E. LeCluyse

发表

Development of an in vitro high content imaging assay for quantitative assessment of CAR-dependent mouse, rat, and human primary hepatocyte proliferation.

M. Andersen, O. J. Trask, D. Cowie, 2016, Toxicology in vitro : an international journal published in association with BIBRA.

Biliary excretion in primary rat hepatocytes cultured in a collagen-sandwich configuration.

Bruno Stieger, John J Lemasters, Kim L R Brouwer, 1999, American journal of physiology. Gastrointestinal and liver physiology.

Leading-Edge Approaches for In Vitro Hepatotoxicity Evaluation

M. Cross, C. Goldring, A. Roth, 2014 .

Avasimibe Induces CYP3A4 and Multiple Drug Resistance Protein 1 Gene Expression through Activation of the Pregnane X Receptor

J. Sahi, Hongbing Wang, M. Milad, 2003, Journal of Pharmacology and Experimental Therapeutics.

The effect of cyclophosphamide with and without dexamethasone on cytochrome P450 3A4 and 2B6 in human hepatocytes.

Hongbing Wang, G. Hamilton, C. Lindley, 2002, Drug metabolism and disposition: the biological fate of chemicals.

Antiplatelet Agents Aspirin and Clopidogrel Are Hydrolyzed by Distinct Carboxylesterases, and Clopidogrel Is Transesterificated in the Presence of Ethyl Alcohol

Jian Yang, B. Yan, E. LeCluyse, 2006, Journal of Pharmacology and Experimental Therapeutics.

Anti-Influenza Prodrug Oseltamivir Is Activated by Carboxylesterase Human Carboxylesterase 1, and the Activation Is Inhibited by Antiplatelet Agent Clopidogrel

F. Akhlaghi, Jian Yang, B. Yan, 2006, Journal of Pharmacology and Experimental Therapeutics.

Response to Comments on “Anti-Influenza Prodrug Oseltamivir Is Activated by Carboxylesterase Human Carboxylesterase 1, and the Activation Is Inhibited by Antiplatelet Agent Clopidogrel”

F. Akhlaghi, Jian Yang, B. Yan, 2007, Journal of Pharmacology and Experimental Therapeutics.

Dodecylphosphocholine-mediated enhancement of paracellular permeability and cytotoxicity in Caco-2 cell monolayers.

D. Thakker, E. LeCluyse, D. Z. Liu, 1999, Journal of pharmaceutical sciences.

In vitro and in vivo analysis of the mechanism of absorption enhancement by palmitoylcarnitine.

J. Hochman, E. LeCluyse, J. Fix, 1994, The Journal of pharmacology and experimental therapeutics.

Identifying qualitative differences in PPARα signaling networks in human and rat hepatocytes and their significance for next generation chemical risk assessment methods.

Melvin E. Andersen, Rebecca A. Clewell, Patrick D. McMullen, 2020, Toxicology in vitro : an international journal published in association with BIBRA.

Dexamethasone differentially regulates expression of carboxylesterase genes in humans and rats.

H. Zhang, He Zhang, L. Song, 2000, Drug metabolism and disposition: the biological fate of chemicals.

Expression and regulation of cytochrome P450 enzymes in primary cultures of human hepatocytes

Kathy Carroll, Andrew Parkinson, Geraldine Hamilton, 2000, Journal of biochemical and molecular toxicology.

Assessing the Hepatic Disposition and Toxicity of Xenobiotics Using Primary Hepatocytes

J. Sahi, Susan Grepper, C. Smith, 2012 .

Regulation of cytochrome P450 2C9 expression in primary cultures of human hepatocytes

J. Sahi, S. Ferguson, C. Lindley, 2009, Journal of biochemical and molecular toxicology.

Modulation of UDP‐glucuronosyltransferase 1A1 in primary human hepatocytes by prototypical inducers

C. Smith, Hongbing Wang, S. Faucette, 2005, Journal of biochemical and molecular toxicology.

Concurrent induction and mechanism-based inactivation of CYP3A4 by an L-valinamide derivative.

R. Dai, L. Gan, Summer L Jolley, 2003, Drug metabolism and disposition: the biological fate of chemicals.

AGI July 40/1

K. Brouwer, P. Meier, B. Stieger, 1999 .

Development of 3 D Dynamic Flow Model of Human Liver and Its Application to Prediction of Metabolic Clearance of 7-Ethoxycoumarin

Russell S. Thomas, M. Andersen, H. Clewell, 2014 .

The Promise of New Technologies to Reduce, Refine, or Replace Animal Use while Reducing Risks of Drug Induced Liver Injury in Pharmaceutical Development.

W. Mattes, F. Sistare, E. LeCluyse, 2016, ILAR journal.

Development of an In Vitro Human Thyroid Microtissue Model for Chemical Screening.

Russell S. Thomas, J. Ford, D. Macmillan, 2019, Toxicological sciences : an official journal of the Society of Toxicology.

Sulfotransferase gene expression in primary cultures of rat hepatocytes.

C. Klaassen, J. Liu, E. LeCluyse, 1996, Biochemical pharmacology.

Predictive Models of Genome-wide Aryl Hydrocarbon Receptor DNA Binding Reveal Tissue Specific Binding Determinants

Suresh Cuddapah, M. Andersen, S. Bhattacharya, 2022, bioRxiv.

Expression and hepatobiliary transport characteristics of the concentrative and equilibrative nucleoside transporters in sandwich-cultured human hepatocytes.

C. Endres, D. Whittington, C. Tse, 2008, American journal of physiology. Gastrointestinal and liver physiology.

Microtubule-associated proteins (MAPs) and the organization of actin filaments in vitro

R. Sattilaro, W. Dentler, E. LeCluyse, 1981, The Journal of cell biology.

Regulation of glutathione S-transferase enzymes in primary cultures of rat hepatocytes maintained under various matrix configurations.

K. Carroll, J. Johnson, A. Parkinson, 2000, Toxicology in vitro : an international journal published in association with BIBRA.

Temporal kinetics and concentration–response relationships for induction of CYP1A, CYP2B, and CYP3A in primary cultures of beagle dog hepatocytes

W. Krol, L. Webster, Liangfu Chen, 2006, Journal of biochemical and molecular toxicology.

P-glycoprotein Expression, Localization, and Function in Sandwich-Cultured Primary Rat and Human Hepatocytes: Relevance to the

K. Brouwer, K. Hoffmaster, R. Kim, 2004 .

Cloning, tissue expression, and regulation of beagle dog CYP4A genes.

W. Krol, R. V. Merrihew, B. Goodwin, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

Evaluation of the contribution of cytochrome P450 3A4 to human liver microsomal bupropion hydroxylation.

C. Lindley, S. Faucette, S. Shord, 2001, Drug metabolism and disposition: the biological fate of chemicals.

Partial Maintenance of Taurocholate Uptake by Adult Rat Hepatocytes Cultured in a Collagen Sandwich Configuration

K. Brouwer, K. Audus, P. Meier, 1998, Pharmaceutical Research.

Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells

W. Cullen, G. Hamilton, W. Reed, 2000, Archives of Toxicology.

Relationship Between Drug Absorption Enhancing Activity and Membrane Perturbing Effects of Acylcarnitines

E. LeCluyse, L. Appel, S. C. Sutton, 2004, Pharmaceutical Research.

Enhanced Bioavailability of Cefoxitin Using Palmitoylcarnitine. II. Use of Directly Compressed Tablet Formulations in the Rat and Dog

E. LeCluyse, K. Engle, J. Fix, 1993, Pharmaceutical Research.

Long-term Engineered Cultures of Primary Mouse Hepatocytes for Strain and Species Comparison Studies During Drug Development.

S. Khetani, B. Ware, V. Soldatow, 2019, Gene expression.

ANTI-INFLUENZA PRODRUG OSELTAMIVIR IS ACTIVATED BY CARBOXYLESTERASE HCE1 AND THE ACTIVATION IS INHIBITED BY ANTI-PLATELET AGENT CLOPIDOGREL

F. Akhlaghi, Jian Yang, B. Yan, 2006 .

The morphology, functionality, and longevity of a novel all human hepatic cell-based tri-culture system.

Jung Bok Lee, Jingsong Chen, M. Taub, 2022, Toxicology in vitro : an international journal published in association with BIBRA.

Tubulin Heterogeneity in the Ciliate, Tetrahymena thermophila

K. Suprenant, E. Hays, W. Dentler, 1986 .

Assessment of a model for measuring drug diffusion through implant-generated fibrous capsule membranes.

E. LeCluyse, J. Fix, R. C. Wood, 1995, Biomaterials.

The Human Sulfotransferase SULT1A1 Gene Is Regulated in a Synergistic Manner by Sp1 and GA Binding Protein

Hongbing Wang, N. Hempel, M. Negishi, 2004, Molecular Pharmacology.

Differential UGT 1 A 1 Induction by Chrysin in Primary Human Hepatocytes and HepG 2 Cells

C. Smith, Hongbing Wang, W. Krol, 2005 .

Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers.

Geraldine A Hamilton, Hongbing Wang, E. Lecluyse, 2004, Drug metabolism and disposition: the biological fate of chemicals.

Metabolism of arsenic in primary cultures of human and rat hepatocytes.

W. Cullen, G. Hamilton, L. D. Del Razo, 1999, Chemical research in toxicology.

Interindividual variation in the metabolism of arsenic in cultured primary human hepatocytes.

S. Waters, M. Stýblo, Z. Drobnâ, 2004, Toxicology and applied pharmacology.

Validation of bupropion hydroxylation as a selective marker of human cytochrome P450 2B6 catalytic activity.

C. Lindley, B. Yan, S. Faucette, 2000, Drug metabolism and disposition: the biological fate of chemicals.

In vitro models for selection of development candidates. Permeability studies to define mechanisms of absorption enhancement

E. LeCluyse, S. C. Sutton, 1997 .

In vitro models for liver toxicity testing.

Ivan Rusyn, Linda G Griffith, I. Rusyn, 2013, Toxicology research.

Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes.

Liang-Shang Gan, Patrick Koch, Andrew Parkinson, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Adam S. Hayward, C. Meyer, S. Dooley, 2013, Archives of Toxicology.

Hepatic stem cells and hepatoblasts: identification, isolation, and ex vivo maintenance.

J. Ludlow, R. McClelland, E. Schmelzer, 2008, Methods in cell biology.

Liver Cell Culture and Lineage Biology

J. Macdonald, L. Reid, H. Kubota, 2002 .

Simultaneous in Vitro Measurement of Intestinal Tissue Permeability and Transepithelial Electrical Resistance (TEER) Using Sweetana–Grass Diffusion Cells

J. Hochman, E. LeCluyse, R. Cargill, 1992, Pharmaceutical Research.

Strategies for restoration and maintenance of normal hepatic structure and function in long-term cultures of rat hepatocytes

Andrew Parkinson, A. Parkinson, P. Bullock, 1996 .

Hemodynamic flow improves rat hepatocyte morphology, function, and metabolic activity in vitro.

T. Pruett, B. Blackman, A. Dash, 2013, American journal of physiology. Cell physiology.

Evaluation of the effect of culture configuration on morphology, survival time, antioxidant status and metabolic capacities of cultured rat hepatocytes.

G. Hamilton, D. Bigot-Lasserre, L. Richert, 2002, Toxicology in vitro : an international journal published in association with BIBRA.

Early Identification of Clinically Relevant Drug Interactions With the Human Bile Salt Export Pump (BSEP/ABCB11)

Christel A. S. Bergström, Per Artursson, Pär Matsson, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro–in vivo correlations

N. Hewitt, S. Ferguson, S S Ferguson, 2007, Xenobiotica; the fate of foreign compounds in biological systems.

Relative Activation of Human Pregnane X Receptor versus Constitutive Androstane Receptor Defines Distinct Classes of CYP2B6 and CYP3A4 Inducers

Hongbing Wang, T. Sueyoshi, M. Negishi, 2007, Journal of Pharmacology and Experimental Therapeutics.

Human Constitutive Androstane Receptor Mediates Induction of CYP2B6 Gene Expression by Phenytoin*

Hongbing Wang, T. Sueyoshi, M. Negishi, 2004, Journal of Biological Chemistry.

A Novel Distal Enhancer Module Regulated by Pregnane X Receptor/Constitutive Androstane Receptor Is Essential for the Maximal Induction of CYP2B6 Gene Expression*

Hongbing Wang, T. Sueyoshi, M. Negishi, 2003, The Journal of Biological Chemistry.

Differential Regulation of Hepatic CYP2B6 and CYP3A4 Genes by Constitutive Androstane Receptor but Not Pregnane X Receptor

C. Smith, Hongbing Wang, T. Sueyoshi, 2006, Journal of Pharmacology and Experimental Therapeutics.

Regulation of cell morphology and cytochrome P450 expression in human hepatocytes by extracellular matrix and cell-cell interactions

G. Hamilton, Summer L Jolley, D. Gilbert, 2001, Cell and Tissue Research.

Isolation and culture of primary human hepatocytes.

G. Hamilton, L. Richert, E. Alexandre, 2005, Methods in molecular biology.

Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing

Melvin E. Andersen, Harvey J. Clewell, Barbara A. Wetmore, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies

Hayley S. Brown, J. Houston, D. Hallifax, 2007, Drug metabolism reviews.

Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation.

E L LeCluyse, E. LeCluyse, 2001, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

A map of the PPARα transcription regulatory network for primary human hepatocytes.

Melvin E Andersen, Rebecca A Clewell, Sudin Bhattacharya, 2014, Chemico-biological interactions.

Development and ciliation of the palate in two frogs, Bombina and Xenopus; a comparative study.

W. Dentler, S. K. Frost, E. LeCluyse, 1985, Tissue & cell.

Asymmetrical microtubule capping structures in frog palate cilia.

W. Dentler, E. LeCluyse, 1984, Journal of ultrastructure research.

Microtubule capping structures at the tips of tracheal cilia: evidence for their firm attachment during ciliary bend formation and the restriction of microtubule sliding.

W. Dentler, E. LeCluyse, E. L. Lecluyse, 1982, Cell motility.

Liver biomarker and in vitro assessment confirm the hepatic origin of aminotransferase elevations lacking histopathological correlate in beagle dogs treated with GABAA receptor antagonist NP260.

P. Watkins, J. Cullen, S. Collins, 2014, Toxicology and applied pharmacology.

CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes.

Sean Kim, Kathy Carroll, Mark Cunningham, 2002, Drug metabolism and disposition: the biological fate of chemicals.

Morphological and Functional Characterization and Assessment of iPSC-Derived Hepatocytes for In Vitro Toxicity Testing.

P. Watkins, Jingtao Lu, E. LeCluyse, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Adam S. Hayward, C. Meyer, S. Dooley, 2013, Archives of Toxicology.

Development of microtubule capping structures in ciliated epithelial cells.

W. Dentler, E. LeCluyse, R. Portman, 1987, Journal of cell science.

Organotypic liver culture models: Meeting current challenges in toxicity testing

Melvin E. Andersen, Mark J. Powers, M. Powers, 2012, Critical reviews in toxicology.

P-glycoprotein Expression, Localization, and Function in Sandwich-Cultured Primary Rat and Human Hepatocytes: Relevance to the Hepatobiliary Disposition of a Model Opioid Peptide

K. Brouwer, K. Hoffmaster, P. Meier, 2004, Pharmaceutical Research.

Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes

L. Lesko, J. Sahi, G. Hamilton, 2000, Xenobiotica; the fate of foreign compounds in biological systems.

Hepatic Progenitors and Strategies for Liver Cell Therapies

D. Gerber, J. Ludlow, K. Bergstrand, 2001, Annals of the New York Academy of Sciences.

Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition.

J. Sahi, Xianxian Zheng, G. Hamilton, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Formation of extensive canalicular networks by rat hepatocytes cultured in collagen-sandwich configuration.

K. Audus, J. Hochman, E. LeCluyse, 1994, The American journal of physiology.

Application of cDNA microarray to the study of arsenic-induced liver diseases in the population of Guizhou, China.

M. Waalkes, J. Liu, M. Cheng, 2001, Toxicological sciences : an official journal of the Society of Toxicology.

Multiple forms of tubulin in the cilia and cytoplasm of Tetrahymena thermophila.

K. Suprenant, E. Hays, W. Dentler, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Cultured rat hepatocytes.

J. Hochman, A. Parkinson, P. Bullock, 1996, Pharmaceutical biotechnology.

In vivo and in vitro induction of human cytochrome P4503A4 by dexamethasone

C. Lindley, J. McCune, E. LeCluyse, 2000, Clinical pharmacology and therapeutics.

Dexamethasone Induction of Cytochrome P450 3A4 Activity in Human Hepatocytes and Healthy Volunteers

C. Lindley, E. LeCluyse, H. Gillenwater, 1999 .

Regeneration and maintenance of bile canalicular networks in collagen-sandwiched hepatocytes.

K. Audus, J. Hochman, E. LeCluyse, 2000, Toxicology in vitro : an international journal published in association with BIBRA.

Co-culture of Hepatocytes and Kupffer Cells as an In Vitro Model of Inflammation and Drug-Induced Hepatotoxicity.

Melvin E Andersen, M. Andersen, A. Green, 2016, Journal of pharmaceutical sciences.

Pregnane X receptor: molecular basis for species differences in CYP3A induction by xenobiotics.

E L LeCluyse, E. LeCluyse, 2001, Chemico-biological interactions.

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution.

L. Moore, T. Willson, S. Kliewer, 2000, Molecular endocrinology.

The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during Evolution

L. Moore, T. Willson, S. Kliewer, 2000 .

Use of Ca2+ modulation to evaluate biliary excretion in sandwich-cultured rat hepatocytes.

R. M. Lightfoot, X Liu, E L LeCluyse, 1999, The Journal of pharmacology and experimental therapeutics.

Correlation of biliary excretion in sandwich-cultured rat hepatocytes and in vivo in rats.

X Liu, J P Chism, E L LeCluyse, 1999, Drug metabolism and disposition: the biological fate of chemicals.

Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice.

Russell S. Thomas, R. Budinsky, J. Rowlands, 2013, Toxicology and applied pharmacology.

Evaluating and Predicting Human Cytochrome P450 Enzyme Induction

S. Ferguson, E. LeCluyse, M. Sinz, 2010 .

Primary human hepatocyte culture for HCV study.

A. Hemming, Chen Liu, E. LeCluyse, 2009, Methods in molecular biology.

Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytes.

Hongbing Wang, T. Sueyoshi, M. Negishi, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Effect of cryopreservation on cytochrome P-450 enzyme induction in cultured rat hepatocytes.

K. Carroll, D. Mudra, A. Parkinson, 1999, Drug metabolism and disposition: the biological fate of chemicals.

Human PXR forms a tryptophan zipper-mediated homodimer.

L. Moore, Hongbing Wang, M. Redinbo, 2006, Biochemistry.

Influence of extracellular matrix overlay and medium formulation on the induction of cytochrome P-450 2B enzymes in primary cultures of rat hepatocytes.

K. Carroll, A. Parkinson, P. Bullock, 1999, Drug metabolism and disposition: the biological fate of chemicals.

Subtoxic Alterations in Hepatocyte-Derived Exosomes: An Early Step in Drug-Induced Liver Injury?

P. Watkins, K. K. Wolf, E. LeCluyse, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

A micropatterned hepatocyte coculture model for assessment of liver toxicity using high-content imaging analysis.

O. J. Trask, E. Lecluyse, A. Moore, 2014, Assay and drug development technologies.

Cross-species comparisons of transcriptomic alterations in human and rat primary hepatocytes exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Michael B. Black, J Craig Rowlands, Robert A Budinsky, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Human CYP2C8 Is Transcriptionally Regulated by the Nuclear Receptors Constitutive Androstane Receptor, Pregnane X Receptor, Glucocorticoid Receptor, and Hepatic Nuclear Factor 4α

J. Goldstein, M. Negishi, S. Ferguson, 2005, Molecular Pharmacology.

Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions

N. Hewitt, I. Maschmeyer, A. Najjar, 2023, Frontiers in Pharmacology.

Differential UGT1A1 Induction by Chrysin in Primary Human Hepatocytes and HepG2 Cells

C. Smith, Hongbing Wang, W. Krol, 2005, Journal of Pharmacology and Experimental Therapeutics.

Evaluation of an in vitro toxicogenetic mouse model for hepatotoxicity.

Ivan Rusyn, Oksana Kosyk, Stephen S Ferguson, 2010, Toxicology and applied pharmacology.

A comprehensive evaluation of metabolic activity and intrinsic clearance in suspensions and monolayer cultures of cryopreserved primary human hepatocytes.

Stephen S Ferguson, J. Sahi, C. Smith, 2012, Journal of pharmaceutical sciences.

Hepatocyte-Derived Exosomes Promote Liver Immune Tolerance: Possible Implications for Idiosyncratic Drug-Induced Liver Injury.

P. Watkins, M. Otieno, Rachel J Church, 2019, Toxicological sciences : an official journal of the Society of Toxicology.

Human and rat primary hepatocyte CYP1A1 and 1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, and 2,3,4,7,8-pentachlorodibenzofuran.

R. Budinsky, S. Ferguson, T. Simon, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

CYP3A induction by N-hydroxyformamide tumor necrosis factor-alpha converting enzyme/matrix metalloproteinase inhibitors use of a pregname X receptor activation assay and primary hepatocyte culture for assessing induction potential in humans.

J. Lehmann, L. Moore, S. Kliewer, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site.

J. Goldstein, M. Negishi, S. Ferguson, 2002, Molecular pharmacology.

Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening.

Robert J Kavlock, Harvey J Clewell, Melvin E Andersen, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

The evolving microenvironment of the human hepatocyte: Healthy vs. cirrhotic liver vs. isolated cells.

J. Tolar, J. Kim, T. Pruett, 2020, Tissue & Cell.

Isolation and culture of primary hepatocytes from resected human liver tissue.

E. Alexandre, Edward L Lecluyse, Eliane Alexandre, 2010, Methods in molecular biology.

Dose-response in a high density three-dimensional liver device with real-time bioenergetic and metabolic flux quantification.

P. Watkins, N. Bhattarai, S. Siler, 2017, Toxicology in vitro : an international journal published in association with BIBRA.

Characteristics of Mg2+-dependent, ATP-activated Ca2+ transport in synaptic and microsomal membranes and in permeabilized synaptosomes.

M. Michaelis, E. Michaelis, E. LeCluyse, 1987, The Journal of biological chemistry.

Optimization of culture conditions for determining hepatobiliary disposition of taurocholate in sandwich-cultured rat hepatocytes

K. Brouwer, E. LeCluyse, Priyamvada Chandra, 2001, In Vitro Cellular & Developmental Biology - Animal.

Reprogramming of Human Hepatic Non‐Parenchymal Cells: Step‐by‐Step Protocol

J. Tolar, T. Pruett, V. Kirchner, 2020 .

miR-122 Release in Exosomes Precedes Overt Tolvaptan-Induced Necrosis in a Primary Human Hepatocyte Micropatterned Coculture Model

P. Watkins, O. J. Trask, W. J. Brock, 2018, Toxicological sciences : an official journal of the Society of Toxicology.

Xenobiotic-Metabolizing Enzyme and Transporter Gene Expression in Primary Cultures of Human Hepatocytes Modulated by Toxcast Chemicals

David M. Reif, Richard S Judson, Andrew L Beam, 2010, Journal of toxicology and environmental health. Part B, Critical reviews.

Kupffer cell-mediated IL-2 suppression of CYP3A activity in human hepatocytes.

A. Kashuba, Angela D M Kashuba, Edward L LeCluyse, 2004, Drug metabolism and disposition: the biological fate of chemicals.

Correlation of glutamate binding activity with glutamate-binding protein immunoreactivity in the brain of control and alcohol-treated rats

M. Michaelis, E. Michaelis, E. LeCluyse, 1987, Neurochemistry International.

Advancing nonclinical innovation and safety in pharmaceutical testing.

E. Berg, J. G. Kenna, P. Watkins, 2019, Drug discovery today.

Role of Orphan Nuclear Receptors in the Regulation of Drug-Metabolising Enzymes

Hongbing Wang, Hongbing Wang, E. LeCluyse, 2003, Clinical pharmacokinetics.

Long‐Term Stability of Primary Rat Hepatocytes in Micropatterned Cocultures

Melvin E Andersen, Chitra Kanchagar, Salman R Khetani, 2013, Journal of biochemical and molecular toxicology.

Induction of drug metabolizing enzymes: a survey of in vitro methodologies and interpretations used in the pharmaceutical industry--do they comply with FDA recommendations?

Nicola J Hewitt, R. de Kanter, N. Hewitt, 2007, Chemico-biological interactions.

Bioactivation and Toxicity of Acetaminophen in a Rat Hepatocyte Micropatterned Coculture System

M. Andersen, S. Khetani, E. LeCluyse, 2013, Journal of biochemical and molecular toxicology.

Hepatocyte size fractionation allows dissection of human liver zonation

P. Artursson, A. Mateus, C. Wegler, 2021, Journal of cellular physiology.

Editor's Highlight: Modeling Compound-Induced Fibrogenesis In Vitro Using Three-Dimensional Bioprinted Human Liver Tissues.

D. Gerber, E. Lecluyse, S. Presnell, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

A comprehensive evaluation of metabolic activity and intrinsic clearance in suspensions and monolayer cultures of cryopreserved primary human hepatocytes.

J. Sahi, C. Smith, S. Ferguson, 2012, Journal of pharmaceutical sciences.

Human and rat primary hepatocyte CYP1A1 and 1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, and 2,3,4,7,8-pentachlorodibenzofuran.

R. Budinsky, T. Simon, J. Rowlands, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Dose-response in a high density three-dimensional liver device with real-time bioenergetic and metabolic flux quantification.

P. Watkins, J. McDunn, N. Bhattarai, 2017, Toxicology in vitro : an international journal published in association with BIBRA.

EFFECTS OF AVASIMIBE ON CYTOCHROME P450 2C9 EXPRESSION IN VITRO AND IN VIVO

J. Sahi, M. Milad, Xianxian Zheng, 2004, Drug Metabolism and Disposition.

Selenium compounds modulate the activity of recombinant rat AsIII-methyltransferase and the methylation of arsenite by rat and human hepatocytes.

S. Waters, M. Stýblo, Summer L Jolley, 2003, Chemical research in toxicology.