C. James

发表

GC-targeted C8-linked pyrrolobenzodiazepine-biaryl conjugates with femtomolar in vitro cytotoxicity and in vivo antitumor activity in mouse models.

P. Jackson, R. B. Pedley, J. Hartley, 2013, Journal of medicinal chemistry.

Antistaphylococcal activity of DNA-interactive pyrrolobenzodiazepine (PBD) dimers and PBD-biaryl conjugates

Denise E. Waldron, M. de la Fuente, P. Taylor, 2012, The Journal of antimicrobial chemotherapy.

Evaluation of the taste-masking effects of (2-hydroxypropyl)-β-cyclodextrin on ranitidine hydrochloride; a combined biosensor, spectroscopic and molecular modelling assessment

S. Haider, A. Keating, D. Craig, 2018, RSC advances.

Novel C8-linked pyrrolobenzodiazepine (PBD)-heterocycle conjugates that recognize DNA sequences containing an inverted CCAAT box.

T. Ellis, J. Hartley, G. Wells, 2011, Bioorganic & medicinal chemistry letters.

An extended pyrrolobenzodiazepine-polyamide conjugate with selectivity for a DNA sequence containing the ICB2 transcription factor binding site.

P. Jackson, T. Ellis, D. Hochhauser, 2013, Journal of medicinal chemistry.

Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor agents.

T. Barata, M. Zloh, S. Neidle, 2010, Journal of medicinal chemistry.

The pyrrolobenzodiazepine dimer SJG-136 forms sequence-dependent intrastrand DNA cross-links and monoalkylated adducts in addition to interstrand cross-links.

A. Thompson, D. Thurston, C. James, 2009, Journal of the American Chemical Society.

Effect of hairpin loop structure on reactivity, sequence preference and adduct orientation of a DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumour agent.

P. Jackson, K. M. Rahman, D. Thurston, 2015, Organic & biomolecular chemistry.

Design and synthesis of a DNA-crosslinking azinomycin analogue.

J. Hartley, L. Patterson, M. Casely-Hayford, 2005, Organic & biomolecular chemistry.

Computational studies support the role of the C7-sibirosamine sugar of the pyrrolobenzodiazepine (PBD) sibiromycin in transcription factor inhibition.

P. Jackson, T. C. Jenkins, K. M. Rahman, 2014, ACS chemical biology.

Observation of a single-stranded DNA/pyrrolobenzodiazepine adduct.

T. Bui, A. Drake, K. M. Rahman, 2011, Journal of the American Chemical Society.

Effect of base sequence on the DNA cross-linking properties of pyrrolobenzodiazepine (PBD) dimers

D. Thurston, C. James, K. M. Rahman, 2011, Nucleic acids research.

Observation of the reversibility of a covalent pyrrolobenzodiazepine (PBD) DNA adduct by HPLC/MS and CD spectroscopy.

D. Thurston, C. James, K. M. Rahman, 2011, Organic & biomolecular chemistry.

DNA Sequence Preference and Adduct Orientation of Pyrrolo[2,1-c][1,4]benzodiazepine Antitumor Agents.

D. Thurston, C. James, K. M. Rahman, 2010, ACS medicinal chemistry letters.

The statistics of ternary complex formation with special reference to biological fluids

S. H. Laurie, C. James, 1983 .

Synthesis, anti-mycobacterial activity and DNA sequence-selectivity of a library of biaryl-motifs containing polyamides.

S. Bhakta, J. Guzman, Arundhati Maitra, 2015, Bioorganic & medicinal chemistry.

Identification of an inhibitory Zn2+ binding site on the human glycine receptor α1 subunit

R. Harvey, A. Wilderspin, T. Smart, 1999, The Journal of physiology.

Observation of a dynamic equilibrium between DNA hairpin and duplex forms of covalent adducts of a minor groove binding agent.

P. Howard, D. Thurston, C. James, 2009, Chemical communications.

DNA Sequence Preference and Adduct Orientation of Pyrrolo[2,1-c][1,4]benzodiazepine Antitumor Agents.

D. Thurston, C. James, K. M. Rahman, 2010, ACS medicinal chemistry letters.

The pyrrolobenzodiazepine dimer SJG-136 forms sequence-dependent intrastrand DNA cross-links and monoalkylated adducts in addition to interstrand cross-links.

A. Thompson, D. Thurston, C. James, 2009, Journal of the American Chemical Society.