J. Leonard

发表

GPR119 agonists for the treatment of type 2 diabetes

Robert M. Jones, J. Leonard, D. Buzard, 2009, Expert opinion on therapeutic patents.

Chapter 7 The Emergence of GPR119 Agonists as Anti-Diabetic Agents

Robert M. Jones, J. Leonard, 2009 .

Discovery of a novel trans-1,4-dioxycyclohexane GPR119 agonist series.

S. H. Kim, Michael E. Morgan, Robert M. Jones, 2015, Bioorganic & medicinal chemistry letters.

Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists.

S. H. Kim, Michael E. Morgan, K. Whelan, 2014, Bioorganic & medicinal chemistry letters.

Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile.

F. Du, C. Sage, Albert S. Ren, 2012, Bioorganic & medicinal chemistry letters.

Alteration of the Glucagon Axis in GPR120 (FFAR4) Knockout Mice

D. Polidori, C. Briscoe, J. Leonard, 2014, The Journal of Biological Chemistry.

Targeting Enteropeptidase with Reversible Covalent Inhibitors To Achieve Metabolic Benefits

Jiejun Wu, M. Cummings, Xuqing Zhang, 2020, The Journal of Pharmacology and Experimental Therapeutics.

Design, synthesis and preclinical evaluation of bio-conjugated amylinomimetic peptides as long-acting amylin receptor agonists.

R. Patch, O. Libiger, S. Edavettal, 2022, European journal of medicinal chemistry.

Conjugation of a peptide to an antibody engineered with free cysteines dramatically improves half-life and activity

R. Patch, S. Edavettal, Wenyu Li, 2020, mAbs.

Discovery of an Isothiazole-Based Phenylpropanoic Acid GPR120 Agonist as a Development Candidate for Type 2 Diabetes.

Z. Sui, Xuqing Zhang, M. Macielag, 2017, ACS medicinal chemistry letters.

Design, synthesis and SAR of a novel series of heterocyclic phenylpropanoic acids as GPR120 agonists.

Z. Sui, Xuqing Zhang, W. Murray, 2017, Bioorganic & medicinal chemistry letters.

Amino acids are sensitive glucagon receptor‐specific biomarkers for glucagon‐like peptide‐1 receptor/glucagon receptor dual agonists

T. Kirchner, Songmao Zheng, Wenying Jian, 2020, Diabetes, obesity & metabolism.

Discovery of N-arylpyrroles as agonists of GPR120 for the treatment of type II diabetes.

Z. Sui, T. Koudriakova, W. Murray, 2018, Bioorganic & medicinal chemistry letters.

Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control.

C. Sage, B. Fioravanti, Albert S. Ren, 2011, Bioorganic & medicinal chemistry letters.

G protein-coupled receptors as therapeutic targets for obesity and type 2 diabetes.

C. Bjenning, W. Thomsen, D. Behan, 2004, Current opinion in investigational drugs.

Sex hormone-binding globulin receptor signal transduction proceeds via a G protein

W. Rosner, J. Leonard, D. Hryb, 1999, Steroids.

Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119.

William Thomsen, B. Fioravanti, Albert S. Ren, 2008, Journal of medicinal chemistry.

N-oleoyldopamine enhances glucose homeostasis through the activation of GPR119.

Robert M. Jones, D. Unett, D. Behan, 2010, Molecular endocrinology.

Discovery of a novel series of guanidinebenzoates as gut-restricted enteropeptidase and trypsin dual inhibitors for the treatment of metabolic syndrome.

M. Cummings, Xuqing Zhang, Weimei Sun, 2021, Bioorganic & Medicinal Chemistry Letters.

A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release.

Robert M. Jones, D. Behan, J. Leonard, 2008, Endocrinology.

CDP840. A prototype of a novel class of orally active anti-inflammatory phosphodiesterase 4 inhibitors.

R. Morphy, B. Mason, R. Allen, 2002, Bioorganic & medicinal chemistry letters.

A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release.

Didier Bagnol, Robert M. Jones, D. Unett, 2007, Endocrinology.

A Long-Acting PYY3-36 Analog Mediates Robust Anorectic Efficacy with Minimal Emesis in Nonhuman Primates.

M. Erion, R. Swanson, Rebecca R. Pick, 2019, Cell metabolism.

6-Benzhydryl-4-amino-quinolin-2-ones as Potent Cannabinoid Type 1 (CB1) Receptor Inverse Agonists and Chemical Modifications for Peripheral Selectivity.

R. DesJarlais, Shuyuan Zhao, M. Macielag, 2018, Journal of medicinal chemistry.

Amino acids are sensitive glucagon receptor‐specific biomarkers for glucagon‐like peptide‐1 receptor/glucagon receptor dual agonists

T. Kirchner, Songmao Zheng, Wenying Jian, 2020, Diabetes, obesity & metabolism.