 2018, Carcinogenesis.

In vitro screening for population variability in chemical toxicity

Ivan Rusyn, I. Rusyn, 2013 .

Evaluation of an in vitro toxicogenetic mouse model for hepatotoxicity.

Ivan Rusyn, Oksana Kosyk, Stephen S Ferguson, 2010, Toxicology and applied pharmacology.

Predictive modeling of chemical hazard by integrating numerical descriptors of chemical structures and short-term toxicity assay data.

Ivan Rusyn, Alexander Tropsha, Kathryn Z Guyton, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Mechanistic considerations for human relevance of cancer hazard of di(2-ethylhexyl) phthalate.

Ivan Rusyn, J Christopher Corton, I. Rusyn, 2012, Mutation research.

Multiparameter In Vitro Assessment of Compound Effects on Cardiomyocyte Physiology Using iPSC Cells

Ivan Rusyn, Oksana Sirenko, Carole Crittenden, 2013, Journal of biomolecular screening.

In vitro screening for population variability in toxicity of pesticide-containing mixtures.

Ivan Rusyn, Fred A Wright, Barbara A Wetmore, 2015, Environment international.

Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel.

Ivan Rusyn, Alison H Harrill, Daniel M Gatti, 2009, Toxicological sciences : an official journal of the Society of Toxicology.

Environmental toxicants, epigenetics, and cancer.

Ivan Rusyn, I. Rusyn, I. Pogribny, 2013, Advances in experimental medicine and biology.

The role of microRNAs in the development and progression of chemical-associated cancers.

Ivan Rusyn, I. Rusyn, I. Pogribny, 2016, Toxicology and applied pharmacology.

Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans.

Ivan Rusyn, Paul B Watkins, Raymond Tennant, 2009, Genome research.

Mouse liver effects of cyproconazole, a triazole fungicide: role of the constitutive androstane receptor.

Ivan Rusyn, I. Rusyn, Jayne Wright, 2007, Toxicological sciences : an official journal of the Society of Toxicology.

In vitro models for liver toxicity testing.

Ivan Rusyn, Linda G Griffith, I. Rusyn, 2013, Toxicology research.

From "Weight of Evidence" to Quantitative Data Integration using Multicriteria Decision Analysis and Bayesian Methods

Igor Linkov, Ivan Rusyn, Thomas Hartung, 2015, ALTEX.

In vitro screening for population variability in chemical toxicity.

Ivan Rusyn, Fred A Wright, Oksana Kosyk, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

IARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to Humans

Per Gustavsson, Tony Fletcher, Linda S. Birnbaum, 2015, Environmental health perspectives.

Assessment of biological responses of EpiAirway 3-D cell constructs versus A549 cells for determining toxicity of ambient air pollution

Ivan Rusyn, William Vizuete, Kim Lichtveld, 2016, Inhalation toxicology.

Population-Based in Vitro Hazard and Concentration–Response Assessment of Chemicals: The 1000 Genomes High-Throughput Screening Study

Ruili Huang, Menghang Xia, Christopher P. Austin, 2015, Environmental health perspectives.

Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases

Andrew B. Nobel, Fred A. Wright, Ivan Rusyn, 2015, Scientific Reports.

Modes of Action and Species-Specific Effects of Di-(2-ethylhexyl)Phthalate in the Liver

Ivan Rusyn, Jeffrey M Peters, I. Rusyn, 2006, Critical reviews in toxicology.

Mechanisms of HCV-induced liver cancer: what did we learn from in vitro and animal studies?

Ivan Rusyn, Stanley M Lemon, I. Rusyn, 2014, Cancer letters.

Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice.

Ivan Rusyn, Eric F Lock, Oksana Kosyk, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Modeling liver-related adverse effects of drugs using knearest neighbor quantitative structure-activity relationship method.

Ivan Rusyn, Alexander Tropsha, Denis Fourches, 2010, Chemical research in toxicology.

Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model.

Ruili Huang, Christopher P Austin, Raymond R Tice, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Genome‐level analysis of genetic regulation of liver gene expression networks

Ivan Rusyn, Lu Lu, Elissa J Chesler, 2007, Hepatology.

Joint Effects of Alcohol Consumption and Polymorphisms in Alcohol and Oxidative Stress Metabolism Genes on Risk of Head and Neck Cancer

Ivan Rusyn, Jill S. Barnholtz-Sloan, Amy H. Herring, 2011, Cancer Epidemiology, Biomarkers & Prevention.

Computational tools for discovery and interpretation of expression quantitative trait loci.

Ivan Rusyn, Fred A Wright, Andrey A Shabalin, 2012, Pharmacogenomics.

Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: A systematic literature review.

Ivan Rusyn, Kathryn Z Guyton, I. Rusyn, 2016, Mutation research. Reviews in mutation research.

Gene expression in nontumoral liver tissue and recurrence-free survival in hepatitis C virus-positive hepatocellular carcinoma

Ivan Rusyn, Hiroshi Kono, Joel S Parker, 2010, Molecular Cancer.

Identification of putative estrogen receptor-mediated endocrine disrupting chemicals using QSAR- and structure-based virtual screening approaches.

Ivan Rusyn, Georgia Melagraki, Alexander Tropsha, 2013, Toxicology and applied pharmacology.

Toxicogenetics: population-based testing of drug and chemical safety in mouse models.

Ivan Rusyn, Daniel M Gatti, David W Threadgill, 2010, Pharmacogenomics.