M. Searcey

发表

A rapid screen for molecules that form duplex to duplex crosslinks in DNA.

D. Russell, María J. Marín, B. Rackham, 2013, Chemical communications.

Efficient solid-phase-based total synthesis of the bisintercalator TANDEM.

Andrew J. Hampshire, M. Zloh, J. Malkinson, 2005, The Journal of organic chemistry.

Bisintercalator natural products with potential therapeutic applications: isolation, structure determination, synthetic and biological studies.

J. Malkinson, M. Searcey, S. Dawson, 2007, Natural product reports.

Identification and characterisation of a G-quadruplex forming sequence in the promoter region of nuclear factor (erythroid-derived 2)-like 2 (Nrf2).

Zoë A. E. Waller, C. Macdonald, M. O'Connell, 2014, Biochemical and biophysical research communications.

Perfluoroarene-based peptide macrocycles that inhibit the Nrf2/Keap1 interaction.

M. O'Connell, M. Searcey, Richard Steel, 2018, Bioorganic & medicinal chemistry letters.

Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity.

P. Loadman, J. Hartley, L. Patterson, 2011, Chemical communications.

A small molecule drug conjugate (SMDC) of DUPA and a duocarmycin built on the solid phase.

D. Boger, M. Searcey, A. Beekman, 2019, MedChemComm.

Synthesis of Small Molecules Targeting Multiple DNA Structures using Click Chemistry

S. Neidle, A. Reszka, M. O'Connell, 2012, ChemMedChem.

Bleomycin mimics. Design and synthesis of an acridine derivative whichcleaves DNA in a sequence-neutral manner

S. McClean, L. P. Wakelin, M. Searcey, 1997 .

(C^Npz^C)AuIII complexes of acyclic carbene ligands: synthesis and anticancer properties.

M. O'Connell, M. Bochmann, J. Fernandez-Cestau, 2017, Dalton transactions.

A peptide-duocarmycin conjugate targeting the Thomsen-Friedenreich antigen has potent and selective antitumour activity.

D. Russell, M. Searcey, A. Beekman, 2020, Bioconjugate chemistry.

Taspine is a natural product that suppresses P2X4 receptor activity via phosphoinositide 3‐kinase inhibition

M. Searcey, S. Fountain, D. Richards, 2021, British journal of pharmacology.

Peptide directed phthalocyanine–gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers

D. A. Russell, D. Russell, María J. Marín, 2020, RSC medicinal chemistry.

Probing cytochrome P450 (CYP) bioactivation with chloromethylindoline bioprecursors derived from the duocarmycin family of compounds.

P. Loadman, L. Patterson, K. Karu, 2021, Bioorganic & medicinal chemistry.

Re-engineering of the duocarmycin structural architecture enables bioprecursor development targeting CYP1A1 and CYP2W1 for biological activity.

M. Ingelman-Sundberg, P. Loadman, S. Mkrtchian, 2013, Journal of medicinal chemistry.

Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry.

A. Mueller, M. O'Connell, L. Howell, 2009, Bioorganic & medicinal chemistry letters.

Catalytic antibody activity elicited by active immunisation. Evidence for natural variation involving preferential stabilization of the transition state.

K. Brocklehurst, G. Gallacher, M. Searcey, 1993, European journal of biochemistry.

A convenient access to benzo-substituted phthalazines as potential precursors to DNA intercalators

M. Searcey, P. G. Tsoungas, 2001 .

A natural product inspired fragment-based approach towards the development of novel anti-bacterial agents

Anthony Maxwell, Mark Searcey, S. Hearnshaw, 2016 .

Acridine-decorated cyclometallated gold(iii) complexes: synthesis and anti-tumour investigations.

Zoë A. E. Waller, M. O'Connell, M. Bochmann, 2018, Dalton transactions.

Cyclometallated Au(iii) dithiocarbamate complexes: synthesis, anticancer evaluation and mechanistic studies.

Zoë A. E. Waller, M. O'Connell, M. Bochmann, 2018, Metallomics : integrated biometal science.

Chemical and biological explorations of the family of CC-1065 and the duocarmycin natural products.

H. Sheldrake, Nandita Ghosh, M. Searcey, 2009, Current topics in medicinal chemistry.

Synthesis of CC-1065 and duocarmycin analogs via intramolecular aryl radical cyclization of a tethered vinyl chloride

D. Boger, M. Searcey, C. Boyce, 1998 .

Solid-Phase Synthesis of Duocarmycin Analogues and the Effect of C-Terminal Substitution on Biological Activity.

M. O'Connell, H. Sheldrake, K. Fox, 2015, The Journal of organic chemistry.

Duocarmycins--natures prodrugs?

M. Searcey, 2002, Current pharmaceutical design.

CBI Prodrug Analogs of CC-1065 and the Duocarmycins

D. Boger, M. Searcey, C. Boyce, 1999 .

Bifunctional alkylating agents derived from duocarmycin SA: potent antitumor activity with altered sequence selectivity.

D. Boger, W. Tse, M. Searcey, 2000, Bioorganic & medicinal chemistry letters.

Amino DSA analogues as payloads for antibody-drug conjugates with multiple sites for conjugation. Initial studies and solid phase synthesis

M. O'Connell, M. Searcey, M. Cominetti, 2021 .

Stereoselectivity, Sequence Specificity and Mechanism of Action of the Azinomycin Epoxide

C. Bailly, M. Kouach, G. Briand, 2006, Chembiochem : a European journal of chemical biology.

A mild procedure for the production of secondary amines from oximes and benzisoxazoles

M. Searcey, P. G. Tsoungas, S. S. Grewal, 2003 .

Design and synthesis of a DNA-crosslinking azinomycin analogue.

J. Hartley, L. Patterson, M. Casely-Hayford, 2005, Organic & biomolecular chemistry.

Synthesis of DNA-directed pyrrolidinyl and piperidinyl confined alkylating chloroalkylaminoanthraquinones: potential for development of tumor-selective N-oxides.

M. Zloh, J. Hartley, L. Patterson, 2006, Journal of medicinal chemistry.

The isolation, total synthesis and structure elucidation of chlorofusin, a natural product inhibitor of the p53-mDM2 protein-protein interaction.

D. Boger, M. Searcey, Sang Yeul Lee, 2009, Natural product reports.

Synthesis of distamycin A polyamides targeting G-quadruplex DNA.

Stephen Neidle, Mark Searcey, S. Neidle, 2006, Organic & biomolecular chemistry.

Design, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions.

Sukwon Hong, Mark Searcey, Dale L Boger, 2009, Journal of the American Chemical Society.

Cytotoxicity of Pyrazine-Based Cyclometalated (C^Npz^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties

Zoë A. E. Waller, J. Angulo, M. O'Connell, 2017, Inorganic chemistry.

Truncated azinomycin analogues intercalate into DNA.

S. Neidle, L. Patterson, M. Casely-Hayford, 2005, Bioorganic & medicinal chemistry letters.

Rationally Engineered Total Biosynthesis of a Synthetic Analogue of a Natural Quinomycin Depsipeptide in Escherichia coli

Kenji Watanabe, K. Hotta, H. Oikawa, 2009, Chembiochem : a European journal of chemical biology.

Anti-inflammatory Effect of a Cell-Penetrating Peptide Targeting the Nrf2/Keap1 Interaction

M. O'Connell, M. Searcey, Richard Steel, 2012, ACS medicinal chemistry letters.

Evaluation of Chlorofusin, its Seven Chromophore Diastereomers, and Key Analogues.

D. Boger, M. Searcey, I. Hwang, 2009, Tetrahedron letters.

Identification of selective protein–protein interaction inhibitors using efficient in silico peptide-directed ligand design† †Electronic supplementary information (ESI) available: Experimental procedures, spectra and processed biophysical assay data. See DOI: 10.1039/c9sc00059c

J. Angulo, S. Walpole, M. O'Connell, 2019, Chemical science.

Development of nonsymmetrical 1,4-disubstituted anthraquinones that are potently active against cisplatin-resistant ovarian cancer cells.

Robert Brown, J. Plumb, Paul J. Smith, 2005, Journal of Medicinal Chemistry.

Targeting Higher‐Order DNA: Beyond the G‐Quadruplex

L. Howell, M. Searcey, 2009, Chembiochem : a European journal of chemical biology.

Chemical Therapeutics Discovery & Preclinical Development Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P 450 1 A 1 in Human Transitional Cell Carcinoma of the Bladder

P. Cooper, P. Loadman, L. Patterson, 2013 .

Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder

P. Cooper, P. Loadman, L. Patterson, 2012, Molecular Cancer Therapeutics.

Isolation of a warfarin binding protein from liver endoplasmic reticulum of Sprague-Dawley and warfarin-resistant rats.

R. Olson, M. Searcey, C. Graves, 1977, The Journal of biological chemistry.

Polyclonal antibody-catalysed amide hydrolysis.

K. Brocklehurst, G. Gallacher, M. Searcey, 1992, The Biochemical journal.

Structural Basis of the Negative Allosteric Modulation of 5-BDBD at Human P2X4 Receptors

R. Schmid, Stefan Bidula, M. Searcey, 2021, Molecular Pharmacology.

The Azinomycins. Discovery, Synthesis, and DNA‐Binding Studies

M. Casely-Hayford, M. Searcey, 2004 .

Active targeting of gold nanoparticles as cancer therapeutics.

D. A. Russell, D. Russell, María J. Marín, 2020, Chemical Society Reviews.

Junctions in DNA: underexplored targets for therapeutic intervention.

M. Searcey, M. Cominetti, Eleanor Ivens, 2022, Bioorganic & medicinal chemistry.

Synthesis, DNA-cleaving properties and cytotoxicity of intercalating chelidamic acid derivatives.

S. McClean, M. Searcey, A. McGown, 1998, Anti-cancer drug design.

Suramin analogues protect cartilage against osteoarthritic breakdown by increasing levels of tissue inhibitor of metalloproteinases 3 (TIMP-3) in the tissue.

S. Wren, J. Green, M. Piras, 2023, Bioorganic & medicinal chemistry.

Solid-phase synthesis of the cyclic peptide portion of chlorofusin, an inhibitor of p53-MDM2 interactions.

M. Zloh, R. Errington, J. Malkinson, 2003, Organic letters.

Solid-phase synthesis of chlorofusin analogues.

J. Malkinson, A. Wilderspin, E. Woon, 2007, The Journal of organic chemistry.

J. Angulo, S. Walpole, M. O'Connell, 2019, Chemical science.

Unveiling the "Three-Finger Pharmacophore" Required for p53-MDM2 Inhibition by Saturation-Transfer Difference (STD) NMR Initial Growth-Rates Approach.

J. Angulo, L. Howell, M. Searcey, 2016, Chemistry.

Identification of a new p53/MDM2 inhibitor motif inspired by studies of chlorofusin.

M. O'Connell, L. Howell, M. Searcey, 2015, Bioorganic & Medicinal Chemistry Letters.

(C^Npz^C)AuIII complexes of acyclic carbene ligands: synthesis and anticancer properties.

M. O'Connell, M. Bochmann, M. Searcey, 2017, Dalton transactions.

Synthesis and evaluation of a novel bleomycin A2 analogue: continuing assessment of the linker domain

D. Boger, W. Tse, B. Aquila, 2000 .