John C W Randell

Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7.

S. Bell, C. Chan, K. Galani, 2010, Molecular cell.

Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase.

S. Bell, J. Randell, Jayson L Bowers, 2006, Molecular cell.

ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication.

S. Bell, Shuyan Chen, J. Randell, 2004, Molecular cell.

Incorporation into the prereplicative complex activates the Mcm2-7 helicase for Cdc7-Dbf4 phosphorylation.

S. Bell, Thomas J. Takara, J. Randell, 2009, Genes & development.