Jinfeng Luo

发表

Design, synthesis, and biological evaluation of 3-(1H-1,2,3-triazol-1-yl)benzamide derivatives as Potent Pan Bcr-Abl inhibitors including the threonine(315)→isoleucine(315) mutant.

Xiaoyun Lu, Zheng-chao Tu, Fengxiang Zhang, 2012, Journal of medicinal chemistry.

Dual targeting delivery of miR-328 by functionalized mesoporous silica nanoparticles for colorectal cancer therapy.

Lisheng He, Peng Zhai, Yue Zhang, 2018, Nanomedicine.

Design and synthesis of N-(4-aminopyridin-2-yl)amides as B-Raf(V600E) inhibitors.

Xiaoyun Lu, Jie Ma, Jiayi Shen, 2016, Bioorganic & medicinal chemistry letters.

Synthesis and Evaluation of Novel Erlotinib-NSAID Conjugates as More Comprehensive Anticancer Agents.

Yanmei Zhang, J. Talley, Zheng-chao Tu, 2015, ACS medicinal chemistry letters.

New thiazole carboxamides as potent inhibitors of Akt kinases.

Honglin Li, Xianwen Cao, Xiaoyun Lu, 2012, Bioorganic & medicinal chemistry letters.

Biological evaluation of 2-methylpyrimidine derivatives as active pan Bcr-Abl inhibitors

Chenzhong Liao, Zheng-chao Tu, Yatao Qiu, 2013, Science China Chemistry.

Synthesis and biological evaluation of novel dasatinib analogues as potent DDR1 and DDR2 kinase inhibitors

Zheng-chao Tu, Jinfeng Luo, Muzammal Hussain, 2017, Chemical biology & drug design.

An Ethnobotanical Study on Chuangqing People of China based on the Herbal Market Survey on Dragon Boat Festival

Jinfeng Luo, Ruyu Yao, Hongxiang Yin, 2020 .

(+/-)-Applanatumines B-D: novel dimeric meroterpenoids from Ganoderma applanatum as inhibitors of JAK3

Zheng-chao Tu, Zhen Wang, Jinfeng Luo, 2017 .

Pyrimido[4,5-d]pyrimidin-4(1H)-one derivatives as selective inhibitors of EGFR threonine790 to methionine790 (T790M) mutants.

Honglin Li, Shaomeng Wang, Shiliang Li, 2013, Angewandte Chemie.

Design, synthesis, and biological evaluation of novel conformationally constrained inhibitors targeting epidermal growth factor receptor threonine⁷⁹⁰ → methionine⁷⁹⁰ mutant.

Ke Ding, Zhang Zhang, Yong Xu, 2012, Journal of medicinal chemistry.

N-(3-Ethynyl-2,4-difluorophenyl)sulfonamide Derivatives as Selective Raf Inhibitors.

Yong Xu, J. Smaill, Donghai Wu, 2015, ACS medicinal chemistry letters.

Identification and optimization of new dual inhibitors of B-Raf and epidermal growth factor receptor kinases for overcoming resistance against vemurafenib.

Xiaoyun Lu, Qingwen Zhang, Zheng-chao Tu, 2014, Journal of medicinal chemistry.

Identification of GZD824 as an orally bioavailable inhibitor that targets phosphorylated and nonphosphorylated breakpoint cluster region-Abelson (Bcr-Abl) kinase and overcomes clinically acquired mutation-induced resistance against imatinib.

Xiaoyun Lu, Zheng-chao Tu, Deping Wang, 2013, Journal of medicinal chemistry.

2-Aminopyrimidine Derivatives as New Selective Fibroblast Growth Factor Receptor 4 (FGFR4) Inhibitors.

Yong Xu, J. Smaill, Xiaoyun Lu, 2017, ACS medicinal chemistry letters.

Dihydrothiophene-condensed chromones from a marine-derived fungus Penicillium oxalicum and their structure-bioactivity relationship.

Jie Bao, Zheng-chao Tu, S. Qi, 2014, Bioorganic & Medicinal Chemistry Letters.

Dihydrothiophene-Condensed Chromones from a Marine-Derived Fungus Penicillium oxalicum and Their Structure—Bioactivity Relationship.

Jie Bao, Zheng-chao Tu, S. Qi, 2014 .

Anti-Inflammatory Polyketide Derivatives from the Sponge-Derived Fungus Pestalotiopsis sp. SWMU-WZ04-2

Hong Niu, Liping Zhang, H. Lei, 2022, Marine drugs.

Compounds from Polyphaga plancyi and their inhibitory activities against JAK3 and DDR1 kinases.

Zheng-chao Tu, Rui Liang, Jinfeng Luo, 2016, Fitoterapia.

Design and Optimization of 3'-(Imidazo[1,2-a]pyrazin-3-yl)-[1,1'-biphenyl]-3-carboxamides as Selective DDR1 Inhibitors.

Yong Xu, Xiaoyun Lu, Zheng-chao Tu, 2020, ACS medicinal chemistry letters.

Discovery and optimization of 3-(2-(Pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as novel selective and orally bioavailable discoidin domain receptor 1 (DDR1) inhibitors.

Ke Ding, Zhang Zhang, Yan Zhang, 2013, Journal of medicinal chemistry.

Novel conjugates of endoperoxide and 4-anilinoquinazoline as potential anticancer agents.

X. Mao, Chongzhao Ran, Zheng-chao Tu, 2017, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological evaluation of 2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidinyl derivatives as new irreversible epidermal growth factor receptor inhibitors with improved pharmacokinetic properties.

Ke Ding, Zhang Zhang, Xiaoyun Lu, 2013, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of novel highly selective polo-like kinase 2 inhibitors based on the tetrahydropteridin chemical scaffold.

Yang Yang, Xuan Xiao, Chenzhong Liao, 2018, European journal of medicinal chemistry.

2-Amino-2,3-dihydro-1H-indene-5-carboxamide-Based Discoidin Domain Receptor 1 (DDR1) Inhibitors: Design, Synthesis, and in Vivo Antipancreatic Cancer Efficacy

A. Bullock, R. Brekken, Xiaoyun Lu, 2019, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of new molecules inhibiting epidermal growth factor receptor threonine790→ methionine790 mutant

Yong Xu, Xiaoyun Lu, Zheng-chao Tu, 2012 .

Structure-Based Design of Tetrahydroisoquinoline-7-carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors

Yong Xu, A. Bullock, L. Yao, 2016, Journal of medicinal chemistry.

2-Oxo-3, 4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors.

Yong Xu, J. Smaill, Xiaoyun Lu, 2017, European journal of medicinal chemistry.

Pyrido[2, 3-d]pyrimidin-7(8H)-ones as new selective orally bioavailable Threonine Tyrosine Kinase (TTK) inhibitors.

Yong Xu, Xiaoyun Lu, Zheng-chao Tu, 2020, European journal of medicinal chemistry.

C5-substituted pyrido[2,3-d]pyrimidin-7-ones as highly specific kinase inhibitors targeting the clinical resistance-related EGFRT790M mutant

Lei-Ping Yu, Jian Ding, Lin-jiang Tong, 2015 .

EpCAM aptamer-functionalized polydopamine-coated mesoporous silica nanoparticles loaded with DM1 for targeted therapy in colorectal cancer

Lisheng He, Kai Ling, Hao Huang, 2017, International journal of nanomedicine.

Rational design, synthesis and biological evaluation of ubiquinone derivatives as IDO1 inhibitors

Zheng-chao Tu, Zhen Wang, Jinfeng Luo, 2019, Bioorganic Chemistry.

4-Oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as New Axl Kinase Inhibitors.

Zheng-chao Tu, Zhengqiu Li, Ke Ding, 2016, Journal of medicinal chemistry.

Structure Based Design of N-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)benzenesulfonamides as Selective Leucine-Zipper and Sterile-α Motif Kinase (ZAK) Inhibitors.

Yan Zhang, Yong Xu, Chih-Yang Huang, 2017, Journal of medicinal chemistry.

Inhibition of ELF3 confers synthetic lethality of PARP inhibitor in non-small cell lung cancer

Yan Wang, Min Zuo, Hongtao Jin, 2020, Journal of receptor and signal transduction research.

Design, Synthesis, and Biological Evaluation of 3-(Imidazo[1,2-a]pyrazin-3-ylethynyl)-4-isopropyl-N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as a Dual Inhibitor of Discoidin Domain Receptors 1 and 2

A. Bullock, R. Brekken, Tingting Xu, 2018, Journal of medicinal chemistry.

Tetrahydroisoquinoline-7-carboxamide Derivatives as New Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors.

A. Bullock, R. Brekken, Xiaoyun Lu, 2017, ACS medicinal chemistry letters.

YL143, a novel mutant selective irreversible EGFR inhibitor, overcomes EGFRL858R, T790M‐mutant resistance in vitro and in vivo

Xiaoyun Lu, Zheng-chao Tu, Liyan Song, 2018, Cancer medicine.

Reducing the cytotoxicity while improving the anti-cancer activity of silver nanoparticles through α-tocopherol succinate modification

Guansong Hu, Zheng-chao Tu, X. Qiao, 2015 .

Design, Synthesis, and Structure-Activity Relationships of 1,2,3-Triazole Benzenesulfonamides as New Selective Leucine-Zipper and Sterile-α Motif Kinase (ZAK) Inhibitors.

Chih-Yang Huang, M. Shibu, C. Yun, 2019, Journal of medicinal chemistry.

GZD2202, a novel TrkB inhibitor, suppresses BDNF-mediated proliferation and metastasis in neuroblastoma models

Xiaoyun Lu, Zheng-chao Tu, Zhen Wang, 2018, Journal of drug targeting.

GZD824 as a FLT3, FGFR1 and PDGFRα Inhibitor Against Leukemia In Vitro and In Vivo

Zheng-chao Tu, Ke Ding, Zhang Zhang, 2020, Translational oncology.

Structure Based Design of N-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)benzenesulfonamides as Selective Leucine-Zipper and Sterile-α Motif Kinase (ZAK) Inhibitors.

Yan Zhang, Yong Xu, Chih-Yang Huang, 2017, Journal of medicinal chemistry.

Quinolone antibiotic derivatives as new selective Axl kinase inhibitors.

Xiaoyun Lu, Zheng-chao Tu, Ke Ding, 2019, European journal of medicinal chemistry.