M. Grumet

发表

Tenascin-C expression by angiogenic vessels in human astrocytomas and by human brain endothelial cells in vitro.

D. Zagzag, D. Friedlander, K. Dorovini-Zis, 1996, Cancer research.

Trauma-induced tumorigenesis of cells implanted into the rat spinal cord.

M. Grumet, Koichi Hasegawa, 2003, Journal of neurosurgery.

Cytotactin, an extracellular matrix protein of neural and non-neural tissues that mediates glia-neuron interaction.

G. Edelman, S. Hoffman, K. Crossin, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Site-restricted expression of cytotactin during development of the chicken embryo

G. Edelman, J. Thiery, S. Hoffman, 1986, The Journal of cell biology.

Critical and optimal Ig domains for promotion of neurite outgrowth by L1/Ng-CAM.

M. Schachner, D. Friedlander, J. Haspel, 2000, Journal of neurobiology.

The Role of the Ankyrin-Binding Protein NrCAM in Node of Ranvier Formation

P. Shrager, M. Grumet, T. Sakurai, 2003, The Journal of Neuroscience.

Cell adhesion and neurite outgrowth are promoted by neurofascin NF155 and inhibited by NF186

M. Grumet, Karthik Raju, D. Koticha, 2005, Molecular and Cellular Neuroscience.

Neurofascin interactions play a critical role in clustering sodium channels, ankyrin G and beta IV spectrin at peripheral nodes of Ranvier.

P. Maurel, J. Salzer, G. Zanazzi, 2006, Developmental biology.

A Glial Signal Consisting of Gliomedin and NrCAM Clusters Axonal Na+ Channels during the Formation of Nodes of Ranvier

S. Frechter, P. Brophy, E. Peles, 2010, Neuron.

Microtubules are critical for radial glial morphology: Possible regulation by MAPs and MARKs

R. Hart, Hedong Li, M. Grumet, 2003, Glia.

Interactions with tenascin and differential effects on cell adhesion of neurocan and phosphacan, two major chondroitin sulfate proteoglycans of nervous tissue.

R. U. Margolis, P. Milev, M. Bourdon, 1994, The Journal of biological chemistry.

Receptor tyrosine phosphatase beta is expressed in the form of proteoglycan and binds to the extracellular matrix protein tenascin.

J. Schlessinger, O. Silvennoinen, G. Barnea, 1994, The Journal of biological chemistry.

Structure and modulation of neural cell adhesion molecules in early and late embryogenesis.

G. Edelman, J. Thiery, C. Chuong, 1983, Cold Spring Harbor symposia on quantitative biology.

Structure of the chicken neuron-glia cell adhesion molecule, Ng-CAM: origin of the polypeptides and relation to the Ig superfamily

G. Edelman, V. Mauro, M. Grumet, 1991, The Journal of cell biology.

The L1CAM extracellular region: a multi-domain protein with modular and cooperative binding modes.

J. Haspel, M. Grumet, 2003, Frontiers in bioscience : a journal and virtual library.

Differential expression and functions of neuronal and glial neurofascin isoforms and splice variants during PNS development.

M. Grumet, Karthik Raju, D. Koticha, 2007, Developmental biology.

Single, high-dose intraspinal injection of chondroitinase reduces glycosaminoglycans in injured spinal cord and promotes corticospinal axonal regrowth after hemisection but not contusion.

W. Young, M. Grumet, T. Iseda, 2008, Journal of neurotrauma.

Trends in mesenchymal stem cell clinical trials 2004‐2018: Is efficacy optimal in a narrow dose range?

M. Grumet, Suneel Kumar, Maciej Kabat, 2019, Stem cells translational medicine.

Molecular Events Implicated in Brain Tumor Angiogenesis and Invasion

G. Semenza, B. Margolis, J. Simons, 2000, Pediatric Neurosurgery.

Small Molecule Activation of Adaptive Gene Expression

D. Geschwind, G. Semenza, G. Coppola, 2008, Annals of the New York Academy of Sciences.

Nitration of Hsp90 induces cell death

M. Beal, S. Barnes, M. Franco, 2013, Proceedings of the National Academy of Sciences.

Activated Notch1 maintains the phenotype of radial glial cells and promotes their adhesion to laminin by upregulating nidogen

Christopher L. Ricupero, K. Mohan, Hedong Li, 2008, Glia.

L1 mediated homophilic binding and neurite outgrowth are modulated by alternative splicing of exon 2.

J. Haspel, M. Grumet, Noriko Kane-Goldsmith, 2002, Journal of neurobiology.

Functional characterization of chondroitin sulfate proteoglycans of brain: interactions with neurons and neural cell adhesion molecules

R. U. Margolis, A. Flaccus, M. Grumet, 1993, The Journal of cell biology.

Migration of Brain Tumor Cells on Extracellular Matrix Proteins in Vitro Correlates with Tumor Type and Grade and Involves αv and β1 Integrins

Jeffrey C. Allen, D. Zagzag, D. Friedlander, 1996 .

Encapsulated mesenchymal stromal cells for in vivo transplantation

M. Yarmush, R. Schloss, S. Otsuka, 2011, Biotechnology and bioengineering.

Long-Term Maintenance of Na+ Channels at Nodes of Ranvier Depends on Glial Contact Mediated by Gliomedin and NrCAM

S. Frechter, E. Peles, A. Vainshtein, 2014, The Journal of Neuroscience.

Contactin-Associated Protein (Caspr) and Contactin Form a Complex That Is Targeted to the Paranodal Junctions during Myelination

E. Peles, J. Salzer, M. Grumet, 2000, The Journal of Neuroscience.

Overlapping functions of the cell adhesion molecules Nr-CAM and L1 in cerebellar granule cell development

Stephen A. Brown, P. Brophy, C. Mason, 2001, The Journal of cell biology.

Nr-CAM and neurofascin interactions regulate ankyrin G and sodium channel clustering at the node of Ranvier

J. Salzer, S. Levinson, G. Zanazzi, 2001, Current Biology.

Axonal cell-adhesion molecule L1 in CNS myelination.

M. Schachner, B. Zalc, C. Lubetzki, 2004, Neuron glia biology.

Cell adhesion molecules and their subgroups in the nervous system

M. Grumet, 1991, Current Opinion in Neurobiology.

Juvenile and adult olfactory ensheathing cells bundle and myelinate dorsal root ganglion axons in culture

W. Young, M. Grumet, J. Babiarz, 2011, Experimental Neurology.

A Role for Nr-CAM in the Patterning of Binocular Visual Pathways

T. Sakurai, C. Mason, D. Colman, 2006, Neuron.

Differential contributions of Ng-CAM and N-CAM to cell adhesion in different neural regions

G. Edelman, C. Chuong, D. Friedlander, 1986, The Journal of cell biology.

Potential risk of clonally expanded amnion mesenchymal stem cell transplants in contused spinal cords.

A. Marcus, D. Woodbury, M. Grumet, 2018, Restorative neurology and neuroscience.

Migration of brain tumor cells on extracellular matrix proteins in vitro correlates with tumor type and grade and involves alphaV and beta1 integrins.

D. Zagzag, D. Friedlander, H. Cohen, 1996, Cancer research.

Purification and characterization of an inhibitor protein with cytochalasin-like acitvity from bovine adrenal medulla

Shin Lin, M. Grumet, 1981 .

A platelet inhibitor protein with cytochalasin-like activity against actin polymerization in vitro

Shin Lin, M. Grumet, 1980, Cell.

Reversal of profilin inhibition of actin polymerization in vitro by erythrocyte cytochalasin-binding complexes and cross-linked actin nuclei.

M. Grumet, S. Lin, 1980, Biochemical and biophysical research communications.

Nr-CAM: A cell adhesion molecule with ligand and receptor functions

M. Grumet, 1997, Cell and Tissue Research.

Rapid induction of genes associated with tissue protection and neural development in contused adult spinal cord after radial glial cell transplantation.

L. Goff, W. Young, E. Tzatzalos, 2009, Journal of neurotrauma.

Polypeptide components and binding functions of neuron-glia cell adhesion molecules.

G. Edelman, C. Chuong, S. Hoffman, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Neuronal cell adhesion molecules and cytotactin are colocalized at the node of Ranvier

G. Edelman, J. K. Daniloff, F. Rieger, 1986, The Journal of cell biology.

Sizes and Sufficient Quantities of MSC Microspheres for Intrathecal Injection to Modulate Inflammation in Spinal Cord Injury.

M. Yarmush, R. Schloss, M. Grumet, 2015, Nano LIFE.

Functions of brain chondroitin sulfate proteoglycans during developments: interactions with adhesion molecules.

D. Friedlander, M. Grumet, T. Sakurai, 1996, Perspectives on developmental neurobiology.

Anti-Inflammatory Effects of Encapsulated Human Mesenchymal Stromal/Stem Cells and a Method to Scale-Up Cell Encapsulation

F. Berthiaume, M. Grumet, Suneel Kumar, 2022, Biomolecules.

Efficacy of MSC in Patients with Severe COVID-19: Analysis of the Literature and a Case Study

M. Grumet, J. Sherman, Barry S Dorf, 2022, Stem cells translational medicine.

J. Schlessinger, G. Barnea, R. U. Margolis, 1994, Cell.

Differential expression of the cell-adhesion molecule Nr-CAM in hyperplastic and neoplastic human pancreatic tissue.

D. Friedlander, J. Scholes, K. Dhodapkar, 2001, Human pathology.

Biochemical characterization and immunolocalization of SC2 protein: SC2 protein is indistinguishable from the cell adhesion molecule axonin-1.

T. Shiga, M. Grumet, H. Tanaka, 1994, Brain research. Developmental brain research.

Multi-ligand interactions with receptor-like protein tyrosine phosphatase beta: implications for intercellular signaling.

J. Schlessinger, E. Peles, J Schlessinger, 1998, Trends in biochemical sciences.

The carbonic anhydrase domain of receptor tyrosine phosphatase β is a functional ligand for the axonal cell recognition molecule contactin

J. Schlessinger, G. Barnea, E. Peles, 1995, Cell.

Nodes of Ranvier and axon initial segments are ankyrin G–dependent domains that assemble by distinct mechanisms

J. Salzer, M. Grumet, Isabel Lam, 2007, The Journal of cell biology.

The neuronal chondroitin sulfate proteoglycan neurocan binds to the neural cell adhesion molecules Ng-CAM/L1/NILE and N-CAM, and inhibits neuronal adhesion and neurite outgrowth

D. Friedlander, R. U. Margolis, P. Milev, 1994, The Journal of cell biology.

Isolation of a novel rat neural progenitor clone that expresses dlx family transcription factors and gives rise to functional gabaergic neurons in culture

J. Corradi, Christopher L. Ricupero, R. Hart, 2012, Developmental neurobiology.

N-CAM at the vertebrate neuromuscular junction

G. Edelman, F. Rieger, M. Grumet, 1985, The Journal of cell biology.

Cell adhesion molecule L1 in folded (horseshoe) and extended conformations.

H. Erickson, J. Haspel, M. Grumet, 2001, Molecular biology of the cell.

Signal transduction pathways implicated in neural recognition molecule L1 triggered neuroprotection and neuritogenesis

Melitta Schachner, Gabriele Loers, M. Schachner, 2005, Journal of neurochemistry.

F3/contactin and TAG1 play antagonistic roles in the regulation of sonic hedgehog-induced cerebellar granule neuron progenitor proliferation

G. Gennarini, A. Furley, M. Grumet, 2011, Development.

Interactions of the chondroitin sulfate proteoglycan phosphacan, the extracellular domain of a receptor-type protein tyrosine phosphatase, with neurons, glia, and neural cell adhesion molecules

D. Friedlander, R. U. Margolis, P. Milev, 1994, The Journal of cell biology.

Neuron-glia adhesion is inhibited by antibodies to neural determinants.

G. Edelman, U. Rutishauser, M. Grumet, 1983, Science.

Neural cell adhesion molecule is on embryonic muscle cells and mediates adhesion to nerve cells in vitro

G. Edelman, U. Rutishauser, M. Grumet, 1982, Nature.

Identification of a novel contactin‐associated transmembrane receptor with multiple domains implicated in protein–protein interactions

J. Schlessinger, E. Peles, G. Plowman, 1997, The EMBO journal.

Vascular Apoptosis and Involution in Gliomas Precede Neovascularization: A Novel Concept for Glioma Growth and Angiogenesis

R. Amirnovin, H. Yee, G. Yancopoulos, 2000, Laboratory Investigation.

Soluble cell adhesion molecule L1-Fc promotes locomotor recovery in rats after spinal cord injury.

W. Young, M. Schachner, D. Friedlander, 2003, Journal of neurotrauma.

Microfibrous substrate geometry as a critical trigger for organization, self‐renewal, and differentiation of human embryonic stem cells within synthetic 3‐dimensional microenvironments

P. Moghe, J. Kohn, Joseph J. Kim, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A cis-element in the Notch1 locus is involved in the regulation of gene expression in interneuron progenitors.

Y. Li, E. Tzatzalos, L. Cai, 2012, Developmental Biology.

Ventral midline cells are required for the local control of commissural axon guidance in the mouse spinal cord.

A. Joyner, M. Matise, M. Grumet, 1999, Development.

Tenascin-C expression in the cyst wall and fluid of human brain tumors correlates with angiogenesis.

P. Kelly, J. Wisoff, D. Zagzag, 1997, Neurosurgery.

Promoter Methylation Analysis on Micro-dissected Paraffin-Embedded Tissues Using Bisulfite Treatment and PCR-SSCP

J. Haspel, M. Grumet, Cy Blanco, 2001 .

Neuronal cell adhesion molecule deletion induces a cognitive and behavioral phenotype reflective of impulsivity

D. Townsend, M. Grumet, H. Grossman, 2008, Genes, brain, and behavior.

Cytochalasins inhibit nuclei-induced actin polymerization by blocking filament elongation

D. C. Lin, M. Grumet, S. Lin, 1980, The Journal of cell biology.

Heterotypic binding between neuronal membrane vesicles and glial cells is mediated by a specific cell adhesion molecule

G. Edelman, M. Grumet, 1984, The Journal of cell biology.

Receptor tyrosine phosphatase R-PTP-kappa mediates homophilic binding

J. Schlessinger, D. Friedlander, J. Sap, 1994, Molecular and cellular biology.

Expression of polypeptide variants of receptor‐type protein tyrosine phosphatase β: The secreted form, phosphacan, increases dramatically during embryonic development and modulates glial cell behavior in vitro

D. Friedlander, M. Grumet, T. Sakurai, 1996, Journal of neuroscience research.

Radial Glial Cell Line C6-R Integrates Preferentially in Adult White Matter and Facilitates Migration of Coimplanted Neurons in Vivo

G. Fishell, I. Fischer, D. Friedlander, 2001, Experimental Neurology.

Initial appearance and regional distribution of the neuron-glia cell adhesion molecule in the chick embryo

G. Edelman, J. Thiery, M. Grumet, 1985, The Journal of cell biology.

Tenascin expression in astrocytomas correlates with angiogenesis.

D. Miller, D. Zagzag, D. Friedlander, 1995, Cancer research.

Receptor Tyrosine Phosphatase f3 Is Expressed in the Form of Proteoglycan and Binds to the

O. Silvennoinen, G. Barnea, J. Sap, 1994 .

NrCAM‐regulating neural systems and addiction‐related behaviors

G. Uhl, T. Sakurai, T. Arinami, 2014, Addiction biology.

NrCAM in Addiction Vulnerability: Positional Cloning, Drug-Regulation, Haplotype-Specific Expression, and Altered Drug Reward in Knockout Mice

G. Uhl, Qing-Rong Liu, M. Morales, 2006, Neuropsychopharmacology.

Structure of a new nervous system glycoprotein, Nr-CAM, and its relationship to subgroups of neural cell adhesion molecules

G. Edelman, V. Mauro, M. Grumet, 1991, The Journal of cell biology.

Functional differentiation of a clone resembling embryonic cortical interneuron progenitors

L. Goff, Christopher L. Ricupero, R. Hart, 2008, Developmental neurobiology.

Neuron-glia cell adhesion molecule interacts with neurons and astroglia via different binding mechanisms

G. Edelman, M. Grumet, M. Grumet, 1988, The Journal of cell biology.

Reduced tumorigenicity of rat glioma cells in the brain when mediated by hygromycin phosphotransferase.

D. Zagzag, D. Friedlander, A. Hormigo, 2001, Journal of neurosurgery.

In Situ Expression of Angiopoietins in Astrocytomas Identifies Angiopoietin-2 as an Early Marker of Tumor Angiogenesis

G. Yancopoulos, D. Zagzag, S. Wiegand, 1999, Experimental Neurology.

E-cadherin-expressing feeder cells promote neural lineage restriction of human embryonic stem cells.

P. Moghe, M. Grumet, Jocie F Cherry, 2012, Stem cells and development.

Evidence for the binding of Ng-CAM to laminin.

G. Edelman, D. Friedlander, M. Grumet, 1993, Cell adhesion and communication.

Structure, expression, and function of, Ng‐CAM a member of the immunoglobulin superfamily involved in neuron‐neuron and neuron‐glia adhesion

M. Grumet, 1992, Journal of neuroscience research.

Two antigenically related neuronal cell adhesion molecules of different specificities mediate neuron-neuron and neuron-glia adhesion.

G. Edelman, S. Hoffman, M. Grumet, 1984, Proceedings of the National Academy of Sciences of the United States of America.

NrCAM Deletion Causes Topographic Mistargeting of Thalamocortical Axons to the Visual Cortex and Disrupts Visual Acuity

B. Philpot, G. Demyanenko, P. Maness, 2011, The Journal of Neuroscience.

Altered expression of neuronal cell adhesion molecules induced by nerve injury and repair

G. Edelman, G. Levi, J. K. Daniloff, 1986, The Journal of cell biology.

Induction of Neurite Outgrowth through Contactin and Nr-CAM by Extracellular Regions of Glial Receptor Tyrosine Phosphatase β

J. Schlessinger, E. Peles, M. Grumet, 1997, The Journal of cell biology.

Spatiotemporal heterogeneity of CNS radial glial cells and their transition to restricted precursors.

Hedong Li, M. Grumet, J. Babiarz, 2004, Developmental biology.

America's Health Care Crisis: An Overview from the Trenches

M. Grumet, 1991 .

Nr‐CAM expression in the developing mouse nervous system: Ventral midline structures, specific fiber tracts, and neuropilar regions

M. Grumet, L. Erskine, T. Sakurai, 2001, The Journal of comparative neurology.

Dual Functional Activity of Semaphorin 3B Is Required for Positioning the Anterior Commissure

J. Sanes, G. Rougon, A. Püschel, 2005, Neuron.

Nerve growth factor enhances expression of neuron-glia cell adhesion molecule in PC12 cells

G. Edelman, D. Friedlander, M. Grumet, 1986, The Journal of cell biology.

Embryonic radial glia bridge spinal cord lesions and promote functional recovery following spinal cord injury

Hedong Li, M. Grumet, Koichi Hasegawa, 2005, Experimental Neurology.

In vitro analysis of mechanisms underlying age‐dependent failure of axon regeneration

D. Sanes, M. Grumet, A. Hafidi, 2004, The Journal of comparative neurology.

Dual Functional Activity of Semaphorin 3B Is Required for Positioning the Anterior Commissure

J. Sanes, G. Rougon, A. Püschel, 2005, Neuron.

Neural cell adhesion molecule mediates initial interactions between spinal cord neurons and muscle cells in culture

G. Edelman, U. Rutishauser, M. Grumet, 1983, The Journal of cell biology.

Neural Cell Adhesion Between Spinal Cord Molecule Mediates Initial Interactions Neurons and Muscle Cells in Culture

G. Edelman, U. Rutishauser, M. Grumet, 2002 .

Nr-CAM promotes neurite outgrowth from peripheral ganglia by a mechanism involving axonin-1 as a neuronal receptor.

M. Grumet, T. Sakurai, M. Lustig, 1999, Developmental biology.

Neuron-glia cell adhesion molecule (Ng-CAM) expression in the chick embryo spinal cord: observations on the earliest developing intersegmental interneurons.

G. Edelman, R. Oppenheim, T. Shiga, 1990, Brain research. Developmental brain research.

BMP and LIF signaling coordinately regulate lineage restriction of radial glia in the developing forebrain

Hedong Li, M. Grumet, 2007, Glia.

System for cleavable Fc fusion proteins using tobacco etch virus (TEV) protease.

J. Haspel, M. Grumet, J. Jacob, 2001, BioTechniques.

ABBA regulates plasma-membrane and actin dynamics to promote radial glia extension

Pekka Lappalainen, Pieta K. Mattila, P. Mattila, 2008, Journal of Cell Science.

Cell adhesion molecules regulate guidance of dorsal root ganglion axons in the marginal zone and their invasion into the mantle layer of embryonic spinal cord.

T. Shiga, M. Grumet, M. Lustig, 1997, Developmental biology.

Generation of a radial-like glial cell line.

G. Fishell, D. Friedlander, M. Grumet, 1998, Journal of neurobiology.

Nr-CAM and TAG-1 are expressed in distinct populations of developing precerebellar and cerebellar neurons

C. Sotelo, E. Bloch-Gallego, M. Grumet, 2002, Neuroscience.

Dose response evaluation of adriamycin in human neoplasia

B. Hoogstraten, L. Baker, S. Salmon, 1977, Cancer.

Transcriptional Regulation of Notch1 Expression by Nkx6.1 in Neural Stem/Progenitor Cells during Ventral Spinal Cord Development

Y. Li, E. Tzatzalos, Kelvin Y. Kwan, 2016, Scientific Reports.

Cover Page Final Narrative Report

M. Grumet, 2022 .

Disulfide‐mediated dimerization of L1 Ig domains

H. Erickson, J. Haspel, M. Grumet, 2001, Journal of neuroscience research.

Purification of Ig-fusion proteins from medium containing Ig.

M. Grumet, C. Roonprapunt, T. Sakurai, 1998, BioTechniques.

Delayed intrathecal delivery of RhoA siRNA to the contused spinal cord inhibits allodynia, preserves white matter, and increases serotonergic fiber growth.

E. Feinstein, H. Kalinski, S. Otsuka, 2011, Journal of neurotrauma.

Proteins and complexes that affect actin-filament assembly and interactions.

J. Wilkins, D. C. Lin, M. Grumet, 1982, Cold Spring Harbor symposia on quantitative biology.

Regions of the human neurokinin A receptor involved in the generation of second messengers and in receptor desensitization.

J. Gardner, R. Kris, V. Chu, 1994, Biochemical and biophysical research communications.

Heterotypic binding between neuronal membrane vesicles and glial cells is mediated by a specific cell adhesion molecule

G. Edelman, M. Grumet, 1984, The Journal of cell biology.

Microscale plasma-initiated patterning of electrospun polymer scaffolds.

Christopher L. Ricupero, S. Meiners, K. Uhrich, 2011, Colloids and surfaces. B, Biointerfaces.

The neuronal chondroitin sulfate proteoglycan neurocan binds to the neural cell adhesion molecules Ng-CAM/L1/NILE and N-CAM, and inhibits neuronal adhesion and neurite outgrowth

D. Friedlander, R. U. Margolis, P. Milev, 1994, The Journal of cell biology.

Two antigenically related neuronal cell adhesion molecules of different specificities mediate neuron-neuron and neuron-glia adhesion.

G. Edelman, S. Hoffman, M. Grumet, 1984, Proceedings of the National Academy of Sciences of the United States of America.

ABBA regulates plasma-membrane and actin dynamics to promote radial glia extension

P. Mattila, M. Salminen, P. Lappalainen, 2008, Journal of Cell Science.

Small Molecule Activation of Adaptive Gene Expression

D. Geschwind, G. Semenza, G. Coppola, 2008, Annals of the New York Academy of Sciences.

Differential expression of neuron‐glia cell adhesion molecule (Ng‐CAM) on developing axons and growth cones of interneurons in the chick embryo spinal cord: An immunoelectron microscopic study

G. Edelman, R. Oppenheim, M. Grumet, 1993, The Journal of comparative neurology.

Heterophilic interactions of the neural cell adhesion molecules Ng-CAM and Nr-CAM with neural receptors and extracellular matrix proteins

M. Grumet, T. Sakurai, 1996 .

Nodes of Ranvier and axon initial segments are ankyrin G–dependent domains that assemble by distinct mechanisms

J. Salzer, M. Grumet, Isabel Lam, 2007, The Journal of cell biology.