David J. Loane

Shruti V. Kabadi, B. Stoica, A. Faden, 2012, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

CR8, a Selective and Potent CDK Inhibitor, Provides Neuroprotection in Experimental Traumatic Brain Injury

Shruti V. Kabadi, B. Stoica, A. Faden, 2011, Neurotherapeutics.

Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies.

A. Faden, D. Loane, Alan I Faden, 2010, Trends in pharmacological sciences.

Chronic Neurodegeneration After Traumatic Brain Injury: Alzheimer Disease, Chronic Traumatic Encephalopathy, or Persistent Neuroinflammation?

A. Faden, D. Loane, David J. Loane, 2014, Neurotherapeutics.

Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states

B. Stoica, A. Faden, M. Burns, 2013, Neurobiology of Aging.

The need to incorporate aged animals into the preclinical modeling of neurological conditions

R. Mychasiuk, S. Shultz, C. Sobey, 2019, Neuroscience & Biobehavioral Reviews.

Neuroprotection for traumatic brain injury.

B. Stoica, A. Faden, D. Loane, 2015, Handbook of clinical neurology.

Microglial/Macrophage Polarization Dynamics following Traumatic Brain Injury.

B. Stoica, A. Faden, D. Loane, 2016, Journal of neurotrauma.

Brain injury accelerates the onset of a reversible age-related microglial phenotype associated with inflammatory neurodegeneration

B. Stoica, A. Faden, Junfang Wu, 2023, Science advances.

PARP-1 inhibition attenuates neuronal loss, microglia activation and neurological deficits after traumatic brain injury.

Shruti V. Kabadi, B. Stoica, A. Faden, 2014, Journal of neurotrauma.

Delayed microglial depletion after spinal cord injury reduces chronic inflammation and neurodegeneration in the brain and improves neurological recovery in male mice

B. Stoica, A. Faden, Junfang Wu, 2020, Theranostics.

Mesenchymal stromal cell secretome for traumatic brain injury: Focus on immunomodulatory action

A. Salgado, D. Loane, E. Zanier, 2022, Experimental Neurology.

Early or Late Bacterial Lung Infection Increases Mortality After Traumatic Brain Injury in Male Mice and Chronically Impairs Monocyte Innate Immune Function

A. Faden, S. Vogel, D. Loane, 2020, Critical care medicine.

Chronic Alterations in Systemic Immune Function after Traumatic Brain Injury.

A. Faden, Elise L. Ma, D. Loane, 2018, Journal of neurotrauma.

Metabotropic glutamate receptors as targets for multipotential treatment of neurological disorders

A. Faden, D. Loane, K. Byrnes, 2011, Neurotherapeutics.

Controlled cortical impact results in an extensive loss of dendritic spines that is not mediated by injury-induced amyloid-beta accumulation.

Charisse N. Winston, D. Loane, David J. Loane, 2013, Journal of neurotrauma.

Microglial Depletion with CSF1R Inhibitor During Chronic Phase of Experimental Traumatic Brain Injury Reduces Neurodegeneration and Neurological Deficits

B. Stoica, A. Faden, Y. Jiao, 2019, The Journal of Neuroscience.

Modulation of amyloid‐β‐induced and age‐associated changes in rat hippocampus by eicosapentaenoic acid

M. Lynch, C. Herron, D. Loane, 2007, Journal of neurochemistry.

Interferon-β Plays a Detrimental Role in Experimental Traumatic Brain Injury by Enhancing Neuroinflammation That Drives Chronic Neurodegeneration

B. Stoica, A. Faden, S. Vogel, 2020, The Journal of Neuroscience.

Role of microglia in neurotrauma

D. Loane, K. Byrnes, David J. Loane, 2010, Neurotherapeutics.

Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury

Jiangyang Zhang, B. Stoica, A. Faden, 2012, Journal of Neuroinflammation.

miR-711 upregulation induces neuronal cell death after traumatic brain injury

B. Stoica, A. Faden, Junfang Wu, 2015, Cell Death and Differentiation.

Downregulation of miR-23a and miR-27a following Experimental Traumatic Brain Injury Induces Neuronal Cell Death through Activation of Proapoptotic Bcl-2 Proteins

B. Stoica, A. Faden, Junfang Wu, 2014, The Journal of Neuroscience.

Traumatic Brain Injury Induces cGAS Activation and Type I Interferon Signaling in Aged Mice

B. Stoica, Surajit Bhattacharya, D. Loane, 2021, Frontiers in Immunology.

NOX2 drives M1-like microglial/macrophage activation and neurodegeneration following experimental traumatic brain injury

B. Stoica, A. Faden, D. Loane, 2016, Brain, Behavior, and Immunity.

Novel mGluR5 Positive Allosteric Modulator Improves Functional Recovery, Attenuates Neurodegeneration, and Alters Microglial Polarization after Experimental Traumatic Brain Injury

B. Stoica, A. Faden, F. Tchantchou, 2014, Neurotherapeutics.

Neuroinflammation after traumatic brain injury: Opportunities for therapeutic intervention

Alok Kumar, David J. Loane, 2012, Brain, Behavior, and Immunity.

Brain-gut axis dysfunction in the pathogenesis of traumatic brain injury.

D. Loane, T. Shea-Donohue, M. Hanscom, 2021, The Journal of clinical investigation.

Acute colitis during chronic experimental traumatic brain injury in mice induces dysautonomia and persistent extraintestinal, systemic, and CNS inflammation with exacerbated neurological deficits

A. Faden, D. Loane, J. Leser, 2021, Journal of neuroinflammation.

Metabotropic glutamate receptor-mediated signaling in neuroglia.

B. Stoica, A. Faden, D. Loane, 2012, Wiley interdisciplinary reviews. Membrane transport and signaling.

NOX2 deficiency alters macrophage phenotype through an IL-10/STAT3 dependent mechanism: implications for traumatic brain injury

B. Stoica, A. Faden, S. Villapol, 2017, Journal of Neuroinflammation.

Activation of mGluR5 and inhibition of NADPH oxidase improves functional recovery after traumatic brain injury.

B. Stoica, A. Faden, K. Byrnes, 2013, Journal of neurotrauma.

Putative mGluR4 positive allosteric modulators activate Gi-independent anti-inflammatory mechanisms in microglia

B. Stoica, A. Faden, D. Loane, 2020, Neurochemistry International.

Enhanced Akt/GSK‐3β/CREB signaling mediates the anti‐inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain injury in male mice

B. Stoica, A. Faden, D. Loane, 2020, Journal of neurochemistry.

Neutral Sphingomyelinase Inhibition Alleviates LPS-Induced Microglia Activation and Neuroinflammation after Experimental Traumatic Brain Injury

B. Stoica, A. Faden, D. Loane, 2019, The Journal of Pharmacology and Experimental Therapeutics.

Microglial-derived microparticles mediate neuroinflammation after traumatic brain injury

S. Thom, B. Stoica, A. Faden, 2017, Journal of Neuroinflammation.

Activation of metabotropic glutamate receptor 5 improves recovery after spinal cord injury in rodents

B. Stoica, A. Faden, D. Loane, 2009, Annals of neurology.

Activation of Metabotropic Glutamate Receptor 5 Modulates Microglial Reactivity and Neurotoxicity by Inhibiting NADPH Oxidase*

B. Stoica, A. Faden, D. Loane, 2009, The Journal of Biological Chemistry.

Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity

B. Stoica, A. Faden, K. Byrnes, 2009, Glia.

Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury

Y. Matsuoka, A. Faden, C. Moussa, 2009, Nature Medicine.

Late exercise reduces neuroinflammation and cognitive dysfunction after traumatic brain injury

B. Stoica, A. Faden, Junfang Wu, 2013, Neurobiology of Disease.

CR8, a Novel Inhibitor of CDK, Limits Microglial Activation, Astrocytosis, Neuronal Loss, and Neurologic Dysfunction after Experimental Traumatic Brain Injury

Shruti V. Kabadi, B. Stoica, A. Faden, 2014, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Comparing the predictive value of multiple cognitive, affective, and motor tasks after rodent traumatic brain injury.

B. Stoica, A. Faden, Zaorui Zhao, 2012, Journal of neurotrauma.

Combined inhibition of cell death induced by apoptosis inducing factor and caspases provides additive neuroprotection in experimental traumatic brain injury

K. Blomgren, B. Stoica, A. Faden, 2012, Neurobiology of Disease.

Inflammatory response of microglia to prions is controlled by sialylation of PrPSc

N. Makarava, I. Baskakov, D. Loane, 2018, Scientific Reports.

Longitudinal assessment of sensorimotor function following controlled cortical impact in mice: comparison of beamwalk, rotarod and automated gait analysis tests.

B. Stoica, A. Faden, David J. Loane, 2020, Journal of neurotrauma.

Understanding microglial responses in large animal models of traumatic brain injury: an underutilized resource for preclinical and translational research

D. K. Cullen, D. Loane, Michael R. Grovola, 2023, Journal of Neuroinflammation.

Sex Differences in Acute Neuroinflammation after Experimental Traumatic Brain Injury Are Mediated by Infiltrating Myeloid Cells.

A. Faden, D. Loane, Rodney Ritzel, 2019, Journal of neurotrauma.

Sexual dimorphism in the inflammatory response to traumatic brain injury

S. Villapol, D. Loane, David J. Loane, 2017, Glia.

Inhibition of autophagy in microglia and macrophages exacerbates innate immune responses and worsens brain injury outcomes

M. Lipinski, Junfang Wu, D. Loane, 2023, Autophagy.

Interleukin-4 mediates the neuroprotective effects of rosiglitazone in the aged brain

M. Lynch, D. Loane, David J. Loane, 2009, Neurobiology of Aging.

Inhibition of miR-155 Limits Neuroinflammation and Improves Functional Recovery After Experimental Traumatic Brain Injury in Mice

B. Stoica, A. Faden, D. Loane, 2018, Neurotherapeutics.

Region-Specific Homeostatic Identity of Astrocytes Is Essential for Defining Their Response to Pathological Insults

J. Simard, N. Makarava, I. Baskakov, 2023, Cells.

Region-specific homeostatic identity of astrocytes is essential for defining their reactive phenotypes following pathological insults

J. Simard, N. Makarava, I. Baskakov, 2023, bioRxiv.

Inhibition of BKCa channel activity by association with calcineurin in rat brain

N. Marrion, D. Loane, B. Perrino, 2006, The European journal of neuroscience.

Translating from mice to humans: using preclinical blood-based biomarkers for the prognosis and treatment of traumatic brain injury

Bridgette D. Semple, E. Zanier, David J. Loane, 2023, bioRxiv.

S100B Inhibition Reduces Behavioral and Pathologic Changes in Experimental Traumatic Brain Injury

Shruti V. Kabadi, B. Stoica, A. Faden, 2015, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Neuroimaging assessment of early and late neurobiological sequelae of traumatic brain injury: implications for CTE

P. Murali Doraiswamy, Rajendra A. Morey, Mark Sundman, 2015, Front. Neurosci..

Modulation of ABCA1 by an LXR agonist reduces β-amyloid levels and improves outcome after traumatic brain injury.

A. Faden, Lilit Vardanian, K. Duff, 2011, Journal of neurotrauma.

Bi-directional neuro-immune dysfunction after chronic experimental brain injury

Yun Li, Sarah J. Doran, David J. Loane, 2024, Journal of neuroinflammation.

The brain-bone marrow axis and its implications for chronic traumatic brain injury

Yun Li, Sarah J. Doran, David J. Loane, 2023, Research square.

Experimental Models of Hospital-Acquired Infections after Traumatic Brain Injury: Challenges and Opportunities.

Bridgette D. Semple, David J. Loane, Natasha Gandasasmita, 2023, Journal of neurotrauma.

The far-reaching scope of neuroinflammation after traumatic brain injury

P. Kochanek, R. Clark, H. Bayır, 2017, Nature Reviews Neurology.

Brain injury accelerates the onset of a reversible age-related microglial phenotype associated with hyperphagocytosis and inflammatory neurodegeneration

B. Stoica, A. Faden, Junfang Wu, 2022, bioRxiv.

Activation of Metabotropic Glutamate Receptor 5 Modulates Microglial Reactivity and Neurotoxicity by Inhibiting NADPH Oxidase*

B. Stoica, A. Faden, K. Byrnes, 2009, The Journal of Biological Chemistry.