Anthony A. Estrada

发表

Effect of selective LRRK2 kinase inhibition on nonhuman primate lung

Paula Katavolos, Brian K. Fiske, Reina N. Fuji, 2015, Science Translational Medicine.

Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.

K. Scearce-Levie, A. Beresford, A. Medhurst, 2012, Journal of medicinal chemistry.

LRRK2 Kinase Activity Regulates Parkinson’s Disease-Relevant Lipids at the Lysosome

Nicholas E. Propson, Michelle L. Reyzer, R. Maciuca, 2022, bioRxiv.

Total synthesis of thiostrepton. Retrosynthetic analysis and construction of key building blocks.

Sang Hyup Lee, K C Nicolaou, Mark Zak, 2005, Journal of the American Chemical Society.

Construction of substituted N-hydroxyindoles: synthesis of a nocathiacin I model system.

K. Nicolaou, M. Zak, Anthony A. Estrada, 2005, Angewandte Chemie.

Recent advances in the chemistry and biology of naturally occurring antibiotics.

K. Nicolaou, Jason S. Chen, Anthony A. Estrada, 2009, Angewandte Chemie.

New synthetic technology for the construction of N-hydroxyindoles and synthesis of nocathiacin I model systems.

K. Nicolaou, Anthony A. Estrada, Sang Hyup Lee, 2007, Tetrahedron.

Synthesis of highly substituted N-hydroxyindoles through 1,5-addition of carbon nucleophiles to in situ generated unsaturated nitrones.

K. Nicolaou, Anthony A. Estrada, Sang Hyup Lee, 2006, Angewandte Chemie.

Total synthesis of thiostrepton, part 2: construction of the quinaldic acid macrocycle and final stages of the synthesis.

K. Nicolaou, M. Zak, Anthony A. Estrada, 2004, Angewandte Chemie.

Total synthesis of thiostrepton, part 1: construction of the dehydropiperidine/thiazoline-containing macrocycle.

K. Nicolaou, M. Zak, Anthony A. Estrada, 2004, Angewandte Chemie.

Total synthesis of thiostrepton. Assembly of key building blocks and completion of the synthesis.

K. Nicolaou, M. Zak, Anthony A Estrada, 2005, Journal of the American Chemical Society.

Discovery of a biologically active thiostrepton fragment.

M. Ghadiri, K. Nicolaou, P. Giannakakou, 2005, Journal of the American Chemical Society.

A mild and selective method for the hydrolysis of esters with trimethyltin hydroxide.

K. Nicolaou, M. Zak, Anthony A Estrada, 2005, Angewandte Chemie.

Minisci alkylations of electron-deficient pyrimidines with alkyl carboxylic acids

J. Lyssikatos, Anthony A. Estrada, D. Shore, 2015 .

Access to Saturated Fused PyrimidineDerivatives via a Flexible N-Vinyl TertiaryEnamide Synthesis

J. Lyssikatos, Anthony A. Estrada, Philippe Bergeron, 2011 .

Mild and General One-Pot Reductionand Cyclization of Aromatic and Heteroaromatic 2-Nitroaminesto Bicyclic 2H-Imidazoles

J. Lyssikatos, B. Chan, Anthony A. Estrada, 2010 .

New Synthetic Technology for the Construction of N‐Hydroxyindoles and Synthesis of Nocathiacin I Model Systems.

K. Nicolaou, Anthony A. Estrada, Sang Hyup Lee, 2007 .

Construction of substituted N-hydroxyindoles: synthesis of a nocathiacin I model system.

K. Nicolaou, M. Zak, Anthony A. Estrada, 2005, Angewandte Chemie.

Synthesis of Highly Substituted N‐Hydroxyindoles Through 1,5‐Addition of Carbon Nucleophiles to in situ Generated Unsaturated Nitrones.

K. Nicolaou, Anthony A. Estrada, Sang Hyup Lee, 2006 .

Total Synthesis of Thiostrepton. Part 1. Construction of the Dehydropiperidine/Thiazoline-Containing Macrocycle.

K. Nicolaou, M. Zak, Anthony A. Estrada, 2004 .

Total synthesis of thiostrepton, part 2: construction of the quinaldic acid macrocycle and final stages of the synthesis.

K. Nicolaou, M. Zak, Anthony A. Estrada, 2004, Angewandte Chemie.

Function and Physiology Lysosomal Storage Disease: Revealing Lysosomal

Sean P. Dougherty, M. Yaylaoglu, L. Honigberg, 2015 .

Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson’s disease

Nicholas E. Propson, R. Maciuca, K. Scearce-Levie, 2022, Science Translational Medicine.

Discovery of potent azaindazole leucine-rich repeat kinase 2 (LRRK2) inhibitors possessing a key intramolecular hydrogen bond - Part 2.

A. Beresford, A. Medhurst, Xingrong Liu, 2019, Bioorganic & medicinal chemistry letters.

Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.

K. Scearce-Levie, A. Beresford, A. Medhurst, 2014, Journal of medicinal chemistry.

From Human Genetics to Drug Candidates: An Industrial Perspective on LRRK2 Inhibition as a Treatment for Parkinson's Disease

Haitao Zhu, Huifen Chen, Z. Sweeney, 2013 .

Discovery of a Highly Selective, Brain-Penetrant Aminopyrazole LRRK2 Inhibitor.

K. Scearce-Levie, A. Beresford, A. Medhurst, 2013, ACS medicinal chemistry letters.

Ser1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations

K. Scearce-Levie, M. P. van der Brug, Xingrong Liu, 2012, Science Translational Medicine.

Discovery of selective LRRK2 inhibitors guided by computational analysis and molecular modeling.

Jason Drummond, Xingrong Liu, Yichin Liu, 2012, Journal of medicinal chemistry.

Pyrimidoaminotropanes as potent, selective, and efficacious small molecule kinase inhibitors of the mammalian target of rapamycin (mTOR).

S. Sideris, L. Friedman, S. Malek, 2013, Journal of medicinal chemistry.

Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349.

M. Belvin, C. Ly, S. Sideris, 2013, ACS medicinal chemistry letters.

Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models.

K. Scearce-Levie, K. Stark, C. Ly, 2015, Journal of medicinal chemistry.

Chemical Biology of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors.

Anthony A Estrada, Zachary K Sweeney, Z. Sweeney, 2015, Journal of medicinal chemistry.

Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease.

Jianping Yin, Xingrong Liu, J. Lyssikatos, 2017, Journal of medicinal chemistry.

Targeting Transferrin Receptor to Transport Antisense Oligonucleotides Across the Blood-Brain Barrier

K. Gadkar, T. Sandmann, C. Koth, 2023, bioRxiv.

Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling.

C. Brotherton-Pleiss, M. Volgraf, Jun Chen, 2018, Journal of medicinal chemistry.

α-Aryl pyrrolidine sulfonamides as TRPA1 antagonists.

Jun Chen, D. Hackos, J. Lyssikatos, 2016, Bioorganic & medicinal chemistry letters.

LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits

Matthew L. Maddess, A. Stepan, T. Sherer, 2020, Science Translational Medicine.

LRRK2 kinase inhibitors induce a reversible effect in the lungs of non-human primates with no measurable pulmonary deficits

Matthew L. Maddess, A. Stepan, T. Sherer, 2018, bioRxiv.

Total synthesis of thiostrepton, part 2: construction of the quinaldic acid macrocycle and final stages of the synthesis.

K. Nicolaou, M. Zak, Anthony A. Estrada, 2004, Angewandte Chemie.