M. Ohta

发表

Synthesis and structure-activity relationship of 4-amino-2-phenylpyrimidine derivatives as a series of novel GPR119 agonists.

K. Negoro, M. Takeuchi, S. Yoshida, 2012, Bioorganic & medicinal chemistry.

Identification of 4-benzylamino-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxamide derivatives as potent and orally bioavailable STAT6 inhibitors.

Hiroyuki Moritomo, S. Kuromitsu, M. Orita, 2008, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of pyrido[3′,2′:4,5]furo[3,2- d ]pyrimidine derivatives as novel PI3 kinase p110α inhibitors

M. Waterfield, P. Workman, P. Parker, 2007 .

Synthesis and pharmacological evaluation of bis-3-(3,4-dichlorophenyl)acrylamide derivatives as glycogen phosphorylase inhibitors.

K. Onda, K. Momose, M. Orita, 2008, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of imidazo[1,2-a]pyridine derivatives as novel PI3 kinase p110alpha inhibitors.

M. Waterfield, P. Workman, P. Parker, 2007, Bioorganic & medicinal chemistry.

Design and synthesis of 6-fluoro-2-naphthyl derivatives as novel CCR3 antagonists with reduced CYP2D6 inhibition.

M. Takeuchi, Keiko Suzuki, M. Ohta, 2008, Bioorganic & medicinal chemistry.

Discovery of novel acetanilide derivatives as potent and selective beta3-adrenergic receptor agonists.

K. Onda, T. Matsui, T. Maruyama, 2009, European journal of medicinal chemistry.

Discovery of novel thiourea derivatives as potent and selective beta3-adrenergic receptor agonists.

K. Onda, Takayuki Suzuki, T. Matsui, 2009, Bioorganic & medicinal chemistry.

Design, synthesis, and pharmacological evaluation of N-bicyclo-5-chloro-1H-indole-2-carboxamide derivatives as potent glycogen phosphorylase inhibitors.

K. Onda, K. Momose, M. Orita, 2008, Bioorganic & medicinal chemistry.

Potent and orally bioavailable CCR4 antagonists: Synthesis and structure-activity relationship study of 2-aminoquinazolines.

M. Takeuchi, Y. Matsumoto, M. Ohta, 2009, Bioorganic & medicinal chemistry.

Discovery of novel and potent CRTH2 antagonists.

Tadashi Terasaka, M. Takeuchi, Y. Imamura, 2012, Bioorganic & medicinal chemistry letters.

Effects of YF476, a potent and selective gastrin/cholecystokinin-B receptor antagonist, on gastric acid secretion in beagle dogs with gastric fistula.

A. Nishida, S. Akuzawa, K. Miyata, 1998, Arzneimittel-Forschung.

(3R)-N-(1-(tert-Butylcarbonylmethyl)-2,3-dihydro-2-oxo-5-(2-pyridyl)- 1H-1,4-benzodiazepin-3-yl)-N′-(3(methylamino)phenyl)urea (YF476): A Potent and Orally Active Gastrin/CCK-B Antagonist.

A. Nishida, H. Ryder, S. Akuzawa, 1997 .

YF476 is a new potent and selective gastrin/cholecystokinin‐B receptor antagonist in vitro and in vivo

A. Nishida, S. Akuzawa, K. Miyata, 1997, Alimentary pharmacology & therapeutics.

(3R)-N-(1-(tert-butylcarbonylmethyl)-2,3-dihydro-2-oxo-5-(2-pyridyl)-1H-1,4-benzodiazepin-3-yl)-N'-(3-(methylamino)phenyl)urea (YF476): a potent and orally active gastrin/CCK-B antagonist.

A. Nishida, H. Ryder, S. Akuzawa, 1997, Journal of medicinal chemistry.

A SIMPLE SYNTHESIS OF 2,4-DIENALS FROM 1-TRIMETHYLSILYL-1,3-DIENES

Keiji. Yamamoto, M. Ohta, J. Tsuji, 1979 .

Identification of 4-quinolone derivatives as inhibitors of reactive oxygen species production from human umbilical vein endothelial cells.

K. Onda, K. Momose, H. Kayakiri, 2011, Bioorganic & medicinal chemistry letters.

Synthesis, biological evaluation, and metabolic stability of acrylamide derivatives as novel CCR3 antagonists.

K. Ohno, M. Takeuchi, Keiko Suzuki, 2009, Bioorganic & medicinal chemistry.

Synthesis and structure-activity relationships of N-{1-[(6-fluoro-2-naphthyl)methyl]piperidin-4-yl}benzamide derivatives as novel CCR3 antagonists.

M. Takeuchi, Keiko Suzuki, M. Ohta, 2008, Bioorganic & medicinal chemistry.

Discovery of potent CCR4 antagonists: Synthesis and structure-activity relationship study of 2,4-diaminoquinazolines.

M. Takeuchi, Y. Matsumoto, M. Ohta, 2008, Bioorganic & medicinal chemistry.

Discovery and structure-activity relationships of urea derivatives as potent and novel CCR3 antagonists.

M. Takeuchi, M. Ohta, T. Morokata, 2012, Bioorganic & medicinal chemistry letters.

Novel potent and selective Ca2+ release-activated Ca2+ (CRAC) channel inhibitors. Part 3: synthesis and CRAC channel inhibitory activity of 4'-[(trifluoromethyl)pyrazol-1-yl]carboxanilides.

M. Takeuchi, Yoji Miyazaki, Y. Yonetoku, 2008, Bioorganic & medicinal chemistry.

Orally available pyridinylpyrimidine derivatives as novel RANKL-induced osteoclastogenesis inhibitors.

M. Takeuchi, Toshihiro Watanabe, M. Ohkubo, 2012, Bioorganic & medicinal chemistry letters.

New thiazole derivatives as potent and selective 5-hydroxytriptamine 3 (5-HT3) receptor agonists for the treatment of constipation.

T. Mase, S. Akuzawa, M. Ohta, 2003, Bioorganic & medicinal chemistry.

Potent and selective TF/FVIIa inhibitors containing a neutral P1 ligand.

M. Okada, T. Niimi, M. Ohta, 2006, Bioorganic & medicinal chemistry.

Binding Modes of Two Novel Non-Nucleoside Reverse Transcriptase Inhibitors, YM-215389 and YM-228855, to HIV Type-1 Reverse Transcriptase

M. Matsuoka, H. Inoue, E. Kodama, 2008, Antiviral Chemistry & Chemotherapy.

Novel potent and selective calcium-release-activated calcium (CRAC) channel inhibitors. Part 2: Synthesis and inhibitory activity of aryl-3-trifluoromethylpyrazoles.

M. Takeuchi, Y. Yonetoku, M. Ohta, 2006, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110alpha inhibitors.

M. Waterfield, P. Workman, P. Parker, 2006, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2 -a]pyridines as novel PI3 kinase p110α inhibitors

M. Waterfield, P. Workman, P. Parker, 2007 .

Synthesis and biological evaluation of imidazo[1,2-a]pyridine derivatives as novel PI3 kinase p110α inhibitors

M. Waterfield, P. Workman, P. Parker, 2007 .

Synthesis and biological evaluation of pyrido[3',2':4,5]furo[3,2-d]pyrimidine derivatives as novel PI3 kinase p110alpha inhibitors.

M. Waterfield, P. Workman, P. Parker, 2007, Bioorganic & medicinal chemistry letters.

Discovery of 2-methyl-1-{1-[(5-methyl-1H-indol-2-yl)carbonyl]piperidin-4-yl}propan-2-ol: a novel, potent and selective type 5 17β-hydroxysteroid dehydrogenase inhibitor.

Kazushi Watanabe, Aya Kikuchi, M. Okada, 2013, Bioorganic & medicinal chemistry.

Discovery and biological evaluation of novel 4-amino-2-phenylpyrimidine derivatives as potent and orally active GPR119 agonists.

K. Negoro, M. Takeuchi, S. Yoshida, 2012, Bioorganic & medicinal chemistry.

Design, synthesis and biological activity of selective and orally available TF/FVIIa complex inhibitors containing non-amidine P1 ligands.

M. Okada, T. Niimi, M. Ohta, 2007, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110alpha inhibitors.

M. Waterfield, P. Workman, P. Parker, 2006, Bioorganic & medicinal chemistry.

Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivatives.

Masaya Orita, Atsushi Ichikawa, Ryo Naito, 2005, Bioorganic & medicinal chemistry.

One‐Pot Preparation of Unsymmetrical Biaryls via Suzuki Cross‐Coupling Reaction of Aryl Halide using Phase‐Transfer Catalyst in a Biphasic Solvent System

M. Okada, M. Ohta, S. Tsukamoto, 2007 .

Studies of non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 2: synthesis and structure-activity relationships of 2-cyano and 2-hydroxy thiazolidenebenzenesulfonamide derivatives.

M. Matsuoka, M. Baba, H. Inoue, 2005, Bioorganic & medicinal chemistry.

Synthesis and evaluation of 2-{[2-(4-hydroxyphenyl)-ethyl]amino}pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors.

S. Kuromitsu, M. Takeuchi, M. Ohta, 2007, Bioorganic & medicinal chemistry.

A new method for the preparation of allylstannanes containing functional groups

Y. Ueno, M. Ohta, M. Okawara, 1980 .

β-Stannylpropionaldehyde. A versatile cyclopropane building-block

Y. Ueno, M. Ohta, M. Okawara, 1982 .

Regioselective Alkylation of Thiazolylsulfonamides: Direct and Efficient Synthesis of 3‐Alkylthiazolidene Derivatives

T. Kontani, Ayako Moritomo, M. Ohta, 2005 .

Identification, synthesis, and biological evaluation of 6-[(6R)-2-(4-fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one (AS1940477), a potent p38 MAP kinase inhibitor.

H. Yamazaki, K. Ohno, M. Takeuchi, 2012, Journal of medicinal chemistry.

Novel 5-hydroxytryptamine (5-HT3) receptor antagonists. I. Synthesis and structure-activity relationships of conformationally restricted fused imidazole derivatives.

T. Suzuki, T. Furuya, K. Miyata, 1996, Chemical & pharmaceutical bulletin.

An end-game strategy for construction of the G-H-I rings of penitrem D, A tremorgenic indole alkaloid

Amos B. Smith, J. W. Leahy, M. Ohta, 1993 .

Discovery of Ipragliflozin (ASP1941): a novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus.

Atsushi Noda, Hiroshi Tomiyama, M. Takeuchi, 2012, Bioorganic & medicinal chemistry.

Synthesis and pharmacological evaluation of 1-isopropyl-1,2,3,4-tetrahydroisoquinoline derivatives as novel antihypertensive agents.

M. Okada, M. Ohta, S. Tsukamoto, 2011, Chemical & pharmaceutical bulletin.

Studies of nonnucleoside HIV-1 reverse transcriptase inhibitors. Part 1: Design and synthesis of thiazolidenebenzenesulfonamides.

M. Matsuoka, M. Baba, H. Inoue, 2004, Bioorganic & medicinal chemistry.

Novel potent and selective calcium-release-activated calcium (CRAC) channel inhibitors. Part 1: synthesis and inhibitory activity of 5-(1-methyl-3-trifluoromethyl-1H-pyrazol-5-yl)-2-thiophenecarboxamides.

M. Takeuchi, Y. Yonetoku, M. Ohta, 2006, Bioorganic & medicinal chemistry.

Novel 5-hydroxytryptamine (5-HT3) receptor antagonists. II. Synthesis and structure-activity relationships of 4,5,6,7-tetrahydro-1H-benzimidazole derivatives.

T. Suzuki, T. Furuya, K. Miyata, 1996, Chemical & pharmaceutical bulletin.

Serotonin (5-HT)3 receptor blocking activities of YM060, a novel 4,5,6,7-tetrahydrobenzimidazole derivative, and its enantiomer in anesthetized rats.

A. Nishida, K. Miyata, R. Tsutsumi, 1991, The Journal of pharmacology and experimental therapeutics.

Pharmacologic profile of (R)-5-[(1-methyl-3-indolyl)carbonyl]-4,5,6,7-tetrahydro-1H- benzimidazole hydrochloride (YM060), a potent and selective 5-hydroxytryptamine3 receptor antagonist, and its enantiomer in the isolated tissue.

A. Nishida, K. Miyata, R. Tsutsumi, 1991, The Journal of pharmacology and experimental therapeutics.

Novel 5-hydroxytryptamine (5-HT3) receptor antagonists. III. Pharmacological evaluations and molecular modeling studies of optically active 4,5,6,7-tetrahydro-1H-benzimidazole derivatives.

T. Suzuki, T. Furuya, K. Miyata, 1996, Chemical & pharmaceutical bulletin.

SYNTHESIS AND BIOLOGICAL ACTIVITY OF 1-ALKYLCARBONYLMETHYL ANALOGUES OF YM022

A. Nishida, H. Ryder, S. Akuzawa, 1996 .

Synthesis and biological activity of 5-heteroaryl benzodiazepines: analogues of YM022

A. Nishida, H. Ryder, S. Akuzawa, 1996 .

Synthesis and biological evaluation of C-glucosides with azulene rings as selective SGLT2 inhibitors for the treatment of type 2 diabetes mellitus: discovery of YM543.

Atsushi Noda, M. Takeuchi, Takayuki Suzuki, 2013, Bioorganic & medicinal chemistry.

Synthesis and pharmacological evaluation of 1-alkyl-N-[(1R)-1-(4-fluorophenyl)-2-methylpropyl]piperidine-4-carboxamide derivatives as novel antihypertensive agents.

M. Okada, M. Ohta, S. Tsukamoto, 2011, Chemical & pharmaceutical bulletin.

Synthesis and pharmacological evaluation of 2-(1-alkylpiperidin-4-yl)-n-[(1r)-1-(4-fluorophenyl)-2-methylpropyl]acetamide Derivatives as Novel Antihypertensive Agents.

M. Okada, M. Ohta, S. Tsukamoto, 2012, Chemical & pharmaceutical bulletin.

Synthesis and pharmacological evaluation of 1-alkyl-N-[2-ethyl-2-(4-fluorophenyl)butyl]piperidine-4-carboxamide derivatives as novel antihypertensive agents.

M. Okada, M. Ohta, S. Tsukamoto, 2011, Bioorganic & medicinal chemistry.

Novel 7H-pyrrolo[2,3-d]pyrimidine derivatives as potent and orally active STAT6 inhibitors.

S. Kuromitsu, K. Ohno, M. Orita, 2009, Bioorganic & medicinal chemistry.

G protein-activated inwardly rectifying K+ channel inhibition and rescue of weaver mouse motor functions by antidepressants

K. Ikeda, M. Ozaki, Yasukazu Ogai, 2006, Neuroscience Research.

Potent CCR4 antagonists: synthesis, evaluation, and docking study of 2,4-diaminoquinazolines.

M. Orita, M. Takeuchi, Y. Matsumoto, 2008, Bioorganic & medicinal chemistry.

Synthesis and evaluation of N-phenyl-(2-aminothiazol-4-yl)acetamides with phenoxypropanolamine moiety as selective β3-adrenergic receptor agonists.

K. Onda, Takayuki Suzuki, T. Matsui, 2012, Chemical & pharmaceutical bulletin.

Synthesis and evaluation of novel phenylethanolamine derivatives containing acetanilides as potent and selective beta3-adrenergic receptor agonists.

K. Onda, Takayuki Suzuki, T. Matsui, 2010, Chemical & pharmaceutical bulletin.

A FACILE LARGE SCALE SYNTHESIS OF OPTICALLY ACTIVE 3-AMINO-5-(2-PYRIDYL)-1,4-BENZODIAZEPIN-2-ONE DERIVATIVES

H. Ryder, M. Ohta, G. Semple, 1996 .

A Facile Large Scale Synthesis of Optically Active 3‐Amino‐5‐(2‐ pyridyl)‐1,4‐benzodiazepin‐2‐one Derivatives.

H. Ryder, M. Ohta, G. Semple, 1996 .

Synthesis of 5-chloro-N-aryl-1H-indole-2-carboxamide derivatives as inhibitors of human liver glycogen phosphorylase a.

K. Onda, K. Negoro, K. Momose, 2008, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors.

M. Waterfield, P. Workman, P. Parker, 2007, Bioorganic & medicinal chemistry.

New 1,4-benzodiazepin-2-one derivatives as gastrin/cholecystokinin-B antagonists.

A. Nishida, T. Mase, K. Murase, 1995, Chemical & pharmaceutical bulletin.

New 1,4‐Benzodiazepin‐2‐one Derivatives as Gastrin/Cholecystokinin‐B Antagonists.

A. Nishida, T. Mase, K. Murase, 1996 .

Novel 5-Hydroxytryptamine (5-HT3) Receptor Antagonists. Synthesis and Structure-Activity Relationships of 9-Methyl-2,3,4,9- tetrahydrothiopyrano(2,3-b)indol-4-one Derivatives.

K. Miyata, M. Ohta, Takeshi Suzuki, 1997 .

Novel 5-hydroxytryptamine (5-HT3) receptor antagonists. Synthesis and structure-activity relationships of 9-methyl-2,3,4,9-tetrahydrothiopyrano[2,3-b]indol-4-one derivatives.

T. Suzuki, K. Miyata, M. Ohta, 1997, Chemical & pharmaceutical bulletin.

SYNTHESIS OF NOVEL RESTRICTED DIAMINES; 2-(1-AMINOCYCLOALKAN-1-YL)ETHYLAMINES

T. Mase, H. Itahana, M. Ohta, 1998 .

Synthesis of Novel Restricted Diamines: 2-(1-Aminocycloalkan-1-yl)ethylamines.

T. Mase, H. Itahana, M. Ohta, 1998 .

Synthesis and structure-activity relationship of fused-pyrimidine derivatives as a series of novel GPR119 agonists.

K. Negoro, Kazuhiko Iikubo, M. Takeuchi, 2012, Bioorganic & medicinal chemistry.

Corrigendum to “Synthesis and structure–activity relationships of N-{1-[(6-fluoro-2-naphthyl)methyl]piperidin-4-yl}benzamide derivatives as novel CCR3 antagonists” [Bioorg. Med. Chem. 16 (2008) 144–156]

M. Takeuchi, Keiko Suzuki, M. Ohta, 2008 .